Suprane

(Desflurane)

ApprovedSmall molecule

Desflurane is an inhaled anesthetic gas used to put patients to sleep during surgery and keep them asleep throughout the procedure.[2] Suprane is currently approved and in use across 27 indications[4].[1]

Suprane is one of 405 small molecule programs targeting Post-Operative Sign or Symptom. It is currently in Approved.

Indications

127

Total Trials

Active Trials

404

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Post-Operative Sign or SymptomApproved

Ischemia Reperfusion InjuryActive, not recruiting

Acute Kidney InjuryActive, not recruiting

Subarachnoid HemorrhageActive, not recruiting

Idiopathic ScoliosisActive, not recruiting

Liver TransplantActive, not recruiting

ObesityNot yet recruiting

AdenomaActive, not recruiting

Hip FractureActive, not recruiting

Bone FractureActive, not recruiting

Post-Operative Sign or SymptomApproved

Approved

Ischemia Reperfusion InjuryPreclinical

Active, not recruiting

Acute Kidney InjuryApproved

Active, not recruiting

Subarachnoid HemorrhageApproved

Active, not recruiting

Idiopathic ScoliosisPreclinical

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

ObesityApproved

Not yet recruiting

AdenomaPreclinical

Active, not recruiting

Hip FracturePreclinical

Active, not recruiting

Bone FracturePreclinical

Active, not recruiting

Showing 10 of 22 indications

Competition

Competitive Landscape

190 competitors in Obesity

#DrugCompanyPhaseTrials

Suprane

BBaxter Healthcare Corporation

Approved

2 2

Maridebart Cafraglutide

Amgen

Phase 3

7 3

Retatrutide

Eli Lilly

Phase 3

6 4

HRS9531

FFujian Shengdi Pharmaceutical Co., Ltd.

Phase 3

1 5

Cagrisema

Novo Nordisk

Phase 3

5 6

Ribupatide

KKailera

Phase 3

3 7

Belantamab Mafodotin-Blmf

Novo Nordisk

Phase 3

1 8

Efsubaglutide Alfa

SShanghai Yinnuo Pharmaceutical Technology Co., Ltd.

Phase 3

1 9

Aleniglipron

GGasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Phase 3

2 10

Avapro

Sanofi

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Total Intravenous Anesthesia

NCT06779890

Q2 2027

ApprovedNot yet recruiting

Obesity

NCT07748247

Q4 2028

Post-ApprovalRecruiting

Delirium

NCT05990790

Q4 2029

N/ARecruiting

Obesity

NCT03756961

Clinical

Trials by Indication[1]

Sevoflurane10 trials

Blood Levels of Sevoflurane and Desflurane

Completed·—··NCT03015350·16 enrolled

Sevoflurane, Propofol and Desflurane on POD/POCD

Unknown status·SShanghai 10th People's Hospital··NCT03326960·300 enrolled

To Compare Effect of Sevoflurane Versus Desflurane on the Return of Swallowing Reflexes in the Elderly

Completed·UUniversity of Malaya·Phase 4·NCT01833676·51 enrolled

Show 7 more trials

Desflurane vs. Sevoflurane in Endovascular Aortic Repair

Completed·BBegoña Quintana Villamandos·Phase 4·NCT03917186·80 enrolled

Effects of Sevoflurane and Desflurane on Treg

Completed·MMahidol University·Phase 2·NCT02559297·40 enrolled

Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Completed·SSeoul National University Hospital·N/A·NCT02096224·108 enrolled

The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung

Completed·IInonu University·N/A·NCT04645316·72 enrolled

Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery

Completed·OOhio State University·Phase 3·NCT01219881·75 enrolled

Low-Flow Desflurane vs Sevoflurane: Impact on Physiology and Recoveryand Recovery Profiles in Adult ENT Surgery

Completed·HHarran University·N/A·NCT07016308·40 enrolled

A Comparison of Desflurane vs. Sevoflurane and the Time to Awakening and the Incidence and Severity of Cough

Completed·NNorthwestern University·N/A·NCT01202162·85 enrolled

Anesthesia6 trials

Effects of Desflurane-propofol Balanced Anesthesia on Visual Evoked Potentials Monitoring

Completed·—·N/A·NCT05465330·70 enrolled

The Change of Tissue Oxygen Saturation Following Volatile Anesthesia

Completed·PPusan National University Hospital··NCT03060798·60 enrolled

Xenon-anesthesia on Patients Undergoing Major Liver-resection

Withdrawn·RRWTH Aachen University·Phase 4·NCT03504033

Show 3 more trials

Anesthesia and Motor Evoked Potential (MEP) Recruitment

Completed·—·N/A·NCT02199314·30 enrolled

Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02872389·90 enrolled

Ventilatory Effect on Speed of Anesthesia Under Various Inhaled Anesthetics

Completed·—·N/A·NCT01171833·36 enrolled

Total Intravenous Anesthesia4 trials

The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia

Withdrawn·YYonsei University·N/A·NCT02003768

Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery

Unknown status·—·Phase 4·NCT01985854·60 enrolled

Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome

Recruiting·GGeorgia Tsaousi·Phase 4·NCT06779890·84 enrolled

Show 1 more trial

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Robotic-assisted Laparoscopic Radical Prostatectomy Under Sevoflurane, Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Completed·YYonsei University·N/A·NCT03539003·69 enrolled

Propofol4 trials

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Completed·MMelbourne Health·Phase 4·NCT00446212·300 enrolled

Desflurane Versus Propofol in the Sitting Position

Completed·GGachon University Gil Medical Center·N/A·NCT01436799·40 enrolled

Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter

Completed·—·Phase 4·NCT07359508·146 enrolled

Show 1 more trial

Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

Completed·—·Phase 4·NCT04226625·18 enrolled

Quality of Recovery4 trials

Quality of Recovery After Robotic Surgery

Completed·NNitin Sethi, DNB·N/A·NCT03659539·120 enrolled

Comparison of Desflurane and Propofol on Quality of Recovery in Patients Undergoing Robotic or Laparoscopic Gastrectomy

Withdrawn·YYonsei University·N/A·NCT02515968

Comparing Quality of Recovery Between Desflurane & Isoflurane in Eye Surgery Patients at Dr George Mukhari Acad Hospital

Completed·—·N/A·NCT04188314·170 enrolled

Show 1 more trial

Effects of General Anesthesia on Quality of Recovery After Transaxillary Endoscopic Breast Augmentation

Completed·CChih-Cheng Hung·N/A·NCT04036487·104 enrolled

75 more indications

Delirium4 trials

Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT02925611·60 enrolled

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Recruiting·MMedical University of Vienna·Phase 4·NCT05990790·1,332 enrolled

Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients

Recruiting·WWest China Hospital·N/A·NCT06176144·890 enrolled

Show 1 more trial

Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Recruiting·SSir Ganga Ram Hospital··NCT04707794·270 enrolled

Analgesic3 trials

The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02609802·77 enrolled

Comparison of Analgesic Effect of Volatile Anesthetics

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02830243·90 enrolled

The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02698514·90 enrolled

General Anesthesia3 trials

Neuronal Mechanisms of Sensory Processing During General Anesthesia

Unknown status·LLudwig-Maximilians - University of Munich·N/A·NCT00434382·768 enrolled

The Effect of General Anesthesia on the Middle Ear Pressure

Completed·—·N/A·NCT03100604·50 enrolled

Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia

Completed·—·Phase 4·NCT01924871·62 enrolled

Coronary Artery Bypass3 trials

Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane

Completed·UUniversity of Melbourne·N/A·NCT00400790·182 enrolled

Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Completed·SSeoul National University Hospital·Phase 4·NCT03209193·72 enrolled

The Effect of Desflurane on Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT02213718·60 enrolled

Tics3 trials

Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics

Withdrawn·SSeoul National University Hospital·N/A·NCT03763305

Comparison of Effect of Equi-MAC Anesthetics on PSI

Completed·KKangbuk Samsung Hospital·N/A·NCT03587779·74 enrolled

Anesthetics in Rhytidoplasty - A Comparison Study

Completed·MMercy Facial Plastic Surgery Center·N/A·NCT02410460·30 enrolled

Elderly Patients2 trials

Optimization of Desflurane in Elderly Patients

Completed·—·Phase 1/2·NCT01700907·20 enrolled

A COMPARATIVE STUDY OF DESFLURANE VERSUS SEVOFLURANE IN ELDERLY PATIENTS: EFFECT ON EARLY RECOVERY

Completed·HHopital Charles Nicolle·Phase 3·NCT07289945·81 enrolled

Preconditioning2 trials

Desflurane Preconditioning in Hepatectomies

Completed·—·N/A·NCT03848780·46 enrolled

Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R

Withdrawn·NNegovsky Reanimatology Research Institute·Phase 4·NCT04287842

Laryngeal Mask Airway2 trials

Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia

Completed·RRWTH Aachen University·Phase 3·NCT02322502·352 enrolled

Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

Completed·UUniversity of Malaya·N/A·NCT01083953·54 enrolled

Bariatric Surgery2 trials

Automated Closed Loop Propofol Anaesthesia Versus Desflurane Inhalation Anaesthesia In Bariatric Surgery

Completed·DDr Nitin Sethi·Phase 4·NCT03099616·40 enrolled

TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery

Completed·OOstfold Hospital Trust·Phase 2·NCT03727607·160 enrolled

Oxidative Stress2 trials

Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy

Completed·RRennes University Hospital·Phase 3·NCT00219856·34 enrolled

The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Completed·YYonsei University·Phase 4·NCT02149628·50 enrolled

Acute Kidney Injury2 trials

Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery

Withdrawn·TTokyo Medical and Dental University·Phase 4·NCT02174575

Anesthesia and Acute Kidney Injury After Nephrectomy

Completed·SSeoul National University Hospital·N/A·NCT04474600·324 enrolled

One-lung Ventilation2 trials

Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation

Completed·SSeoul National University Hospital·N/A·NCT02191371·104 enrolled

Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Active, not recruiting·JJuntendo University·N/A·NCT02324283·80 enrolled

Concentration2 trials

Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Completed·—·Phase 4·NCT02379715·26 enrolled

Automated Control of End-tidal Volatile Anesthetic Concentration

Completed·RRuhr University of Bochum·N/A·NCT02342509·63 enrolled

Postoperative Recovery2 trials

The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery

Completed·MMedical University of Vienna·Phase 4·NCT05331027·190 enrolled

Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.

Completed·KKocaeli City Hospital·Approved·NCT07123870·210 enrolled

Agitation2 trials

Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery

Completed·—·Phase 4·NCT01878656·144 enrolled

Emergence Agitation Between Sevoflurane and Desflurane in Pediatric

Completed·PPrince of Songkla University·N/A·NCT01235143·136 enrolled

Laparoscopic Cholecystectomy2 trials

Pain After Laparoscopic Cholecystectomy

Completed·—·N/A·NCT00983918·80 enrolled

The Effect of Low-Flow Sevoflurane and Low-Flow Desflurane Anesthesia on Postoperative Sore Throat in Laparoscopic Cholecystectomy Surgery

Completed·KKayseri City Hospital·Preclinical·NCT07440758·80 enrolled

Obesity2 trials

Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

Recruiting·GGöteborg University·N/A·NCT03756961·220 enrolled

Desflurane Versus Sevoflurane-Desflurane Swap in Adults Undergoing Bariatric Surgery: A Randomized Non-Inferiority Trial on Extubation Time

Not yet recruiting·CClínica Dávila·Approved·NCT07748247·82 enrolled

Total Knee Replacement1 trial

Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement

Completed·PPedro Paulo Tanaka·Phase 4·NCT01270620·100 enrolled

Nausea1 trial

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Completed·SStony Brook University·Phase 4·NCT03435003·83 enrolled

Pectus Excavatum1 trial

Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum

Unknown status·TThe Catholic University of Korea·Phase 4·NCT01486953·70 enrolled

Remifentanil1 trial

Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.

Completed·FFederal University of Minas Gerais·Phase 4·NCT02631525·40 enrolled

Gut Microbiota1 trial

Anesthesia on Gut Microbiota and Metabolomics

Unknown status·NNational Taiwan University Hospital·N/A·NCT04767503·60 enrolled

Laparoscopy1 trial

ONSD According to the Position During Laparoscopy

Completed·—·N/A·NCT01937104·60 enrolled

Sedation1 trial

Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation

Completed·RRuhr University of Bochum·N/A·NCT03860129·30 enrolled

Hepatic Function1 trial

Effect of Desflurane Versus Sevoflurane With Recent Bio-markers on Renal and Hepatic Functions

Completed·TTheodor Bilharz Research Institute··NCT05027191·70 enrolled

Scoliosis1 trial

Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients

Completed·NNationwide Children's Hospital·N/A·NCT01549873·30 enrolled

Mechanical Ventilation1 trial

Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery

Recruiting·NNational and Kapodistrian University of Athens·N/A·NCT07304479·50 enrolled

Pancreatic Adenocarcinoma1 trial

CTC Pancreatic Adenocarcinoma

Completed·UUniversity of Zurich·Phase 4·NCT02335151·86 enrolled

Hypotension1 trial

Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension

Completed·UUfuk University·Phase 4·NCT02834845·95 enrolled

Injury1 trial

Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Unknown status·—·Phase 1·NCT05246371·30 enrolled

Vasodilation1 trial

Vasodilation Effect of Inhalational Anesthetics

Completed·NNanjing Medical University·N/A·NCT00815269·300 enrolled

Hip Fracture1 trial

Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

Completed·YYonsei University·N/A·NCT02458547·186 enrolled

Post Operative Sore Throat1 trial

Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

Unknown status·KKeimyung University Dongsan Medical Center·N/A·NCT03259672·100 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Bone Fracture1 trial

Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture

Unknown status·—·N/A·NCT05774366·58 enrolled

Renal Transplantation1 trial

Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation

Completed·YYonsei University·Phase 4·NCT01132157·99 enrolled

Down syndrome1 trial

The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients

Completed·—·Phase 2·NCT02971254·39 enrolled

Gastrointestinal1 trial

The Effect of Anesthetic Methods on Gastrointestinal Motility

Completed·—·N/A·NCT05951686·61 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Anaesthesia for Laparoscopic Sleeve Gastrectomy

Completed·MMenoufia University·N/A·NCT03029715·100 enrolled

Colorectal Surgery1 trial

IOP Changes With Different Anesthetic Agents During Laparoscopic Colorectal Surgery

Completed·SSaint Vincent's Hospital, Korea·N/A·NCT03016234·50 enrolled

Ambulatory Surgery1 trial

Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery

Completed·XXiaoliang Gan·N/A·NCT02922660·209 enrolled

Acute Respiratory Distress Syndrome1 trial

Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients

Unknown status·TTianjin First Central Hospital·Phase 4·NCT05783518·165 enrolled

Epidural Analgesia1 trial

Xenon Combined With Intraoperative Thoracic Epidural Analgesia

Completed·CCentre Leon Berard·Phase 2·NCT01696630·31 enrolled

Intraoperative1 trial

The Effect of BIS Monitorization to Intraoperative Anesthetic Consumption During Coronary Artery Surgery

Completed·—·N/A·NCT02520947·50 enrolled

Cognitive Function1 trial

Early Cognitive Function in Elderly Patients After Laser Laryngeal Surgery: Des vs Prop

Unknown status·EEye & ENT Hospital of Fudan University·Phase 4·NCT03194074·70 enrolled

Hyperalgesia1 trial

The Effect of Remimazolam on Opioid Induced Hyperalgesia

Completed·WWonkwang University Hospital·N/A·NCT05866315·108 enrolled

Splenectomy1 trial

Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy

Completed·TTheodor Bilharz Research Institute·N/A·NCT02079064·30 enrolled

Myocardial Protection1 trial

Desflurane-induced Myocardial Protection

Unknown status·NNobuyuki Katori·Phase 4·NCT02019797·50 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Adenoma1 trial

Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection

Completed·—·N/A·NCT05088252·112 enrolled

Nephrectomy1 trial

A Comparison of Kidney Function After Nephrectomy in Living Donors Under Sevoflurane and Desflurane Anesthesia

Completed·YYonsei University··NCT01549990·236 enrolled

Fatigue1 trial

Postoperative Fatigue and Nausea Related to Choice of Anaesthetic Regimens

Completed·SSykehuset Telemark·Phase 4·NCT01125982·130 enrolled

Pulmonary Function1 trial

Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Unknown status·IIstanbul University·N/A·NCT02709863·90 enrolled

Hemodynamic1 trial

Hemodynamics for Equi-MAC Anesthesia

Completed·KKangbuk Samsung Hospital·N/A·NCT03570164·70 enrolled

Liver Transplant1 trial

The Effect of Inhalation Agent on the QTc Interval During Liver Transplantation: Sub Study (NCT01886664)

Completed·SSeoul National University Hospital··NCT01899248·52 enrolled

Phase 21 trial

Japan Phase 2/3 Clinical Study With BLM-240 (Desflurane)

Completed·BBaxter Healthcare Corporation·Phase 2/3·NCT00762372·216 enrolled

Obese Patients1 trial

Anesthesia for Obese Patients: Desflurane Versus Xenon

Completed·—·Phase 4·NCT01167803·192 enrolled

Urologic Surgery1 trial

Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females

Completed·—·Phase 4·NCT01310582·57 enrolled

Mortality1 trial

Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery

Completed·UUniversity of Zurich·Phase 4·NCT01452256·460 enrolled

Dexmedetomidine1 trial

Effect of Dexmedetomidine After Thyroidectomy

Completed·—·N/A·NCT02412150·139 enrolled

Age1 trial

Comparison of PRS According to Inhalation Agent During LDLT

Completed·SSeoul National University Hospital·Phase 4·NCT01886664·70 enrolled

Preoperative1 trial

The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery

Completed·IInje University·N/A·NCT02916407·56 enrolled

Nausea and vomiting1 trial

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Cardiac1 trial

The Effect of Anaesthesia Depth on Oculo-cardiac Reflex

Completed·TTokat Gaziosmanpasa University·Phase 4·NCT02379546·64 enrolled

Prostatectomy1 trial

Analysis of Change of Optic Nerve Sheath Diameter in Robot Assisted Laparoscopic Radical Prostatectomy

Completed·SSeoul National University Hospital·N/A·NCT03152981·60 enrolled

Craniotomy1 trial

Desflurane and Brain Relaxation in Craniotomy

Completed·—·N/A·NCT04691128·111 enrolled

Subarachnoid Hemorrhage1 trial

Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT02987218·100 enrolled

Recovery1 trial

Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge

Withdrawn·TThe Cleveland Clinic·N/A·NCT06252207

Neuromuscular Block1 trial

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

Completed·UUniversity of California, San Francisco·Phase 4·NCT01199237·107 enrolled

Complication1 trial

The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia

Unknown status·—·Phase 4·NCT03006250·220 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery

Completed·OOhio State University·N/A·NCT02643615·20 enrolled

Respiratory Mechanics1 trial

Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial

Completed·KKonya City Hospital·Preclinical·NCT07295158·138 enrolled

Postoperative Cognitive Dysfunction (POCD)1 trial

Comparison of Desflurane, Sevoflurane, and Total Intravenous Anesthesia Methods in Terms of Postoperative Cognitive Dysfunction in Ear Surgery Performed Under Controlled Hypotension

Completed·DDr. Lutfi Kirdar Kartal Training and Research Hospital·Preclinical·NCT07792759·69 enrolled

Intracranial Pressure1 trial

Comparison of the Effects of Sevoflurane and Desflurane Used for Anesthesia Maintenance on Optic Nerve Sheath Diameter in the Trendelenburg Position

Completed·MMedipol University·Preclinical·NCT07525648·63 enrolled

Unspecified2 trials

Hemifacial Spasm and Desflurane

Unknown status·UUniversity of Manitoba··NCT01726725·25 enrolled

The Effect of Desfluran On Global Dna Methylation

Completed·MMuğla Sıtkı Koçman University··NCT05111717·40 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 18, 1992

SUPRANE

NDA NDA020118

Sep 18, 1992

SUPRANE

NDA NDA020118

Jul 5, 1995

SUPRANE

NDA NDA020118

Dec 16, 1997

SUPRANE

NDA NDA020118

Dec 9, 1998

SUPRANE

NDA NDA020118

Dec 2, 1999

SUPRANE

NDA NDA020118

Aug 8, 2002

SUPRANE

NDA NDA020118

May 8, 2006

SUPRANE

NDA NDA020118

Aug 14, 2006

SUPRANE

NDA NDA020118

Dec 15, 2006

SUPRANE

NDA NDA020118

Apr 14, 2009

SUPRANE

NDA NDA020118

Apr 5, 2010

SUPRANE

NDA NDA020118

Sep 23, 2013

SUPRANE

NDA NDA020118

Sep 27, 2013

SUPRANE

NDA NDA020118

Feb 26, 2015

SUPRANE

NDA NDA020118

Nov 4, 2016

SUPRANE

NDA NDA020118

Apr 27, 2017

SUPRANE

NDA NDA020118

Mar 1, 2019

SUPRANE

NDA NDA020118

Mar 1, 2019

SUPRANE

NDA NDA020118

Nov 1, 2022

SUPRANE

NDA NDA020118

Sources

References

[1]
ClinicalTrials.gov — 127 trial records for Desflurane. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Suprane drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Desflurane compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Desflurane. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020118). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Baxter Healthcare Corporation company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Potassium Channel Subfamily K Member 10 Opener; Potassium Channel Subfamily K Member 18 Opener; Potassium Channel Subfamily K Member 2 Opener; Potassium Channel Subfamily K Member 9 Opener; GABA-a Receptor; Anion Channel Positive Allosteric Modulator; Glycine Receptor (alpha-1/beta) Positive Modulator; Potassium Channel Subfamily K Member 3 Opener[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: BBaxter Healthcare Corporation