VivoSeq
Metabolic & Endocrine

Adrenal Insufficiency

17

Pipeline Programs↗

4

Active Trials↗

7

Companies Involved↗

Adrenal insufficiency is an emerging landscape with 17 programs across 7 companies. The most active players are Danco, Takeda, Inflabloc Pharmaceuticals. 3 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

45/100

Pipeline Velocity

0/100

Mech. Concentration

60/100

Completion Rate

76/100

Attrition Rate

17/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

D

Danco

1 program

Phase 2Takeda logo

Takeda

2 programs

Phase 3I

Inflabloc Pharmaceuticals

1 program

Phase 3Eli Lilly logo

Eli Lilly

1 program

ApprovedP

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

2 programs

ApprovedNovartis logo

Novartis

2 programs

Preclinical

Pipeline

Programs by Phase

Preclinical4

Megestrol Acetate

Bristol-Myers Squibb

Glucocorticoids

Novartis

Cosyntropin

Novartis

Ovine Corticotropin-Releasing Hormone (ocrh)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Phase 1
No programs
Phase 24

Mifepristone

Danco

Chronocort

Neurocrine UK Limited

Hydrocortisone Intramuscular First

Bruno Allolio

Plenadren

University of Roma La Sapienza

Phase 36

Infacort

Neurocrine UK Limited

Prednisolone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Dehydroepiandrosterone

Inflabloc Pharmaceuticals

Dual-Release Hydrocortisone

University of Palermo

Conventional Glucocortidois

University of Palermo

Approved3

Prednisone

Roxane Laboratories

Hydrocortisone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Fludrocortisone 0.1 Milligrams (mg)

Ganin Fertility Center

Analysis

Trial Status

24

clinical trials

Completed13 · 54%
Recruiting3 · 13%
Unknown status3 · 13%
Terminated3 · 13%
Not yet recruiting1 · 4%
Withdrawn1 · 4%

Clinical Trials

Trial Activity

24 trials

Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
Recruiting·—·Phase 4·NCT05435781·250 enrolled
Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment
Recruiting·—·Phase 4·NCT05193396·100 enrolled
Evaluation of Children With Endocrine and Metabolic-Related Conditions
Recruiting·Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·N/A·NCT02769975·15,000 enrolled
Ramadan Fasting Outcomes in Patients With Secondary Adrenal Insufficiency Before and After the Treatment of Hypotension.
Not yet recruiting·HHopital La Rabta·Phase 4·NCT06832566·20 enrolled
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency
Completed·—·Phase 2·NCT01450930·12 enrolled
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
Completed·Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·N/A·NCT00001180·2,250 enrolled
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT)
Completed·UUniversity Medical Center Groningen·Phase 4·NCT01546922·63 enrolled
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT00975078·39 enrolled
Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency
Completed·UUniversity Hospital Tuebingen·Phase 3·NCT00575341·23 enrolled
Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis
Completed·UUniversity of Virginia·N/A·NCT04642391·76 enrolled
Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency
Completed·UUniversity of Palermo·Phase 3·NCT06260462·88 enrolled
Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?
Completed·UUniversity of Virginia·Phase 3·NCT03368066·100 enrolled
Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency
Completed·NNeurocrine UK Limited·Phase 2·NCT05222152·58 enrolled
Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency
Completed·Takeda logoTakeda·Phase 2/3·NCT00915343·64 enrolled
Treatment of Adrenal Insufficiency in Children
Completed·NNeurocrine UK Limited·Phase 3·NCT02720952·24 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)