Pitocin

(Oxytocin)

ApprovedSmall molecule

Oxytocin is used to start or strengthen labor contractions during childbirth and to control bleeding after delivery. It's also sometimes used to help with milk letdown in breastfeeding.[2] Pitocin is currently approved and in use across 62 indications[4].[1]

Pitocin is one of 779 small molecule programs targeting Abortion. It is currently in Approved.

Indications

438

Total Trials

Active Trials

778

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

AbortionActive, not recruiting

Interstitial CystitisActive, not recruiting

Myocardial IschemiaActive, not recruiting

Sexual DysfunctionApproved

Depressive DisorderApproved

Alcohol DependenceApproved

Anxiety DisorderApproved

Attention Deficit Hyperactivity DisorderApproved

SunburnApproved

GastroparesisApproved

AbortionApproved

Active, not recruiting

Interstitial CystitisApproved

Active, not recruiting

Myocardial IschemiaApproved

Active, not recruiting

Sexual DysfunctionApproved

Approved

Depressive DisorderApproved

Approved

Alcohol DependenceApproved

Approved

Anxiety DisorderApproved

Approved

Attention Deficit Hyperactivity DisorderApproved

Approved

SunburnApproved

Approved

GastroparesisApproved

Approved

Showing 10 of 60 indications

Competition

Competitive Landscape

174 competitors in Schizophrenia

#DrugCompanyPhaseTrials

Pitocin

RRetrophin

Approved

12 2

Inapsine

Jazz Pharmaceuticals

Preclinical

1 3

Ozempic

Novo Nordisk

Preclinical

1 4

Resotran

Takeda

Preclinical

1 5

Depakote

Ibrance

Lunesta

3 8

Persantine

Boehringer Ingelheim

Preclinical

1 9

Luvox

SSolvay Pharmaceuticals

Preclinical

1 10

Catapres

Boehringer Ingelheim

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Not yet recruiting

Autism Spectrum Disorder

NCT05864508

Phase 2Recruiting

Arginine Vasopressin Deficiency

NCT06808516

Phase 1Recruiting

Opioid Abuse

NCT05761860

Phase 1Recruiting

Opioid

NCT04218409

N/ARecruiting

Oxytocin

NCT06334172

N/ANot yet recruiting

Cesarean Section

NCT07188207

Clinical

Trials by Indication[1]

Oxytocin52 trials

Oxytocin Effects on Likeability After Being Liked or Disliked

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT02745431·86 enrolled

The Influence of Oxytocin on Automatic Imitation Behaviour in Healthy Adults

Completed·UUniversity Ghent·Phase 3·NCT01767025·60 enrolled

Adult Study Oxytocin - Behavioral

Completed·UUniversity of California, San Francisco·Phase 1·NCT02567032·324 enrolled

Show 49 more trials

Dyad Oxytocin Study (DOS)

Completed·UUniversity of California, San Francisco·Phase 1·NCT02302209·104 enrolled

The Influence of Oxytocin on the Processing of Social Contact

Completed·UUniversity Hospital, Bonn·Phase 1·NCT01939639·40 enrolled

Influence of Oxytocin on Neurophysiological Responses to Live Faces

Completed·KKU Leuven·Phase 1/2·NCT03272321·56 enrolled

The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories

Completed·—·N/A·NCT03875391·217 enrolled

Influence of Oxytocin on Approach-avoidance Tendencies to Social and Non-social Stimuli

Completed·KKU Leuven·N/A·NCT04443647·64 enrolled

The Effect of Oxytocin on Face Perception

Suspended·SSoroka University Medical Center·Phase 1·NCT02091817·100 enrolled

The Role of Oxytocin in Regulating Blood Glucose

Recruiting·UUniversity Hospital, Gentofte, Copenhagen·N/A·NCT06334172·20 enrolled

Intranasal Oxytocin Administration and the Neural Correlates of Social and Non-Social Visual Perception

Completed·YYale University·Phase 1·NCT02238379·26 enrolled

Sex- and Context-dependent Effects of Oxytocin on Social Reward Processing

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03085628·252 enrolled

Oxytocin Effects on the Prosocial Learning

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT04105140·90 enrolled

The Influence of Intranasal Oxytocin on Communication

Completed·UUniversity of British Columbia·N/A·NCT02415920·50 enrolled

Outcomes After the Implementation of a New Oxytocin Protocol

Completed·—·N/A·NCT02722356·64 enrolled

Brief Cognitive Behavioral Conjoint Therapy for PTSD With Adjunctive Intranasal Oxytocin

Completed·SSan Diego Veterans Healthcare System·Phase 2·NCT05207436·20 enrolled

Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)

Completed·MMedical University of South Carolina·Phase 2·NCT03846505·192 enrolled

Oxytocin Effects on Food Motivation Pathways

Completed·MMassachusetts General Hospital·Phase 1·NCT02276677·10 enrolled

Continued Versus Discontinued Oxytocin Stimulation of Labour

Completed·UUniversity of Aarhus·Phase 4·NCT02553226·1,200 enrolled

Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT02647268·26 enrolled

Effects of Vaginal Oxytocin Gel on Vaginal Cytologic Parameters in Postmenopausal Woman

Terminated·DDepartment of Medical Services Ministry of Public Health of Thailand·Phase 2/3·NCT05627791·6 enrolled

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

Completed·UUniversity of Colorado, Boulder·Phase 1·NCT03060031·51 enrolled

Oxytocin and Resting State fMRI

Completed·UUniversity Hospital Heidelberg·N/A·NCT02689596

Oxytocin and Non-verbal Communication

Completed·—·Phase 2·NCT03228901·104 enrolled

Prophylactic Use of Intraumbilical Vein Oxytocin Injection in The Management of Third Stage of Labor

Unknown status·—·Phase 1·NCT02680938·1 enrolled

Deciphering the Role of Oxytocin in Motivation: an fMRI Study

Completed·TTiffany Love·Phase 2·NCT01722071·20 enrolled

Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation

Completed·NNorthwestern University·Phase 4·NCT02487797·1,003 enrolled

Temporal Dynamics and Pharmacokinetics of Intranasally Administered Oxytocin

Completed·UUniversity Hospital, Bonn·Phase 1·NCT03011970·116 enrolled

Oxytocin on Approach Bias and Craving

Withdrawn·JJennifer Mitchell·Phase 2·NCT03865615

Oxytocin, Emotions and Mirror Neurons

Completed·UUniversity of Maryland, Baltimore·Phase 1·NCT02228031·44 enrolled

Intra-Umbilical Vein Oxytocin Injection as an Adjunct to Active Management of the Third Stage of Labour

Completed·DDangana Zakari Adeka·N/A·NCT07436286·416 enrolled

Oxytocin and Interpersonal Motor Resonance

Completed·KKU Leuven·Phase 4·NCT03010670·27 enrolled

Oxytocin Add on Study for Stable Schizophrenic Patients

Terminated·DDavid Feifel·N/A·NCT00506909·21 enrolled

Oxytocin-augmented Cognitive-behavioral Group-based Short-term Intervention for Loneliness

Unknown status·UUniversity Hospital, Bonn·Phase 1·NCT04137432·60 enrolled

The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

Completed·—·N/A·NCT03031405·220 enrolled

Effect of Oral Oxytocin on Women's Response to Emotional Stimuli

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT05073939·80 enrolled

Oral Oxytocin Modulation of Responses to Emotional Stimuli

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT04320706·80 enrolled

Oxytocin Administration to Therapists and Its Effects on Patient-perceived Attunement and Responsiveness

Not yet recruiting·SShalvata Mental Health Center·Phase 1·NCT06332066·20 enrolled

Social Safety Learning in the Brain Oxytocin System

Completed·UUniversity of Washington·Phase 2·NCT05968651·121 enrolled

Effects of Oxytocin on Cognitive and Reactive Fear

Unknown status·UUniversity Hospital, Bonn·Phase 1·NCT04292444·60 enrolled

Dose-dependent Effects of Oxytocin on the Amygdala and Reward System

Completed·UUniversity Hospital, Bonn·Phase 1·NCT03846739·92 enrolled

Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy

Completed·KKing's College London·N/A·NCT05383300·72 enrolled

Oxytocin on Cold Water Task Performance and Recovery

Completed·FFlorida Institute for Human and Machine Cognition·Phase 2·NCT04738838·17 enrolled

Use of Intranasal Oxytocin During Detoxification of Crack Cocaine

Unknown status·PPontificia Universidade Católica do Rio Grande do Sul·Phase 1/2·NCT04306354·96 enrolled

The Effects of Oxytocin in Obese Adults

Completed·MMassachusetts General Hospital·Phase 2·NCT03043053·61 enrolled

Oxytocin's Effect on Socioemotional Aging

Completed·UUniversity of Florida·N/A·NCT01823146·106 enrolled

Target Engagement and Response to Oxytocin

Completed·UUniversity of California, Los Angeles·Phase 4·NCT03245437·120 enrolled

Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD

Recruiting·VVA Office of Research and Development·Phase 2·NCT06194851·240 enrolled

The Effects of Intranasal and Oral Administration of Oxytocin on Responses to Emotional Scenes

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT05532501·160 enrolled

Oxytocin and Human Defensive Responses in a Dynamic Situation

Recruiting·UUniversity of Electronic Science and Technology of China·N/A·NCT07162584·80 enrolled

Oxytocin and Cognitive Control in Adult ADHD

Completed·MMassachusetts General Hospital·Phase 1·NCT03136263·24 enrolled

Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin

Completed·UUniversity Hospital, Bonn·Phase 1·NCT04330677·487 enrolled

Cesarean Section7 trials

Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section

Not yet recruiting·—·N/A·NCT07188207·282 enrolled

Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain

Completed·—··NCT06692621·120 enrolled

Oxytocin Induction in Full Term Pregnant Women With Cesarean Section of Prelabor Rupture of Membranes

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University··NCT05333731·528 enrolled

Show 4 more trials

Does the Rapid Intravenous Administration of Oxytocin After Delivery of the Baby Decrease the Bleeding During Cesarean Section in Women at Risk of Bleeding During Cesarean Section?

Completed·UUniversity of British Columbia·N/A·NCT00257803·150 enrolled

Oxytocin Dosing at Planned Cesarean Section and Anemia

Withdrawn·MMilton S. Hershey Medical Center·Phase 4·NCT03361124

Oxytocin to Decrease Blood Loss During Cesarean Section

Completed·—·N/A·NCT00891150·200 enrolled

Comparison of IV Ergonovine With IM Carboprost, With Oxytocin IV, During Cesarean Section for Failure to Progress

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01869556·105 enrolled

Schizophrenia6 trials

Administrating Oxytocin to Treat Treatment Schizophrenia and Schizo-affective Patients

Unknown status·SSheba Medical Center·Phase 2·NCT01598623·48 enrolled

Effects of Oxytocin on Negative Symptoms and Social Cognition in Schizophrenia and Its Possible Mechanisms

Completed·SShanghai Mental Health Center·N/A·NCT03662425·43 enrolled

Neurobiological Effects of Oxytocin in Schizophrenia

Unknown status·NNational Institute of Mental Health and Neuro Sciences, India·N/A·NCT04177719·44 enrolled

Show 3 more trials

Effects of Intranasal Oxytocin on Satiety Signaling in People With Schizophrenia

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT01614093·24 enrolled

Oxytocin and Social Cognition in Schizophrenia

Completed·UUniversity of Maryland, Baltimore·Phase 2·NCT00884897·28 enrolled

Oxytocin and Social Decision Making in Schizophrenia

Completed·NNational Institute of Mental Health and Neuro Sciences, India·N/A·NCT04176835·55 enrolled

Induction of Labor6 trials

A Study Comparing Vaginal Misoprostol and Intravenous Oxytocin for Induction of Labor

Completed·VVanderbilt University Medical Center·N/A·NCT01634854·130 enrolled

Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon

Completed·AAultman Health Foundation·N/A·NCT01139801·50 enrolled

Induction of Labor With Oxytocin: When Should Oxytocin be Held?

Completed·LLehigh Valley Hospital·N/A·NCT00957593·252 enrolled

Show 3 more trials

Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop

Unknown status·SShaare Zedek Medical Center·Phase 4·NCT02801227·68 enrolled

Breast Stimulation Versus Pitocin for Induction of Labor

Unknown status·HHadassah Medical Organization·N/A·NCT00984347·150 enrolled

Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite Prostaglandin

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT02720978·1,200 enrolled

Autism6 trials

Triadic Interactions of Families With Autism and Oxytocin

Withdrawn·UUniversity of California, San Francisco·Phase 1·NCT01912378

Modulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin

Completed·KKU Leuven·Phase 3·NCT03640156·25 enrolled

An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism

Completed·—·Phase 1·NCT00263796·16 enrolled

Show 3 more trials

Intranasal Oxytocin in the Treatment of Autism

Completed·EEvdokia Anagnostou·Phase 2·NCT00490802·19 enrolled

Intranasal Oxytocin Treatment for Social Deficits in Children With Autism

Completed·SStanford University·Phase 2·NCT01624194·54 enrolled

Intranasal Oxytocin in Youth With Autism

Not yet recruiting·OOslo University Hospital·Phase 2·NCT05934812·128 enrolled

82 more indications

Cesarean Delivery5 trials

Does Intramyometrial Oxytocin Improve Outcome in Elective Cesarean Delivery?

Withdrawn·UUniversity of Saskatchewan·Phase 4·NCT01252342

Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia

Completed·MMansoura University··NCT05269537·60 enrolled

Tranexamic Acid Plus Buccal Misoprostol on Blood Loss During and After Cesarean Delivery

Completed·—·N/A·NCT03710304·400 enrolled

Show 2 more trials

Oxytocin And Uterotonic Agent Use For Cesarean Delivery

Completed·—·Phase 4·NCT01549223·60 enrolled

Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.

Completed·SStanford University·Phase 3·NCT01932060·51 enrolled

Labor5 trials

Labor Scale Versus WHO Partograph in the Management of Labor

Unknown status·—·N/A·NCT02486822·120 enrolled

Labor Scale Versus WHO Partograph for Management of Labor (ScaLP)

Unknown status·—·N/A·NCT05341076·206 enrolled

Active Versus Expectant Management of the Third Stage of Labor

Completed·CChristiana Care Health Services·N/A·NCT00473707·218 enrolled

Show 2 more trials

Management of Prelabor Rupture of the Membranes at Term

Recruiting·RRambam Health Care Campus·N/A·NCT04307069·524 enrolled

Management of the Third Stage of Labor

Unknown status·YYariv yogev·Phase 3·NCT02319707·500 enrolled

Cognition5 trials

Effects of Oxytocin on Emotion Recognition and Response Inhibition

Unknown status·RRWTH Aachen University·Phase 2·NCT02350946·40 enrolled

Understanding Cognition, Oxytocin & Pain in Elders

Completed·UUniversity of Florida·Phase 2/3·NCT03878589·83 enrolled

Pharmacological Approach to Improve the Outcome of Social Cognition Training

Completed·VVA Greater Los Angeles Healthcare System·Phase 1·NCT01517360·27 enrolled

Show 2 more trials

Oxytocin Administration and Emotion Recognition Abilities in Adults Reporting Adverse Childhood Experiences

Completed·RRuhr University of Bochum·N/A·NCT03335085·80 enrolled

Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers

Completed·UUniversity of California, San Francisco·Phase 4·NCT01829516·32 enrolled

Anxiety4 trials

Effect of Intranasal Neuropeptide on Emotion Perception in Trait Anxiety

Completed·MMassachusetts General Hospital·N/A·NCT01551303·47 enrolled

Trait Anxiety and Defensive Networks

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT02682888·131 enrolled

Oxytocin Add-on Study for Stable Anxiety Patients

Terminated·UUniversity of California, San Diego·N/A·NCT00989937·17 enrolled

Show 1 more trial

Multiple Dose Effect of Oxytocin on Males With High or Low Trait Anxiety

Completed·UUniversity of Electronic Science and Technology of China·Phase 1·NCT03085654·147 enrolled

Intravenous4 trials

The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels

Unknown status·KKasr El Aini Hospital·Phase 4·NCT02602301·327 enrolled

Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography

Recruiting·WWake Forest University Health Sciences·Phase 2·NCT07409753·60 enrolled

A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects

Completed·WWake Forest University Health Sciences·Phase 1·NCT05672667·25 enrolled

Show 1 more trial

Comparison of the Mean Duration of 3rd Stage of Labour Between Intraumbilical and Intravenous Oxytocin

Completed·RRESnTEC, Institute of Research·N/A·NCT07053930·100 enrolled

Attention3 trials

Differential Effects of Oral and Intranasal Oxytocin on Attention Control

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT04815395·151 enrolled

Oxytocin's Effect on Attention Training

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03128242·60 enrolled

Oral Oxytocin's Effects on Attention Control

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT04493515·80 enrolled

Cervical Ripening3 trials

Study of the Effectiveness of Cervical Ripening Balloon With and Without Oxytocin

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT03138252·180 enrolled

A Randomized, Control Trial for Preinduction Cervical Ripening

Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT00393731·540 enrolled

Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction

Terminated· Ferring logo

Ferring·Phase 4·NCT01190163·170 enrolled

Pregnancy3 trials

Amniotomy for Second-trimester Pregnancy Termination

Completed·—·N/A·NCT04906278·60 enrolled

Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption

Completed·TThe University of Western Australia·N/A·NCT00120042·251 enrolled

Is Oxytocin Given During Surgical Procedure for Abortion Before 12 Weeks of Pregnancy Useful?

Completed·—·N/A·NCT00540748·400 enrolled

Treatment3 trials

Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01689298·20 enrolled

Alcohol and Cigarette Craving During Oxytocin Treatment

Completed·—·Phase 1·NCT04071119·19 enrolled

The Effects of Oxytocin Treatment on Social Touch

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT05265806·180 enrolled

Misoprostol3 trials

Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)

Unknown status·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT05568745·520 enrolled

Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy

Recruiting·—·Phase 3·NCT06325501·56 enrolled

PROMMO Trial: Oral Misoprostol vs IV Oxytocin

Completed·UUniversity of Wisconsin, Madison·Phase 1·NCT04478942·138 enrolled

Labor Induction3 trials

Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term

Completed·SSeoul National University Hospital·N/A·NCT02618096·154 enrolled

Breast Stimulation vs. Low Dose Oxytocin Augmentation for Labor Induction

Unknown status·WWestern Galilee Hospital-Nahariya·Phase 1/2·NCT05510310·200 enrolled

Foley Labor Induction Trial at Term and in PROM

Completed·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT02098421·312 enrolled

Caesarean Section2 trials

Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section

Completed·UUniversity of Zimbabwe·Phase 3·NCT03463993·506 enrolled

Uterotonic Efficacy of Oxytocin 2.5 Versus 10 Units During Caesarean Section at Mulago Hospital

Completed·FFaculty of Medicine·N/A·NCT01726478·386 enrolled

Function2 trials

Study of Wellness Behaviors as a Function of Oxytocin vs Placebo

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01929161·239 enrolled

Effects of Intranasal Oxytocin on Functional Brain Network in Resting-state and Tasks

Completed·—·N/A·NCT03428906·34 enrolled

Substance Use Disorders2 trials

Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress

Completed·MMedical University of South Carolina·Phase 1·NCT02058251·73 enrolled

Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress

Completed·JJennifer Mitchell·Phase 2·NCT02742532·63 enrolled

Hysterectomy2 trials

IV Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

Withdrawn·—·Phase 4·NCT05608070

Role of Uterotonics in Reducing Intraoperative Blood Loss in Patients With PASD Undergoing Cesarean Hysterectomy

Recruiting·—·N/A·NCT06493968·70 enrolled

Experimental2 trials

Experimental Study on Alcohol Use and Behavior in Young Adults

Terminated·KKarolinska Institutet·Phase 2·NCT06199076·206 enrolled

The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers

Completed·UUniversitätsklinikum Hamburg-Eppendorf·N/A·NCT01886014·80 enrolled

Tranexamic Acid2 trials

Intravenous Oxytocin Versus Tranexamic Acid in Reducing Blood Loss During Abdominal Myomectomy.

Completed·—·Phase 4·NCT03892668·150 enrolled

Tranexamic Acid for the Prevention of Postpartum Haemorrhage

Unknown status·—·Phase 1/2·NCT04707950·60 enrolled

Hemorrhage2 trials

Carbetocin Versus Oxytocin for Prophylaxis Against Atonic Primary Post-partum Hemorrhage

Unknown status·SSohag University·N/A·NCT05479357·80 enrolled

Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage

Completed·HHormozgan University of Medical Sciences·Phase 1·NCT01863706·400 enrolled

Postpartum Hemorrhage2 trials

Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients

Completed·—·N/A·NCT07380529·300 enrolled

Oxytocin, Carbetocin and Misopristol for Treatment of Postpartum Hemorrhage: A Multicentric Randomized Trial

Unknown status·SSohag University·N/A·NCT01600612·300 enrolled

Infusion2 trials

Maintenance Infusion of Oxytocin Following Elective Cesarean Deliveries

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT04946006·40 enrolled

Up-Down Oxytocin Infusion

Completed·IIWK Health Centre·Phase 4·NCT00785395·40 enrolled

Alcohol Use Disorder2 trials

Oxytocin and Stress Response in Alcohol Use Disorder

Completed·MMedical University of South Carolina·Phase 2·NCT03610633·11 enrolled

Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder

Completed·—·Phase 2/3·NCT05093296·62 enrolled

Intranasal Administration2 trials

The Effect of Intranasal Administration of Oxytocin on Empathic Abilities.

Unknown status·SShalvata Mental Health Center·Phase 2·NCT00813436·100 enrolled

Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Healthy Adults

Completed·OOptiNose AS·Phase 1·NCT01983514·19 enrolled

Phelan-McDermid syndrome1 trial

Piloting Treatment With Intranasal Oxytocin in Phelan-McDermid Syndrome

Completed·AAlexander Kolevzon·Phase 2·NCT02710084·18 enrolled

Depressed1 trial

Oxytocin Add-on for Stable Depressed Patients

Terminated·DDavid Feifel·N/A·NCT01211756·1 enrolled

Dystocia1 trial

Accelerated Titration of Oxytocin for Nulliparous Patients With Labour Dystocia: ACTION Pilot Study

Terminated·OOttawa Hospital Research Institute·Phase 3·NCT01397630·79 enrolled

Depression1 trial

Oxytocin and Dyadic Psychotherapy in the Treatment of Post Partum Depression

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT02191423·50 enrolled

Laparoscopic1 trial

Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

Unknown status·YYangzhou University·N/A·NCT04109339·80 enrolled

Prolonged1 trial

Prolonged Exposure and Oxytocin

Completed·MMedical University of South Carolina·Phase 2·NCT03238924·17 enrolled

Social Anxiety Disorder1 trial

Effect of Oxytocin Nasal Sprays on Social Behavior in Social Anxiety Disorder

Completed·—·Phase 1/2·NCT01856530·60 enrolled

Eating Disorder1 trial

The Moderating Role of Baseline Oxytocin on Its Psychotherapy-facilitating Effects Among Patients With Eating Disorders

Unknown status·SShalvata Mental Health Center·Phase 1·NCT05865288·90 enrolled

Obesity1 trial

The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity

Completed·SSara Espinoza·Phase 1/2·NCT03119610·23 enrolled

Opioid1 trial

Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination

Recruiting·UUniversity of Florida·Phase 1·NCT04218409·45 enrolled

Cytokines1 trial

Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Completed·MMedical University of Vienna··NCT00360048·10 enrolled

AIN1 trial

Translating Neuroprediction Into Precision Medicine Via Brain Priming

Terminated·YYale University·Phase 2·NCT03370510·5 enrolled

Remission1 trial

Pre-operative Intranasal Oxytocin for Enhancing Bariatric-induced Diabetes Remission

Unknown status·SSoroka University Medical Center·N/A·NCT05207774·3 enrolled

Premature rupture of membranes1 trial

Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management

Completed·RRambam Health Care Campus·N/A·NCT02825641·458 enrolled

Gastric Emptying1 trial

The Effect of Oxytocin on Gastric Emptying

Completed·SSkane University Hospital·N/A·NCT01152047·14 enrolled

Analgesic1 trial

Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

Terminated·WWake Forest University Health Sciences·Phase 2·NCT04431206·7 enrolled

Heart Rate Variability1 trial

Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)

Completed·WWake Forest University Health Sciences·Phase 4·NCT04105998·22 enrolled

Unknown status·SSheba Medical Center·Phase 2/3·NCT03001635·52 enrolled

Smoking Behavior1 trial

Mindfulness Training Plus Oxytocin Effects on Smoking Behavior

Terminated·UUniversity of Southern California·Phase 2/3·NCT03819231·20 enrolled

Bleeding1 trial

Methods Decreasing Bleeding in Open Myomectomy

Unknown status·—·Phase 4·NCT05806307·105 enrolled

Wound Healing1 trial

Role of Local Skin Incision Infiltration by Oxytocin On Wound Healing

Unknown status·EEgymedicalpedia·N/A·NCT05745935·120 enrolled

Abortion1 trial

Oxytocin Infusion vs. Spontaneous Follow-up for Third-stage of Labor After Second-trimester Abortion

Completed·—·Phase 4·NCT02485444·160 enrolled

Treatment Resistant Depression1 trial

Oxytocin and Tibolone Adjuncts in Treatment Resistant Depression - A Pilot Study

Unknown status·TThe Alfred·Phase 1·NCT01239888·15 enrolled

Labour Induction1 trial

A Randomized Trial of Oral Misoprostol Alone Versus Oral Misoprostol Followed by Oxytocin for Labour Induction

Completed·UUniversity of Liverpool·Phase 4·NCT03749902·520 enrolled

Addiction1 trial

Oxytocin and Brain Responses in Maternal Addiction

Terminated·—·Phase 2·NCT02979093·59 enrolled

Clinical Trial1 trial

Minimum Oxytocin Dose for Cesarean During Labor: Adaptative Clinical Trial

Unknown status·—·Phase 3·NCT02794779·64 enrolled

Autism Spectrum Disorder1 trial

Interest of Oxytocin as an Adjuvant Treatment of Psycho-educational Measures in Challenging Behaviors in Children With Autism Spectrum Disorders and Moderate to Severe Intellectual Disability: Feasibility and Safety Study.

Not yet recruiting·UUniversity Hospital, Toulouse·Phase 2·NCT05864508·30 enrolled

Opiate Dependence1 trial

Oxytocin in Opiate Dependence: A Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence

Unknown status·MMacDonald, Kai, M.D.·Phase 1·NCT02052258

Aggression1 trial

Oxytocin, Alcohol Craving, and Intimate Partner Aggression

Completed·MMedical University of South Carolina·Phase 2·NCT03046836·200 enrolled

COVID-191 trial

Phase II RCT to Assess Efficacy of Intravenous Administration of Oxytocin in Patients Affected by COVID-19

Withdrawn·AAzienda Ospedaliero-Universitaria di Parma·Phase 2·NCT04386447

Cardiac Electrophysiology1 trial

Oxytocin Effects on Cardiac Electrophysiology

Completed·WWilliam Whang·Phase 1·NCT01780337·12 enrolled

Effectiveness1 trial

Oxytocin Effectiveness in First Trimester Dilatation and Curettage

Not yet recruiting·—·N/A·NCT06469203·160 enrolled

Vaginal Delivery1 trial

An Evidence Based Protocol for Oxytocin Administration in Vaginal Delivery

Withdrawn·NNYU Langone Health·Phase 4·NCT02410655

Thromboelastometry1 trial

The Use of Thromboelastometry (ROTEM) to Evaluate the Changes in Coagulation With Two Different Doses of Oxytocin Following Cesarean Delivery

Withdrawn·—·N/A·NCT02063568

Stress Response1 trial

Oxytocin Buffers Stress Response in Individuals With Impaired Coping Abilities

Completed·—·N/A·NCT01065610

Gestational Diabetes1 trial

Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study

Suspended·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT06285396·96 enrolled

Tic Disorder1 trial

A Study of Oxytocin in Children and Adolescents With Autistic Disorder

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT01308749·25 enrolled

CAR1 trial

Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium

Recruiting·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT06930391·40 enrolled

Tinnitus1 trial

High Dose Oxytocin Nasal Spray for Treatment of Tinnitus

Terminated·NNYU Langone Health·Phase 3·NCT04210310·33 enrolled

Women1 trial

In Vitro Myometrial Contractions in Laboring and Non-laboring Women

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01689311·53 enrolled

Ehlers-Danlos syndrome1 trial

Oxytocin for Hypermobile Ehlers-Danlos Syndrome

Terminated·—·Phase 1/2·NCT05405257·2 enrolled

Adolescent1 trial

Effects of Intranasal Oxytocin on Emotion Regulation in Adolescents

Completed·—·Phase 1·NCT02301715·29 enrolled

Analgesia1 trial

Effect of Oxytocin Nasal Inhalation on Empathy Analgesia

Completed·PPeking University People's Hospital·Phase 4·NCT05823441·120 enrolled

Oxidative Stress1 trial

Oxytocin for Oxidative Stress and Inflammation

Completed·FFlorida Institute for Human and Machine Cognition·Phase 2·NCT04732247·40 enrolled

Arginine Vasopressin Deficiency1 trial

Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls

Recruiting·UUniversity Hospital, Basel, Switzerland·Phase 2·NCT06808516·42 enrolled

Withdrawal1 trial

Effects of Intranasal Oxytocin in the Treatment of Benzodiazepine Withdrawal: A Pilot RCT

Recruiting·SSt. Olavs Hospital·Phase 2·NCT06757517·60 enrolled

Efficacy1 trial

Efficacy of Spinal Oxytocin in Healthy Volunteers

Terminated·WWake Forest University Health Sciences·Phase 2·NCT01996605·20 enrolled

Fragile X Syndrome1 trial

Double-blind Placebo Controlled Study of Oxytocin in Fragile X Syndrome

Completed·SStanford University·Phase 2·NCT01254045·10 enrolled

Interaction1 trial

The Interaction Between Oxytocin and Serotonin

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03426176·100 enrolled

Methamphetamine1 trial

Intranasal Oxytocin for Methamphetamine Withdrawal in Women

Completed·TTurning Point·N/A·NCT05760807·10 enrolled

Central diabetes insipidus1 trial

Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls

Recruiting·UUniversity Hospital, Basel, Switzerland·Phase 2·NCT06676774·42 enrolled

Opioid Abuse1 trial

The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

Recruiting·UUniversity of Florida·Phase 1·NCT05761860·45 enrolled

OIC1 trial

Faces: Choices Study

Withdrawn·UUniversity of Florida·Phase 2/3·NCT02409862

Atrophy1 trial

Study to Evaluate Efficacy of Vagitocin in Postmenopausal Women With Vulvovaginal Atrophy Symptoms

Completed·PPepTonic Medical AB·Phase 2·NCT04629885·202 enrolled

Dilation and Evacuation1 trial

Effects of Oxytocin on Bleeding Outcomes During Dilation and Evacuation

Completed·UUniversity of Hawaii·N/A·NCT02083809·166 enrolled

Prader-Willi syndrome1 trial

Effect of Intranasal Oxytocin on Dysphagia in Children and Adolescents With Prader-Willi Syndrome

Completed·UUniversity Hospital, Toulouse·Phase 2/3·NCT05298085·25 enrolled

Social Behavior1 trial

Oxytocin and Social Behavior Over the Lifespan

Completed·—·Phase 1·NCT00914953·41 enrolled

Regulatory

FDA Approval Timeline[5]

Nov 19, 1980

PITOCIN

NDA NDA018261

Jan 1, 1982

OXYTOCIN

NDA NDA018243

Jan 1, 1982

OXYTOCIN

NDA NDA018248

Jan 1, 1982

SYNTOCINON

NDA NDA012285

Jan 1, 1982

SYNTOCINON

NDA NDA018245

Jan 1, 1982

PITOCIN

NDA NDA018261

Mar 29, 1985

OXYTOCIN 10 USP UNITS IN DEXTROSE 5%

NDA NDA019185

Sep 19, 1986

PITOCIN

NDA NDA018261

Jan 29, 1987

PITOCIN

NDA NDA018261

Feb 16, 1988

PITOCIN

NDA NDA018261

Jul 3, 1990

PITOCIN

NDA NDA018261

May 27, 1994

PITOCIN

NDA NDA018261

Aug 9, 1994

PITOCIN

NDA NDA018261

Aug 23, 1994

PITOCIN

NDA NDA018261

Feb 22, 1996

PITOCIN

NDA NDA018261

Jul 10, 1997

PITOCIN

NDA NDA018261

Jul 29, 1997

PITOCIN

NDA NDA018261

Feb 22, 1999

PITOCIN

NDA NDA018261

Nov 10, 1999

PITOCIN

NDA NDA018261

Mar 1, 2000

PITOCIN

NDA NDA018261

Mar 23, 2000

PITOCIN

NDA NDA018261

Oct 25, 2000

PITOCIN

NDA NDA018261

Mar 8, 2001

PITOCIN

NDA NDA018261

Mar 8, 2001

PITOCIN

NDA NDA018261

Mar 8, 2001

PITOCIN

NDA NDA018261

Sep 24, 2001

PITOCIN

NDA NDA018261

Jan 10, 2002

PITOCIN

NDA NDA018261

Mar 24, 2003

PITOCIN

NDA NDA018261

Jul 27, 2007

PITOCIN

NDA NDA018261

Jun 18, 2014

PITOCIN

NDA NDA018261

Oct 2, 2014

PITOCIN

NDA NDA018261

Aug 15, 2016

PITOCIN

NDA NDA018261

May 11, 2021

PITOCIN

NDA NDA018261

Sources

References

[1]
ClinicalTrials.gov — 438 trial records for Oxytocin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Pitocin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Oxytocin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Oxytocin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA018261). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Retrophin company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Oxytocin Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: RRetrophin

Pitocin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Oxytocin52 trials

Cesarean Section7 trials

Schizophrenia6 trials

Induction of Labor6 trials

Autism6 trials

Cesarean Delivery5 trials

Labor5 trials

Cognition5 trials

Anxiety4 trials

Intravenous4 trials

Attention3 trials

Cervical Ripening3 trials

Pregnancy3 trials

Treatment3 trials

Misoprostol3 trials

Labor Induction3 trials

Caesarean Section2 trials

Function2 trials

Substance Use Disorders2 trials

Hysterectomy2 trials

Experimental2 trials

Tranexamic Acid2 trials

Hemorrhage2 trials

Postpartum Hemorrhage2 trials

Infusion2 trials

Alcohol Use Disorder2 trials

Intranasal Administration2 trials

Phelan-McDermid syndrome1 trial

Depressed1 trial

Dystocia1 trial

Depression1 trial

Laparoscopic1 trial

Prolonged1 trial

Social Anxiety Disorder1 trial

Eating Disorder1 trial

Obesity1 trial

Opioid1 trial

Cytokines1 trial

AIN1 trial

Remission1 trial

Premature rupture of membranes1 trial

Gastric Emptying1 trial

Analgesic1 trial

Heart Rate Variability1 trial

Magnetic Resonance Imaging1 trial

Alcohol Use Disorders1 trial

Cardiovascular1 trial

Myocardial Infarction1 trial

Smoking Behavior1 trial

Bleeding1 trial

Wound Healing1 trial

Abortion1 trial

Treatment Resistant Depression1 trial

Labour Induction1 trial

Addiction1 trial

Clinical Trial1 trial

Autism Spectrum Disorder1 trial

Opiate Dependence1 trial

Aggression1 trial

COVID-191 trial

Cardiac Electrophysiology1 trial

Effectiveness1 trial

Vaginal Delivery1 trial

Thromboelastometry1 trial

Stress Response1 trial

Gestational Diabetes1 trial

Tic Disorder1 trial

CAR1 trial

Tinnitus1 trial

Women1 trial

Ehlers-Danlos syndrome1 trial

Adolescent1 trial

Analgesia1 trial

Oxidative Stress1 trial