Pitocin

(Oxytocin)

ApprovedSmall molecule

Oxytocin is used to start or strengthen labor contractions during childbirth and to control bleeding after delivery. It's also sometimes used to help with milk letdown in breastfeeding.[2] Pitocin is currently approved and in use across 84 indications[4].[1]

Pitocin is one of 1322 small molecule programs targeting Body Weight Gain. It is currently in Approved.

Indications

435

Total Trials

Active Trials

1,321

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Body Weight GainApproved

DystociaActive, not recruiting

Benign Muscle NeoplasmApproved

GastroparesisApproved

Cardiac ArrhythmiaApproved

Nicotine DependenceActive, not recruiting

Neuropathic PainApproved

Premature Rupture of MembranesActive, not recruiting

Frontotemporal DementiaActive, not recruiting

Depressive DisorderApproved

Body Weight GainApproved

Approved

DystociaPhase 3

Active, not recruiting

Benign Muscle NeoplasmApproved

Approved

GastroparesisApproved

Approved

Cardiac ArrhythmiaApproved

Approved

Nicotine DependencePreclinical

Active, not recruiting

Neuropathic PainApproved

Approved

Premature Rupture of MembranesPreclinical

Active, not recruiting

Frontotemporal DementiaPhase 1

Active, not recruiting

Depressive DisorderApproved

Approved

Showing 10 of 82 indications

Competition

Competitive Landscape

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

Pitocin

RRetrophin

Approved

1 2

Biaxin

AbbVie

Preclinical

2 3

Stivarga

Bayer

Preclinical

1 4

Aimovig

Amgen

Preclinical

1 5

Calciferol

Alnylam Pharmaceuticals

Activella

SARS-COV-2 VACCINE

2 8

Calcium

Eli Lilly

Preclinical

—9

Conventional

PPopulation Health Research Institute

Preclinical

1 10

Biological Collection

AAssistance Publique - Hôpitaux de Paris

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Oxytocin

NCT06181396

Phase 1Recruiting

Opioid Abuse

NCT05761860

N/ARecruiting

Oxytocin

NCT06334172

N/ANot yet recruiting

Cesarean Section

NCT07188207

Clinical

Trials by Indication[1]

Oxytocin51 trials

Continued Versus Discontinued Oxytocin Stimulation of Labour

Completed·UUniversity of Aarhus·Phase 4·NCT02553226·1,200 enrolled

Oxytocin Administration in the Third Stage of Labour - A Study of Appropriate Route and Dose

Completed·MMemorial University of Newfoundland·Phase 4·NCT00200252·300 enrolled

The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories

Completed·—·N/A·NCT03875391·217 enrolled

Show 48 more trials

Ergometrine Versus Oxytocin in the Management of Atonic Post-partum Haemorrhage (PPH) in Women Delivered Vaginally

Unknown status·—·Phase 3·NCT02306733·200 enrolled

Influence of Oxytocin on Approach-avoidance Tendencies to Social and Non-social Stimuli

Completed·KKU Leuven·N/A·NCT04443647·64 enrolled

Oxytocin for Couples Conflict Resolution

Completed·MMedical University of South Carolina·Phase 2·NCT02941692·66 enrolled

Oxytocin Dosage to Decrease Induction Duration

Completed·UUniversity of Arizona·Phase 4·NCT03140488·140 enrolled

Effects of Oxytocin and Vasopressin on Moral Decision Making

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT04890470·180 enrolled

The Effect of Oxytocin on Face Perception

Suspended·SSoroka University Medical Center·Phase 1·NCT02091817·100 enrolled

The Role of Oxytocin in Regulating Blood Glucose

Recruiting·UUniversity Hospital, Gentofte, Copenhagen·N/A·NCT06334172·20 enrolled

Oxytocin and Emotion Processing

Completed·UUniversity Hospital, Bonn·Phase 1·NCT02156661·97 enrolled

Intranasal Oxytocin Administration and the Neural Correlates of Social and Non-Social Visual Perception

Completed·YYale University·Phase 1·NCT02238379·26 enrolled

Assessment of Pharmacokinetics and Bioavailability of Carbon-14 ([14C])-Labelled Oxytocin

Withdrawn·OOxytone Bioscience BV·Phase 1·NCT02911480

Effect of Oxytocin on Craving and Therapy Response

Completed·MMedical University of South Carolina·N/A·NCT01827332·16 enrolled

Effects of Intranasal Oxytocin and Stress on Belief Updating

Completed·—·N/A·NCT03597893·131 enrolled

Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT02647268·26 enrolled

Sex- and Context-dependent Effects of Oxytocin on Social Reward Processing

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03085628·252 enrolled

Effects of Vaginal Oxytocin Gel on Vaginal Cytologic Parameters in Postmenopausal Woman

Terminated·DDepartment of Medical Services Ministry of Public Health of Thailand·Phase 2/3·NCT05627791·6 enrolled

Oxytocin Effects on the Prosocial Learning

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT04105140·90 enrolled

Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor

Completed·EErzincan Military Hospital·Phase 3·NCT01094028·412 enrolled

Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT04433741

Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)

Completed·MMedical University of South Carolina·Phase 2·NCT03846505·192 enrolled

Influence of Oxytocin on Neurophysiological Responses to Live Faces

Completed·KKU Leuven·Phase 1/2·NCT03272321·56 enrolled

Role of Oxytocin in Telling and Detecting Lies

Withdrawn·UUniversity of Texas at Austin·Phase 1·NCT02361177

Oxytocin Effects on Food Motivation Pathways

Completed·MMassachusetts General Hospital·Phase 1·NCT02276677·10 enrolled

Deciphering the Role of Oxytocin in Motivation: an fMRI Study

Completed·TTiffany Love·Phase 2·NCT01722071·20 enrolled

Adult Study Oxytocin - fMRI

Completed·UUniversity of California, San Francisco·Phase 1·NCT02566356·59 enrolled

Temporal Dynamics and Pharmacokinetics of Intranasally Administered Oxytocin

Completed·UUniversity Hospital, Bonn·Phase 1·NCT03011970·116 enrolled

Oxytocin on Approach Bias and Craving

Withdrawn·JJennifer Mitchell·Phase 2·NCT03865615

The Modulatory Effect of Oxytocin on Interoception

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT03074409·83 enrolled

Oxytocin, Emotions and Mirror Neurons

Completed·UUniversity of Maryland, Baltimore·Phase 1·NCT02228031·44 enrolled

High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour

Completed·GGöteborg University·N/A·NCT01587625·1,376 enrolled

Adult Oxytocin Study

Completed·UUniversity of California, San Francisco·Phase 1·NCT02577575·120 enrolled

Deciphering the Role of Oxytocin in Motivation: an fMRI Study. Part II

Unknown status·UUniversity of Utah·Phase 2·NCT02652195·88 enrolled

Investigating the Effect of Extracellular Calcium on Oxytocin-induced Human Myometrial Contractility In-vitro

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT02274454·41 enrolled

Oxytocin Effects on Self and Other Processing

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT02963194·44 enrolled

Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes

Recruiting·RRambam Health Care Campus·N/A·NCT06181396·120 enrolled

The Neural Basis of Oxytocin's Effects on Empathy

Completed·UUniversity of Electronic Science and Technology of China·Phase 1·NCT03084029·72 enrolled

Effects of Intranasal Oxytocin on Emotion Regulation

Unknown status·UUniversity of Electronic Science and Technology of China·Phase 1·NCT03055546·80 enrolled

High Or Low Dose pOstpartUm Oxytocin at the Time of Cesarean Birth

Withdrawn·UUniversity of Chicago·Phase 2·NCT06550089

The Influence of Oxytocin on Socio-communicative Sensitivity

Completed·KKU Leuven·Phase 1/2·NCT03096249·31 enrolled

Oxytocin and Interpersonal Motor Resonance

Completed·KKU Leuven·Phase 4·NCT03010670·27 enrolled

The Influence of Oxytocin on the Processing of Social Contact

Completed·UUniversity Hospital, Bonn·Phase 1·NCT01939639·40 enrolled

Oxytocin Add on Study for Stable Schizophrenic Patients

Terminated·DDavid Feifel·N/A·NCT00506909·21 enrolled

Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor

Completed·TThe University of Texas Medical Branch, Galveston·Phase 4·NCT05782816·170 enrolled

Oxytocin Administration to Therapists and Its Effects on Patient-perceived Attunement and Responsiveness

Not yet recruiting·SShalvata Mental Health Center·Phase 1·NCT06332066·20 enrolled

Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy

Completed·KKing's College London·N/A·NCT05383300·72 enrolled

Oxytocin-augmented Cognitive-behavioral Group-based Short-term Intervention for Loneliness

Unknown status·UUniversity Hospital, Bonn·Phase 1·NCT04137432·60 enrolled

The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

Completed·—·N/A·NCT03031405·220 enrolled

Effect of Oral Oxytocin on Women's Response to Emotional Stimuli

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT05073939·80 enrolled

Social Safety Learning in the Brain Oxytocin System

Completed·UUniversity of Washington·Phase 2·NCT05968651·121 enrolled

Cesarean Section12 trials

Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain

Completed·—··NCT06692621·120 enrolled

Effects of Oxytocin and Carbetocin on Renal System in Cesarean Sections

Unknown status·UUfuk University··NCT03939806·100 enrolled

Combined Use of Oxytocin and Misoprostol Versus Oxytocin Infusion and Misoprostol Alone to Reduce Blood Loss at Cesarean Section

Completed·QQazvin University Of Medical Sciences·Phase 1/2·NCT01571323·150 enrolled

Show 9 more trials

Carbetocin vs. Oxytocin at Elective Cesarean Section

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT03168698·278 enrolled

Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section

Not yet recruiting·—·N/A·NCT07188207·282 enrolled

Uterotonics Using to Reduce Bleeding at Cesarean Section

Completed·—·Phase 2·NCT02562300·120 enrolled

Carbetocin Versus Oxytocin Infusion Plus Tranexamic Acid During Cesarean Section

Unknown status·—·N/A·NCT03777878·400 enrolled

Ideal Time of Oxytocin Infusion During Cesarean Section

Terminated·LLoyola University·Phase 4·NCT03246919·68 enrolled

Oxytocin Dosing at Planned Cesarean Section and Anemia

Withdrawn·MMilton S. Hershey Medical Center·Phase 4·NCT03361124

Oxytocin to Decrease Blood Loss During Cesarean Section

Completed·—·N/A·NCT00891150·200 enrolled

Oxytocin Administration During Cesarean Section

Completed·—·Phase 4·NCT03344302·200 enrolled

Comparison of IV Ergonovine With IM Carboprost, With Oxytocin IV, During Cesarean Section for Failure to Progress

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01869556·105 enrolled

Schizophrenia9 trials

A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in Schizophrenia

Terminated·VVA Office of Research and Development·Phase 2·NCT03900754·26 enrolled

Neurobiological Effects of Oxytocin in Schizophrenia - Imaging Study

Completed·NNational Institute of Mental Health and Neuro Sciences, India·N/A·NCT04158167·90 enrolled

Effects of Oxytocin on Negative Symptoms and Social Cognition in Schizophrenia and Its Possible Mechanisms

Completed·SShanghai Mental Health Center·N/A·NCT03662425·43 enrolled

Show 6 more trials

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

Completed·VVA Greater Los Angeles Healthcare System·N/A·NCT01312272·24 enrolled

Effects of Intranasal Oxytocin on Satiety Signaling in People With Schizophrenia

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT01614093·24 enrolled

Neurobiological Effects of Oxytocin in Schizophrenia

Unknown status·NNational Institute of Mental Health and Neuro Sciences, India·N/A·NCT04177719·44 enrolled

Oxytocin and Social Cognition in Schizophrenia

Completed·UUniversity of Maryland, Baltimore·Phase 2·NCT00884897·28 enrolled

Oxytocin as Adjunctive Therapy for Schizophrenia

Completed·IIRCCS Centro San Giovanni di Dio Fatebenefratelli·Phase 2·NCT01699997·32 enrolled

Oxytocin and Social Decision Making in Schizophrenia

Completed·NNational Institute of Mental Health and Neuro Sciences, India·N/A·NCT04176835·55 enrolled

Postpartum Hemorrhage7 trials

Oxytocin Via Intramuscular Injection and Intravenous Bolus or Infusion for Prevention of Postpartum Hemorrhage

Completed·GGynuity Health Projects·N/A·NCT01914419·4,983 enrolled

The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS

Completed·—·Phase 4·NCT03680339·200 enrolled

Buccal Misoprostol Versus IV Oxytocin in Prevention of Postpartum Hemorrhage

Completed·—·Phase 4·NCT03676621·154 enrolled

Show 4 more trials

Misoprostol for the Treatment of Postpartum Hemorrhage

Completed·GGynuity Health Projects·N/A·NCT00116350·1,786 enrolled

Oxytocin Versus, Sublingual Misoprostol in the Secondary Prevention of Postpartum Hemorrhage After Vaginal Delivery

Unknown status·—·N/A·NCT05077540·150 enrolled

Carbetocin and Oxytocin in Elective Caesarean Section With High Risk of Postpartum Hemorrhage

Completed·GGhamra Military Hospital·Phase 4·NCT02391636·264 enrolled

Oxytocin, Carbetocin and Misopristol for Treatment of Postpartum Hemorrhage: A Multicentric Randomized Trial

Unknown status·SSohag University·N/A·NCT01600612·300 enrolled

Cesarean Delivery6 trials

Ergot and Oxytocin During Cesarean Delivery Following Failure to Progress in Labour

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT00481533·47 enrolled

Carbetocin Compared To Oxytocin During Cesarean Delivery

Unknown status·—··NCT05758012·260 enrolled

Blood Loss During Cesarean Delivery in Placenta Previa Patients

Completed·—·Phase 4·NCT05340205·81 enrolled

Show 3 more trials

Pharmacokinetics of Oxytocin at Cesarean Delivery

Completed·WWashington University School of Medicine··NCT03898882·30 enrolled

Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia

Completed·MMansoura University··NCT05269537·60 enrolled

Tranexamic Acid Plus Buccal Misoprostol on Blood Loss During and After Cesarean Delivery

Completed·—·N/A·NCT03710304·400 enrolled

80 more indications

Misoprostol6 trials

Sublingual Misoprostol in Reduction of Caesarean Blood Loss

Unknown status·OOZORI EBIOGBO STANLEY·N/A·NCT05532215·152 enrolled

Pitocin or Oral Misoprostol for PROM IOL

Completed·UUniversity of Pennsylvania·Phase 4·NCT04028765·108 enrolled

Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)

Unknown status·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT05568745·520 enrolled

Show 3 more trials

A Trial of Oral Misoprostol for Labor Augmentation

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00906347·350 enrolled

Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy

Recruiting·—·Phase 3·NCT06325501·56 enrolled

PROMMO Trial: Oral Misoprostol vs IV Oxytocin

Completed·UUniversity of Wisconsin, Madison·Phase 1·NCT04478942·138 enrolled

Labor6 trials

Labor Scale Versus WHO Partograph for Management of Labor (ScaLP)

Unknown status·—·N/A·NCT05341076·206 enrolled

Active Versus Expectant Management of the Third Stage of Labor

Completed·CChristiana Care Health Services·N/A·NCT00473707·218 enrolled

Labor Protocol Study

Terminated·MMontefiore Medical Center··NCT04004845·66 enrolled

Show 3 more trials

Management of Prelabor Rupture of the Membranes at Term

Recruiting·RRambam Health Care Campus·N/A·NCT04307069·524 enrolled

Management of the Third Stage of Labor

Unknown status·YYariv yogev·Phase 3·NCT02319707·500 enrolled

Labor Scale Versus WHO Partograph in the Management of Labor

Unknown status·—·N/A·NCT02486822·120 enrolled

Induction of Labor5 trials

Foley With Oxytocin Versus Foley no Oxytocin for Induction of Labor

Completed·CChristiana Care Health Services·Phase 4·NCT02273115·323 enrolled

Induction of Labor With Oxytocin: When Should Oxytocin be Held?

Completed·LLehigh Valley Hospital·N/A·NCT00957593·252 enrolled

Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop

Unknown status·SShaare Zedek Medical Center·Phase 4·NCT02801227·68 enrolled

Show 2 more trials

Breast Stimulation Versus Pitocin for Induction of Labor

Unknown status·HHadassah Medical Organization·N/A·NCT00984347·150 enrolled

Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite Prostaglandin

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT02720978·1,200 enrolled

Tranexamic Acid4 trials

Comparison Study of Oxytocin Versus Tranexamic Acid and Etamsylaye Versus Placebo(Saline)

Completed·EEgymedicalpedia·N/A·NCT05273632·300 enrolled

Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH (TRANOXY2015)

Withdrawn·AAzienda U.S.L. 1 di Massa e Carrara·Phase 3·NCT02503319

Intravenous Oxytocin Versus Tranexamic Acid in Reducing Blood Loss During Abdominal Myomectomy.

Completed·—·Phase 4·NCT03892668·150 enrolled

Show 1 more trial

Tranexamic Acid for the Prevention of Postpartum Haemorrhage

Unknown status·—·Phase 1/2·NCT04707950·60 enrolled

Cervical Ripening3 trials

Study of the Effectiveness of Cervical Ripening Balloon With and Without Oxytocin

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT03138252·180 enrolled

Cervical Ripening With Cook Catheter Plus Low Dose Oxytocin

Completed·HHenry Ford Health System·N/A·NCT02465164·26 enrolled

A Comparison of Balloon Catheter Versus Ocytocin for Cervical Ripening on Scarred Uterus With Unfavorable Cervix

Completed·PPoitiers University Hospital·N/A·NCT01711060·204 enrolled

Cognition3 trials

Pharmacological Approach to Improve the Outcome of Social Cognition Training

Completed·VVA Greater Los Angeles Healthcare System·Phase 1·NCT01517360·27 enrolled

Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers

Completed·UUniversity of California, San Francisco·Phase 4·NCT01829516·32 enrolled

Effects of Oxytocin on Emotion Recognition and Response Inhibition

Unknown status·RRWTH Aachen University·Phase 2·NCT02350946·40 enrolled

Function3 trials

Effects of Intranasal Oxytocin on Striatal Functional Connectivity

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT03128203·135 enrolled

Effects of Intranasal Oxytocin on Functional Brain Network in Resting-state and Tasks

Completed·—·N/A·NCT03428906·34 enrolled

PK Sampling After IV Oxytocin and Effects on Sensory Function in Healthy Volunteers

Completed·WWake Forest University Health Sciences·Phase 4·NCT03929367·11 enrolled

Treatment3 trials

Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01689298·20 enrolled

Alcohol and Cigarette Craving During Oxytocin Treatment

Completed·—·Phase 1·NCT04071119·19 enrolled

The Effects of Oxytocin Treatment on Social Touch

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT05265806·180 enrolled

Labor Induction3 trials

Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term

Completed·SSeoul National University Hospital·N/A·NCT02618096·154 enrolled

Foley Labor Induction Trial at Term and in PROM

Completed·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT02098421·312 enrolled

Breast Stimulation vs. Low Dose Oxytocin Augmentation for Labor Induction

Unknown status·WWestern Galilee Hospital-Nahariya·Phase 1/2·NCT05510310·200 enrolled

Obesity2 trials

The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity

Completed·SSara Espinoza·Phase 1/2·NCT03119610·23 enrolled

The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals with Obesity

Completed·UUniversity Hospital, Gentofte, Copenhagen·N/A·NCT06189001·25 enrolled

Attention2 trials

Differential Effects of Oral and Intranasal Oxytocin on Attention Control

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT04815395·151 enrolled

Oxytocin's Effect on Attention Training

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03128242·60 enrolled

Hemorrhage2 trials

Sublingual Oxytocin for the Prevention of Post-partum Hemorrhage

Not yet recruiting·IInsud Pharma·Phase 2·NCT06968481·330 enrolled

Carbetocin Versus Oxytocin for Prevention of Postcesarean Hemorrhage in Pregnancy With High Risk for PPH

Completed·DDepartment of Medical Services Ministry of Public Health of Thailand·Phase 1·NCT04089176·120 enrolled

Premature rupture of membranes2 trials

Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of Membranes

Unknown status·Ssammour.rami·N/A·NCT04143685·200 enrolled

Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management

Completed·RRambam Health Care Campus·N/A·NCT02825641·458 enrolled

Clinical Trial2 trials

Randomized Clinical Trial for Comparison Of Intravenous Carbeitocin Versus Oxytocin In Management Of Placental Delivery In Second Trimester Interruption

Unknown status·WWafaa Uthman Ahmed·Phase 4·NCT01827124·140 enrolled

Minimum Oxytocin Dose for Cesarean During Labor: Adaptative Clinical Trial

Unknown status·—·Phase 3·NCT02794779·64 enrolled

Hysterectomy2 trials

Role of Uterotonics in Reducing Intraoperative Blood Loss in Patients With PASD Undergoing Cesarean Hysterectomy

Recruiting·—·N/A·NCT06493968·70 enrolled

IV Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

Withdrawn·—·Phase 4·NCT05608070

Intravenous2 trials

The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels

Unknown status·KKasr El Aini Hospital·Phase 4·NCT02602301·327 enrolled

A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects

Completed·WWake Forest University Health Sciences·Phase 1·NCT05672667·25 enrolled

Prolonged2 trials

Best Partograph Action Line to Prevent Prolonged Labour

Completed·UUniversity of Benin·N/A·NCT02911272·640 enrolled

Prolonged Exposure and Oxytocin

Completed·MMedical University of South Carolina·Phase 2·NCT03238924·17 enrolled

Analgesic1 trial

Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

Terminated·WWake Forest University Health Sciences·Phase 2·NCT04431206·7 enrolled

Heart Rate Variability1 trial

Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)

Completed·WWake Forest University Health Sciences·Phase 4·NCT04105998·22 enrolled

Magnetic Resonance Imaging1 trial

Oxytocin Effect on Attentional Bias Towards Emotional Expression Faces in Individuals With High and Low Autistic Traits: A Functional Magnetic Resonance Imaging (fMRI) Study

Unknown status·UUniversity of Electronic Science and Technology of China·Phase 1·NCT02741063·120 enrolled

Autism1 trial

Modulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin

Completed·KKU Leuven·Phase 3·NCT03640156·25 enrolled

Alcohol Use Disorders1 trial

Oxytocin Treatment for Alcohol Use Disorders

Withdrawn·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT03636555

Cytokines1 trial

Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Completed·MMedical University of Vienna··NCT00360048·10 enrolled

Autism Spectrum Disorder1 trial

Brain Imaging Study of Adults With Autism Spectrum Disorders

Completed·NNational Institute of Mental Health (NIMH)·Phase 1·NCT01093768·38 enrolled

Cognitive impairment1 trial

Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia

Completed·UUniversity of Maryland, Baltimore·Phase 2·NCT01012167·86 enrolled

Obstructive Sleep Apnea1 trial

Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine

Recruiting·VVivek Jain·Phase 1·NCT03860233·40 enrolled

Intranasal Administration1 trial

Tolerance of Intranasal Administration of OT in Prader-Willi Newborn Babies

Completed·UUniversity Hospital, Toulouse·Phase 1/2·NCT01548521·5 enrolled

Tolerance1 trial

Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants

Completed·UUniversity Hospital, Toulouse·Phase 1/2·NCT02205034·18 enrolled

Post-Traumatic Stress Disorder, PTSD1 trial

The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)

Unknown status·SSheba Medical Center·N/A·NCT01039766·24 enrolled

Postpartum Depression1 trial

Preventing Postpartum Depression With Intranasal Oxytocin

Completed·MMassachusetts General Hospital·Phase 2·NCT02505984·56 enrolled

Prevention1 trial

Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering

Unknown status·LLagos State Health Service Commission·Phase 2·NCT02441673·130 enrolled

Emotional Processing1 trial

Oxytocin's Effects on Emotional Processing and Its Acting Routes

Recruiting·UUniversity of Electronic Science and Technology of China·N/A·NCT07425938·120 enrolled

Borderline personality disorder1 trial

"The Effects of Oxytocin on Patients With Borderline Personality Disorder"

Completed·—·N/A·NCT01243658·138 enrolled

Randomized1 trial

Randomized Control Trial of Intracervical Balloon Placement vs Oxytocin in Women With Term PROM and Unripe Cervices

Withdrawn·NNorthwestern University·N/A·NCT03172858

Cardiovascular1 trial

Haemodynamic and Cardiovascular Effects of Carbetocin and Oxytocin

Completed·UUniversiti Kebangsaan Malaysia Medical Centre·N/A·NCT01719952·50 enrolled

AIN1 trial

Translating Neuroprediction Into Precision Medicine Via Brain Priming

Terminated·YYale University·Phase 2·NCT03370510·5 enrolled

Morbid Obesity1 trial

In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01865669·44 enrolled

Methadone1 trial

Methadone Oxytocin Option

Completed·UUniversity of California, San Francisco·Phase 1·NCT01728909·64 enrolled

Completed·UUniversity of Nebraska·Phase 2·NCT02824627·58 enrolled

Smoking Behavior1 trial

Mindfulness Training Plus Oxytocin Effects on Smoking Behavior

Terminated·UUniversity of Southern California·Phase 2/3·NCT03819231·20 enrolled

Bleeding1 trial

Methods Decreasing Bleeding in Open Myomectomy

Unknown status·—·Phase 4·NCT05806307·105 enrolled

Gastric Emptying1 trial

The Effect of Oxytocin on Gastric Emptying

Completed·SSkane University Hospital·N/A·NCT01152047·14 enrolled

Sleep Apnea1 trial

Oxytocin on HR in Sleep Apnea Patient

Completed·GGeorge Washington University·Phase 1·NCT02564068·8 enrolled

Wound Healing1 trial

Role of Local Skin Incision Infiltration by Oxytocin On Wound Healing

Unknown status·EEgymedicalpedia·N/A·NCT05745935·120 enrolled

Abortion1 trial

Oxytocin Infusion vs. Spontaneous Follow-up for Third-stage of Labor After Second-trimester Abortion

Completed·—·Phase 4·NCT02485444·160 enrolled

Substance Use Disorders1 trial

Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress

Completed·JJennifer Mitchell·Phase 2·NCT02742532·63 enrolled

Treatment Resistant Depression1 trial

Oxytocin and Tibolone Adjuncts in Treatment Resistant Depression - A Pilot Study

Unknown status·TThe Alfred·Phase 1·NCT01239888·15 enrolled

Labour Induction1 trial

A Randomized Trial of Oral Misoprostol Alone Versus Oral Misoprostol Followed by Oxytocin for Labour Induction

Completed·UUniversity of Liverpool·Phase 4·NCT03749902·520 enrolled

Infusion1 trial

Maintenance Infusion of Oxytocin Following Elective Cesarean Deliveries

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT04946006·40 enrolled

Addiction1 trial

Oxytocin and Brain Responses in Maternal Addiction

Terminated·—·Phase 2·NCT02979093·59 enrolled

Aggression1 trial

Oxytocin, Alcohol Craving, and Intimate Partner Aggression

Completed·MMedical University of South Carolina·Phase 2·NCT03046836·200 enrolled

COVID-191 trial

Phase II RCT to Assess Efficacy of Intravenous Administration of Oxytocin in Patients Affected by COVID-19

Withdrawn·AAzienda Ospedaliero-Universitaria di Parma·Phase 2·NCT04386447

Myocardial Ischemia1 trial

Cardiac Effects of Oxytocin Administrated During Cesarean Section, Signs of Myocardial Ischemia

Completed·UUppsala University·Phase 4·NCT00777166·103 enrolled

Rehabilitation1 trial

A Pilot Feasibility Study of IM OXT on Fear of Pain and Trust in Physical Therapist During OP Rehabilitation After TKA

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT04493229

Placebo Effect1 trial

Can Oxytocin Enhance the Placebo Effect?

Completed·UUniversity of Electronic Science and Technology of China·Phase 1·NCT02745522·224 enrolled

Trial1 trial

Carbetocin Myocardium Trial 2014 Part 2

Completed·OOslo University Hospital·Phase 4·NCT03899961·240 enrolled

Heart Disease1 trial

Elective Induction vs Spontaneous Labour in Patients With Heart Disease

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·N/A·NCT01677364·50 enrolled

Stress Response1 trial

Oxytocin Buffers Stress Response in Individuals With Impaired Coping Abilities

Completed·—·N/A·NCT01065610

Pregnancy1 trial

Is Oxytocin Given During Surgical Procedure for Abortion Before 12 Weeks of Pregnancy Useful?

Completed·—·N/A·NCT00540748·400 enrolled

Alcohol Use Disorder1 trial

Oxytocin and Stress Response in Alcohol Use Disorder

Completed·MMedical University of South Carolina·Phase 2·NCT03610633·11 enrolled

Women1 trial

In Vitro Myometrial Contractions in Laboring and Non-laboring Women

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01689311·53 enrolled

Randomised Controlled Trial1 trial

Carbetocin Versus Oxytocin in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial

Completed·—·Phase 3·NCT02304055·100 enrolled

Phelan-McDermid syndrome1 trial

Piloting Treatment With Intranasal Oxytocin in Phelan-McDermid Syndrome

Completed·AAlexander Kolevzon·Phase 2·NCT02710084·18 enrolled

Vaginal Delivery1 trial

Prophylactic Oxytocin Before Versus After Placental Delivery to Reduce Blood Loss in Vaginal Delivery

Unknown status·—·Phase 2·NCT03006380·400 enrolled

Preeclampsia1 trial

ST- Depression on Electrocardiogram During Caesarean Section in Regional Anaesthesia in Women With Preeclampsia

Completed·UUppsala University Hospital·N/A·NCT01530230·25 enrolled

Efficacy1 trial

Efficacy of Intrathecal Oxytocin to Speed Recovery After Hip Surgery

Terminated·WWake Forest University Health Sciences·Phase 2·NCT03011307·126 enrolled

Cocaine-dependent1 trial

Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals

Completed·MMedical University of South Carolina·Phase 2·NCT01963091·33 enrolled

Neonatal1 trial

Intrapartum Oxytocin Administration Affects Primitive Neonatal Reflexes

Completed·PPuerta de Hierro University Hospital··NCT01891201·98 enrolled

Memory1 trial

The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)

Completed·MMassachusetts General Hospital·N/A·NCT01466127·60 enrolled

CAR1 trial

Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium

Recruiting·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT06930391·40 enrolled

Tinnitus1 trial

High Dose Oxytocin Nasal Spray for Treatment of Tinnitus

Terminated·NNYU Langone Health·Phase 3·NCT04210310·33 enrolled

Ehlers-Danlos syndrome1 trial

Oxytocin for Hypermobile Ehlers-Danlos Syndrome

Terminated·—·Phase 1/2·NCT05405257·2 enrolled

Adolescent1 trial

Effects of Intranasal Oxytocin on Emotion Regulation in Adolescents

Completed·—·Phase 1·NCT02301715·29 enrolled

Analgesia1 trial

Effect of Oxytocin Nasal Inhalation on Empathy Analgesia

Completed·PPeking University People's Hospital·Phase 4·NCT05823441·120 enrolled

Caesarean Section1 trial

Uterotonic Efficacy of Oxytocin 2.5 Versus 10 Units During Caesarean Section at Mulago Hospital

Completed·FFaculty of Medicine·N/A·NCT01726478·386 enrolled

Fragile X Syndrome1 trial

Double-blind Placebo Controlled Study of Oxytocin in Fragile X Syndrome

Completed·SStanford University·Phase 2·NCT01254045·10 enrolled

Opioid Abuse1 trial

The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

Recruiting·UUniversity of Florida·Phase 1·NCT05761860·45 enrolled

Oxidative Stress1 trial

Oxytocin for Oxidative Stress and Inflammation

Completed·FFlorida Institute for Human and Machine Cognition·Phase 2·NCT04732247·40 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

OXYTOCIN

NDA NDA018248

Jan 1, 1982

OXYTOCIN

NDA NDA018243

Jan 1, 1982

PITOCIN

NDA NDA018261

Jan 1, 1982

SYNTOCINON

NDA NDA018245

Jan 1, 1982

SYNTOCINON

NDA NDA012285

Mar 29, 1985

OXYTOCIN 10 USP UNITS IN DEXTROSE 5%

NDA NDA019185

Sources

References

[1]
ClinicalTrials.gov — 435 trial records for Oxytocin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Pitocin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Oxytocin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Oxytocin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA019185). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Retrophin company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Oxytocin Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: RRetrophin

Pitocin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Oxytocin51 trials

Cesarean Section12 trials

Schizophrenia9 trials

Postpartum Hemorrhage7 trials

Cesarean Delivery6 trials

Misoprostol6 trials

Labor6 trials

Induction of Labor5 trials

Tranexamic Acid4 trials

Cervical Ripening3 trials

Cognition3 trials

Function3 trials

Treatment3 trials

Labor Induction3 trials

Obesity2 trials

Attention2 trials

Hemorrhage2 trials

Premature rupture of membranes2 trials

Clinical Trial2 trials

Hysterectomy2 trials

Intravenous2 trials

Prolonged2 trials

Analgesic1 trial

Heart Rate Variability1 trial

Magnetic Resonance Imaging1 trial

Autism1 trial

Alcohol Use Disorders1 trial

Cytokines1 trial

Autism Spectrum Disorder1 trial

Cognitive impairment1 trial

Obstructive Sleep Apnea1 trial

Intranasal Administration1 trial

Tolerance1 trial

Post-Traumatic Stress Disorder, PTSD1 trial

Postpartum Depression1 trial

Prevention1 trial

Emotional Processing1 trial

Borderline personality disorder1 trial

Randomized1 trial

Cardiovascular1 trial

AIN1 trial

Morbid Obesity1 trial

Methadone1 trial

Menstrual Cycle1 trial

Desensitization1 trial

Mood Disorder1 trial

Smoking Behavior1 trial

Bleeding1 trial

Gastric Emptying1 trial

Sleep Apnea1 trial

Wound Healing1 trial

Abortion1 trial

Substance Use Disorders1 trial

Treatment Resistant Depression1 trial

Labour Induction1 trial

Infusion1 trial

Addiction1 trial

Aggression1 trial

COVID-191 trial

Myocardial Ischemia1 trial

Rehabilitation1 trial

Placebo Effect1 trial

Trial1 trial

Heart Disease1 trial

Stress Response1 trial

Pregnancy1 trial

Alcohol Use Disorder1 trial

Women1 trial

Randomised Controlled Trial1 trial

Phelan-McDermid syndrome1 trial

Vaginal Delivery1 trial

Preeclampsia1 trial

Efficacy1 trial

Cocaine-dependent1 trial