Anerem
(Remimazolam)ApprovedSmall molecule
Remimazolam is used for sedation during medical procedures and for inducing anesthesia before surgery, helping patients stay calm and comfortable during these medical interventions.[2] Anerem is currently approved and in use across 40 indications[4].[1]
Anerem is one of 491 small molecule programs targeting Sedation. It is currently in Approved.
40
Indications
136
Total Trials
44
Active Trials
490
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
11
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 38 indications
Competition
Competitive Landscape
137 competitors in Atrial Fibrillation
#DrugCompanyPhaseTrials
1Anerem
AAcacia Pharma Ltd
Approved
Calquence
AstraZenecaPreclinical
Rituxan
RochePreclinical
Coumadin
AAbbott
Preclinical
Brukinsa
BBeOne Medicines
Preclinical
Imbruvica
PPharmacyclics LLC.
Preclinical
Versed
CConrado Roberto Hoffmann Filho
Preclinical
Ondexxya
UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology
Preclinical
Statin
Bristol-Myers SquibbPreclinical
Low-Molecular-Weight Heparin
Daiichi SankyoPreclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Sedation19 trials
Median Effective Dose of Remimazolam for Sedation in Elderly Patients
Completed·—·Phase 4·NCT05468996·60 enrolled
Show 16 more trials
ED90 of Remimazolam Loading Dose for Sedation in Patients Under Monitored Anesthetic Care
Completed·—·Phase 4·NCT05340335·50 enrolled
Comparison of Recovery Profiles Among Propofol, Remimazolam, and Dexmedetomidine After Intraoperative Sedation
Completed·—·Phase 4·NCT05688345·120 enrolled
COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)
Completed·—·Phase 3·NCT06013345·127 enrolled
Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Completed·—·Phase 4·NCT05379777·51 enrolled
Remimazolam16 trials
Show 13 more trials
Varied Remimazolam Dosages for Pediatric Endoscopy
Completed·—·N/A·NCT07083440·180 enrolled
Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery
Recruiting·—·Phase 4·NCT06507202·116 enrolled
General Anesthesia7 trials
Show 4 more trials
The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function
Not yet recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·N/A·NCT06775366·174 enrolled
Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia
Completed·—·Phase 4·NCT06513923·136 enrolled
Anesthesia Induction6 trials
Show 3 more trials
Clinical Studies of the Efficacy and Safety of Remimazolam for Anesthesia Induction and Maintenance in Elderly Patients
Recruiting·—·Phase 4·NCT06690424·60 enrolled
Delirium5 trials
Show 2 more trials
65 more indications
Hypotension4 trials
Show 1 more trial
Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery
Completed·—·Phase 4·NCT05651399·78 enrolled
Efficacy and Safety4 trials
A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy
Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT04919174·364 enrolled
Safety and Efficacy3 trials
Anxiety3 trials
Intravenous Anesthesia2 trials
Bronchoscopy2 trials
Quality of Recovery2 trials
Nausea and vomiting2 trials
Intraoperative2 trials
Overweight2 trials
Total Intravenous Anesthesia2 trials
Sleep2 trials
Abuse Potential1 trial
Fiberoptic Bronchoscopy1 trial
Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy
Not yet recruiting·—·N/A·NCT06531915·190 enrolled
Esketamine1 trial
Thoracoscopic Lobectomy1 trial
Respiratory Depression1 trial
Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care
Completed·—·Phase 4·NCT07076628·76 enrolled
Lumbar Fusion Surgery1 trial
Remifentanil1 trial
Glioma1 trial
The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Recruiting·—··NCT06138340·120 enrolled
Tonsillectomy1 trial
Coronary Artery Bypass1 trial
Gastrointestinal Endoscopy1 trial
Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy
Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 4·NCT05406102·300 enrolled
Gynecologic Surgery1 trial
Vascular Disease1 trial
Remimazolam and Endovascular Procedures of Cerebrovascular Diseases
Completed·—·N/A·NCT04950621·142 enrolled
Hypothermia1 trial
One-lung Ventilation1 trial
Tracheal Intubation1 trial
The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation
Unknown status·—·Phase 4·NCT06095570·150 enrolled
Loss of consciousness1 trial
The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients
Unknown status·—·N/A·NCT05434494·80 enrolled
COVID-191 trial
Complication1 trial
Medical Procedure1 trial
Bone Fracture1 trial
Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture
Unknown status·—·N/A·NCT05774366·58 enrolled
Cardiac Electrophysiology1 trial
Elderly Patients1 trial
Painless Gastrointestinal Endoscopy1 trial
Scoliosis1 trial
Remimazolam and Scoliosis Orthopedics
Unknown status·—·N/A·NCT05519371·148 enrolled
Hemodynamic Stability1 trial
Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position
Completed·—·Phase 4·NCT05644483·94 enrolled
Gastric Cancer1 trial
Endoscopy1 trial
Laparoscopic1 trial
Intraoperative Hypotension1 trial
Coronary Artery Disease1 trial
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting: a Study Protocol for a Prospective, Single-centre, Randomized, Controlled Trial
Not yet recruiting·CChinese Academy of Medical Sciences, Fuwai Hospital·Preclinical·NCT07787364·416 enrolled
Peritoneal Neoplasms1 trial
Myocardial Injury1 trial
Effects of Remimazolam and Propofol on Postoperative Myocardial Injury in Elderly Patients Undergoing General Anesthesia
Enrolling by invitation·AAffiliated Hospital of Jiaxing University·Preclinical·NCT07725185·80 enrolled
Cholelithiasis1 trial
General Anesthetic1 trial
Emergence Agitation1 trial
Effect of Drug1 trial
Post-Operative Delirium1 trial
Regulatory
FDA Approval Timeline[5]
Oct 6, 2020
BYFAVO
NDA NDA212295
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Anerem drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Remimazolam. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]FDA Orange Book — Patent and exclusivity data for Anerem. U.S. Food & Drug Administration.
- [7]
Details
Drug Info
Quick Facts
- Mechanism of Action
- GABA-a Receptor; Anion Channel Positive Allosteric Modulator[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- AAcacia Pharma Ltd