Marcaine

(Bupivacaine)

ApprovedSmall molecule

Bupivacaine is a local anesthetic used to numb specific areas of the body during medical procedures or surgery, and can also be used to relieve pain after surgery or for chronic pain conditions.[2] Marcaine is currently approved and in use across 123 indications[4].[1]

Marcaine is one of 1081 small molecule programs targeting Hysterectomy. It is currently in Approved.

123

Indications

630

Total Trials

Active Trials

1,080

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

HysterectomyCompleted

Total Knee ArthroplastyCompleted

Hip FractureWithdrawn

Liposomal BupivacaineUnknown status

Interscalene BlockRecruiting

Complex Regional Pain SyndromesActive, not recruiting

Erector Spinae Plane BlockTerminated

NeurotoxicityActive, not recruiting

MigraineActive, not recruiting

NeuralgiaActive, not recruiting

HysterectomyApproved

Completed

Total Knee ArthroplastyApproved

Completed

Hip FractureApproved

Withdrawn

Liposomal BupivacaineApproved

Unknown status

Interscalene BlockApproved

Recruiting

Complex Regional Pain SyndromesPhase 2

Active, not recruiting

Erector Spinae Plane BlockPhase 3

Terminated

NeurotoxicityApproved

Active, not recruiting

MigraineApproved

Active, not recruiting

NeuralgiaApproved

Active, not recruiting

Showing 10 of 118 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Marcaine

IInnocoll

Approved

3 2

Zolymbus

AbbVie

Preclinical

1 3

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 4

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 5

Spravato

WWim Janssens

Preclinical

2 6

Acupan

YYonsei University

Preclinical

1 7

Nubain

AAultman Health Foundation

Preclinical

1 8

Vfend

PPrism Pharmaceuticals

Rilvegostomig

1 10

Paracetamol

GSK

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Post-ApprovalRecruiting

Interscalene Block

NCT06143306

Phase 3Not yet recruiting

Hypospadias

NCT06789393

Post-ApprovalRecruiting

Spine Fusion

NCT05996133

Q3 2027

Phase 1Active, not recruiting

Analgesia

NCT04126824

Q3 2029

Post-ApprovalRecruiting

Extremity

NCT07221019

Q4 2029

Phase 2Recruiting

Bupivacaine

NCT06635889

Clinical

Trials by Indication[1]

Bupivacaine11 trials

Comparative Mixture of Non-racemic and Racemic Enantiomers of Bupivacaine in Cesarean

Withdrawn·CCristália Produtos Químicos Farmacêuticos Ltda.·Phase 3·NCT01303107

Use of Continuous Wound Infusion of Bupivacaine for Analgesia Following Axillary Clearance Surgery

Unknown status·—·Phase 3·NCT01314144·42 enrolled

Ropivacaine Versus Bupivacaine for Spinal Anaesthesia in Patients Undergoing Unilateral Lower Limb Surgery

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00358280·220 enrolled

Show 8 more trials

Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE

Terminated·WWake Forest University·Phase 4·NCT01005459·46 enrolled

Effect of Bupivacaine Application on Postthyroidectomy Pain

Completed·IIstanbul University·N/A·NCT02981095·91 enrolled

Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia

Completed·GGovernment Medical College, Haldwani·N/A·NCT02513433·90 enrolled

Continuous Subacromial Bupivacaine

Completed·TTurku University Hospital·N/A·NCT01377415·90 enrolled

Single Dose Pharmacokinetics and Pharmacodynamics of Bupivacaine Following Transversus Abdominis Plane (TAP) Block in Neonates

Completed·—··NCT01557985·10 enrolled

Comparing Heavy Levobupivacaine With Enantiomeric Excess of 50% and Heavy Racemic Bupivacaine.

Withdrawn·CCristália Produtos Químicos Farmacêuticos Ltda.·Phase 3·NCT01308047

Bupivacaine Versus Lidocaine on Inflammatory Regulation

Completed·—·Phase 4·NCT01060774·11 enrolled

Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain

Recruiting·UUniversity of Chicago·Phase 2·NCT06635889·116 enrolled

Cesarean Section9 trials

Management of Postoperative Pain With Preemptive Analgesia in Cesarean Section

Unknown status·MMark Kosanovich·N/A·NCT02879435·120 enrolled

Intrathecal Nalbuphine Versus Midazolam in Cesarean Section

Completed·ZZagazig University·Phase 1·NCT03918187·90 enrolled

Subarachnoid Block With Ultrasound-Guided Transversalis Fascia Plane Block for Cesarean Section

Completed·—·Phase 4·NCT04172727·60 enrolled

Show 6 more trials

Comparing the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section

Completed·SSouth Valley University·N/A·NCT06290583·120 enrolled

Comparison of Standard and Minidose Spinal Anesthesia for Cesarean Section Operation Using Marcaine Spinal 0.5% Heavy

Unknown status·—·Phase 4·NCT01303731·100 enrolled

Low-Doses Of Isobaric Bupivacaine On Intraoperative Hemodynamics In Spinal Anesthesia During Cesarean Section

Completed·—·N/A·NCT05136040·80 enrolled

Role of Dexamethasone in Transversus Abdominis Plane Block After Cesarean Section

Completed·—·N/A·NCT03767920·120 enrolled

Preventive Intramuscular Phenylephrine in Elective Cesarean Section Under Spinal Anesthesia

Completed·XXuzhou Medical University·N/A·NCT03507387·99 enrolled

Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia

Not yet recruiting·MMansoura University·N/A·NCT05785377·58 enrolled

Dexmedetomidine8 trials

Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity

Unknown status·—·Phase 1/2·NCT03024957·30 enrolled

Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Completed·—·Phase 4·NCT03164590·60 enrolled

Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block

Completed·TTC Erciyes University·Phase 4·NCT02064530·90 enrolled

Show 5 more trials

Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block

Completed·—·Phase 2/3·NCT03328299·24 enrolled

Dexmedetomidine as an Additive for (Ipack)Block in Knee Surgery

Completed·—·N/A·NCT07058493·40 enrolled

Dexmedetomidine Versus Fentanyl as Adjuvants to Bupivacaine in Ultrasound Guided Transversus Abdominis Plane Block

Unknown status·—·N/A·NCT04318158·60 enrolled

Dexmedetomidine vs Ketamine as Adjuvants to Bupivacaine in Transversus Abdominus Plane Block in Inguinal Hernioplasty

Completed·—·Phase 3·NCT07194694·60 enrolled

Comparing the Hemodynamic Effects of Epinephrine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Caudal Anaesthesia Assessed by Cardiometry

Unknown status·KKasr El Aini Hospital·N/A·NCT05860010·39 enrolled

Post Operative Pain7 trials

A Study of Epidural Bupivacain-soaked Absorbable Gelatin Sponge on Post-operative Pain in Lumbar Laminectomy

Withdrawn·TThe Cleveland Clinic·N/A·NCT01847339

The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery

Completed·—·Phase 4·NCT02052557·51 enrolled

The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Posterior Fossa Surgery

Completed·IIstanbul University·Phase 2·NCT02852382·45 enrolled

Show 4 more trials

Effect of Intrathecal vs Intraarticular Dexmedetomidine on Postoperative Pain Following Arthroscopy

Completed·—·N/A·NCT02581566·90 enrolled

Decreasing Postoperative Pain Following Endometrial Ablation

Completed·CChristiana Care Health Services·N/A·NCT02660918·84 enrolled

Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy

Completed·KKarolinska Institutet·Phase 3·NCT03639389·211 enrolled

Bupivacaine for Post-operative Pain in Mohs

Completed·UUniversity of Missouri-Columbia·Phase 4·NCT04362566·174 enrolled

Liposomal Bupivacaine7 trials

Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair

Completed·UUniversity of Minnesota·Phase 4·NCT03587584·80 enrolled

Liposomal Bupivacaine for Pain Control Following Thoracic Surgery.

Unknown status·MMassachusetts General Hospital·Phase 2/3·NCT03036085·200 enrolled

The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery

Completed·UUniversity of California, San Francisco·Phase 4·NCT03196505·231 enrolled

Show 4 more trials

Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures

Terminated·UUniversity of California, Irvine·Phase 3·NCT04849858·13 enrolled

Liposomal Bupivacaine vs Bupivacaine for Pain Control After Sternotomy

Unknown status·UUniversity of Kansas Medical Center·Phase 1·NCT04585867·80 enrolled

Subcostal TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Donor Nephrectomy Patients: A Prospective Study

Completed·UUniversity of Minnesota·Phase 4·NCT02287623·60 enrolled

Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery

Completed·—·Phase 4·NCT02222129·206 enrolled

106 more indications

Erector Spinae Plane Block6 trials

Erector Spinae Plane Block Versus Thoracic Epidural Block for Chest Trauma

Completed·SSameh Fathy·N/A·NCT03797079·50 enrolled

Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia

Recruiting·—·N/A·NCT07139522·150 enrolled

Inter-semispinal Fascial Plane Block (ISPB) Versus Erector Spinae Plane Block (ESPB) in Posterior Cervical Spine Surgery

Active, not recruiting·FFayoum University·Phase 4·NCT07340801·102 enrolled

Show 3 more trials

Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Thoracotomy

Completed·—·N/A·NCT04221880·60 enrolled

Erector Spinae Plane Block Versus Serratus Plane Block for Breast Surgery

Completed·—·N/A·NCT03538483·60 enrolled

Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery

Completed·HHospital for Special Surgery, New York·Phase 4·NCT04156581·46 enrolled

Dexamethasone6 trials

Effect of Dexamethasone Added To Bupivacaine During Caudal Block

Unknown status·LLagos State University·Phase 2·NCT02496299·96 enrolled

REDUCE Trial: Perineural Dexamethasone on Scalp Nerve Blocks

Completed·—·N/A·NCT04648358·156 enrolled

Dexamethasone & Ketamine as Adjuvants to Bupivacaine for Incisional Infiltration in Pediatric Abdominal Operations

Completed·—·N/A·NCT05190952·150 enrolled

Show 3 more trials

Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone

Terminated·TThe Cleveland Clinic·N/A·NCT00519584·218 enrolled

Comparison of the Effects of Dexamethasone and magnesıum Sulphate Used as Adjuvant in Infraclavicular Nerve Block.

Completed·YYuzuncu Yil University·N/A·NCT06085417·90 enrolled

The Effect of Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine or Bupivacaine

Terminated·TThe Cleveland Clinic·N/A·NCT00801138·218 enrolled

Laparoscopic Cholecystectomy5 trials

Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy

Completed·—·N/A·NCT04609033·110 enrolled

Analgesic Efficacy of Bupivacaine Infiltration, Erector Spinae Plane Block, and Intrathecal Morphine in Laparoscopic Cholecystectomy

Not yet recruiting·—·N/A·NCT07203794·132 enrolled

Dexmedetomidine in Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy

Completed·IImam Abdulrahman Bin Faisal University·Phase 1/2·NCT02031510·195 enrolled

Show 2 more trials

Oblique Subcostal Tap Block Efficacy in Laparoscopic Cholecystectomy

Unknown status·IIuliu Hatieganu University of Medicine and Pharmacy·Phase 2/3·NCT02707250·120 enrolled

Intraperitoneal Ketamine Versus Bupivacaine for Postoperative Pain Control After Laparoscopic Cholecystectomy

Completed·LLiaquat National Hospital & Medical College·Phase 1·NCT06807554·92 enrolled

Total Knee Arthroplasty5 trials

Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

Completed·HHenry Ford Health System·Phase 4·NCT02980926·32 enrolled

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02713490·140 enrolled

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Completed·—·Phase 4·NCT00562627·102 enrolled

Show 2 more trials

Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty

Completed·—·Phase 4·NCT02777749·155 enrolled

Efficacy of Single Injection Femoral Nerve Block With Liposomal Bupivacaine for Total Knee Arthroplasty

Withdrawn·SSt. Luke's-Roosevelt Hospital Center·Phase 4·NCT01977339

Nerve Block4 trials

Clonidine for Infra-orbital Nerve Block During Pediatric Cleft Lip Revision Surgeries

Unknown status·—·N/A·NCT05790044·86 enrolled

A Study Comparing Continuous Sciatic Nerve Block to Single Shot Sciatic Nerve Block

Terminated·NNorthwestern University·Phase 4·NCT01615939·17 enrolled

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

Completed·CCarilion Clinic·Phase 4·NCT05482113·17 enrolled

Show 1 more trial

Comparison of the Efficacy of Pericapsular Nerve Group Block Alone Versus Pericapsular Nerve Group Block Combined With Superior Cluneal and Superior Gluteal Nerve Blocks in Patients Undergoing Hip Surgery

Enrolling by invitation·—·N/A·NCT07255768·60 enrolled

Hysterectomy4 trials

TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Robotic Hysterectomy

Completed·UUniversity of Minnesota·Phase 4·NCT02289079·60 enrolled

The Effect of Pre-sacral Nerve Block on Immediate Post-operative Pain Following Laparoscopic Hysterectomy.

Unknown status·MMount Sinai Hospital, Canada·Phase 4·NCT03646006·60 enrolled

TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy

Unknown status·—·Phase 2/3·NCT02930707·60 enrolled

Show 1 more trial

Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.

Completed·UUniversity of Tennessee·Phase 3·NCT03027661·41 enrolled

Postoperative Analgesia4 trials

Use of Exparel for Postoperative Analgesia Following Bariatric Surgery

Unknown status·MMcMaster University·Phase 4·NCT03975283·80 enrolled

Comparison Between Bupivacaine and Bupivacaine- Dexamethasone QLB for Postoperative Analgesia

Completed·—·Phase 1·NCT05918796·60 enrolled

Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery.

Completed·—·Phase 2/3·NCT02514980·30 enrolled

Show 1 more trial

Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH Surgery

Not yet recruiting·—·N/A·NCT07385352·54 enrolled

Analgesic Efficacy3 trials

The Analgesic Efficacy of Two Bupivacaine Concentrations for Combined Ilioinguinal and Iliohypogastric Nerve Block in Postherniorrhaphy Pain

Unknown status·TTanta University·Phase 1·NCT05687981·90 enrolled

Analgesic Efficacy of Fascia Iliaca Compartment Block

Unknown status·SSamaa Rashwan·Phase 1·NCT03957499·60 enrolled

Evaluating the Analgesic Efficacy of Combined Individual Nerve Block in Comparison to Interscalene Nerve Block

Completed·—·N/A·NCT04709250·128 enrolled

Analgesia3 trials

Effect of Addition of Steroids on Duration of Analgesia

Active, not recruiting·UUniversity of California, Los Angeles·Phase 1·NCT04126824·28 enrolled

SPI-directed Analgesia for Lumbar Discectomy

Completed·MMedical University of Silesia·N/A·NCT02971540·132 enrolled

Serratus Posterior Superior Intercostal Plane Block for Analgesia in Off-Pump Minimally Invasive CABG

Recruiting·—·N/A·NCT07412522·60 enrolled

Postoperative Pain Control3 trials

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

Withdrawn·RRush University Medical Center·Phase 4·NCT03119038

Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally

Unknown status·SSohag University·Phase 2·NCT05186454·60 enrolled

TAP Block for Postoperative Pain Control

Terminated·JJoshua Herskovic·Phase 3·NCT02652156·14 enrolled

Spinal Anesthesia3 trials

Phase III, Evaluate Noninferiority Between Levobupivacaine and Bupivacaine in Spinal Anesthesia.

Withdrawn·CCristália Produtos Químicos Farmacêuticos Ltda.·Phase 3·NCT01994967

Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl

Completed·—·Phase 4·NCT01880775·50 enrolled

Local Anesthetic Infiltration VS Trasversalis Fascia Block VS Spinal Anesthesia

Unknown status·IIstituti Ospitalieri di Cremona·N/A·NCT03128216·48 enrolled

Hernia3 trials

Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

Completed·TThe Cleveland Clinic·Phase 4·NCT03541941·164 enrolled

Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs

Active, not recruiting·LLeslie Son·Phase 1·NCT05177991·200 enrolled

Study to Evaluate Reduction in Pain After Laparoscopic Hernia Repair With Mesh Soaked in Bupivacaine Solution

Unknown status·—·N/A·NCT03035617·100 enrolled

Quadratus Lumborum Block3 trials

Post-operative Analgesia Efficacy Using Ultrasound-guided Transmuscular Quadratus Lumborum Block Versus Ultrasound-guided Quadratus Lumborum Type II Block.

Unknown status·TTri-Service General Hospital·Phase 4·NCT03100994·180 enrolled

Analgesic Efficacy of Ultrasound Guided Quadratus Lumborum Block During ESWL

Completed·—·Phase 4·NCT03080363·40 enrolled

Dexmedetomidine Added to Bupivacaine Versus Bupivacaine inTransincisionalU/S Guided Quadratus Lumborum Block in Open Renal Surgeries , A New Technique

Completed·—·Phase 4·NCT03869047·80 enrolled

Laparoscopic3 trials

Does Bupivacaine in Laparoscopic Portals Reduce Post Surgery Pain in Tubal Ligation by Electrocoagulation?

Unknown status·HHospital de Clinicas de Porto Alegre·N/A·NCT00810563·46 enrolled

Unilateral TAP Block for Laparoscopic Gastric Sleeve Surgery

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT03856788·43 enrolled

Laparoscopic Assisted Plane Block (LAPB) Trial

Terminated·SSanta Barbara Cottage Hospital·Phase 4·NCT03730402·34 enrolled

Epidural Analgesia3 trials

Epidural Analgesia and Postoperative Respiratory Functions (EPAPRES)

Completed·—·N/A·NCT03643757·62 enrolled

Thoracic Epidural Analgesia in Multiple Traumatic Fracture Ribs

Unknown status·—·N/A·NCT03595397·60 enrolled

Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery.

Completed·UUniversity of California, San Francisco·Phase 4·NCT03307174·120 enrolled

Amputation2 trials

Pathophysiology of Post Amputation Pain

Completed·SShirley Ryan AbilityLab·Phase 4·NCT01632709·16 enrolled

Epidural Oxycodone for Pain Management for Lower Limb Amputation

Unknown status·KKafrelsheikh University·N/A·NCT06276179·40 enrolled

Total Knee Replacement2 trials

Ultrasound-guided Adductor Canal Block for Total Knee Replacement

Completed·NNorthwestern University·Phase 4·NCT02100579·40 enrolled

Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement

Not yet recruiting·HHuazhong University of Science and Technology·Phase 4·NCT06653621·144 enrolled

Headache2 trials

Sphenopalatine Ganglion Block for Post-Dural Puncture Headache

Withdrawn·WWake Forest University Health Sciences·N/A·NCT02181205

Sphenopalatine Nerve Block for Headache Tx360

Completed·IIndiana University·Phase 3·NCT01939314·93 enrolled

Postoperative Pain Management2 trials

COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS

Completed·FFatih Sultan Mehmet Training and Research Hospital·Phase 4·NCT03790007·3 enrolled

COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY

Completed·FFatih Sultan Mehmet Training and Research Hospital·Phase 4·NCT03790020·3 enrolled

Supraclavicular Brachial Plexus Block2 trials

Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative Opioi

Completed·MMansoura University·N/A·NCT03372486·64 enrolled

Efficacy and Safety of Dexmedetomidine to Bupivacaine in Supraclavicular Brachial Plexus Block

Completed·KKafrelsheikh University·N/A·NCT06020781·75 enrolled

Mastectomy2 trials

Adding Magnesium Sulfate to Local Anesthetic in Combined Pectoral Nerve and Stellate Ganglion Block for Postoperative Pain Control After Modified Radical Mastectomy

Recruiting·—·N/A·NCT06815887·70 enrolled

Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection

Completed·—·N/A·NCT03341234·48 enrolled

Interscalene Block2 trials

Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

Recruiting·UUniversity of Minnesota·Phase 4·NCT06143306·110 enrolled

Evaluation of Diaphragm Movement After an Interscalene Block

Completed·UUniversity of Minnesota·Phase 4·NCT03636542·26 enrolled

Spine Fusion2 trials

Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery

Recruiting·HHartford Hospital·Phase 4·NCT05996133·38 enrolled

Utility of Exparel Based ESP Blocks in Elective Posterior Spine Fusion

Unknown status·HHartford Hospital·Phase 4·NCT06107660·100 enrolled

Intravenous2 trials

Erector Spinae Plane (ESP) Block vs Intravenous Lignocaine Infusion in (VATS)

Completed·CCentral Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland·N/A·NCT06289790·61 enrolled

Comparative Study of Ultrasound-guided Paravertebral Block Versus Intravenous Tramadol in Percutaneous Nephrolithotomy

Completed·—·Phase 4·NCT02412930·53 enrolled

Gynecologic Surgery1 trial

A Comparison of Exparel to Bupivacaine in TAP Block for Abdominal Gynecologic Surgery

Unknown status·—·Phase 3·NCT03304444·128 enrolled

Nephrectomy1 trial

Comparison Between Different Anaesthesia Techniques Protecting Renal Function in Children Undergoing Radicle Nephrectomy

Completed·—·Phase 2/3·NCT05271253·75 enrolled

Hypotension1 trial

Phenylephrine and Noradrenaline for Post Spinal Anesthesia Hypotension

Completed·KKasr El Aini Hospital·Phase 2·NCT03015857·200 enrolled

Clavicle Fracture1 trial

Does Liposomal Bupivacaine Provide Improved Pain Management for ORIF of Midshaft Clavicle Fractures?

Withdrawn·UUniversity of Minnesota·Phase 4·NCT03020563

Prostatectomy1 trial

Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort

Withdrawn·—·Phase 1/2·NCT01565512

Superficial Cervical Plexus Block1 trial

Safety and Efficacy of Bilateral Superficial Cervical Plexus Block in Thyroidectomy

Completed·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 2·NCT01454609·60 enrolled

Neuropathic Pain1 trial

Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain

Completed·UUniversity Health Network, Toronto·Phase 3·NCT03009500·3 enrolled

Shoulder Arthroplasty1 trial

ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

Enrolling by invitation·WWashington University School of Medicine·Phase 4·NCT07280195·86 enrolled

Neurotoxicity1 trial

Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine

Unknown status·—·Phase 4·NCT03293472·60 enrolled

Vaginal Delivery1 trial

DEXMEDETOMIDINE in NORMAL VAGINAL DELIVERY

Unknown status·MMenoufia University·Phase 4·NCT05840328·60 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block

Completed·SSouth Egypt Cancer Institute·Phase 3·NCT03063073·60 enrolled

Open Heart Surgery1 trial

Transversus Thoracic Muscle Plane Block for Open Heart Surgery

Completed·—·N/A·NCT04094532·48 enrolled

Opioid Use Disorder1 trial

Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine

Withdrawn·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT06784180

Congenital hip dislocation1 trial

Erector Spinae Plane Block for Congenital Hip Dislocation Surgery

Completed·—·N/A·NCT03949686·60 enrolled

Functional Endoscopic Sinus Surgery1 trial

Opioid Sparing Effect of Sphenopalatine Ganglion Block in Functional Endoscopic Sinus Surgery: a Randomized Controlled Clinical Trial.

Not yet recruiting·—·Phase 4·NCT06752525·60 enrolled

Extremity1 trial

Single Shot Exparel vs Catheters in Lower Extremity Trauma

Recruiting·GGeorge Washington University·Phase 4·NCT07221019·90 enrolled

Interscalene Brachial Plexus Block1 trial

Comparison Between Perineural and Systemic Effect of Dexamethasone for Interscalene Brachial Plexus Block.

Unknown status·HHillel Yaffe Medical Center·N/A·NCT02190760·90 enrolled

Migraine1 trial

Greater Occipital Nerve Block With Bupivacaine for Acute Migraine

Completed·MMontefiore Medical Center·Phase 3·NCT02665273·28 enrolled

Local Infiltration1 trial

Ultrasound Guided Local Infiltration Analgesia for Hip Arthroscopy

Terminated·TTrinity Health Of New England·N/A·NCT01907191·23 enrolled

Rhomboid Intercostal Block1 trial

Bilateral Rhomboid Intercostal Block for Perioperative Analgesia in Patients Undergoing Bilateral Reduction Mammoplasty

Completed·ZZagazig University·N/A·NCT06225895·72 enrolled

Ankle Block1 trial

Comparison Between Ultrasound-guided and Landmark-guided Ankle Blocks

Unknown status·HHillel Yaffe Medical Center··NCT01684774·100 enrolled

Hemorrhage1 trial

Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage

Terminated·IIndiana University School of Medicine·Phase 2·NCT02343263·18 enrolled

Surgery1 trial

Efficiency of Thoracolumbar Interfascial Plane Block in Lumbar Disk Surgery

Unknown status·—·Phase 4·NCT03180099·50 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Efficacy Of Quadratus Lumborum II Block For Laparoscopic Sleeve Gastrectomy

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT04073056·41 enrolled

Colorectal Surgery1 trial

Evaluation of a TAP Block Given During Laparoscopic Colorectal Surgery to Help Control Pain

Completed·UUniversity Hospitals Cleveland Medical Center·N/A·NCT01731782·79 enrolled

Ultrasound1 trial

Comparing Analgesic Effects of Three Ultrasound Guided Regional Anesthetic Techniques in Pediatrics

Completed·IIstanbul University·N/A·NCT03780790·135 enrolled

Cardiovascular1 trial

Cardiovascular Safety Research: Bupivacaine With Vasoconstrictor Versus Ropivacaine in Brachial Plexus Block

Unknown status·UUniversity of Sao Paulo·Phase 4·NCT00523289·48 enrolled

Spinal Surgery1 trial

Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery

Completed·—·Phase 4·NCT03079076·40 enrolled

Breast Surgery1 trial

Effect of Addition of Fentanyl or Dexamethasone or Both to Bupivacaine in Paravertebral Block for Patients Undergoing Major Breast Surgery

Unknown status·—·N/A·NCT03480308·1 enrolled

Multimodal Analgesia1 trial

PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery

Completed·WWashington University School of Medicine·Phase 2·NCT03084536·134 enrolled

Renal Transplant1 trial

Dual Transversus Abdominis Plane Block in Pediatric Renal Transplant: Effect on Pain Control

Completed·—·N/A·NCT02858622·44 enrolled

Mucositis1 trial

Local Anesthetic Treatment of Oral Pain in Patients With Mucositis

Completed·HHvidovre University Hospital·Phase 2·NCT02252926·70 enrolled

Epilepsy1 trial

Conscious Sedation for Epilepsy Surgery

Completed·MMenoufia University·N/A·NCT02988050·60 enrolled

Postsurgical Pain Management1 trial

A Study to Evaluate Safety, PK, Efficacy of TLC590 for Postsurgical Pain Management Following Bunionectomy

Completed·TTaiwan Liposome Company·Phase 2·NCT03838133·150 enrolled

Thoracic Paravertebral Block1 trial

Comparison of Erector Spinae Plane Block With Thoracic Paravertebral Block for Video Assisted Thoracoscopic Surgery

Completed·—·N/A·NCT03538496·60 enrolled

Virtual Reality1 trial

Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Adult Patients for Pain Control During Spinal Injections (SI)

Withdrawn·—·Phase 2·NCT03787147

Cleft Palate1 trial

Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery

Completed·—·Phase 2/3·NCT02923869·60 enrolled

GAN1 trial

Sphenopalatine Ganglion Block Study

Completed·MMontefiore Medical Center·Phase 1·NCT05707754·220 enrolled

Bleeding1 trial

The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

Completed·SSt. Olavs Hospital·Phase 4·NCT01964781·30 enrolled

Infusion1 trial

Determining the Prognostic Value of Continuous Intrathecal Infusion

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT03523000·36 enrolled

Axillary Nerve Block1 trial

Dexamethasone as Adjuvant to Bupivacaine in Suprazygomatic Maxillary Nerve Block

Unknown status·—·N/A·NCT05530811·34 enrolled

Tibial Plateau Fracture1 trial

Continuous Femoral Nerve Block With a Tibial Plateau Fracture

Completed·UUniversity of Utah·Phase 1·NCT02168959·5 enrolled

Knee Arthroplasty1 trial

Comparison of Local Anesthetic Dose in Ipack Block Performed in Knee Arthroplasty Operations

Completed·IIstanbul University·N/A·NCT05963139·112 enrolled

Hemodynamic Stability1 trial

Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization

Completed·HHelse Fonna·Phase 4·NCT02368054·34 enrolled

Geriatric Patients1 trial

Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients

Completed·—·Phase 3·NCT06165679·112 enrolled

Umbilical hernia1 trial

Analgesic Efficacy After Umbilical Hernia Repair in Children

Completed·—·N/A·NCT00578136·52 enrolled

Cerebral Oxygen Saturation1 trial

The Effects of Anesthetic Method on Cerebral Oxygen Saturation in Geriatric Patients Undergoing Transurethral Surgery

Completed·YYonsei University·N/A·NCT01147146·64 enrolled

Perioperative Analgesia1 trial

Perioperative Analgesia Using Ultrasound (US) Guided Transversus Abdominis Plane (TAP) Block

Unknown status·KKing Saud University·Phase 1·NCT00819962·42 enrolled

Paralysis1 trial

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Recruiting·—··NCT04209504·60 enrolled

Wound Infection1 trial

Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing in Paediatrics Inguinal Herniotomy

Completed·UUniversity of Alexandria·N/A·NCT03563625·50 enrolled

Anesthesia1 trial

Effect of Anesthesia in Fracture Healing

Completed·—·Phase 4·NCT02621255·30 enrolled

Postoperative Pain Relief1 trial

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

Terminated·VVirtua Health, Inc.·Phase 4·NCT03514277·19 enrolled

Postoperative Quality of Recovery1 trial

Postoperative Quality of Recovery After Transurethral Resection of the Bladder

Unknown status·—·N/A·NCT02534623·70 enrolled

Tonsillectomy1 trial

Peri Tonsillar Infiltration of Ketamine or Bupivacaine for Post Tonsillectomy Analgesia

Completed·SSohag University·Phase 4·NCT05341323·80 enrolled

Neostigmine1 trial

Epidural Neostigmine for Labor Pain

Completed·WWake Forest University·Phase 1·NCT00779467·200 enrolled

Labor Analgesia1 trial

PIEB vs CEI for Labor Analgesia: An MLAC Study

Terminated·SStanford University·Phase 4·NCT02573597·31 enrolled

Total Shoulder Arthroplasty1 trial

Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty

Completed·UUniversity of Virginia·Phase 3·NCT04974385·80 enrolled

ACL Reconstruction1 trial

A Novel Analgesia Technique for ACL Reconstruction

Completed·HHospital for Special Surgery, New York·Phase 4·NCT03292926·78 enrolled

Abdominal Cancer Surgery1 trial

Intrathecal Ketamine, Dexmedetomidine and Both With Bupivacaine for Postoperative Abdominal Cancer Surgery Pain

Unknown status·—·Phase 2/3·NCT02455609·90 enrolled

Cesarean Delivery1 trial

Postoperative Cesarean Delivery Pain Relief; Diclofenac Versus Bupivacaine

Completed·DDepartment of Medical Services Ministry of Public Health of Thailand·Phase 4·NCT03039426·120 enrolled

Peripheral Nerve Block1 trial

Perineural Steroids for Peripheral Nerve Blocks

Completed·WWake Forest University Health Sciences·Phase 4·NCT02462148·85 enrolled

Ketorolac1 trial

Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Completed·—·Phase 1·NCT02973958·30 enrolled

Femoral Nerve Block1 trial

Ultrasound Guided Femoral Nerve Block

Completed·—·N/A·NCT02381717·44 enrolled

Chronic pain1 trial

Para-vertebral Dexmedetomidine and the Incidence of Postoperative Chronic Pain

Completed·—·N/A·NCT03632161·60 enrolled

Stellate Ganglion Block1 trial

Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 1·NCT02775318·20 enrolled

Randomized Controlled Trial1 trial

Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial

Completed·UUniversity of Massachusetts, Worcester·N/A·NCT01583166·90 enrolled

Knee Arthroscopy1 trial

Spinal Anaesthesia for Knee Arthroscopy: Does Lignocaine Shorten the Effect of Bupivacaine

Completed·—·Phase 4·NCT01245868·60 enrolled

Pediatrics1 trial

Transversus Abdominis Plane Versus Caudal Block for Pediatrics

Completed·MMansoura University·Phase 1·NCT02398123·28 enrolled

Spine Surgery1 trial

Pain Relief at Iliac Crest Bone Harvest Sites in Spine Surgery Using Bupivacaine

Completed·VVanderbilt University·N/A·NCT01087931·40 enrolled

Sedation1 trial

Impact of Analgesia on Success of External Version: Comparison of Spinal Anesthesia Versus Sedation

Unknown status·—·Phase 3·NCT02801201·200 enrolled

Rectus Sheath Block1 trial

Pilot Study: Rectus Sheath Blocks for Improving Abdominal Surgery Conditions

Terminated·UUniversity of Arkansas·N/A·NCT02447965·6 enrolled

Regional Anaesthesia1 trial

Regional Anaesthesia

Completed·RReham Ali Abdelhaleem Abdelrahman·N/A·NCT06055101·54 enrolled

Diabetic Foot1 trial

POPLITEAL SCIATIC NERVE BLOCK FOR DIABETIC FOOT SURGERIES

Unknown status·—·N/A·NCT04903743·50 enrolled

Hypospadias1 trial

Comparison of the Efficacy of Bupivacaine with and Without Dexmedetomidine As an Adjuvant on Penile Block for Postoperative Pain Relief in Pediatrics Undergoing Hypospadias Repair Surgery

Not yet recruiting·—·Phase 3·NCT06789393·80 enrolled

Local Anesthetic1 trial

Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain

Terminated·HHvidovre University Hospital·Phase 2·NCT01584947·31 enrolled

Liposome Bupivacaine1 trial

Liposome Bupivacaine Interscalene Total Shoulder

Completed·UUniversity of Minnesota·Phase 2·NCT03587636·77 enrolled

AIN1 trial

Status Migrainosus - Differentiating Between Responders and Non-responders

Unknown status·HHartford HealthCare·Phase 1/2·NCT03066544·50 enrolled

Radius Fracture1 trial

Magnesium Sulfate and Bupivacaine for Rehabilitation After Distal Radius Fractures

Completed·UUniversidad Autonoma de Nuevo Leon·N/A·NCT02514343·40 enrolled

Shoulder pain1 trial

Superficial Cervical Plexus Block for Shoulder Pain After Lung Surgery

Terminated·UUniversity of Washington·Phase 4·NCT01550302·10 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study

Completed·—·Phase 1·NCT03411330·64 enrolled

Erector Spinae Block1 trial

Erector Spinae Block for Spine Surgery

Terminated·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT05417113·13 enrolled

Prevention1 trial

Peribulbar Block for Prevention of Oculocardiac Reflex

Unknown status·FFayoum University Hospital·Phase 4·NCT04549844·70 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 3, 1972

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 13, 1976

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jun 7, 1976

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jun 10, 1976

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jun 10, 1976

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jul 7, 1976

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Nov 30, 1976

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jun 15, 1978

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jun 15, 1978

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Apr 4, 1979

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Apr 4, 1979

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jun 18, 1979

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Dec 6, 1979

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 21, 1980

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 21, 1980

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Nov 3, 1980

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 21, 1981

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 21, 1981

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Dec 28, 1981

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 1, 1982

BUPIVACAINE HYDROCHLORIDE

NDA NDA018053

Jan 1, 1982

SENSORCAINE

NDA NDA018304

Jan 1, 1982

MARCAINE HYDROCHLORIDE

NDA NDA016964

Jan 27, 1982

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 21, 1983

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jul 13, 1983

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jul 13, 1983

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Nov 21, 1983

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Dec 1, 1983

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Mar 2, 1984

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

May 4, 1984

MARCAINE

NDA NDA018692

May 4, 1984

MARCAINE

NDA NDA018692

May 20, 1985

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 19, 1985

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 24, 1985

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Sep 11, 1985

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 27, 1987

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 27, 1987

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jul 13, 1987

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Sep 15, 1987

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Apr 27, 1988

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Feb 6, 1991

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Feb 6, 1991

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 8, 1991

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Sep 3, 1992

BUPIVACAINE HYDROCHLORIDE KIT

NDA NDA019978

Jan 25, 1993

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Apr 9, 1997

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Mar 9, 1999

MARCAINE

NDA NDA018692

Mar 9, 1999

MARCAINE

NDA NDA018692

Mar 11, 1999

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Mar 11, 1999

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Mar 11, 1999

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Mar 11, 1999

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 31, 2001

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 21, 2001

MARCAINE

NDA NDA018692

Jun 12, 2003

MARCAINE

NDA NDA018692

Oct 30, 2005

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Sep 27, 2006

VIVACAINE

NDA ANDA077250

Nov 29, 2007

VIVACAINE

NDA ANDA077250

Feb 19, 2010

MARCAINE

NDA NDA018692

Feb 19, 2010

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Oct 28, 2011

EXPAREL

NDA NDA022496

Jan 30, 2012

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Jan 30, 2012

MARCAINE

NDA NDA018692

Mar 28, 2013

VIVACAINE

NDA ANDA077250

Jul 30, 2013

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Sep 19, 2014

MARCAINE

NDA NDA018692

Sep 19, 2014

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Dec 15, 2014

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 27, 2015

VIVACAINE

NDA ANDA077250

Nov 2, 2018

MARCAINE

NDA NDA018692

Nov 2, 2018

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 21, 2020

MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE W/ EPINEPHRINE

NDA NDA016964

Aug 28, 2020

XARACOLL

NDA NDA209511

Feb 1, 2021

POSIMIR

NDA NDA204803

Sep 28, 2022

MARCAINE

NDA NDA018692

Sources

References

[1]
ClinicalTrials.gov — 630 trial records for Bupivacaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Marcaine drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Bupivacaine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Bupivacaine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA018692). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Marcaine. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Innocoll company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Protein Type IV Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: IInnocoll

Patent Landscape[6]

Patent Cliff

May 20, 2029

Earliest patent expiration — generic entry possible after this date

Patent #Expires

RE47826May 20, 2029

11746141Jan 9, 2033

11400019Jan 12, 2041

11771624Jan 12, 2041

11179336Jan 22, 2041

20 more patents

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