VivoSeq
Other

Contracture

14

Pipeline Programs↗

3

Active Trials↗

9

Companies Involved↗

Contracture is an emerging landscape with 14 programs across 9 companies. The most active players are GSK, Alnylam Pharmaceuticals, Endo Pharmaceuticals. 1 therapy is approved with 4 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

42/100

Pipeline Velocity

6/100

Mech. Concentration

50/100

Completion Rate

83/100

Attrition Rate

12/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

GSK logo

GSK

1 program

Phase 2Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

Phase 2Endo Pharmaceuticals logo

Endo Pharmaceuticals

2 programs

Phase 3V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 3Tanabe Pharma Corporation logo

Tanabe Pharma Corporation

1 program

Phase 3Eli Lilly logo

Eli Lilly

1 program

Approved

Pipeline

Programs by Phase

Analysis

Trial Status

26

clinical trials

Completed15 · 58%
Unknown status5 · 19%
Terminated3 · 12%
Active, not recruiting1 · 4%
Recruiting1 · 4%
Not yet recruiting1 · 4%

Clinical Trials

Trial Activity

26 trials

Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture
Recruiting·—·Phase 4·NCT05440240·400 enrolled
Trial Comparing Treatment Strategies in Dupuytren's Contracture
Active, not recruiting·TTampere University·Phase 4·NCT03192020·302 enrolled
Collagenase Injection for Contracture and Spasticity Management
Not yet recruiting·TThe University of Texas Health Science Center, Houston·Phase 1·NCT07693556·15 enrolled
A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture
Completed·Endo Pharmaceuticals logoEndo Pharmaceuticals·Phase 1·NCT00528931·16 enrolled
Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex)
Completed·Pfizer logoPfizer·Phase 3·NCT01229436·254 enrolled
Injectable Collagenase and Percutaneous Needle Fasciotomy for Dupuytren's Contracture
Completed·—·N/A·NCT01538017·50 enrolled
Administration of Two Injections for Multiple Dupuytren's Contractures
Completed·Endo Pharmaceuticals logoEndo Pharmaceuticals·Phase 3·NCT01407068·60 enrolled
Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren's Contractures
Completed·Endo Pharmaceuticals logoEndo Pharmaceuticals·Phase 3·NCT01674634·715 enrolled
MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex
Completed·HHospital for Special Surgery, New York·Phase 4·NCT01450397·5 enrolled
Collagenase Option for Reduction of Dupuytren's Contracture in Japan
Completed·AAsahi Kasei Pharma Corporation·Phase 3·NCT01588353·104 enrolled
AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture
Completed·Endo Pharmaceuticals logoEndo Pharmaceuticals·Phase 3·NCT00528606·308 enrolled
Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb
Completed·IIndiana Hand to Shoulder Center·Phase 4·NCT01265420·7 enrolled
Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures
Completed·HHopital Foch·Phase 2·NCT02986880·14 enrolled
Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture
Completed·SSunnybrook Health Sciences Centre·Phase 3·NCT00565019·51 enrolled
Investigations of Mechanisms and Treatment in Post-traumatic Joint Contractures
Completed·UUniversity of Calgary·Phase 2·NCT01902017·152 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)