Xylitol

Phase 3Small molecule

JJoseph Zabner

Xylitol is one of 129 small molecule programs targeting Sinusitis. It is currently in Phase 3.

Indications

Total Trials

Active Trials

128

Competitors

Pipeline

Status by Indication[3][1]

Indication

SinusitisActive, not recruiting

Inflammatory Bowel DiseaseActive, not recruiting

Acute Otitis MediaActive, not recruiting

Cystic FibrosisActive, not recruiting

SinusitisPreclinical

Active, not recruiting

Inflammatory Bowel DiseasePhase 1

Active, not recruiting

Acute Otitis MediaPhase 3

Active, not recruiting

Cystic FibrosisPhase 1/Phase 2

Active, not recruiting

Competition

Competitive Landscape

386 competitors in Cystic Fibrosis

#DrugCompanyPhaseTrials

Xylitol

JJoseph Zabner

Phase 3

2 2

Onglyza

AstraZeneca

Preclinical

2 3

Calciferol

Alnylam Pharmaceuticals

Preclinical

1 4

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

3 5

Actimmune

HHorizon Therapeutics Ireland DAC

Preclinical

2 6

Proair HFA

GGlaxo Dba Glaxosmithkline

Preclinical

2 7

Aztreonam Lysine

Gilead

Preclinical

5 8

Serevent

GGlaxo Dba Glaxosmithkline

Preclinical

1 9

Amitiza

SSucampo Pharma Americas, LLC

Preclinical

1 10

Capromorelin

UUniversity of Aarhus

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2031

Phase 1Not yet recruiting

Inflammatory Bowel Disease

NCT06799039

Q1 2033

Phase 1Not yet recruiting

Colonization

NCT05852587

Clinical

Trials by Indication[1]

Cystic Fibrosis2 trials

Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects

Completed·JJoseph Zabner·Phase 1/2·NCT00928135·63 enrolled

Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis

Completed·JJoseph Zabner·Phase 1/2·NCT01355796·30 enrolled

Sinusitis2 trials

Xylitol Versus Saline in Chronic Sinusitis

Completed·UUniversity of Iowa·N/A·NCT00924404·53 enrolled

Xylitol for Chronic Sinusitis

Completed·OOchsner Health System·Phase 2/3·NCT03229551·1 enrolled

MPA1 trial

Impact of Maternal Xylitol Consumption on Mutans Sterptococci

Completed·KKing Abdulaziz University·Phase 4·NCT02036151·60 enrolled

Stem Cell Transplant Patients1 trial

Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Patients

Terminated·—·Phase 2·NCT04117477·46 enrolled

Acute otitis media1 trial

Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children

Completed·—·Phase 3·NCT01044030·326 enrolled

4 more indications

Functional Endoscopic Sinus Surgery1 trial

Efficacy and Safety of Xylitol Nasal Irrigation After Functional Endoscopic Sinus Surgery

Completed·TTaichung Veterans General Hospital·N/A·NCT06108921·79 enrolled

Inflammatory Bowel Disease1 trial

Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease

Not yet recruiting·—·Phase 1·NCT06799039·69 enrolled

Colonization1 trial

Xylitol Use for Decolonization of C. Difficile in Patients With IBD

Not yet recruiting·—·Phase 1·NCT05852587·99 enrolled

Chlorhexidine1 trial

Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk

Completed·—·Phase 2/3·NCT04399161·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 11 trial records for Xylitol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Xylitol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Xylitol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Joseph Zabner company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: JJoseph Zabner

Xylitol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2031

Q1 2033

Trials by Indication[1]

Cystic Fibrosis2 trials

Sinusitis2 trials

MPA1 trial

Stem Cell Transplant Patients1 trial

Acute otitis media1 trial

Functional Endoscopic Sinus Surgery1 trial

Inflammatory Bowel Disease1 trial

Colonization1 trial

Chlorhexidine1 trial

References

Drug Info

Quick Facts

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