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Other/Colonization

Colonization

8

Pipeline Programs↗

17

Active Trials↗

5

Companies Involved↗

Colonization is an early-stage landscape with 8 programs across 5 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

43/100

Pipeline Velocity

22/100

Mech. Concentration

100/100

Completion Rate

79/100

Attrition Rate

14/100

Pipeline

Programs by Phase

Preclinical4

Pluronic

University of Virginia

Mupirocin

Padagis LLC

Chlorhexidine Baths

Duke University

Chlorhexidine Gluconate

Dexcel Pharma Technologies Ltd.

Phase 11

Xylitol

Joseph Zabner

Phase 22

Florajen3

Marquette University

Donor FMT

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase 31

Allogenic FMT

University Hospital, Ghent

Approved

No programs

Analysis

Trial Status

59

clinical trials

Completed30 · 51%

Recruiting13 · 22%

Terminated7 · 12%

Unknown status4 · 7%

Not yet recruiting2 · 3%

Enrolling by invitation1 · 2%

Other2 · 3%

Clinical Trials

Trial Activity

59 trials

Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology

Recruiting·TThe University of Texas Medical Branch, Galveston·N/A·NCT05275335·400 enrolled

Microbial Evaluation in Patients Wear Double Structure Bars Implant Supported Mandibular Overdentures Attached by Clips or MK-1 Attachments

Recruiting·MMansoura University·Preclinical·NCT07817498·7 enrolled

Risk Factors and Clinical Implications of Double-J Ureteral Stent Bacterial Colonization: A Prospective Cohort Study

Recruiting·AAl-Azhar University·N/A·NCT07760792·300 enrolled

"Restoration of the Gut Microbiome After Cesarean Section (RestoreGut)" - A Double-blinded Randomized Placebo-controlled Trial

Recruiting·—·Phase 1·NCT06264219·80 enrolled

Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP

Recruiting·UUniversity of Virginia·Phase 4·NCT05094570·20 enrolled

Decolonization of Gram-negative Multi-resistant Organisms (MDRO) with Donor Microbiota (FMT)

Recruiting·UUniversity Hospital, Ghent·Phase 2/3·NCT04188743·150 enrolled

Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery

Recruiting·UUniversité de Montréal·N/A·NCT02996656·88 enrolled

Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients

Recruiting·NNantes University Hospital·Phase 3·NCT04028401·110 enrolled

PMT for MDRO Decolonization

Recruiting·UUniversity of Pennsylvania·Phase 2·NCT05632315·150 enrolled

Bacterial Decolonization Within Dyads

Recruiting·—·N/A·NCT06541145·20 enrolled

MRSA Decolonization in Complicated Carriage

Recruiting·LLeiden University Medical Center·N/A·NCT05268120·211 enrolled

FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae

Recruiting·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·Phase 1/2·NCT04759001·52 enrolled

FMT to Eradicate Intestinal Colonization by Carbapenem-resistant Enterobacteriaceae

Recruiting·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·Phase 1/2·NCT05791396·36 enrolled

The Efficacy of Probiotics to Reduce Antepartum Group B Streptococcus Colonization.

Active, not recruiting·MMarquette University·Phase 2·NCT03696953·109 enrolled

Enteral Nutrition to Enhance Colonization Resistance Through Gut Microbiota Modulation in Critically Ill Patients: A Randomized Controlled Pilot Trial

Not yet recruiting·IIuliu Hatieganu University of Medicine and Pharmacy·Preclinical·NCT07719673·60 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)