Ketalar

(Ketamine Hydrochloride)

ApprovedSmall molecule

Ketamine is used as an anesthetic to put patients to sleep during surgery and procedures. It is also increasingly used in lower doses to treat severe depression and chronic pain when other treatments haven't worked.[2] Ketalar is currently approved and in use across 41 indications[4].[1]

Ketalar is one of 756 small molecule programs targeting Sleep. It is currently in Approved.

Indications

Total Trials

Active Trials

755

Competitors

Pipeline

Status by Indication[4][1]

Indication

SleepActive, not recruiting

Neuropathic PainActive, not recruiting

Cardiac ArrestActive, not recruiting

Bipolar I DisorderActive, not recruiting

Low Back PainActive, not recruiting

Depressive DisorderActive, not recruiting

Psychiatric DisorderActive, not recruiting

SuicideActive, not recruiting

HemorrhageActive, not recruiting

Anorexia NervosaActive, not recruiting

SleepPreclinical

Active, not recruiting

Neuropathic PainPhase 3

Active, not recruiting

Cardiac ArrestPreclinical

Active, not recruiting

Bipolar I DisorderPhase 2

Active, not recruiting

Low Back PainPhase 2

Active, not recruiting

Depressive DisorderPhase 2

Active, not recruiting

Psychiatric DisorderPhase 1

Active, not recruiting

SuicidePhase 2

Active, not recruiting

HemorrhageApproved

Active, not recruiting

Anorexia NervosaPhase 1

Active, not recruiting

Showing 10 of 37 indications

Competition

Competitive Landscape

386 competitors in Major Depressive Disorder

#DrugCompanyPhaseTrials

Ketalar

Boehringer Ingelheim

Approved

3 2

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

5 3

Risperdal

WWim Janssens

Phase 3

2 4

Clozaril

LLife Extension Foundation Inc.

Phase 3

1 5

Fetzima

AbbVie

Phase 3

9 6

Brenipatide

DVS-233

9 8

Seroquel IR

Otsuka

Phase 3

1 9

SR58611A

Sanofi

Phase 3

4 10

NMRA-335140

NNeumora Therapeutics, Inc.

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 3Recruiting

Suicide

NCT04763343

Q4 2026

Phase 2/3Recruiting

Suicidal Ideation

NCT06891300

Phase 2Recruiting

Methamphetamine Use Disorder

NCT06496750

Phase 2Recruiting

Depressed

NCT05803551

Phase 2/3Recruiting

Suicidal Ideation

NCT05696691

Q2 2027

PreclinicalActive, not recruiting

Study completion

NCT04589208

Clinical

Trials by Indication[1]

Ketamine11 trials

Imaging Neural Correlates of Ketamine Using PET/MR

Recruiting·MMedical University of Vienna·Phase 1·NCT04587778·65 enrolled

Chart Review of Patients Undergoing Ketamine Infusions

Completed·BBrain and Cognition Discovery Foundation··NCT04209296·891 enrolled

Endogenous Opioid Modulation by Ketamine

Withdrawn·UUniversity of Utah·Phase 3·NCT03051945

Show 8 more trials

Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)

Enrolling by invitation·MMedical University of Gdansk··NCT05565352·140 enrolled

Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department

Terminated·—·Phase 3·NCT04260607·1 enrolled

Optimal Timing of Ketamine Initiation for SCD Pain

Not yet recruiting·—·Phase 3·NCT07450430·90 enrolled

Ketamine Therapy Experiential Education Study

Unknown status·IIntegrative Psychiatry Institute·Phase 1·NCT05468047·500 enrolled

Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts

Not yet recruiting·NNew York State Psychiatric Institute·Phase 4·NCT07139106·12 enrolled

Reward Emotion Learning and Ketamine Study

Unknown status·UUniversity of Oxford·N/A·NCT04850911·70 enrolled

The Impact of Ketamine on the Reward Circuitry of Suicidal Patients

Withdrawn·MMassachusetts General Hospital·Phase 3·NCT02532153

Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD

Withdrawn·UUniversity of New Mexico·Phase 1/2·NCT06036511

Suicidal Ideation6 trials

Ketamine & Crisis Response Plan for Suicidal Ideation in the ED

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 2/3·NCT05696691·24 enrolled

A Single Ketamine Infusion Combined With Music for Suicidal Ideation

Unknown status·TThe University of Texas Health Science Center at Tyler·Phase 2·NCT04658420·200 enrolled

Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation

Recruiting·—·N/A·NCT06366334·20 enrolled

Show 3 more trials

NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression

Unknown status·NNeuroRx, Inc.·Phase 3·NCT03396601·150 enrolled

Understanding and Treating Suicidal Ideation With Ketamine

Recruiting·TThe Royal's Institute of Mental Health Research·Phase 2/3·NCT06891300·36 enrolled

Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation

Unknown status·UUniversity of Ottawa·Phase 3·NCT05468840·20 enrolled

Depression5 trials

Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine

Completed·DDan Iosifescu·Phase 2/3·NCT04216888·9 enrolled

Ketamine for OUD and Comorbid Depression (OUDCD)

Terminated·UUniversity of Maryland, Baltimore·Phase 1·NCT05051449·5 enrolled

Chart Review of Patients Undergoing Ketamine Treatments for Depression

Completed·SSunnybrook Health Sciences Centre··NCT07099235·250 enrolled

Show 2 more trials

The Neurobiology of Suicide

Recruiting·NNational Institute of Mental Health (NIMH)·Phase 2·NCT02543983·325 enrolled

Ketamine for Combined Depression and Alcohol Use Disorder: A Blinded Randomized Active Placebo-controlled Trial (the KeDA Trial)

Recruiting·UUniversity Hospital of North Norway·Preclinical·NCT06090422·34 enrolled

Treatment Resistant Depression4 trials

Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

Not yet recruiting·UUniversity of Rochester·Phase 2·NCT07247006·25 enrolled

Psilocybin Versus Ketamine in Treatment-Resistant Depression

Unknown status·NNational Institute of Mental Health, Czech Republic·Phase 2·NCT05383313·60 enrolled

Ketamine Augmentation of ECT in Treatment-Resistant Depression

Recruiting·UUniversità Vita-Salute San Raffaele·Phase 3·NCT07088380·30 enrolled

Show 1 more trial

i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

Recruiting·UUniversity Health Network, Toronto·Phase 2·NCT06480500·110 enrolled

Sedation4 trials

Low Dose Perioperative Ketamine Infusion and it's Effect on Postoperative Pain Score, Sedation Score and Narcotic Consumption in Patients Undergoing Spine Surgery: A Prospective Randomized Double Blind Control Trial.

Unknown status·SServices Institute of Medical Sciences, Pakistan·Phase 1·NCT04259476·60 enrolled

Ketamine Sedation in the ICU (KANINE) RCT

Not yet recruiting·MMcMaster University·Phase 3·NCT06767358·54 enrolled

Sedation for Non-invasive Ventilation in Blunt Chest Trauma

Completed·—·N/A·NCT05175781·45 enrolled

Show 1 more trial

Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II)

Completed·UUniversidade Federal de Goias·Phase 4·NCT03290625·12 enrolled

47 more indications

Major Depressive Disorder3 trials

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

Recruiting·—·Phase 3·NCT05603104·1,254 enrolled

Ketamine Co-induction for Patients With Major Depressive Disorder

Unknown status·UUniversity of Saskatchewan·Phase 4·NCT03666494·50 enrolled

The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Recruiting·—·Phase 3·NCT05973851·418 enrolled

Bipolar Disorder2 trials

Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder

Terminated·JJuvenile Bipolar Research Foundation·Phase 2/3·NCT01504659·5 enrolled

Ketamine for Treatment-Resistant Bipolar Disorder

Completed·JJoshua Rosenblat·Phase 2·NCT05004896·71 enrolled

Dexmedetomidine2 trials

The Effect of Intraoperative Infusion of Dexmedetomidine Versus Low Dose Ketamine

Unknown status·—·Phase 1·NCT05828199·80 enrolled

Dexmedetomidine and Ketamine in VATS Surgery

Recruiting·CCiusss de L'Est de l'Île de Montréal·N/A·NCT03596424·120 enrolled

Memory2 trials

A Study in Healthy Men to Test Whether BI 474121 Can Reverse the Memory Problems Caused by Ketamine

Withdrawn· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT05451095

Glutamate Emotion Memory Study

Recruiting·UUniversity of Oxford·N/A·NCT05809609·60 enrolled

Acute Traumatic Pain2 trials

Intranasal Ketamine for Acute Traumatic Pain

Completed·—·Phase 4·NCT02817477·90 enrolled

Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain

Active, not recruiting·JJason McMullan·Phase 3·NCT02866071·224 enrolled

Neuropathic Pain2 trials

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial

Completed·UUnity Health Toronto·Phase 4·NCT05639322·30 enrolled

Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain

Unknown status·UUniversity of Glasgow·Phase 3·NCT01316744·214 enrolled

Analgesia2 trials

Morphine or Ketamine for Analgesia

Not yet recruiting·—·Phase 3·NCT06835504·1,010 enrolled

Prehospital Analgesia INtervention Trial (PAIN)

Recruiting·JJason Sperry·Phase 3·NCT05437575·994 enrolled

Major Depression2 trials

The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.

Completed·MMayo Clinic·Phase 4·NCT03156504·75 enrolled

An EEG Study of Intravenous Ketamine for Major Depression Disorder

Unknown status·EEhave Inc.·Phase 4·NCT05506462·35 enrolled

Treatment2 trials

Oral Ketamine for Treatment of Vaso-Occlusive Pain

Recruiting·—·Phase 3·NCT05378555·10 enrolled

Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics

Completed·KKlarisana Physician Services PLLC··NCT03947099·7 enrolled

Irritability1 trial

Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets

Completed·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT05046184·165 enrolled

Intraoperative1 trial

Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery

Unknown status·—·N/A·NCT03344393·60 enrolled

Anemia1 trial

Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia

Unknown status·KKing Saud University·N/A·NCT04857450·60 enrolled

Cardiac Arrest1 trial

The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study

Unknown status·FFraser Health·N/A·NCT04360070·24 enrolled

Gulf War Illness1 trial

Ketamine in Veterans With Gulf War Illness

Terminated·—·Phase 1·NCT04712071·1 enrolled

Treatment-resistant Bipolar Depression1 trial

Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression

Completed·JJoshua Rosenblat·Phase 2·NCT05339074·41 enrolled

Idiopathic Scoliosis1 trial

Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery

Completed·FFundació Sant Joan de Déu·Phase 2·NCT02571491·48 enrolled

Hemorrhage1 trial

Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT03621085·43 enrolled

Low back pain1 trial

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

Recruiting·VVA Office of Research and Development·Phase 2·NCT06419439·44 enrolled

Erector Spinae Plane Block1 trial

Ketamine and Magnesium in Erector Spinae Plane Block

Completed·—·Phase 4·NCT05855798·60 enrolled

Children1 trial

Pharmacokinetics of Ketamine in Infants and Children

Completed·SStanford University·N/A·NCT00553839·21 enrolled

Cognition1 trial

HNC: Human Neural Circuits Electrophysiology During Cognition

Recruiting·SStanford University·Phase 1·NCT05962424·120 enrolled

Alcohol Use Disorder1 trial

Inpatient Single Dose Interventions for Alcohol Use Disorder

Completed·—·Phase 1·NCT04562779·44 enrolled

Palliative Care1 trial

Study of Ketamine for Depression in Cancer Patients Receiving Palliative Care

Completed·UUniversity Health Network, Toronto·Phase 2·NCT03410446·22 enrolled

Endoscopic Retrograde Cholangiopancreatography (ERCP)1 trial

Evaluation of Ketamine as Sedative Agent in Endoscopic Retrograde Cholangiopancreatography (ERCP)

Recruiting·UUniversiti Kebangsaan Malaysia Medical Centre·Phase 4·NCT04490031·140 enrolled

Depressed1 trial

A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients

Recruiting·MMayo Clinic·Phase 2·NCT05803551·50 enrolled

Midazolam1 trial

IM Ketamine vs Midazolam for Suicidal ER Patients

Suspended·NNew York State Psychiatric Institute·Phase 4·NCT04640636·90 enrolled

Opioid Use Disorder1 trial

Ketamine for the Treatment of Opioid Use Disorder and Depression

Completed·MMedical University of South Carolina·Phase 2·NCT04177706·21 enrolled

Parkinson's Disease1 trial

Imaging Depression in Parkinson's Disease

Recruiting·YYale University·Phase 2·NCT06402955·120 enrolled

Analgesic1 trial

Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation

Completed·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·N/A·NCT05360030·45 enrolled

Laparoscopic Cholecystectomy1 trial

The Effect of Low Dose Ketamine on Narcotic Consumption in Patients Undergoing Laparoscopic Cholecystectomy

Completed·—·N/A·NCT05444777·86 enrolled

Postoperative Pain Control1 trial

Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery

Unknown status·—·Phase 4·NCT06066879·40 enrolled

Cesarean Section1 trial

Comparison of Ketamine Plus Dexamethasone Versus Ketamine Alone for Prevention of Severe Shivering After Spinal Anesthesia in Cesarean Section

Completed·KKasr El Aini Hospital·N/A·NCT06091657·110 enrolled

Post-cardiac Surgery1 trial

Effect of Ketamine on Analgesia Post-Cardiac Surgery

Completed·JJewish General Hospital·Phase 4·NCT02925858·80 enrolled

Tobacco Use Disorder1 trial

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Completed·MMedical University of South Carolina·Phase 1·NCT05796791·7 enrolled

Suicidality1 trial

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

Completed·UUniversity of Texas Southwestern Medical Center·Phase 3·NCT04592809·50 enrolled

Methamphetamine Use Disorder1 trial

Ketamine for Methamphetamine Use Disorder

Recruiting·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT06496750·120 enrolled

Erector Spinae Block1 trial

Dexametomedine Versus Ketamine as an Adjuvant in Erector Spinae Block for Perioperative Thoracotomy Pain Control

Completed·KKasr El Aini Hospital·Phase 4·NCT05552391·90 enrolled

Epilepsy1 trial

The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy

Recruiting·MMadeline Fields·Phase 2·NCT05019885·8 enrolled

Brain Injury1 trial

Ketamine in Severe Traumatic Brain Injury

Recruiting·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT06062628·10 enrolled

Agitation1 trial

Intramuscular Ketamine Effect on Postnasal Surgery Agitation

Completed·JJordanian Royal Medical Services·Phase 2·NCT05313659·193 enrolled

Lidocaine1 trial

Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

Terminated·GGil Yosipovitch·Phase 2·NCT03096444·13 enrolled

Tonsillectomy1 trial

Ketamine Versus Magnesium as Analgesic Adjuvants in Pediatric Adenotonsillectomy

Completed·—·Phase 4·NCT05565664·38 enrolled

Emergencies1 trial

Intranasal Ketamine and Fracture Reduction in Pediatric Emergencies (KETAPED)

Completed·FFondation Lenval·Phase 3·NCT03525821·9 enrolled

Suicide1 trial

Ketamine Treatment of Youth Suicide Attempters

Recruiting·—·Phase 3·NCT04763343·60 enrolled

Effectiveness1 trial

Effectiveness of Ketamine Treatment for Three Consecutive Days in Depression

Completed·MMahidol University·Phase 4·NCT05026203·24 enrolled

Subarachnoid Hemorrhage1 trial

Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage

Withdrawn·—·Phase 2/3·NCT05032118

Unspecified1 trial

Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1)

Active, not recruiting·NNew York State Psychiatric Institute·Preclinical·NCT04589208·35 enrolled

Sources

References

[1]
ClinicalTrials.gov — 87 trial records for Ketamine Hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ketalar drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Ketamine Hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Ketamine Hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Boehringer Ingelheim company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glutamate [NMDA] Receptor Negative Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Boehringer Ingelheim

Ketalar

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2027

Trials by Indication[1]

Ketamine11 trials

Suicidal Ideation6 trials

Depression5 trials

Treatment Resistant Depression4 trials

Sedation4 trials

Major Depressive Disorder3 trials

Bipolar Disorder2 trials

Dexmedetomidine2 trials

Memory2 trials

Acute Traumatic Pain2 trials

Neuropathic Pain2 trials

Analgesia2 trials

Major Depression2 trials

Treatment2 trials

Irritability1 trial

Intraoperative1 trial

Anemia1 trial

Cardiac Arrest1 trial

Gulf War Illness1 trial

Treatment-resistant Bipolar Depression1 trial

Idiopathic Scoliosis1 trial

Hemorrhage1 trial

Low back pain1 trial

Erector Spinae Plane Block1 trial

Children1 trial

Cognition1 trial

Alcohol Use Disorder1 trial

Palliative Care1 trial

Endoscopic Retrograde Cholangiopancreatography (ERCP)1 trial

Depressed1 trial

Midazolam1 trial

Opioid Use Disorder1 trial

Parkinson's Disease1 trial

Analgesic1 trial

Laparoscopic Cholecystectomy1 trial

Postoperative Pain Control1 trial

Cesarean Section1 trial

Post-cardiac Surgery1 trial

Tobacco Use Disorder1 trial

Suicidality1 trial

Methamphetamine Use Disorder1 trial

Erector Spinae Block1 trial

Epilepsy1 trial

Brain Injury1 trial

Agitation1 trial

Lidocaine1 trial

Tonsillectomy1 trial

Emergencies1 trial

Suicide1 trial

Effectiveness1 trial

Subarachnoid Hemorrhage1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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