VivoSeq
Other

Amputation

33

Pipeline Programs↗

17

Active Trials↗

15

Companies Involved↗

Amputation is a moderately active landscape with 33 programs across 15 companies. The most active players are Revance Therapeutics, Inc., AbbVie, TLC Biopharmaceuticals, Inc.. 9 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

56/100

Pipeline Velocity

30/100

Mech. Concentration

15/100

Completion Rate

63/100

Attrition Rate

18/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

R

Revance Therapeutics, Inc.

1 program

Phase 1AbbVie logo

AbbVie

1 program

Phase 2T

TLC Biopharmaceuticals, Inc.

1 program

ApprovedPfizer logo

Pfizer

1 program

ApprovedD

Dexcel Pharma Technologies Ltd.

1 program

ApprovedSanofi logo

Sanofi

2 programs

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

95%

Small molecule

40 of 42 classified programs — the dominant modality here.

5%ALL OTHERSMonoclonal antibody12%Cell therapy12%

Small molecule leads; the ring shows all 42 classified programs, each share of the total. Modality classified for 100% of 43 pipeline programs.

Analysis

Trial Status

50

clinical trials

Completed15 · 30%
Recruiting12 · 24%
Unknown status9 · 18%
Terminated8 · 16%
Not yet recruiting3 · 6%
Active, not recruiting2 · 4%
Other1 · 2%

Clinical Trials

Trial Activity

50 trials

Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
Recruiting·National Cancer Institute, Egypt·N/A·NCT07276867·58 enrolled
Experimental Study to Investigate Sensory Control of the Upper Limb Through Microneurography and to Restore Near-natural Tactile Sensations Through Intraneural Microstimulation in Healthy and Amputee Subjects
Recruiting·AAzienda Ospedaliero, Universitaria Pisana·Preclinical·NCT07691957·100 enrolled
A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception
Recruiting·BBrigham and Women's Hospital·Preclinical·NCT03882073·20 enrolled
A Novel Approach to Lower Extremity Residual Limb Revision to Augment Volitional Motor Control, Restore Proprioception and Reverse Limb Atrophy
Recruiting·BBrigham and Women's Hospital·Preclinical·NCT04063592·26 enrolled
Adaptive Mobility Technology: A Comparative Study of C-Leg and Bio Leg
Recruiting·UUniversity of Florida·Preclinical·NCT07613502·12 enrolled
Toward Restoration of Normative Postural Control and Stability Using Neural Control of Powered Prosthetic Ankles
Recruiting·North Carolina State University·Preclinical·NCT06452186·50 enrolled
The Relationship Between Lost Extremity Percentage and Postural Control, Neck and Low Back Pain, Daily Living Activities, and Reaction Time in Individuals With Unilateral Upper Limb Amputation
Recruiting·HHacettepe University·N/A·NCT07677969·15 enrolled
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)
Recruiting·AAtriCure, Inc.·N/A·NCT06908538·2,000 enrolled
Using Sensorimotor Reorganization Following Upper Limb Amputation to Improve Prosthetic Control
Recruiting·UUnion de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est·Preclinical·NCT07666204·50 enrolled
Identification of Limiting Factors in the Locomotor Activity of Individuals With Lower Limb Amputation: Biomechanical, Physiological, Psychological.
Recruiting·CCentre Hospitalier Universitaire de Nīmes·N/A·NCT06415955·200 enrolled
Clinical Evaluation of System for Bionic Arm Gesture Control (CYBORG)
Recruiting·PPhantom Neuro Inc.·Preclinical·NCT07325708·10 enrolled
Prosthetic Performance Enhancement Trial
Recruiting·UUniversity of Nevada, Las Vegas·Preclinical·NCT06419920·35 enrolled
Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Active, not recruiting·UUniversity of California, San Diego·Phase 4·NCT03461120·203 enrolled
A Feasibility Study Evaluating the Magnetic Bead Tracking System and Its Safety and Efficacy When Used With the e-OPRA Implant System and a Bionic External Prosthesis to Improve Prosthetic Controllability for Persons With Transtibial Amputation
Active, not recruiting·BBrigham and Women's Hospital·Preclinical·NCT06391697·7 enrolled
Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT
Not yet recruiting·SStanford University·N/A·NCT06964347·62 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)