OxyContin
(Oxycodone)ApprovedSmall molecule
Oxycodone is a strong painkiller used to treat moderate to severe pain, such as pain from cancer, surgery, or serious injuries. It works by changing how the brain responds to pain signals.[2] OxyContin is currently approved and in use across 68 indications[4].[1]
OxyContin is one of 1132 small molecule programs targeting Total Joint Arthroplasty. It is currently in Approved.
68
Indications
240
Total Trials
26
Active Trials
1,131
Competitors
9
FDA Applications
NDA/BLA/ANDA regulatory filings
19
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 63 indications
Competition
Competitive Landscape
1399 competitors in Prostate Cancer
#DrugCompanyPhaseTrials
1OxyContin
PProtega
Approved
Novantrone
PfizerPreclinical
Mekinist
NovartisPreclinical
Trexall
Alnylam PharmaceuticalsPreclinical
Jatenzo
GGrupo Espanol de Tumores Neuroendocrinos
Preclinical
Viagra
VViatris Specialty LLC
Preclinical
Prednisone/prednisolone
RochePreclinical
Ifex
BBaxter Healthcare Corporation
Preclinical
Osmitrol
BB. Braun Medical Inc.
Preclinical
Xylocaine
MMEDRx USA, Inc.
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Oxycodone14 trials
Show 11 more trials
Cancer Pain8 trials
Post Operative Pain8 trials
Show 5 more trials
Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
Unknown status·—·Phase 4·NCT03105518·100 enrolled
Pain Management6 trials
Hysterectomy5 trials
108 more indications
Pain Control5 trials
Abuse Potential5 trials
Analgesic5 trials
Opioids4 trials
Reducing the Abuse Liability of Prescription Opioids
Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT04587115·15 enrolled
Show 1 more trial
Osteoarthritis4 trials
Total Knee Arthroplasty4 trials
Postoperative Analgesia3 trials
Interaction3 trials
Low back pain3 trials
Tonsillectomy3 trials
Non-opioids for Analgesia After Adenotonsillectomy in Children
Terminated·—·Phase 1/2·NCT03618823·268 enrolled
Celecoxib After Tonsillectomy
Completed·—·Phase 2·NCT02934191·172 enrolled
Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy
Terminated·—·Phase 1/2·NCT04791761·73 enrolled
Buprenorphine3 trials
Pregabalin3 trials
After Cardiac Surgery2 trials
Pain Management After Cardiac Surgery - Opioids or NSAID
Completed·—·Phase 4·NCT02479165·182 enrolled
ACL Reconstruction2 trials
Nausea and vomiting2 trials
Chronic pain2 trials
Cesarean Delivery2 trials
Effectiveness2 trials
Intravenous2 trials
Impairment2 trials
Dexmedetomidine2 trials
Fed2 trials
Visceral Pain2 trials
Postoperative Pain Control2 trials
Multimodal Analgesia2 trials
Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery
Completed·—·Phase 4·NCT04110665·92 enrolled
Analgesic Efficacy2 trials
Opioid2 trials
Gastrointestinal1 trial
Postoperative Pain Management1 trial
Personalized Post-Operative Pain Management
Active, not recruiting·UUniversity of Tennessee Graduate School of Medicine·Phase 4·NCT06669650·208 enrolled
Total Hip Replacement1 trial
Abortion1 trial
ESS1 trial
Short Title: Standard vs. Lower Pressure Pneumoperitoneum
Recruiting·—·N/A·NCT06338865·294 enrolled
Adverse Effect1 trial
Total Joint Arthroplasty1 trial
Head and Neck Cancer1 trial
Colorectal Surgery1 trial
Clinical Trial1 trial
Experimental1 trial
Radius Fracture1 trial
Spinal Cord Injury1 trial
Sleep Apnea1 trial
Impact of Tramadol and Oxycodone on Sleep Apnea
Completed·—·Phase 4·NCT03454217·60 enrolled
Third Molar1 trial
Surgical1 trial
Obesity1 trial
Infants1 trial
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
Recruiting·—··NCT03511118·1,600 enrolled
Opioid Misuse1 trial
Abdominal Cancer Surgery1 trial
Total Hip Arthroplasty1 trial
Withdrawal1 trial
Pediatric1 trial
Arterial Occlusive Disease1 trial
Magnesium Oral Supplementation to Reduce Pain Inpatients With Severe Peripheral Arterial Occlusive Disease
Unknown status·AAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia·N/A·NCT02455726·150 enrolled
Analgesia1 trial
Sedation1 trial
Adolescent1 trial
Epidural Analgesia1 trial
Postoperative Pain Relief1 trial
Bronchoscopy1 trial
Emergency Department Patient1 trial
Laceration1 trial
The Addition of Oral Analgesics to LET During Laceration Repair
Suspended·—·N/A·NCT01268670·150 enrolled
Liposomal Bupivacaine1 trial
Oral Mucositis1 trial
Mucositis1 trial
Early Use of Opioid in Radiation Mucositis
Completed·—·Phase 2·NCT02309437·200 enrolled
Knee Replacement Surgery1 trial
Craniotomy1 trial
Tics1 trial
Chronic Kidney Disease1 trial
Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis
Unknown status·EEmerio & Lourdes Linares Research and Education Center·Phase 4·NCT02452437·20 enrolled
Nausea1 trial
Hip Fracture1 trial
Patient Satisfaction1 trial
Perioperative Analgesia1 trial
Ankle Surgery1 trial
Inflammatory Response1 trial
The Effects of Oxycodone Versus Sufentanil on Pain and Inflammatory Response After TACE
Completed·TThe First Affiliated Hospital with Nanjing Medical University·Phase 4·NCT06041425·40 enrolled
Opioid Use1 trial
Postherpetic Neuralgia1 trial
Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia
Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·N/A·NCT03120962·140 enrolled
Multimodal Pain Management1 trial
Prostate Cancer1 trial
Inguinal hernia1 trial
Opioid Abuse1 trial
Unspecified3 trials
Tapentadol (CG5503)
Completed·
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 3·NCT00421928·1,030 enrolled
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 3·NCT00421928·1,030 enrolledRegulatory
FDA Approval Timeline[5]
Oct 26, 1998
ROXICODONE
NDA NDA020932
May 15, 2009
ROXICODONE
NDA NDA021011
Apr 5, 2010
OXYCONTIN
NDA NDA022272
Oct 20, 2010
OXYCODONE HYDROCHLORIDE
NDA NDA200534
Jun 17, 2011
OXAYDO
NDA NDA202080
Jan 12, 2012
OXYCODONE HYDROCHLORIDE
NDA NDA201194
Aug 22, 2013
OXYCODONE HYDROCHLORIDE
NDA NDA200535
Apr 26, 2016
XTAMPZA ER
NDA NDA208090
Apr 20, 2017
ROXYBOND
NDA NDA209777
Sources
References
- [1]
- [2]MedlinePlus Drug Information — OxyContin drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Oxycodone. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
- [7]