Musculoskeletal

Bone Fracture

38

Pipeline Programs↗

2

Active Trials↗

26

Companies Involved↗

Bone Fracture is a moderately active landscape with 38 programs across 26 companies. The most active players are TNF Pharmaceuticals, Inc., EMD Serono, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.. 23 therapies are approved with 5 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

55/100

Pipeline Velocity

0/100

Mech. Concentration

16/100

Completion Rate

70/100

Attrition Rate

19/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

TNF Pharmaceuticals, Inc.

1 program

EMD Serono

1 program

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

1 program

Eli Lilly

1 program

Boehringer Ingelheim

1 program

Hyundai Pharmaceutical Co., LTD.

1 program

Analysis

Modality Breakdown

93%

Small molecule

38 of 41 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 41 classified programs, each share of the total. Modality classified for 100% of 42 pipeline programs.

Analysis

Trial Status

16

clinical trials

Completed7 · 44%

Unknown status4 · 25%

Withdrawn2 · 13%

Terminated1 · 6%

Recruiting1 · 6%

Not yet recruiting1 · 6%

Clinical Trials

Trial Activity

16 trials

Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture

Recruiting·ZZetrOZ, Inc.·Phase 1·NCT05883241·90 enrolled

Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hip or Thigh Bone Fractures

Not yet recruiting·TTNF Pharmaceuticals, Inc.·Phase 2·NCT06942182·60 enrolled

Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Surgery For Long Bone Fracture

Completed· Pfizer logo

Pfizer·Phase 4·NCT00824564·82 enrolled

Efficacy of Sublingual Midazolam in Association With Oral Morphine in Children Analgesia After Bone Fracture

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00416039·60 enrolled

36-month Special Drug Use Surveillance on Frequency of Bone Fractures With Sodium Risedronate 75 mg Tablets

Completed· Takeda logo

Takeda·N/A·NCT02106442·579 enrolled

Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00088010·9,369 enrolled

Preemptive Analgesia With OxyContin Versus Placebo Before Surgery for Long Bone Fractures

Completed·RRambam Health Care Campus·Phase 4·NCT00254631·65 enrolled

Treatment of Non Union of Long Bone Fractures by Autologous Mesenchymal Stem Cell

Completed·RRoyan Institute·Phase 1·NCT01206179·6 enrolled

RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child

Completed·IIRCCS Burlo Garofolo·Phase 4·NCT00560443·133 enrolled

Evaluation of Safety and Efficacy of Nasea(R)/Ramosetron Inj. in Patients Undergoing Facial Bone Fracture Operations

Terminated·SSeoul National University Hospital·Phase 4·NCT01637545·49 enrolled

Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures

Withdrawn·TThe University of Texas Health Science Center, Houston·Phase 2·NCT04061330

Bimodal Analgesia as Form of Pain Control Post Long Bone Fracture

Withdrawn·—·N/A·NCT00240396

Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture

Unknown status·—·N/A·NCT05774366·58 enrolled

Dexketoprofen and Ibuprofen in Long Bone Fractures

Unknown status·—·Phase 4·NCT06060236·100 enrolled

Oral vs IV Acetaminophen for Long-bone Fracture in Children

Unknown status·—·Phase 4·NCT05557344·20 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)