Anerem

(Remimazolam)

ApprovedSmall molecule

Remimazolam is used for sedation during medical procedures and for inducing anesthesia before surgery, helping patients stay calm and comfortable during these medical interventions.[2] Anerem is currently approved and in use across 29 indications[4].[1]

Anerem is one of 498 small molecule programs targeting Glioma. It is currently in Approved.

Indications

126

Total Trials

Active Trials

497

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

GliomaActive, not recruiting

Coronary Artery DiseaseActive, not recruiting

Childhood Acute Lymphoblastic LeukemiaApproved

AbortionActive, not recruiting

Bone FractureActive, not recruiting

Parkinson DiseaseApproved

Medical ProcedureActive, not recruiting

DeliriumActive, not recruiting

Respiratory DepressionActive, not recruiting

Post-Operative DeliriumCompleted

GliomaPreclinical

Active, not recruiting

Coronary Artery DiseasePreclinical

Active, not recruiting

Childhood Acute Lymphoblastic LeukemiaApproved

Approved

AbortionPhase 2

Active, not recruiting

Bone FracturePreclinical

Active, not recruiting

Parkinson DiseaseApproved

Approved

Medical ProcedurePhase 2/Phase 3

Active, not recruiting

DeliriumPreclinical

Active, not recruiting

Respiratory DepressionApproved

Active, not recruiting

Post-Operative DeliriumPreclinical

Completed

Showing 10 of 27 indications

Competition

Competitive Landscape

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

Anerem

AAcacia Pharma Ltd

Approved

1 2

COVID-19 Vaccine

Moderna

Preclinical

27 3

Nexavar

Bayer

Preclinical

1 4

Tricor

JJagotec

Preclinical

1 5

Benadryl

PParkedale

Preclinical

1 6

Nitrostat

VViatris Specialty LLC

Preclinical

1 7

Orap

Teva

Preclinical

1 8

Calcium

Eli Lilly

Preclinical

—9

Biological Data

UUniversity Hospital, Bordeaux

Preclinical

3 10

Olokizumab

UCB

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Tonsillectomy

NCT07118579

Post-ApprovalNot yet recruiting

Postoperative Sleep Quality

NCT07094945

Q4 2026

Post-ApprovalRecruiting

Bladder Cancer

NCT04532606

N/ARecruiting

Atrial Fibrillation

NCT05891145

Phase 1/2Not yet recruiting

Thoracoscopic Lobectomy

NCT07086911

N/ANot yet recruiting

Coronary Artery Bypass

NCT06496165

Clinical

Trials by Indication[1]

Sedation20 trials

Sedation With Remimazolam During Spinal Anesthesia

Completed·GGangnam Severance Hospital·N/A·NCT05305248·62 enrolled

Ideal Dosage for Sedation of Obese Patients Undergoing Knee or Hip Arthroplasty Under Spinal Anesthesia

Completed·SSeoul National University Hospital·Phase 4·NCT05760534·110 enrolled

Remimazolam vs Midazolam Cognitive and Motor Recovery After Intravenous Conscious Sedation for Dental Extractions.

Unknown status·GGuy's and St Thomas' NHS Foundation Trust·Phase 3·NCT05220462·128 enrolled

Show 17 more trials

Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam

Unknown status·ZZhujiang Hospital·N/A·NCT05160987·440 enrolled

Median Effective Dose of Remimazolam for Sedation in Elderly Patients

Completed·—·Phase 4·NCT05468996·60 enrolled

Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation

Unknown status·TTianjin Nankai Hospital·Phase 4·NCT04815265·488 enrolled

Moderate Sedation Combined With Acupuncture Anesthesia in Gastroscopy and Colonoscopy on Screening Research

Completed·TThe Affiliated Hospital of Qingdao University·N/A·NCT05485064·108 enrolled

Remimazolam Versus Midazolam for Sedation During Upper GI Endoscopy: a Randomized Controlled Trial

Recruiting·KKoen Munters·Phase 4·NCT06614036·148 enrolled

Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation

Completed·SSeoul National University Hospital·Phase 4·NCT05447507·104 enrolled

COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)

Completed·—·Phase 3·NCT06013345·127 enrolled

The Impact of Remimazolam for Postoperative Sedation on the Left Ventricular Systolic Performance in Cardiac Surgery

Unknown status·KKonkuk University Medical Center·Phase 4·NCT05041725·15 enrolled

Remimazolam Sedation for Nerve Blocks

Completed·UUniversity of Utah··NCT05415202·100 enrolled

Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia

Completed·—·Phase 4·NCT05379777·51 enrolled

Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy

Completed·SSamsung Medical Center·Phase 3·NCT05836545·132 enrolled

Comparison of Recovery Profiles Among Propofol, Remimazolam, and Dexmedetomidine After Intraoperative Sedation

Completed·—·Phase 4·NCT05688345·120 enrolled

ED90 of Remimazolam Loading Dose for Sedation in Patients Under Monitored Anesthetic Care

Completed·—·Phase 4·NCT05340335·50 enrolled

Comparison of Procedural Sedation in TEE

Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT06129188·105 enrolled

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

Recruiting·MMassachusetts General Hospital·Phase 3·NCT07269808·100 enrolled

Remimazolam Besylate in Sedation of Postcardioperative Patients

Recruiting·FFirst Affiliated Hospital of Zhejiang University·N/A·NCT06716840·120 enrolled

Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients

Completed·PPeking University·Phase 4·NCT04602845·81 enrolled

Remimazolam16 trials

Effect of Combined Administration of Sevoflurane and Remimazolam on Emergence

Completed·PPusan National University Yangsan Hospital·N/A·NCT06385002·146 enrolled

The Median Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg

Unknown status·TTianjin Nankai Hospital·Phase 4·NCT04969068·50 enrolled

Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments

Recruiting·KKaohsiung Veterans General Hospital.·Phase 4·NCT06777758·90 enrolled

Show 13 more trials

Explore the Advantages of Remimazolam Used on Gastroscopy

Unknown status·SSichuan Provincial People's Hospital·Phase 4·NCT05429086·287 enrolled

Dose of Remimazolam in Children for Intubation

Unknown status·ZZhihong LU·N/A·NCT06170918·40 enrolled

Comparison of the Effect of Remimazolam With Sevoflurane on Postanesthetic Shivering

Completed·WWonkwang University Hospital··NCT05523037·74 enrolled

Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment

Completed·YYeongseok Yun·Phase 4·NCT06664138·30 enrolled

Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery

Recruiting·—·Phase 4·NCT06507202·116 enrolled

Absolute Oral Bioavailability of Remimazolam

Completed·PPaion UK Ltd.·Phase 1·NCT04113564·14 enrolled

A Trial of Intranasal Remimazolam Pharmacokinetics, Pharmacodynamics, Safety and Bioavailability

Completed·PPaion UK Ltd.·Phase 1·NCT03329014·12 enrolled

Varied Remimazolam Dosages for Pediatric Endoscopy

Completed·—·N/A·NCT07083440·180 enrolled

The 90% Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg

Unknown status·JJianbo Yu·N/A·NCT05053763·120 enrolled

Oral Remimazolam With and Without Alcohol in Healthy Female Subjects

Completed·PPaion UK Ltd.·Phase 1·NCT04113343·21 enrolled

Remimazolam Phase II Cardiac Anesthesia Study

Completed·PPaion UK Ltd.·Phase 2·NCT01937767·90 enrolled

Remimazolam in High Risk ERCP Patients

Not yet recruiting·NNational Taiwan University Hospital·N/A·NCT06258356·60 enrolled

The Effect of Intraoperative Remimazolam Administration on the Incidence of Postoperative Acute Kidney Injury After Hepatobiliary and Pancreatic Surgery : a Prospective Randomized Controlled Trial

Not yet recruiting·SSeoul National University Bundang Hospital·Preclinical·NCT07674719·78 enrolled

Delirium7 trials

Comparison of Emergence Delirium: Remimazolam vs Sevoflurane Anesthesia

Unknown status·SSecond Affiliated Hospital of Wenzhou Medical University·Phase 4·NCT06214117·90 enrolled

Remimazolam and Emergence Delirium in Pediatrics

Recruiting·PPeking University First Hospital·Phase 4·NCT07046364·248 enrolled

Effect of Remimazolam and Propofol on Postoperative Delirium

Recruiting·IInje University·N/A·NCT05514405·82 enrolled

Show 4 more trials

Remimazolam for Emergence Delirium Prevention in Patients Undergoing Rhinoseptoplasty, FESS or Septoplasty

Unknown status·UUniversity Hospital of Split·Phase 2·NCT06398275·80 enrolled

Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy

Not yet recruiting·TThe First Affiliated Hospital with Nanjing Medical University·N/A·NCT07351474·170 enrolled

Effect of Remimazolam on Postoperative Delirium

Completed·ZZhihong LU·N/A·NCT06180876·264 enrolled

Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery

Not yet recruiting·YYonsei University·Phase 4·NCT07265128·300 enrolled

General Anesthesia7 trials

Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia

Not yet recruiting·SSecond Hospital of Shanxi Medical University·Phase 1·NCT07012902·125 enrolled

The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function

Not yet recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·N/A·NCT06775366·174 enrolled

Electroencephalographic Profiles During General Anesthesia: a Comparative Study of Remimazolam and Propofol

Unknown status·SSecond Affiliated Hospital of Nanchang University·N/A·NCT05533567·12 enrolled

Show 4 more trials

Differential Effects of Remimazolam and Propofol on Dynamic Cerebral Autoregulation During General Anesthesia

Unknown status·SSecond Affiliated Hospital of Nanchang University·N/A·NCT05533580·50 enrolled

Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological Surgeries

Not yet recruiting·SSecond Hospital of Shanxi Medical University·N/A·NCT06990763·40 enrolled

Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia

Completed·—·Phase 4·NCT06513923·136 enrolled

Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy

Completed·SSun Yat-sen University·Phase 3·NCT06714669·88 enrolled

Anesthesia Induction6 trials

ED90 of Remimazolam Anesthesia Induction in Painless Bidirectional Endoscopy in Children

Completed·TTongji Hospital·N/A·NCT06121609·165 enrolled

Clinical Studies of the Efficacy and Safety of Remimazolam for Anesthesia Induction and Maintenance in Elderly Patients

Recruiting·—·Phase 4·NCT06690424·60 enrolled

Effects of Remimazolam and Propofol on Anesthesia Induction

Unknown status·ZZheng Guo·N/A·NCT06009055·80 enrolled

Show 3 more trials

Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery

Unknown status·KKonkuk University Medical Center·Phase 4·NCT05412914·40 enrolled

Remimazolam Versus Propofol for General Anesthesia Induction in Patients on Renin-angiotensin System Blockers Undergoing Robot-assisted Laparoscopic Prostatectomy

Completed·YYonsei University·N/A·NCT06093971·112 enrolled

The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction

Not yet recruiting·JJun Zhang·Phase 4·NCT07303985·40 enrolled

55 more indications

Efficacy and Safety4 trials

Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery

Terminated·PPaion UK Ltd.·Phase 3·NCT02523859·25 enrolled

A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients

Completed·PPaion UK Ltd.·Phase 3·NCT02290873·461 enrolled

Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia

Completed·RR-Pharm·Phase 3·NCT03669484·150 enrolled

Show 1 more trial

A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT04919174·364 enrolled

Hypotension4 trials

The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery

Completed·YYonsei University·N/A·NCT05164146·100 enrolled

The Effect of Remimazolam and Dexmedetomidine on the Incidence of Hypotension During Spinal Anesthesia

Unknown status·PPusan National University Yangsan Hospital·N/A·NCT05935657·72 enrolled

Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery

Completed·—·Phase 4·NCT05651399·78 enrolled

Show 1 more trial

REmimazolam vs PrOpofol on Intraoperative hypotenSion in Major Noncardiac surgEry

Completed·NNanfang Hospital, Southern Medical University·Phase 4·NCT05436522·340 enrolled

Safety and Efficacy3 trials

Safety and Efficacy of Remimazolam in OPCAB Surgery

Unknown status·—·N/A·NCT05396690·94 enrolled

Safety and Efficacy Evaluation of Remimazolam for Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy

Unknown status·TThe Third Xiangya Hospital of Central South University·N/A·NCT05437497·264 enrolled

Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy

Completed·PPaion UK Ltd.·Phase 3·NCT02532647·79 enrolled

Bronchoscopy2 trials

A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy

Completed·PPaion UK Ltd.·Phase 3·NCT02296892·446 enrolled

Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy

Completed·ZZhejiang Cancer Hospital·Phase 4·NCT05468671·34 enrolled

Nausea and vomiting2 trials

Effect of Remimazolam on Postoperative Nausea and Vomiting

Completed·IInje University·N/A·NCT05439057·108 enrolled

Remimazolam and Postoperative Nausea and Vomiting in High-risk Patients

Completed·PPeking University First Hospital·Phase 4·NCT04861337·552 enrolled

Anxiety2 trials

Esketamine vs Remimazolam for Postoperative Sleep Disturbance and Anxiety

Completed·TTianjin Medical University General Hospital·N/A·NCT06284668·315 enrolled

Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

Recruiting·TTianjin Medical University General Hospital·N/A·NCT06108830·400 enrolled

Dexmedetomidine2 trials

The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy

Not yet recruiting·FFu Jen Catholic University Hospital·N/A·NCT07459322·60 enrolled

Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy

Completed·TTongji Hospital·N/A·NCT06755996·150 enrolled

Overweight2 trials

The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients

Recruiting·RRenJi Hospital·N/A·NCT06187896·600 enrolled

The Effects of Remimazolam on the Incidence of Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients

Not yet recruiting·RRenJi Hospital·N/A·NCT06004843·600 enrolled

Quality of Recovery2 trials

Effects of Remimazolam on Quality of Recovery After Ambulatory Surgery

Completed·SSeoul National University Bundang Hospital··NCT05320016·38 enrolled

Quality of Recovery of Remimazolam Versus Sevoflurane in Transurethral Bladder Resection.

Completed·KKangbuk Samsung Hospital·N/A·NCT05356091·36 enrolled

Total Intravenous Anesthesia2 trials

Remimazolam Versus Propopol Based Total Intravenous Anesthesia for Breast Surgery

Withdrawn·SSeoul National University Hospital·N/A·NCT05375747

REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry

Recruiting·NNanfang Hospital, Southern Medical University·Phase 4·NCT05728775·7,188 enrolled

Coronary Artery Bypass1 trial

Remimazolam Besylate and Propofol Sedation on Hemodynamic for Coronary Artery Bypass Graft Patients

Not yet recruiting·SShanghai Zhongshan Hospital·N/A·NCT06496165·338 enrolled

Premedication1 trial

Intranasal Remimazolam for Premedication in Pediatric Patient

Completed·SSecond Affiliated Hospital of Wenzhou Medical University·Phase 4·NCT04720963·90 enrolled

Children1 trial

Dose of Remi in Children

Unknown status·ZZhihong LU·N/A·NCT05990673·25 enrolled

Atrial Fibrillation1 trial

Remimazolam for Postoperative Atrial Fibrillation

Recruiting·YYangzhou University·N/A·NCT05891145·50 enrolled

Loss of consciousness1 trial

The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients

Unknown status·—·N/A·NCT05434494·80 enrolled

Intraoperative1 trial

Effects of Remimazolam on the Intraoperative Hemodynamics in Bypass Surgery

Unknown status·SSeoul National University Hospital·N/A·NCT05557253·72 enrolled

Gastrointestinal Endoscopy1 trial

Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 4·NCT05406102·300 enrolled

Thoracoscopic Lobectomy1 trial

The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy

Not yet recruiting·JJinqiao Qian·Phase 1/2·NCT07086911·150 enrolled

Postoperative Sleep Quality1 trial

The Effect of Remimazolam on Postoperative Sleep Quality

Not yet recruiting·TTongji Hospital·Phase 4·NCT07094945·260 enrolled

Parkinson's Disease1 trial

Ketamine for Veterans With Parkinson's Disease

Recruiting·VVA Office of Research and Development·Phase 2·NCT06231563·80 enrolled

COVID-191 trial

REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study

Completed·NNantes University Hospital·Phase 2·NCT04611425·30 enrolled

Complication1 trial

Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery

Completed·SSecond Affiliated Hospital of Nanchang University·N/A·NCT05527314·110 enrolled

Remifentanil1 trial

Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil

Completed·PPaion UK Ltd.·Phase 1·NCT04670471·28 enrolled

Bone Fracture1 trial

Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture

Unknown status·—·N/A·NCT05774366·58 enrolled

Fiberoptic Bronchoscopy1 trial

Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy

Not yet recruiting·—·N/A·NCT06531915·190 enrolled

Intravenous Anesthesia1 trial

Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery

Completed·PPaion UK Ltd.·Phase 3·NCT03661489·469 enrolled

Esketamine1 trial

Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children

Completed·TTongji Hospital·N/A·NCT05686863·106 enrolled

One-lung Ventilation1 trial

Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation

Completed·PPusan National University Yangsan Hospital·N/A·NCT05907525·66 enrolled

Hemodynamic Stability1 trial

Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position

Completed·—·Phase 4·NCT05644483·94 enrolled

Tracheal Intubation1 trial

The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation

Unknown status·—·Phase 4·NCT06095570·150 enrolled

Gynecologic Surgery1 trial

Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery

Not yet recruiting·IIlsan Cha hospital·N/A·NCT07251101·58 enrolled

Vascular Disease1 trial

Remimazolam and Endovascular Procedures of Cerebrovascular Diseases

Completed·—·N/A·NCT04950621·142 enrolled

Hypothermia1 trial

Comparison of the Effect of Remimazolam and Propofol on Perioperative Hypothermia Under Spinal Anesthesia

Completed·WWonkwang University Hospital·N/A·NCT05574257·82 enrolled

Glioma1 trial

The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

Recruiting·—··NCT06138340·120 enrolled

Hemodynamic1 trial

Effect of Remazolam on Hemodynamics During Hepatectomy

Completed·JJun Zhang·Phase 4·NCT06565715·70 enrolled

Cardiac Electrophysiology1 trial

RCT Comparing Remimazolam With Propofol Under EEG DSA Guidance During Cardiac Electrophysiology Studies and Ablation

Enrolling by invitation·TTaipei Veterans General Hospital, Taiwan·N/A·NCT06700681·200 enrolled

Hyperalgesia1 trial

The Effect of Remimazolam on Opioid Induced Hyperalgesia

Completed·WWonkwang University Hospital·N/A·NCT05866315·108 enrolled

Painless Gastrointestinal Endoscopy1 trial

Paradoxical Reactions of Remimazolam in Pediatric Painless Gastrointestinal Endoscopy

Completed·TTongji Hospital·N/A·NCT06419543·333 enrolled

Abortion1 trial

Remimazolam Versus Propofol for Painless Abortion

Completed·MMaternal and Child Health Hospital of Hubei Province·Phase 2·NCT05635955·100 enrolled

Scoliosis1 trial

Remimazolam and Scoliosis Orthopedics

Unknown status·—·N/A·NCT05519371·148 enrolled

Elderly Patients1 trial

Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients

Completed·TTongji Hospital·N/A·NCT05801757·114 enrolled

Neuroimaging1 trial

Remimazolam NeuroImaging

Recruiting·KKeith M Vogt·Phase 1·NCT07290205·60 enrolled

Bladder Cancer1 trial

Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

Recruiting·PPeking University First Hospital·Phase 4·NCT04532606·1,128 enrolled

Tonsillectomy1 trial

Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy

Recruiting·TTongji Hospital·Phase 4·NCT07118579·114 enrolled

Abuse Potential1 trial

Abuse Potential of Intravenous Remimazolam Compared to Midazolam and Placebo in Recreational CNS Depressant Users

Completed·PPaion UK Ltd.·Phase 1·NCT04110535·83 enrolled

LAM1 trial

The Application of Remazolam in Gastroenteroscopy

Completed·YYangzhou University·N/A·NCT05357430·83 enrolled

Respiratory Depression1 trial

Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care

Completed·—·Phase 4·NCT07076628·76 enrolled

Medical Procedure1 trial

Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures

Active, not recruiting·AAcacia Pharma Ltd·Phase 2/3·NCT04851717·100 enrolled

Cataract1 trial

Remimazolam for Cataract Surgery

Recruiting·UUniversity of California, Los Angeles·Phase 4·NCT05980117·120 enrolled

Neuromuscular Block1 trial

Remimazolam and Remifentanil Without Neuromuscular Blocking Agent

Completed·SSeoul National University Bundang Hospital··NCT05025410·38 enrolled

Lumbar Fusion Surgery1 trial

Comparison of Postoperative QoR-15 Scores Between Desflurane and Remimazolam in Lumbar Fusion Surgery

Completed·GGangnam Severance Hospital·N/A·NCT04983966·76 enrolled

Laparoscopic1 trial

The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time in Patients Undergoing Laparoscopic Hepatectomy: A Randomized Controlled Trial

Recruiting·XXuyu Zhang·Approved·NCT07611344·82 enrolled

Effect of Drug1 trial

The 90% Effective Dose (ED90) of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscope in Adult: an up and Down Sequential Trial

Completed·TTongji Hospital·Approved·NCT06333145·165 enrolled

Post-Operative Delirium1 trial

Effect of Remimazolam Versus Propofol Anesthesia on Postoperative Delirium in Neurosurgical Patients: A Randomised, Controlled, Noninferiority Trial

Completed·SSamsung Medical Center·Preclinical·NCT06115031·696 enrolled

Hysteroscopy1 trial

Remimazolam With Planned Flumazenil Reversal Versus Sevoflurane-based Balanced Anesthesia for Hysteroscopic Day Surgery: A Randomized Controlled Trial

Not yet recruiting·CChung-Ang University Gwangmyeong Hospital·Approved·NCT07663877·124 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 6, 2020

BYFAVO

NDA NDA212295

Sources

References

[1]
ClinicalTrials.gov — 126 trial records for Remimazolam. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Anerem drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Remimazolam compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Remimazolam. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA212295). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Anerem. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Acacia Pharma Ltd company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: GABA-a Receptor; Anion Channel Positive Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AAcacia Pharma Ltd

Patent Landscape[6]

Patent Cliff

Jul 10, 2027

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10961250Jul 10, 2027

10472365Jul 10, 2027

9777007Jul 10, 2027

9914738Jul 10, 2027

9737547Nov 7, 2031

6 more patents

10195210Nov 7, 2031

10342800Nov 7, 2031

10052334Nov 7, 2031

10722522Nov 7, 2031

9561236Apr 30, 2033

9827251Jan 13, 2034

Anerem

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Sedation20 trials

Remimazolam16 trials

Delirium7 trials

General Anesthesia7 trials

Anesthesia Induction6 trials

Efficacy and Safety4 trials

Hypotension4 trials

Safety and Efficacy3 trials

Bronchoscopy2 trials

Nausea and vomiting2 trials

Anxiety2 trials

Dexmedetomidine2 trials

Overweight2 trials

Quality of Recovery2 trials

Total Intravenous Anesthesia2 trials

Coronary Artery Bypass1 trial

Premedication1 trial

Children1 trial

Atrial Fibrillation1 trial

Loss of consciousness1 trial

Intraoperative1 trial

Gastrointestinal Endoscopy1 trial

Thoracoscopic Lobectomy1 trial

Postoperative Sleep Quality1 trial

Parkinson's Disease1 trial

COVID-191 trial

Complication1 trial

Remifentanil1 trial

Bone Fracture1 trial

Fiberoptic Bronchoscopy1 trial

Intravenous Anesthesia1 trial

Esketamine1 trial

One-lung Ventilation1 trial

Hemodynamic Stability1 trial

Tracheal Intubation1 trial

Gynecologic Surgery1 trial

Vascular Disease1 trial

Hypothermia1 trial

Glioma1 trial

Hemodynamic1 trial

Cardiac Electrophysiology1 trial

Hyperalgesia1 trial

Painless Gastrointestinal Endoscopy1 trial

Abortion1 trial

Scoliosis1 trial

Elderly Patients1 trial

Neuroimaging1 trial

Bladder Cancer1 trial

Tonsillectomy1 trial

Abuse Potential1 trial

LAM1 trial

Respiratory Depression1 trial

Medical Procedure1 trial

Cataract1 trial

Neuromuscular Block1 trial

Lumbar Fusion Surgery1 trial

Laparoscopic1 trial

Effect of Drug1 trial

Post-Operative Delirium1 trial

Hysteroscopy1 trial

FDA Approval Timeline[5]

References

Drug Info

Quick Facts

Patent Landscape[6]

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