VivoSeq
Musculoskeletal

Carpal Tunnel Syndrome

42

Pipeline Programs↗

16

Active Trials↗

23

Companies Involved↗

Carpal Tunnel Syndrome is a moderately active landscape with 42 programs across 23 companies. The most active players are Sanofi, AbbVie, Merck & Co.. 11 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

59/100

Pipeline Velocity

30/100

Mech. Concentration

35/100

Completion Rate

89/100

Attrition Rate

5/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Sanofi logo

Sanofi

1 program

Phase 1AbbVie logo

AbbVie

1 program

Phase 1Merck & Co. logo

Merck & Co.

2 programs

Phase 1Z

ZARS Pharma Inc.

1 program

Phase 2V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2Jazz Pharmaceuticals logo

Jazz Pharmaceuticals

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical14

Mepivacaine

Pfizer

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Midazolam

Conrado Roberto Hoffmann Filho

Prednisolone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Triamcinolone

Bassett Healthcare

Phase 13

Platelet Rich Plasma

Zagazig University

Insulin

Merck & Co.

Sodium Hyaluronate

Sanofi

Phase 28

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Cannabidiol

Jazz Pharmaceuticals

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Fisetin

Mayo Clinic

Alpha Lipoic Acid

National Center for Complementary and Integrative Health (NCCIH)

Phase 36

Betamethasone

Schering-Plough

Acetyl-L-Carnitine

Mario Negri Institute for Pharmacological Research

Xylocaine

AstraZeneca

Platlet Rich Plasma

Tanta University

SHINCORT

Taipei Medical University Hospital

Approved11

Gabapentin

Viatris Specialty LLC

Dexamethasone

Aspen Global Incorporated

Lidocaine

MEDRx USA, Inc.

Methylprednisolone

Pfizer

Ibuprofen

Kenvue Brands

Analysis

Modality Breakdown

97%

Small molecule

63 of 65 classified programs — the dominant modality here.

3%ALL OTHERSProtein / enzyme23%

Small molecule leads; the ring shows all 65 classified programs, each share of the total. Modality classified for 100% of 67 pipeline programs.

Analysis

Trial Status

77

clinical trials

Completed39 · 51%
Unknown status17 · 22%
Recruiting7 · 9%
Not yet recruiting7 · 9%
Withdrawn3 · 4%
Suspended1 · 1%
Other3 · 4%

Clinical Trials

Trial Activity

77 trials

Efficacy of Steroid Injection in Patients With Bifid Median Nerve Diagnosed Carpal Tunnel Syndrome
Recruiting·—·N/A·NCT06599086·40 enrolled
Effectiveness of Corticosteroid and 5% Dextrose Versus USG-guided Ozone Injections in Patients With Carpal Tunnel Syndrome: Three Blind Randomized Studies
Recruiting·—·N/A·NCT07002892·72 enrolled
Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief
Recruiting·TTanta University·N/A·NCT06133712·135 enrolled
The ACTS Trial: N-acetylcysteine (NAC) and Night-splinting as a Non-operative Treatment for Carpal Tunnel Syndrome
Recruiting·—·Phase 4·NCT04460521·240 enrolled
Ultrasound-guided Dextrose Injection Versus Dextrose With Methylprednisolone in Carpal Tunnel Syndrome
Recruiting·GGeneral and Veteran Hospital Croatian Pride Knin·Phase 3·NCT06045013·70 enrolled
A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome
Recruiting·—·Phase 4·NCT05306548·258 enrolled
Effectiveness of Matrix Rhythm Therapy on Symptom Severity and Function in Carpal Tunnel Syndrome: A Randomized, Placebo-Controlled, Assessor-Blinded Trial
Recruiting·IIzmir Bakircay University·Preclinical·NCT07660913·84 enrolled
Comparison of the Efficacy of Different Treatment Methods in Patients With Carpal Tunnel Syndrome
Active, not recruiting·—·Phase 4·NCT05475808·60 enrolled
Topical Cannabidiol for Treating Carpal Tunnel Syndrome
Not yet recruiting·UUniversity of Virginia·Phase 2·NCT06108349·20 enrolled
4AP for Carpal Tunnel Syndrome (CTS)
Not yet recruiting·—·Phase 2·NCT06294821·160 enrolled
Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids
Not yet recruiting·MMinia University Hospital·Phase 3·NCT07474714·60 enrolled
The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes
Not yet recruiting·HHaydarpasa Numune Training and Research Hospital·N/A·NCT07433257·60 enrolled
Does it Matter the Volume of Injectate on the Outcome of Ultrasound-guided Perineural Injection for Carpal Tunnel Syndrome
Not yet recruiting·—·Phase 4·NCT07283874·35 enrolled
Comparison of Initial Treatment for Carpal Tunnel Syndrome Related to Rheumatic Diseases: Corticosteroid Injection Versus Nighttime Splinting
Not yet recruiting·—·N/A·NCT07042282·248 enrolled
Comparison of Corticosteroid Injection, Nighttime Splinting, or Their Combination for Initial Treatment of Moderate-to-Severe Carpal Tunnel Syndrome
Not yet recruiting·—·N/A·NCT07043179·318 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)