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Peridex

(Chlorhexidine gluconate)

Phase 3Small molecule

MMedline Industries

Chlorhexidine gluconate is an antimicrobial rinse used to reduce bacteria in the mouth to treat and prevent gum disease, and it's also used as a skin cleanser before surgery or for wound care to prevent infection.[1] Peridex is currently being investigated across 27 indications[3], with its most advanced program in Phase 3.[1]

Peridex is one of 486 small molecule programs targeting HIV infection. It is currently in Phase 3.

27

Indications

75

Total Trials

4

Active Trials

485

Competitors

Pipeline

Status by Indication[3][1]

Indication

HIV InfectionActive, not recruiting

AbscessActive, not recruiting

Peri-ImplantitisActive, not recruiting

Vulvovaginal CandidiasisActive, not recruiting

Aphthous UlcerActive, not recruiting

Head and Neck Malignant NeoplasiaActive, not recruiting

MucositisActive, not recruiting

Nosocomial InfectionActive, not recruiting

Skin CancerActive, not recruiting

MortalityActive, not recruiting

HIV InfectionPhase 2

Active, not recruiting

AbscessPhase 2

Active, not recruiting

Peri-ImplantitisPhase 3

Active, not recruiting

Vulvovaginal CandidiasisPhase 2

Active, not recruiting

Aphthous UlcerPreclinical

Active, not recruiting

Head and Neck Malignant NeoplasiaPhase 1

Active, not recruiting

MucositisPhase 2

Active, not recruiting

Nosocomial InfectionPreclinical

Active, not recruiting

Skin CancerPhase 3

Active, not recruiting

MortalityPhase 3

Active, not recruiting

Showing 10 of 27 indications

Competition

Competitive Landscape

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

Peridex

MMedline Industries

Bnt162b2

Nexavar

Calciferol

Alnylam Pharmaceuticals

Angiomax

BBaxter Healthcare Corporation

Benadryl

Statin

Bristol-Myers Squibb

Glucocorticoid

Nadroparin

HB-Admscs

HHope Biosciences Research Foundation

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Infection Pro

NCT06464770

Q4 2028

Phase 3Recruiting

Infection Pro

NCT06126614

Q4 2030

Phase 3Recruiting

Skin Cancer

NCT07142408

Clinical

Trials by Indication[1]

Chlorhexidine15 trials

Clinical Performance of a Chlorhexidine Antimicrobial Dressing

Completed·SSolventum US LLC·Phase 2/3·NCT00516906·68 enrolled

A Study of Chlorhexidine in the Prevention of HIV-1 Transmission From Mothers to Their Babies

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00006075·150 enrolled

Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans

Unknown status·—·Phase 3·NCT03061916·21 enrolled

Show 12 more trials

Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients

Completed·KKing Edward Memorial Hospital·Phase 4·NCT00610324·512 enrolled

Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study

Completed·—·Phase 4·NCT01213550·50 enrolled

Chlorhexidine Drying Time

Completed·UUniversity of British Columbia··NCT02095535·20 enrolled

Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers

Completed·MMedline Industries·Phase 3·NCT02526667·340 enrolled

Effect of Chlorhexidine Gel on Bacterial Count During Fixed Orthodontic Treatment

Unknown status·KKing Abdulaziz University·Phase 1·NCT02001311·20 enrolled

Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy

Completed·—·Phase 2/3·NCT02943759·40 enrolled

Zambia Chlorhexidine Application Trial

Completed·—·Phase 2/3·NCT01241318·77,535 enrolled

Development and Evaluation of a ChlorHexidine Gluconate bAthing pRotocol for Healthcare Settings in Low- and Middle-income Countries

Terminated·UUniversity of Pennsylvania·N/A·NCT06590675·19 enrolled

Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age

Completed·CCeleste Chandonnet·Phase 1·NCT02326467·10 enrolled

Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects

Completed·MMedline Industries·Phase 3·NCT02222896·347 enrolled

Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth

Unknown status·—·N/A·NCT03588351·45 enrolled

Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma

Completed·SSt. Joseph's Hospital and Medical Center, Phoenix·N/A·NCT01382446·66 enrolled

Gingivitis4 trials

Comparisons Of Different Antiplaque Agents On Gingivitis In Orthodontic Patients

Completed·AAnam Sattar·N/A·NCT06305546·80 enrolled

Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis

Unknown status·—·Phase 3·NCT03142607·90 enrolled

"The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients.

Completed·TTatyasaheb Kore Dental College·Phase 4·NCT02154594·60 enrolled

Show 1 more trial

Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis and Gingivitis

Completed·UUniversidade Federal do Rio Grande do Norte·Phase 2·NCT02639377·29 enrolled

Colonization3 trials

Umbilical Cord Care for the Prevention of Colonization

Unknown status·UUniversity of Virginia·N/A·NCT01893060·100 enrolled

Effect of Bed Bathing Methods on VRE Colonization in ICU Patients

Completed·ÖÖzkan Kasap·N/A·NCT07364435·210 enrolled

Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization

Completed·LLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center·Phase 2·NCT02589067·67 enrolled

Surgical2 trials

BPO vs Hibiclens Soap for Surgical Preparation

Completed·UUniversity of Washington·Phase 4·NCT04021524·50 enrolled

Microsurgical Versus Conventional Semilunar Coronally Advanced Flap

Completed·UUniversidade Federal Fluminense·Phase 4·NCT02433899·14 enrolled

Infection Pro2 trials

Optimizing Infection Prophylaxis Prior to Shoulder Surgery

Recruiting·UUniversity of Washington·N/A·NCT06464770·40 enrolled

Infection Prophylaxis in Total Joint Replacement

Recruiting·HHamilton Health Sciences Corporation·Phase 3·NCT06126614·21,006 enrolled

42 more indications

Sepsis2 trials

Topical Antisepsis in Head and Neck Cancer Surgery

Completed·MMedical College of Wisconsin··NCT04721626·25 enrolled

Study of Chlorhexidine Gluconate as a Preoperative Antisepsis

Completed·SSeung Duk Lee·Phase 3·NCT01495117·534 enrolled

Methicillin-resistant Staphylococcus Aureus2 trials

Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections

Completed·CChristiana Care Health Services·N/A·NCT00779246·1,518 enrolled

Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees

Completed·HHenry M. Jackson Foundation for the Advancement of Military Medicine·N/A·NCT01105767·30,209 enrolled

Effectiveness2 trials

Evaluating Safety and Effectiveness of Octenidine Dihydrochloride

Completed·CC. R. Bard·Phase 2·NCT03140254·145 enrolled

A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions

Completed·UUniversity of Michigan·N/A·NCT01216761·3,879 enrolled

Efficacy2 trials

Evaluation of the Residual Antimicrobial Efficacy of One Test Material Based on a Modification of ASTM E1115-11 Test Method

Completed·MMolnlycke Health Care AB·Phase 4·NCT04654182·32 enrolled

Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse

Completed·CColgate Palmolive·Phase 3·NCT01024738·22 enrolled

Preoperative2 trials

Preoperative CHG Cloth on Healthy Subjects

Completed·MMedline Industries·Phase 3·NCT02291601·879 enrolled

Preoperative Skin Preparation Evaluation

Completed·CC. R. Bard·Phase 3·NCT00636480·60 enrolled

Infection2 trials

Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction

Completed·UUniversity of California, San Francisco·Phase 3·NCT05110001·330 enrolled

Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection

Completed·CCentro Universitario de Lavras·N/A·NCT02126267·77 enrolled

Surgical Site Infections2 trials

Checklist to Prevent MRSA Surgical Site Infections

Completed·VVA Office of Research and Development·N/A·NCT02216227·1,794 enrolled

The Efficacy of Chlorhexidine Gluconate Pre - Disinfection Scrubbing in Preventing Surgical Site Infections for Hepatectomy Patients

Completed·—·Phase 4·NCT01782573·100 enrolled

Abscess1 trial

Evaluation of a Staphylococcus Eradication Protocol for Patients Who Present to the ED With Cutaneous Abscess

Completed·TTufts Medical Center·Phase 4·NCT01537783·50 enrolled

Resistance1 trial

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT03489629·37 enrolled

Peri-Implantitis1 trial

Surgical Treatment of Peri-implantitis

Completed·GGöteborg University·Phase 4·NCT01857804·100 enrolled

Mucositis1 trial

Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis

Completed·UUniversidade Federal do Rio Grande do Norte·Phase 2·NCT02605382·37 enrolled

Trial1 trial

Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome

Completed·—·N/A·NCT02513784·20 enrolled

Healing1 trial

The Effect of Different Types of Mouthwash on Extraction Sockets' Healing

Not yet recruiting·UUniversity of Jordan·Phase 4·NCT06587880·100 enrolled

Mortality1 trial

Oropharyngeal and Nasopharyngeal Decontamination With Chlorhexidine Gluconate in the Reduction of the Postoperative Morbidity and Mortality After Major Pulmonary Resections

Completed·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT01613365·474 enrolled

Tics1 trial

Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics

Completed·CC. R. Bard·Phase 3·NCT00692484·122 enrolled

Impacted Mandibular Third Molar1 trial

Chlorhexidine Gel Versus Alvogyl Following Surgical Extraction of Impacted Mandibular Third Molar

Completed·UUniversity of Baghdad·Phase 4·NCT06144983·51 enrolled

Gingival Recession1 trial

Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival Recessions

Completed·UUniversidade Federal Fluminense·Phase 4·NCT02433912·36 enrolled

AIN1 trial

Training and Calibration of Dental Examiners

Completed·CColgate Palmolive·Phase 3·NCT00765167·18 enrolled

Fungal Infection1 trial

The Safety and Effectiveness of Peridex in Preventing or Delaying Fungal Infections of the Mouth in HIV-Infected Patients

Completed·PProcter and Gamble·N/A·NCT00002431

Early Childhood Caries1 trial

Prevention Management Model for Early Childhood Caries (MAYA Project)

Completed·UUniversity of California, San Francisco·Phase 3·NCT00066950·361 enrolled

Tracheal Intubation1 trial

Effect of Chlorhexidine Gluconate in Oral Care of Patients With Endotracheal Intubation Based on 16sRNA Technology

Completed·SShanghai 10th People's Hospital·N/A·NCT06691841·76 enrolled

Oral1 trial

Evaluate Clinical Research From Commerical Oral Care Products

Completed·CColgate Palmolive·Phase 3·NCT00759187·25 enrolled

Single Dose1 trial

Single Dose CHG Pharmacokinetic Study

Completed·MMedline Industries·Phase 1·NCT03331263·12 enrolled

Soft Tissue Infections1 trial

A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs

Completed·GGabriel John Culbert·Phase 4·NCT06733506·56 enrolled

Nosocomial Infection1 trial

Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit

Completed·JJoshua Swan·N/A·NCT01640925·350 enrolled

Endometritis1 trial

Vaginal Cleansing With Chlorhexidine Versus Iodine for Prevention of Endometritis

Completed·FFederal Teaching Hospital Abakaliki·N/A·NCT06936475·239 enrolled

Peritoneal Dialysis1 trial

Daily Chlorhexidine Care at the Exit Site in Peritoneal Dialysis Patients

Completed·—·Phase 4·NCT02446158·89 enrolled

Post Operative Sore Throat1 trial

Triamcinolone Paste to Reduce the Incidence of Postoperative Sore Throat

Completed·SSoonchunhyang University Hospital·N/A·NCT00908817·150 enrolled

Cesarean Delivery1 trial

Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery

Completed·MMetro Health, Michigan·Phase 4·NCT03133312·100 enrolled

Microbial Colonization1 trial

Comparison of Oral Care Solutions on Oral Microbial Colonization in Neurosurgical ICU Patients

Completed·HHarran University·N/A·NCT07365956·90 enrolled

Dermatitis1 trial

Bacterial Decolonization to Prevent Radiation Dermatitis

Completed·MMontefiore Medical Center·Phase 2/3·NCT03883828·80 enrolled

MPA1 trial

Comparing Mouth Rinses (and Chewing Gum) in Regard to Streptococcus Mutans Reduction

Terminated·MMontefiore Medical Center·Phase 2·NCT02598778·12 enrolled

Prevention1 trial

Prevention of Nosocomial Bacteremia Among Zambian Neonates

Completed·—·N/A·NCT02386592·9,410 enrolled

Skin Cancer1 trial

The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal

Recruiting·TThe Cooper Health System·Phase 3·NCT07142408·848 enrolled

Infections1 trial

Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization

Completed·UUniversity of California, Irvine·Phase 4·NCT03118232·13,952 enrolled

Ventilator-Associated Pneumonia1 trial

Prehospital Ventilator-Associated Pneumonia Prevention Trial

Completed·NNicholas M Mohr··NCT01902446·70 enrolled

Irritation1 trial

A 96-hour Patch Test Study Using Healthy Human Volunteers to Assess the Skin Irritation Potential of 11 Topically Applied Formulations

Unknown status·MMolnlycke Health Care AB·Phase 4·NCT04942496·44 enrolled

Stomatitis1 trial

Hyaluronic Acid in Counteracting Aphthous Stomatitis

Completed·—··NCT04884464·49 enrolled

Oral ulcer1 trial

Comparison of the Effects of Oral Ulceration Healing in Patients Wearing a Removable Denture

Completed·MMedical University of Silesia·N/A·NCT06531720·27 enrolled

Adult1 trial

Removal of Bacterial Spores in Adults on Skin

Completed·CCaroline Scott·Phase 4·NCT03372122·32 enrolled

Vulvovaginal Candidiasis1 trial

A Clinical Trial for Chlorhexidine as Treatment for Vulvovaginal Candidiasis

Unknown status·KKarolinska Institutet·Phase 2·NCT05059145·60 enrolled

Unspecified1 trial

Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients.

Completed·UUniversity of Sao Paulo·Phase 1·NCT02337192·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 75 trial records for Chlorhexidine gluconate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Chlorhexidine gluconate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Chlorhexidine gluconate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Medline Industries company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMedline Industries

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