VivoSeq
Other

Critical Illness

5

Pipeline Programs↗

13

Active Trials↗

3

Companies Involved↗

Critical Illness is an early-stage landscape with 5 programs across 3 companies. The most active players are Neurim Pharmaceuticals Ltd., Fresenius, David T Huang. 5 therapies are approved.

Intelligence

Pipeline Metrics

Competitive Density

38/100

Pipeline Velocity

34/100

Mech. Concentration

50/100

Completion Rate

79/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

N

Neurim Pharmaceuticals Ltd.

1 program

ApprovedF

Fresenius

0 programs

PreclinicalD

David T Huang

0 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

29

clinical trials

Completed11 · 38%
Not yet recruiting6 · 21%
Recruiting4 · 14%
Active, not recruiting3 · 10%
Unknown status2 · 7%
Terminated2 · 7%
Other1 · 3%

Clinical Trials

Trial Activity

29 trials

Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency
Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT04404400·1,092 enrolled
Platform of Randomized Adaptive Clinical Trials in Critical Illness
Recruiting·UUniversity Health Network, Toronto·N/A·NCT05440851·6,250 enrolled
Delirium Evaluation With Longitudinal Tau Assessment
Recruiting·SScripps Health·N/A·NCT07694206·100 enrolled
Pervasive Sensing and Artificial Intelligence in Intelligent ICU Subtitles: -Intelligent Intensive Care Unit (I2CU): Pervasive Sensing and Artificial Intelligence for Augmented Clinical Decision-making -ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention
Recruiting·UUniversity of Florida·N/A·NCT05127265·400 enrolled
Long Term Outcomes of Patients With COVID-19
Active, not recruiting·UUniversity of Chicago·N/A·NCT04360538·500 enrolled
Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes
Active, not recruiting·UUniversity of Chicago·N/A·NCT04552834·500 enrolled
Real-time Evaluation of an Outlier-based Alerting System
Active, not recruiting·—·Preclinical·NCT06996626·7,445 enrolled
Collaborative Risk-stratified Investigation in Teen Inpatients With Critical Illness: Anticoagulation With LMWH in Kids for ThromboProphylaxis (CRITICAL-Kids-TP)
Not yet recruiting·JJohns Hopkins All Children's Hospital·Phase 3·NCT06628778·802 enrolled
Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU
Not yet recruiting·RRutgers, The State University of New Jersey·Approved·NCT07691996·30 enrolled
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress: Lift RCT (Lift 3)
Not yet recruiting·DDuke University·Preclinical·NCT07634419·450 enrolled
Construction and Evaluation of a Bristol Stool Form Scale-Based Nursing Care Pathway for Enteral Nutrition-Associated Diarrhea in Critically Ill Patients: A Prospective, Randomized, Controlled, Single-Center Trial
Not yet recruiting·TTang-Du Hospital·Preclinical·NCT07683364·60 enrolled
Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study
Not yet recruiting·UUniversity of Wisconsin, Madison·N/A·NCT07613918·125 enrolled
A Randomized Trial of REFRAME: an Emotion Regulation Intervention to Improve Psychological Outcomes in Surrogate Decision-Makers of the Critically Ill
Not yet recruiting·CCase Western Reserve University·Preclinical·NCT07630844·387 enrolled
Efficacy of Enteral Iron Supplementation in Critical Illness
Completed·WWeill Medical College of Cornell University·Phase 2·NCT00450177·200 enrolled
The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
Completed·—·Phase 2·NCT01985685·66 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)