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Psychiatry/Borderline Personality Disorder

Borderline Personality Disorder

11

Pipeline Programs↗

18

Active Trials↗

13

Companies Involved↗

Borderline personality disorder is an emerging landscape with 11 programs across 13 companies.

Intelligence

Pipeline Metrics

Competitive Density

46/100

Pipeline Velocity

27/100

Mech. Concentration

17/100

Completion Rate

80/100

Attrition Rate

10/100

Pipeline

Programs by Phase

Preclinical9

Guanfacine

Promius Pharma, LLC

Divalproex Sodium

Teva

Fludrocortisone

Jazz Pharmaceuticals

Oxytocin

Retrophin

Psychopharmaceuticals

Francisco Miguel Correia Sampaio

Phase 1

No programs

Phase 22

Psilocybin

COMPASS Pathways

Ketamine Hydrochloride

Boehringer Ingelheim

Phase 3

No programs

Approved

No programs

Analysis

Trial Status

58

clinical trials

Completed28 · 48%

Recruiting11 · 19%

Unknown status5 · 9%

Active, not recruiting4 · 7%

Terminated4 · 7%

Not yet recruiting3 · 5%

Other3 · 5%

Clinical Trials

Trial Activity

58 trials

Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder

Recruiting·MMassachusetts General Hospital·Preclinical·NCT07714005·12 enrolled

The Effects of MDMA (3,4-methylenedioxymethamphetamine) in Social Cognition in Borderline Personality Disorder

Recruiting·YYale University·Phase 2·NCT06683014·10 enrolled

Effectiveness of Enhanced Dialectical Behavior Therapy Skills Training Group for Borderline Personality Disorder: A Pragmatic, Multicenter, Randomized Non-inferiority Trial

Recruiting·HHospital Dr Sotero del Rio·Preclinical·NCT07875166·360 enrolled

MBT-EVOLVE: Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences: A 10+ Year Follow-up of Two Types of MBT for BPD - Quantitative and Qualitative Perspectives on Long-term Functioning

Recruiting·—·N/A·NCT07509216·113 enrolled

Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients

Recruiting·IIcahn School of Medicine at Mount Sinai·Preclinical·NCT06772831·130 enrolled

A Multi-center, Patient-blinded and Investigator-blinded, Randomized, Parallel-group, Superiority Study to Compare the Efficacy of Four Sessions of Amygdala fMRI-BOLD Neurofeedback With Yoked Sham-control Neurofeedback in the Treatment of Dysregulated Affect in Borderline Personality Disorder

Recruiting·CCentral Institute of Mental Health, Mannheim·Preclinical·NCT06626789·164 enrolled

CLINICAL TRIAL: Treatment of Borderline Personality Disorder by Targeting Ventrolateral Prefrontal-amygdala Circuit With Network-based Neuronavigated Transcranial Magnetic Stimulation

Recruiting·UUniversity of California, Los Angeles·Preclinical·NCT07197502·30 enrolled

A Pilot Trial of One Day Accelerated Intermittent Theta-burst Stimulation Plus D-cycloserine in Suicidal Patients With Borderline Personality Disorder (ONE-D BPD)

Recruiting·MMclean Hospital·Preclinical·NCT07460947·20 enrolled

Combining Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder: A Phase II Randomized, Midazolam-Controlled Clinical Trial (KET-DBT)

Recruiting·—·Phase 2·NCT07569198·120 enrolled

Conceptualizing Borderline Personality Disorder as a Relationship Use Disorder

Recruiting·UUniversity Hospital, Montpellier·Preclinical·NCT07337889·194 enrolled

A Novel Drug for Borderline Personality Disorder

Recruiting·—·Phase 2·NCT02097706·150 enrolled

Mindfulness-based Neurofeedback to Augment Dialectical Behavior Therapy (DBT) for Adults With Borderline Personality Disorder (Aim 1)

Active, not recruiting·YYale University·Phase 2·NCT06446765·46 enrolled

Effects of Psychiatric Admissions on Self-harm and Suicide in People With Borderline Personality Disorder

Active, not recruiting·LLund University·N/A·NCT06424509·390 enrolled

A Pilot Randomized Controlled Trial Evaluating an Alliance-Focused Dialectical Behaviour Therapy Training Intervention for Borderline Personality Disorder

Active, not recruiting·York University·Preclinical·NCT07119541·80 enrolled

Emotional Regulation and Impulsivity Among Adolescents with Borderline Personality Disorder

Active, not recruiting·IInstitut National de la Santé Et de la Recherche Médicale, France·Phase 2·NCT03209102·66 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)