Deltasone

(Prednisolone)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Prednisolone is a steroid medication used to reduce inflammation and suppress the immune system, helping treat conditions like autoimmune diseases, allergies, asthma, and certain cancers.[2] Deltasone is currently approved and in use across 197 indications[4].[1]

Deltasone is one of 2418 small molecule programs targeting Insulin resistance. It is currently in Approved.

197

Indications

368

Total Trials

Active Trials

2,417

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Insulin ResistanceActive, not recruiting

Pyoderma GangrenosumActive, not recruiting

Juvenile DermatomyositisActive, not recruiting

Metabolic SyndromeActive, not recruiting

Glycogen Storage Disease Due to Glucose-6-Phosphatase Deficiency Type IAApproved

HIV InfectionApproved

HemangiomaApproved

ColitisApproved

Systemic Lupus ErythematosusActive, not recruiting

AscitesActive, not recruiting

Insulin ResistancePreclinical

Active, not recruiting

Pyoderma GangrenosumPhase 3

Active, not recruiting

Juvenile DermatomyositisPhase 2

Active, not recruiting

Metabolic SyndromePreclinical

Active, not recruiting

Glycogen Storage Disease Due to Glucose-6-Phosphatase Deficiency Type IAApproved

Approved

HIV InfectionApproved

Approved

HemangiomaApproved

Approved

ColitisApproved

Approved

Systemic Lupus ErythematosusApproved

Active, not recruiting

AscitesPhase 3

Active, not recruiting

Showing 10 of 194 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Deltasone

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

1 2

Prolia

Amgen

Preclinical

14 3

Spravato

WWim Janssens

Preclinical

2 4

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 5

Tricor

JJagotec

Preclinical

1 6

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 7

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

3 8

Fentanyl Citrate

IINSYS Therapeutics Inc

Preclinical

2 9

Recombinant Human Endostatin

PPeking University Third Hospital

Preclinical

1 10

Neoadjuvant Treatment

SShanghai Zhongshan Hospital

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Active, not recruiting

Lymphoma

NCT04479267

Phase 2Active, not recruiting

Sudden Sensorineural Hearing Loss

NCT05776459

N/ANot yet recruiting

Diffuse Large B-Cell Lymphoma

NCT05990985

Q4 2026

N/AActive, not recruiting

Airway Disease

NCT00555607

Post-ApprovalRecruiting

Steroid

NCT05412394

Post-ApprovalRecruiting

Treatment

NCT03781700

Clinical

Trials by Indication[1]

Lymphoma14 trials

Combination Chemotherapy in Treating Older Patients With Intermediate- or High-Grade Non-Hodgkin's Lymphoma

Completed·CCancer Research Campaign Clinical Trials Centre·Phase 3·NCT00002576·200 enrolled

Treatment of Patients With Diffuse Large B Cell Lymphoma Who Are Not Suitable for Anthracycline Containing Chemotherapy

Completed·UUniversity College, London·Phase 2·NCT01679119·129 enrolled

High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma

Unknown status·CCancer Research UK·Phase 2·NCT00669812·60 enrolled

Show 11 more trials

Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma

Completed·UUniversity College, London·Phase 2·NCT00666484·47 enrolled

Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphoma

Active, not recruiting·BBarbara Ann Karmanos Cancer Institute·Phase 2·NCT04479267·8 enrolled

Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma

Completed·LLymphoma Trials Office·Phase 3·NCT00005867·310 enrolled

Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 2·NCT00025064·260 enrolled

Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma

Completed·UUniversity College, London·Phase 3·NCT00678327·1,202 enrolled

Study of Combination of PIGEV Before Autologous Stem Cell Transplant in Patients With Hodgkin's Lymphoma

Unknown status·—·Phase 1·NCT01884428·24 enrolled

A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)

Active, not recruiting·PPeter MacCallum Cancer Centre, Australia·Phase 1/2·NCT04914741·80 enrolled

Surgery Alone or With CYC VBL and PRED or CVP Alone in Stage IA or IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Completed·CChristine Mauz-Körholz·Phase 4·NCT01088750·225 enrolled

Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas

Completed·UUniversity of Colorado, Denver·Phase 1/2·NCT03586999·18 enrolled

Combination Chemotherapy Plus Filgrastim in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma

Unknown status·LLymphoma Trials Office·Phase 1/2·NCT00032149·30 enrolled

Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Peripheral T-Cell Lymphoma

Unknown status·CCancer Research UK·Phase 1·NCT00562068·30 enrolled

Acute Lymphoblastic Leukemia12 trials

Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study

Unknown status·NNational University Hospital, Singapore·Phase 4·NCT02894645·500 enrolled

Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Unknown status·OOhio State University Comprehensive Cancer Center·Phase 2·NCT01005758·180 enrolled

Ma-Spore ALL 2020 Study

Recruiting·NNational University Hospital, Singapore·Phase 2·NCT06336395·500 enrolled

Show 9 more trials

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)

Completed·GGoethe University·Phase 4·NCT00198991·1,883 enrolled

Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

Recruiting·MMartin Schrappe·Phase 3·NCT03643276·5,000 enrolled

Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Unknown status·MMedical Research Council·Phase 3·NCT00003437·1,800 enrolled

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

Recruiting·NNational Hospital Organization Nagoya Medical Center·Phase 2·NCT03286634·60 enrolled

Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)

Completed·CChildren's Oncology Group·Phase 1·NCT03792256·12 enrolled

Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·—·Phase 2·NCT00618501·50 enrolled

Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma

Unknown status·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003728·1,500 enrolled

Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT03007147·475 enrolled

Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia

Completed·DDutch Childhood Oncology Group·Phase 3·NCT00015873·350 enrolled

Prednisolone10 trials

The Treatment of Adrenal Crisis With Inhaled Prednisolone

Unknown status·UUniversity Medical Center Groningen·Phase 1·NCT05639127·12 enrolled

Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae

Unknown status·MMashhad University of Medical Sciences·Phase 2·NCT00723268·30 enrolled

Prednisolone Trial in Children Younger Than 4 Years

Completed·—·Phase 3·NCT03141970·170 enrolled

Show 7 more trials

A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte

Completed·BBausch & Lomb Incorporated·Phase 3·NCT00198523·132 enrolled

Deflazacort Vs. Prednisolone in Acute-stage ABPA

Active, not recruiting·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT04227483·150 enrolled

PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide

Completed·AAmsterdam UMC, location VUmc·N/A·NCT00744224·8 enrolled

Comparison of Tofacitinib and Prednisolone in the Treatment of Active Takayasu's Arteritis

Unknown status·CChinese SLE Treatment And Research Group·Phase 3·NCT05749666·50 enrolled

Biomarkers of Prednisolone Treatment (P05888)

Completed· Merck & Co. logo

Merck & Co.·N/A·NCT00971724·72 enrolled

Comparison Between Symbicort® and Prednisolone in COPD

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00259779·120 enrolled

Prednisolone Urinary Excretion Kinetics

Withdrawn·UUniversity Hospital, Strasbourg, France··NCT05300490

Prostate Cancer10 trials

A Study to Assess the Benefit of Treatment Beyond Progression With Enzalutamide in Men Who Are Starting Treatment With Docetaxel After Worsening of Their Prostate Cancer When Taking Enzalutamide Alone

Completed· Astellas logo

Astellas·Phase 3·NCT02288247·688 enrolled

Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer

Completed· Sanofi logo

Sanofi·Phase 4·NCT02441894·21 enrolled

A Registry Study to Observe Clinical Outcomes of Participants With High-risk Metastatic Hormone-naïve Prostate Cancer in Japan

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT04034095·979 enrolled

Show 7 more trials

A Study of Abiraterone Acetate in Metastatic Castration-Resistant Prostate Cancer Participants Who Responded Poorly to the First-line Combined Androgen Blockade Therapy

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT02405858·51 enrolled

Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy

Completed·UUniversity Hospital Birmingham·Phase 2·NCT00554918·300 enrolled

Urokinase Plasminogen Activator Receptor in Abiraterone Treated Patients With Castration Resistant Prostate Cancer

Terminated·KKristoffer Rohrberg··NCT02125617·3 enrolled

A Study of Abiraterone Acetate (JNJ-212082) and Prednisolone in Patients With Advanced Prostate Cancer

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01685983·82 enrolled

Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT03834519·793 enrolled

Dose Escalation Study With Cabazitaxel in Combination With Daily Prednisolone in Patients With Hormone Refractory Prostate Cancer

Completed· Sanofi logo

Sanofi·Phase 1·NCT01324583·48 enrolled

Evaluation of Safety of Cabazitaxel (Jevtana) in Patients With Metastatic Hormone Refractory Prostate Cancer

Completed· Sanofi logo

Sanofi·Phase 4·NCT02074137·10 enrolled

Hepatitis7 trials

A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis

Completed·SSouthern California Institute for Research and Education·Phase 2·NCT01903798·4 enrolled

Role of Extended Low Dose Prednisolone in Achieving Clinical and Biochemical Remission in Steroid Responsive Severe Alcoholic Hepatitis

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06155760·150 enrolled

Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

Completed·UUniversity Hospital, Lille·Phase 3·NCT02281929·297 enrolled

Show 4 more trials

Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH)

Completed· Gilead logo

Gilead·Phase 2·NCT02854631·104 enrolled

Steroids in Fulminant Hepatitis A in the Pediatric Age Group

Completed·NNational Liver Institute, Egypt·Phase 4·NCT02375867·33 enrolled

PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis

Not yet recruiting·UUniversity Hospital, Lille·Phase 3·NCT06956482·477 enrolled

Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline

Unknown status·IInje University·Phase 3·NCT01455337·126 enrolled

106 more indications

Diffuse Large B-Cell Lymphoma5 trials

Study of Ibrutinib in Combination With Rituximab-CHOP in Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma

Completed·SSamsung Medical Center·Phase 2·NCT02670616·24 enrolled

R-CMOP in Patients With Newly Diagnosed Diffuse Large B-cell Lymphoma

Recruiting·IInstitute of Hematology & Blood Diseases Hospital, China·Phase 1/2·NCT06594640·108 enrolled

Multicentre Study to Determine the Cardiotoxicity of R-CHOP Compared to R-COMP in Patients With Diffuse Large B-Cell Lymphoma

Completed·AArbeitsgemeinschaft medikamentoese Tumortherapie·Phase 2·NCT00575406·94 enrolled

Show 2 more trials

The Efficacy and Safety of the RCMOP Sequential Therapy as a First-line Treatment for Patients With Intermediate-to-high Risk Diffuse Large B-cell Lymphoma Who Had Incomplete Remission.

Not yet recruiting·TThe First Hospital of Jilin University·N/A·NCT05990985·20 enrolled

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 2·NCT05406401·60 enrolled

Corticosteroids4 trials

Progression of HIV-Disease Under Low Dose Corticosteroids

Completed·MMedical Mission Institute, Germany·Phase 2·NCT01299948·326 enrolled

Postoperative Oral Corticosteroids Following Tonsillectomy

Unknown status·WWayne State University·N/A·NCT03352115·200 enrolled

Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)

Terminated· Biogen logo

Biogen·Phase 4·NCT01211665·3 enrolled

Show 1 more trial

Corticosteroids in the Treatment of Tuberculous Pleurisy

Completed·GGuangxi Medical University·N/A·NCT00338793·1,500 enrolled

Rheumatoid Arthritis4 trials

Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis

Not yet recruiting·SSeoul National University Hospital·Phase 4·NCT07227428·206 enrolled

Early Phase Study to Assess Efficacy and Safety of AZD9567 Versus Prednisolone in Patients With Rheumatoid Arthritis

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT03368235·21 enrolled

A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis

Completed·ZZalicus·Phase 2·NCT01369745·294 enrolled

Show 1 more trial

A Single Dose Of Compound SB-681323 Compared To Prednisolone On A Protein That Is an Indicator For Rheumatoid Arthritis

Completed· GSK logo

GSK·Phase 2·NCT00134693·77 enrolled

Steroid4 trials

Early Administration of Steroids in the Ambulance Setting

Completed·UUniversity of Florida·Phase 4·NCT03962894·834 enrolled

Effect of AIN457 on Ozone-induced Airway Neutrophilia Compared to Placebo and Corticosteroid in Healthy Subjects

Completed· Novartis logo

Novartis·Phase 1/2·NCT00920933·24 enrolled

Once Weekly Infant Corticosteroid Trial for DMD

Recruiting·—·Phase 4·NCT05412394·26 enrolled

Show 1 more trial

Corticosteroid Reduction in COPD

Completed·CChronic Obstructive Pulmonary Disease Trial Network, Denmark·Phase 4·NCT02857842·318 enrolled

Polymyalgia Rheumatica3 trials

Treatment With Leflunomide in Patients With Polymyalgia Rheumatica

Unknown status·EElisabeth Brouwer·Phase 3·NCT03576794·94 enrolled

Timed Release Tablet Prednisone in Polymyalgia Rheumatica

Completed·UUniversity Hospitals Bristol and Weston NHS Foundation Trust·Phase 2/3·NCT00836810·12 enrolled

A Trial of Prednisolone in Combination With SPI-62 in Participants With Polymyalgia Rheumatica (PMR)

Terminated·SSparrow Pharmaceuticals·Phase 1·NCT06281236·1 enrolled

Asthma3 trials

A Study to Measure Serum Periostin, Asthma-Related Biomarkers and Response to Prednisolone in Adult and Adolescent Patients With Severe Oral Corticosteroid-Dependent Asthma

Completed· Roche logo

Roche·Phase 2·NCT01948401·54 enrolled

Dexamethasone Versus Prednisolone in Acute Exacerbation of Childhood Asthma

Completed·MMuhammad Aamir Latif·N/A·NCT07275593·224 enrolled

Prednisolone Pharmacokinetics in Severe Asthma

Completed·IImperial College London·Phase 4·NCT00662298·5 enrolled

Infantile Spasms3 trials

A Study to Prevent Infantile Spasms Relapse

Recruiting·UUniversity of California, Los Angeles·Phase 2·NCT06819670·40 enrolled

Prednisolone Versus Vigabatrin in the First-line Treatment of Infantile Spasms

Withdrawn·TThe Hospital for Sick Children·Phase 3·NCT02299115

Addition of Pyridoxine to Prednisolone in Infantile Spasms

Completed·LLady Hardinge Medical College·Phase 3·NCT01828437·62 enrolled

Follicular Lymphoma3 trials

Study of Tazemetostat in Newly Diagnosed Diffuse Large B Cell and Follicular Lymphoma Patients Treated by Chemiotherapy

Active, not recruiting·TThe Lymphoma Academic Research Organisation·Phase 1/2·NCT02889523·214 enrolled

A Trial Looking at Rituximab and Chemotherapy as a Treatment for Follicular Lymphoma in Elderly Patients

Completed·UUniversity of Liverpool·Phase 3·NCT01303887·680 enrolled

Radiotherapy Versus Radiotherapy Plus Chemotherapy in Early Stage Follicular Lymphoma

Completed·TTrans Tasman Radiation Oncology Group·Phase 3·NCT00115700·150 enrolled

Leukemia3 trials

Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents

Active, not recruiting·UUniversity Hospital Muenster·Phase 3·NCT03206671·650 enrolled

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

Unknown status·HHannover Medical School·Phase 2·NCT00002532

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Active, not recruiting·CChildren's Oncology Group·Phase 2·NCT05761171·78 enrolled

Cataract3 trials

Pilocarpine After Combined Cataract/Trabectome Surgery

Withdrawn·MMontefiore Medical Center·Phase 3·NCT04005079

Study to Evaluate the Safety for the Treatment of Inflammation Associated With Cataract Surgery

Completed·IICON Bioscience Inc·Phase 3·NCT02547623·194 enrolled

A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms

Completed· AbbVie logo

AbbVie·Phase 4·NCT02028754·180 enrolled

Erythema2 trials

Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum

Active, not recruiting·LLondon School of Hygiene and Tropical Medicine·N/A·NCT03775460·550 enrolled

Ciclosporin in the Management of New Erythema Nodosum Leprosum

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 2·NCT00919542·12 enrolled

Lupus Nephritis2 trials

Steroids in the Maintenance of Remission of Proliferative Lupus Nephritis

Withdrawn·—·Phase 3·NCT00539799·15 enrolled

Efficacy of Lower Dose Prednisolone in the Induction of Remission of Lupus Nephritis

Completed·—·Phase 4·NCT04146220·32 enrolled

Ulcerative Colitis2 trials

Budesonide Multimatrix(MMX) Versus Prednisolone in Management of Mild to Moderate Ulcerative Colitis

Unknown status·—·Phase 2/3·NCT05341401·100 enrolled

Conventional Step-Up Versus Infliximab Monotherapy in Patients With Ulcerative Colitis (P05553)

Terminated· Merck & Co. logo

Merck & Co.·Phase 3·NCT00984568·28 enrolled

Nephropathy2 trials

Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN)

Recruiting·MMayo Clinic·Phase 2·NCT06676579·16 enrolled

Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy

Completed·UUniversity of Aarhus·Phase 4·NCT03210688·71 enrolled

Renal Transplantation2 trials

Steroid Withdrawal Immunosuppression After Renal Transplantation

Unknown status·—·Phase 4·NCT01550445·30 enrolled

RituxiMab INDuction in Renal Transplantation

Unknown status·GGuy's and St Thomas' NHS Foundation Trust·Phase 4·NCT01095172·100 enrolled

Leprosy2 trials

Efficacy and Safety Study of Dovramilast in People With Leprosy Type 2 Reaction

Not yet recruiting·MMedicines Development for Global Health·Phase 2·NCT07172659·45 enrolled

Ciclosporin in the Management of New Type 1 Reactions in Leprosy

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 2/3·NCT00919815·73 enrolled

Glucocorticoids2 trials

Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants

Terminated·PProf. Dominique de Quervain, MD·Phase 2·NCT02935101·4 enrolled

Oral Glucocorticoids Effect on Post Endodontic Pain

Completed·—·Phase 4·NCT02819648·400 enrolled

Hodgkin's Disease2 trials

Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease

Completed·MMedical Research Council·Phase 3·NCT00003421·800 enrolled

Combination Chemotherapy Given With Radiation Therapy or Radiation Therapy Alone in Treating Patients With Early-Stage Hodgkin's Disease

Unknown status·MMedical Research Council·Phase 3·NCT00002987·400 enrolled

Oral Lichen Planus2 trials

A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus

Completed·—·Phase 4·NCT02587117·28 enrolled

Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus

Completed·NNourhan M.Aly·Phase 2/3·NCT04652739·20 enrolled

Immune Thrombocytopenia2 trials

Newly Diagnosed Immune Thrombocytopenia Testing the Standard Steroid Treatment Against Combined Steroid & Mycophenolate

Completed·UUniversity Hospitals Bristol and Weston NHS Foundation Trust·Phase 3·NCT03156452·123 enrolled

Role of Eltrombopag as First Line Therapy in Primary Immune Thrombocytopenia.

Recruiting·RRenata PLC·Phase 1/2·NCT06531018·100 enrolled

Hemangioma2 trials

Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas

Terminated·NNancy Bauman·Phase 2·NCT00967226·19 enrolled

Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy

Completed·TThe Hospital for Sick Children·Phase 3·NCT00312520·20 enrolled

IgA Nephropathy2 trials

Efficacy of Immunosuppressive Therapy for IgA Nephropathy With Stage 3 or 4 CKD

Recruiting·—·Phase 3·NCT05510323·208 enrolled

Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy

Unknown status·SSun Yat-sen University·Phase 2/3·NCT02662283·75 enrolled

Chronic Obstructive Pulmonary Disease2 trials

Prednisolone Novel Endpoint Study in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Completed· GSK logo

GSK·Phase 1·NCT00379730·90 enrolled

Study of SB681323 and Prednisolone on Biomarkers in COPD (Chronic Obstructive Pulmonary Disease) Patients

Completed· GSK logo

GSK·Phase 1·NCT00380133·20 enrolled

Multiple Myeloma2 trials

Chemotherapy Plus Steroid Therapy in Treating Patients With Multiple Myeloma

Unknown status·RRiverside Haematology Group·Phase 3·NCT00003603·660 enrolled

Efficacy and Safety Study of SyB L-0501 for Patients With Multiple Myeloma

Terminated·SSymBio Pharmaceuticals·Phase 2·NCT01179490·5 enrolled

Liver Disease1 trial

Evaluation of HepQuant SHUNT to Assess Liver Disease; Substudy Within GS-US-416-2124

Withdrawn·HHepQuant, LLC·Phase 1·NCT03087968

Polyp1 trial

Medical Polypectomy and Predictors of Response

Completed·UUniversity of Dundee·Phase 4·NCT00788749·60 enrolled

Atopic Dermatitis1 trial

Standardized Time- and Score-oriented Treatment of Moderate and Severe Atopic Dermatitis

Completed·TTechnische Universität Dresden·N/A·NCT00148746

Acupuncture1 trial

Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China

Unknown status·XXijing Hospital·N/A·NCT01201642·1,800 enrolled

Facet Joint Syndrome1 trial

Platelet-rich Plasma Infiltration Versus Corticosteroid Infiltration (Prednisolone) in Treatment of Lumbar Facet Joint Syndrome

Completed·CCHU de Reims·N/A·NCT05105256·76 enrolled

Osteoarthritis1 trial

CRx-102 Osteoarthritis Multicenter Evaluation Trial

Terminated·ZZalicus·Phase 2·NCT00521989·279 enrolled

Spironolactone1 trial

Spironolactone Versus Prednisolone in DMD

Terminated·KKevin Flanigan·Phase 1·NCT03777319·2 enrolled

Pathophysiology1 trial

TReatment for ImmUne Mediated PathopHysiology

Recruiting·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT04862221·163 enrolled

Psychosis1 trial

The Norwegian Prednisolone in Early Psychosis Study

Terminated·HHaukeland University Hospital·Phase 2·NCT03340909·12 enrolled

Miscarriage1 trial

Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages

Recruiting·LLeiden University Medical Center·Phase 4·NCT05725512·490 enrolled

Safety and Efficacy1 trial

Multicenter Study of Safety and Efficacy Nivolumab at the Fixed Dose 40 mg (Nivo40) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed PMBL

Recruiting·NNational Research Center for Hematology, Russia·Phase 3·NCT06188676·100 enrolled

Glucocorticoid1 trial

Prevention of Glucocorticoid Induced Impairment of Bone Metabolism

Completed·SSahlgrenska University Hospital·N/A·NCT04767711·50 enrolled

Mantle Cell Lymphoma1 trial

Combination Chemotherapy With or Without Bortezomib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

Completed·UUniversity Hospital Plymouth NHS Trust·Phase 2·NCT00513955·50 enrolled

Kaposiform Hemangioendothelioma1 trial

Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma

Completed·WWest China Hospital·Phase 2·NCT03188068·30 enrolled

Duchenne Muscular Dystrophy1 trial

Historically Controlled Trial of Corticosteroids in Young Boys With Duchenne Muscular Dystrophy

Completed·WWashington University School of Medicine·Phase 2·NCT02167217·25 enrolled

Trial1 trial

Descemet Endothelial Thickness Comparison Trial

Unknown status·OOregon Health and Science University·Phase 4·NCT02373137·38 enrolled

Neoadjuvant Therapy1 trial

Neoadjuvant Therapy of Abiraterone Plus ADT for Intraductal Carcinoma of the Prostate

Unknown status·WWest China Hospital·Phase 2·NCT04736108·50 enrolled

Type 2 Diabetes1 trial

Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults With Type 2 Diabetes

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT04556760·46 enrolled

Natural Killer Cell1 trial

Effect of Prednisolone Treatment on Uterine Natural Killer Cells

Recruiting·—·Phase 3·NCT03902912·84 enrolled

Minimal Change Disease1 trial

Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease

Completed·IImperial College Healthcare NHS Trust·Phase 4·NCT00982072·52 enrolled

Cardiomyopathy1 trial

Immunosuppressive Treatment in Chronic Virus-Negative Inflammatory Cardiomyopathy

Terminated·LLMU Klinikum·Phase 2/3·NCT05570409·9 enrolled

Lymphoblastic Lymphoma1 trial

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Recruiting·UUniversity Hospital Muenster·Phase 3·NCT04043494·683 enrolled

Giant Cell Arteritis1 trial

A Placebo-controlled Phase 2 Trial to Investigate the Safety and Efficacy of Secukinumab in Giant Cell Arteritis

Completed· Novartis logo

Novartis·Phase 2·NCT03765788·52 enrolled

Soft Tissue Sarcoma1 trial

A 3 Arm Randomized Study on Health-related QoL of Elderly Patients With Advanced Soft Tissue Sarcoma

Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT04780464·14 enrolled

Dexamethasone1 trial

Bioequivalence Study of Prednisolone and Dexamethasone

Unknown status·UUniversity Medical Center Groningen·Phase 1·NCT04733144·24 enrolled

COVID-191 trial

Corticosteroid Therapy in Pulmonary Sequelae of Covid-19

Completed·UUniversity of Sao Paulo·Phase 1·NCT07380152·100 enrolled

Kidney Transplant1 trial

A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Kidney Transplantation

Completed· Astellas logo

Astellas·Phase 3·NCT00481819·240 enrolled

Carpal Tunnel Syndrome1 trial

Acupuncture in Patients With Carpal Tunnel Syndrome ~ A Randomized Controlled Trial

Completed·—·N/A·NCT01014221·77 enrolled

Sudden Sensorineural Hearing Loss1 trial

Efficacy and Safety of AC102 Compared to Steroids in Adults With Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL)

Active, not recruiting·AAudioCure Pharma GmbH·Phase 2·NCT05776459·210 enrolled

Adult Acute Lymphoblastic Leukemia1 trial

High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)

Unknown status·JJapan Adult Leukemia Study Group·Phase 3·NCT00131027·240 enrolled

Vasculitis1 trial

Rituximab and Belimumab Combination Therapy in PR3 Vasculitis

Unknown status·RRachel Jones·Phase 2·NCT03967925·31 enrolled

Single Dose1 trial

A Phase 1 Multiple-Dose Escalation and Single Dose (Tablet) Study of PF-04171327 in Healthy Volunteers

Completed· Pfizer logo

Pfizer·Phase 1·NCT00812825·78 enrolled

Colitis1 trial

Vedolizumab for Immune Mediated Colitis

Unknown status·UUniversity of Copenhagen·Phase 2·NCT04797325·82 enrolled

EBV-Positive DLBCL, Nos1 trial

Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 2·NCT04181489·55 enrolled

Nephrotic Syndrome1 trial

Study of Initial Steroid Treatment in Young Children With Nephrotic Syndrome

Withdrawn·—·Phase 3·NCT04536181

Necrosis1 trial

Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases

Recruiting·IInstitut Cancerologie de l'Ouest·Phase 3·NCT06471465·84 enrolled

Treatment1 trial

Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy

Recruiting·DDalarna County Council, Sweden·Phase 4·NCT03781700·500 enrolled

Single Ascending Dose1 trial

A Single Ascending Dose Study To Assess The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of AZD9567.

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT02512575·72 enrolled

Airway Disease1 trial

Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease

Active, not recruiting·KKarolinska Institutet·N/A·NCT00555607·233 enrolled

Circadian Rhythm1 trial

CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning

Completed·UUniversity of Aarhus·N/A·NCT06035081·10 enrolled

Pericarditis1 trial

A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis

Completed·UUniversity of Cape Town·Phase 3·NCT00810849·1,400 enrolled

Bone Disease1 trial

Identifying Individuals At Risk of Glucocorticoid-Induced Impairment of Bone Disease

Recruiting·OOdense University Hospital·Phase 2·NCT06421597·36 enrolled

Mycoplasma pneumoniae pneumonia1 trial

Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia

Unknown status·SSeoul National University Hospital·Phase 4·NCT02618057·80 enrolled

Chronic Rhinosinusitis1 trial

Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis.

Unknown status·MMenoufia University·Phase 2·NCT05369039·60 enrolled

Ankylosing Spondylitis1 trial

Prednisolone in Active Ankylosing Spondylitis (AS)

Unknown status·—·Phase 2/3·NCT00244166·75 enrolled

Epilepsy1 trial

Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody

Unknown status·SSeoul National University Hospital·Phase 4·NCT02695797·40 enrolled

Myopathy1 trial

Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need Ventilators

Recruiting· Astellas logo

Astellas·Phase 1/2·NCT07052929·9 enrolled

Bullous Pemphigoid1 trial

Efficacy and Safety of add-on Dapsone Versus add-on Methotrexate in Patients With Bullous Pemphigoid

Completed·—·Phase 4·NCT05984381·62 enrolled

Biliary Atresia1 trial

RCT of Steroids Following Kasai Portoenterostomy for Biliary Atresia.

Unknown status·KKing's College Hospital NHS Trust·Phase 3·NCT00539565·100 enrolled

Hyperthyroidism1 trial

Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism

Unknown status·—·Phase 3·NCT03303053·135 enrolled

Richter's Syndrome1 trial

A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome

Recruiting·UUniversity of Birmingham·Phase 2·NCT03899337·105 enrolled

CAR1 trial

Pilocarpine Use After Kahook Goniotomy

Recruiting·MMontefiore Medical Center·Phase 3·NCT03933631·142 enrolled

Liver Transplant1 trial

Safety Study of Calcineurin-Inhibitor-Free Immunosuppression After Liver Transplantation

Unknown status·AArmin Goralczyk·Phase 2·NCT00890253·29 enrolled

Adverse Effect1 trial

Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease

Unknown status·UUniversity Hospital Birmingham·Phase 4·NCT00609752·80 enrolled

Juvenile Dermatomyositis1 trial

Absorption of Corticosteroids in Children With Juvenile Dermatomyositis

Completed·NNorthwestern University·Phase 2·NCT00004357·6 enrolled

Anosmia1 trial

Preparation and Characterization Intranasal Film Loaded With Steroid as a Local Treatment of Anosmia in Compare to Insulin Intranasal Film

Completed·—·Phase 1/2·NCT05328414·200 enrolled

Intracytoplasmic Sperm Injection1 trial

The Value of Prednisolone With Aspirin Before Embryo Transfer in Intracytoplasmic Sperm Injection (ICSI) Cycles

Completed·KKasr El Aini Hospital·Phase 2/3·NCT03503227·250 enrolled

Atopic Eczema1 trial

Prednisolone vs. Ciclosporine in Severe Atopic Eczema

Completed·TTechnische Universität Dresden·Phase 4·NCT00445081·66 enrolled

Takayasu arteritis1 trial

A Study to Evaluate the Efficacy and Safety of Upadacitinib in Participants With Takayasu Arteritis (TAK)

Active, not recruiting· AbbVie logo

AbbVie·Phase 3·NCT04161898·56 enrolled

Sepsis1 trial

The Effect of Moderate-Dose Steroid Therapy in Sepsis

Completed·TTC Erciyes University·Phase 4·NCT01275638·55 enrolled

Breast Cancer1 trial

Cyclophosphamide, Methotrexate, and Prednisolone With or Without Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast Cancer

Unknown status·NNational Cancer Centre, Singapore·Phase 2·NCT00687648·70 enrolled

Refractory1 trial

E3-Hormone Refractory Prostrate Cancer Taxotere Combination

Completed· Sanofi logo

Sanofi·Phase 2·NCT00498797·86 enrolled

Lymphadenitis1 trial

Applying Shear Wave Elastography for Adjunct Steroid on Tuberculous Lymphadenitis

Unknown status·NNational Taiwan University Hospital·N/A·NCT05861440·50 enrolled

Obstructive Sleep Apnea1 trial

Oral Corticosteroids' Role in Pediatric Obstructive Sleep Apnea

Completed·HHotel Dieu de France Hospital·N/A·NCT06917768·87 enrolled

Injury1 trial

Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver Injury

Terminated·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02686385·4 enrolled

Crohn's Disease1 trial

Comparison of Quality of Life During a Flare of Crohn's Disease Treated With Prednisolone or aCDED With PEN in Adult Patients

Recruiting·UUniversity Hospital Tuebingen·Phase 2·NCT06953791·52 enrolled

Mortality1 trial

Comparison Between Prednisolone and Dexamethasone on Mortality in Patients on Oxygen Therapy, with CoViD-19

Completed·HHôpital NOVO·Phase 3·NCT04765371·89 enrolled

Pulpitis1 trial

Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT02629042·5 enrolled

Advanced Cancer1 trial

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Therapies in Japanese Participants With Advanced Cancer

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT04071262·6 enrolled

Adverse Drug Reactions1 trial

Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions

Completed·—·N/A·NCT01276314·135 enrolled

Tic Disorder1 trial

Prednisolone Addition for Patients With Recent-onset Psychotic Disorder

Terminated·UUMC Utrecht·Phase 4·NCT02949232·42 enrolled

Psoriatic Arthritis1 trial

Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis

Unknown status·UUniversity of Erlangen-Nürnberg Medical School·Phase 3·NCT04610476·270 enrolled

Complication1 trial

Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair

Terminated·FFrancis Schneck·N/A·NCT02162810·28 enrolled

Stroke1 trial

High Dose Steroids in Children With Stroke

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 3·NCT04873583·70 enrolled

Methotrexate1 trial

Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate Monotherapy

Terminated·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 3·NCT02930343·136 enrolled

Langerhans Cell Histiocytosis1 trial

Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis

Completed·HHistiocyte Society·N/A·NCT00276757·376 enrolled

Immune Suppression1 trial

Immune Suppression Of Infants Treated With Steroids

Completed·MMedical College of Wisconsin··NCT00433940·16 enrolled

Headache1 trial

Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache

Completed·SSorlandet Hospital HF·Phase 3·NCT00135122·100 enrolled

Chronic Hepatitis1 trial

Prednisolone Priming Study in Patients With Chronic Hepatitis B

Unknown status·YYun-Fan Liaw·Phase 4·NCT00778596·160 enrolled

Cardiac Sarcoidosis1 trial

PET/MR Imaging In Patients With Cardiac Sarcoidosis

Completed·UUniversity of Edinburgh·N/A·NCT03705884·40 enrolled

Inflammation1 trial

Intraorbital Injection Versus Oral Steroid in Anterior Idiopathic Orbital Inflammation

Unknown status·IIran University of Medical Sciences·Phase 3·NCT03958344·120 enrolled

Unspecified3 trials

Phase I Methodology Study to Validate the Cantharidin Blister Model in Healthy Volunteers

Completed· GSK logo

GSK·Phase 1·NCT01762787·40 enrolled

Velcade (Bortezomib) Consolidation After Transplant

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01539083·256 enrolled

The Electroretinogram in Healthy and Glucose Intolerant Young Men

Completed·GGlostrup University Hospital, Copenhagen·N/A·NCT01140932·10 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

STERANE

NDA NDA011446

Jan 1, 1982

HYDELTRASOL

NDA NDA011028

Jan 1, 1982

ECONOPRED

NDA NDA017468

Jan 1, 1982

OMNIPRED

NDA NDA017469

Jan 1, 1982

PRED FORTE

NDA NDA017011

Jan 1, 1982

PRED MILD

NDA NDA017100

Jan 1, 1982

DELTA-CORTEF

NDA NDA009987

Jan 1, 1982

METI-DERM

NDA NDA010209

Jan 1, 1982

STERANE

NDA NDA009996

Jan 1, 1982

HYDELTRASOL

NDA NDA011583

Jan 1, 1982

METICORTELONE

NDA NDA010255

May 28, 1986

PEDIAPRED

NDA NDA019157

Jun 1, 2006

ORAPRED ODT

NDA NDA021959

Jan 17, 2008

FLO-PRED

NDA NDA022067

Sources

References

[1]
ClinicalTrials.gov — 368 trial records for Prednisolone. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Deltasone drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Prednisolone compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Prednisolone. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA022067). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Deltasone. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glucocorticoid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Patent Landscape[6]

Patent Cliff

Oct 11, 2028

Earliest patent expiration — generic entry possible after this date

Patent #Expires

7799331Oct 11, 2028