Ketalar

(Ketamine)

ApprovedSmall molecule

Ketamine is used as an anesthetic to put patients to sleep during surgery and medical procedures. In recent years, it has also been used in small doses to treat severe depression and chronic pain when other treatments haven't worked.[2] Ketalar is currently approved and in use across 126 indications[4].[1]

Ketalar is one of 1808 small molecule programs targeting ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder. It is currently in Approved.

126

Indications

734

Total Trials

Active Trials

1,807

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Total Joint ArthroplastyActive, not recruiting

Nicotine DependenceApproved

Neuropathic PainApproved

Cardiac ArrestApproved

Rib FractureActive, not recruiting

Depressive DisorderActive, not recruiting

Eating DisorderActive, not recruiting

Liver TransplantActive, not recruiting

ToxicityActive, not recruiting

Approved

Total Joint ArthroplastyPhase 1

Active, not recruiting

Nicotine DependenceApproved

Approved

Neuropathic PainApproved

Approved

Cardiac ArrestApproved

Approved

Rib FractureApproved

Active, not recruiting

Depressive DisorderPhase 1

Active, not recruiting

Eating DisorderPhase 2

Active, not recruiting

Liver TransplantApproved

Active, not recruiting

ToxicityPhase 2

Active, not recruiting

Showing 10 of 118 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Ketalar

AAultman Health Foundation

Approved

3 2

Halaven

Eisai

Preclinical

38 3

Tecentriq

Roche

Preclinical

36 4

Cymbalta

Alnylam Pharmaceuticals

Preclinical

3 5

Lexiscan

Astellas

Preclinical

1 6

Adenocard

Astellas

Preclinical

1 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 8

Spravato

WWim Janssens

Preclinical

2 9

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 10

Chirocaine

PPurdue Pharma LP

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Active, not recruiting

Multiple Sclerosis

NCT05378100

Post-ApprovalRecruiting

Acute Pain

NCT06853041

Post-ApprovalRecruiting

Endometriosis

NCT06951802

Phase 1Recruiting

Treatment

NCT05327699

Q2 2027

Phase 1/2Recruiting

Sedation

NCT07443254

Q1 2028

Phase 1Recruiting

Major Depressive Disorder

NCT03065335

Clinical

Trials by Indication[1]

Ketamine26 trials

Ketamine-assisted Therapy for Advanced GI Cancer

Terminated·—·Phase 4·NCT06077487·1 enrolled

Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling

Completed·YYale University·Phase 1·NCT02037035·36 enrolled

Effect of Ketamine Infusion on BIS Values

Completed·UUniversity of Padova··NCT05799729·40 enrolled

Show 23 more trials

Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients

Completed·KKing Faisal Specialist Hospital & Research Center·Phase 3·NCT04075006·84 enrolled

Escalating Ketamine Doses and Pre-emption

Completed·TTel-Aviv Sourasky Medical Center·N/A·NCT01070108·120 enrolled

Ketamine Infusion Therapy for PTSD in Combat Veterans

Completed·KKlarisana Physician Services PLLC··NCT03088384·30 enrolled

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial

Completed·YYale University·Phase 1·NCT03367533·13 enrolled

Ketamine and Epigenetic Aging

Unknown status·TTruDiagnostic·Phase 2·NCT05294835·20 enrolled

CYP2B6 Polymorphisms in Ketamine

Completed·WWashington University School of Medicine·N/A·NCT01988922·30 enrolled

Ketamine Prevent POCD

Unknown status·RRenJi Hospital·N/A·NCT02220400·484 enrolled

Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT04173962·24 enrolled

The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital

Unknown status·MMakerere University·Phase 4·NCT01339065·30 enrolled

Combined Ketamine and eCBT Intervention for PTSD

Unknown status·QQueen's University·Phase 2·NCT04771767·16 enrolled

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

Recruiting·YYale University·Phase 1·NCT05915013·50 enrolled

Cognitive Biases Under Ketamine

Completed·—·N/A·NCT02235012·84 enrolled

Ketamine Versus Etomidate for Rapid Sequence Intubation

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT01823328·143 enrolled

Ketamine for Older Adults Pilot

Completed·WWashington University School of Medicine·Phase 4·NCT04504175·25 enrolled

Ketamine in Chronic Kid's (KiCK) Pain

Terminated·MMedical University of South Carolina·Phase 2·NCT01755169·7 enrolled

Effects of Ketamine on Eye Movements, Perception and Brain Function

Completed·UUniversity of Bonn·N/A·NCT02701933·24 enrolled

A Blinded, Four-Way Crossover in Healthy Subjects to Assess EEG After Administration of Ketamine, Placebo and AZD6765

Terminated· AstraZeneca logo

AstraZeneca·Phase 1·NCT01130909·36 enrolled

Comparison of Propofol/Alfentanil With Propofol/Ketamine

Unknown status·RRabin Medical Center·N/A·NCT02000206·80 enrolled

Understanding How Ketamine Brings About Rapid Improvement in OCD

Active, not recruiting·SStanford University·Phase 2·NCT02624596·120 enrolled

The Electroencephalogram and Clinical Effect of Ketamine

Terminated·NNational Taiwan University Hospital·N/A·NCT03679390·17 enrolled

The Effect of Ketamine Infusion on Lumbar Surgery

Unknown status·YYonsei University·Phase 4·NCT02154438·56 enrolled

The UTHealth Ketamine Project

Terminated·TThe University of Texas Health Science Center, Houston·Phase 2·NCT02882711·10 enrolled

The Effect of Ketamine on Attentiveness

Completed· Johnson & Johnson Pharmaceutical Research & Development, L.L.C. logo

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 1·NCT01165294·24 enrolled

Sedation12 trials

Sedation During Spinal Anesthesia

Completed·—·Phase 2·NCT03133780·80 enrolled

The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation

Unknown status·LLebanese American University Medical Center·Phase 3·NCT04096768·394 enrolled

Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Active, not recruiting·—·Phase 1·NCT07040163·276 enrolled

Show 9 more trials

IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures

Withdrawn·PPhoenix Children's Hospital·Phase 1·NCT03466242

Prospective IR-led Sedation Feasibility

Recruiting·—·Phase 1/2·NCT07443254·40 enrolled

The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST)

Unknown status·MMedical University of Warsaw·Phase 1·NCT04409665·60 enrolled

Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT00997321·100 enrolled

Sedation During Pediatric Diagnostic Gastrointestinal Endoscopy Gastrointestinal Endoscopy

Unknown status·—·N/A·NCT03235609·60 enrolled

Use of Ketamine Associate With an Opioid for Sedation in ICU

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT01560390·164 enrolled

Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case

Completed·OOndokuz Mayıs University·N/A·NCT06412861·60 enrolled

Ketamine-fentanyl VS Fentanyl for Analgosedation in SICU

Completed·MMahidol University·Phase 4·NCT03879564·118 enrolled

Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy

Completed·—·Phase 4·NCT06181188·66 enrolled

Depression7 trials

Subanesthetic IV Bolus Ketamine in the Treatment of Acute Depression

Terminated·UUnited States Naval Medical Center, San Diego·Phase 1·NCT02378415·20 enrolled

Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department

Withdrawn·MMaria Pacella·Phase 2/3·NCT03436121

Ketamine in the Treatment of Depression

Completed·—·Phase 2·NCT01558063·38 enrolled

Show 4 more trials

Pharmacologic Treatment Augmentation in Chronic Depression

Recruiting·UUniversity Hospital Tuebingen·Phase 2·NCT06410599·60 enrolled

Ketamine for Treatment Resistant Late-Life Depression

Completed·VVA Office of Research and Development·Phase 3·NCT02556606·33 enrolled

Ketamine and Nitroprusside for Depression

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT03102736·40 enrolled

Ketamine for Depression Relapse Prevention Following ECT

Completed·SSt Patrick's Hospital, Ireland·Phase 1·NCT02414932·6 enrolled

Major Depressive Disorder6 trials

Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder

Completed·MMassachusetts General Hospital·N/A·NCT01667926·37 enrolled

Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.

Completed·SSunnybrook Health Sciences Centre·Phase 1·NCT02593643·9 enrolled

Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality

Completed·—·N/A·NCT04101474·36 enrolled

Show 3 more trials

Open Label Ketamine Treatment for Major Depressive Disorder in Veterans

Completed·VVA Connecticut Healthcare System·Phase 2·NCT03053830·11 enrolled

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Recruiting·NNational Institute of Mental Health (NIMH)·Phase 1·NCT03065335·150 enrolled

Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder

Withdrawn·MMassachusetts General Hospital·N/A·NCT01613820

Treatment Resistant Depression6 trials

Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression

Completed·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT05045378·12 enrolled

Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression

Completed·TThe Cleveland Clinic·N/A·NCT02522377·15 enrolled

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression

Completed· Novartis logo

Novartis·Phase 2·NCT03756129·70 enrolled

Show 3 more trials

Optimization of IV Ketamine for Treatment Resistant Depression

Completed·—·Phase 2·NCT00768430·73 enrolled

Ketamine in Adolescents With Treatment-Resistant Depression

Completed·UUniversity of Minnesota·Phase 2·NCT02078817·14 enrolled

D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression

Unknown status·SSheba Medical Center·Phase 4·NCT02772211·60 enrolled

101 more indications

Dexmedetomidine5 trials

Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy

Completed·UUniversity of Patras·Phase 3·NCT06185127·50 enrolled

Dexmedetomidine, Ketamine and Dexmetedomidine-Ketamine Combination for Control of Shivering During Regional Anaethesia

Completed·—·Phase 4·NCT03302351·94 enrolled

Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures

Completed·NNational Cancer Institute, Egypt·N/A·NCT04597268·75 enrolled

Show 2 more trials

Comparison of Pain Using CPOT Score With Ketamine vs. Dexmedetomidine in Post-Craniotomy ICU Patients

Completed·UUniversitas Sumatera Utara·N/A·NCT07254936·38 enrolled

Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Completed·—·Phase 4·NCT03164590·60 enrolled

Children4 trials

Low-Dose Ketamine in Children With ADNP Syndrome

Completed·AAlexander Kolevzon·Phase 1/2·NCT04388774·10 enrolled

Ketamine Pharmacokinetics in Children Having Heart Surgery

Completed·—·N/A·NCT00598195·18 enrolled

Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children

Completed·WWashington University School of Medicine·N/A·NCT01669642·111 enrolled

Show 1 more trial

Transversus Abdominis Plane Block In Children

Unknown status·EErzincan University·N/A·NCT02990975·60 enrolled

Treatment4 trials

Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain

Terminated·WWashington University School of Medicine·N/A·NCT02430818·13 enrolled

Novel Topical Therapies for the Treatment of Genital Pain

Completed·UUniversity of Rochester·Phase 2/3·NCT02099006·9 enrolled

Ketamine for Treatment Resistant MDD

Unknown status·HHadassah Medical Organization·N/A·NCT04021433·20 enrolled

Show 1 more trial

Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine

Recruiting·EEmory University·Phase 1·NCT05327699·140 enrolled

Status Epilepticus3 trials

Ketamine for the Treatment of Refractory Status Epilepticus

Not yet recruiting·TThomas Jefferson University·Phase 4·NCT07177235·50 enrolled

Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest

Recruiting·UUniversity of Milano Bicocca··NCT05756621·80 enrolled

Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus

Withdrawn·MMid-Atlantic Epilepsy and Sleep Center, LLC·Phase 3·NCT02726867

Neuropathic Pain3 trials

Methadone and Ketamine for Neuropathic Pain Treatment

Completed·UUniversidade Federal de Santa Maria·Phase 4·NCT02233452·37 enrolled

Oral Ketamine Administration in Patients With Peripheral Neuropathic Pain

Completed·UUniversity Hospital, Toulouse·Phase 2·NCT00961194·22 enrolled

Ketamine and fMRI for Neuropathic Pain

Completed·UUniversity Health Network, Toronto·N/A·NCT02373449·39 enrolled

Midazolam3 trials

Ketamine and Midazolam Infusions for CRPS: Feasibility Study

Withdrawn·SStanford University·Phase 2·NCT05945147

Comparison Between Dexmeditomidine, Midazolam and Ketamine as a Sedative to Help Cannula Insertion in Pediatric Patient

Completed·—·Phase 2/3·NCT04704622·150 enrolled

Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.

Completed·NNational University of Malaysia·Phase 2·NCT06111872·90 enrolled

Major Depression3 trials

Continuation Ketamine in Major Depression

Completed·JJames Murrough·Phase 1·NCT00548964·36 enrolled

N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression

Terminated·MMassachusetts General Hospital·Phase 4·NCT01260649·17 enrolled

Biomarkers of Fast Acting Therapies in Major Depression

Completed·UUniversity of California, Los Angeles·Phase 1·NCT02165449·60 enrolled

Postoperative Analgesia3 trials

Ketamine and Postoperative Analgesia in Children

Unknown status·NNantes University Hospital·Phase 4·NCT00200564·74 enrolled

Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative Analgesia

Completed·ZZagazig University·N/A·NCT04525274·60 enrolled

Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery.

Completed·—·Phase 2/3·NCT02514980·30 enrolled

General Anesthesia3 trials

EEG Studies of Ketamine General Anesthesia

Completed·MMassachusetts General Hospital·Phase 2/3·NCT03553758·16 enrolled

The Effect of Ketamine on the WAVCNS Index During General Anesthesia: A Feasibility Study

Completed·FFraser Health·N/A·NCT02908945·30 enrolled

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Completed·—·N/A·NCT05279898·70 enrolled

Suicide3 trials

Ketamine for Depression and Suicide Risk

Completed·MMayo Clinic·Phase 2·NCT02094898·12 enrolled

Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT03666390·48 enrolled

miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome

Completed·UUniversity of Alabama at Birmingham·Phase 2·NCT02418195·247 enrolled

Chronic PTSD2 trials

Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT04889664·16 enrolled

TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD

Unknown status·TThe Cooper Health System·N/A·NCT02766192·50 enrolled

Post-Traumatic Stress Disorder2 trials

Intraoperative Subanesthetic Ketamine Versus Dexmedetomidine Infusion for Prevention of Post-traumatic Stress Disorder After Traumatic Brain Surgeries

Enrolling by invitation·ZZagazig University·N/A·NCT06498700·52 enrolled

Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2/3·NCT02397889·30 enrolled

Multimodal Analgesia2 trials

Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery

Completed·KKasr El Aini Hospital·N/A·NCT07001605·62 enrolled

Multimodal Analgesia in Cardiac Surgery (Pilot Study)

Terminated·VVirginia Commonwealth University·Phase 4·NCT02734940·3 enrolled

Post Operative Pain2 trials

Ketamine for Postoperative Pain in Bariatric Surgery

Unknown status·LLithuanian University of Health Sciences·Phase 4·NCT03389022·64 enrolled

Administration of Ketamine to Prevent the Post-operative Pain

Completed·IInstitut Bergonié·Phase 3·NCT00210210·230 enrolled

Pediatric Patients2 trials

A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients

Completed·AArlyne Thung·Phase 2·NCT03714919·10 enrolled

The Effects of Dexmedetomidine on Early Stage Renal Functions in Pediatric Patients

Completed·TTC Erciyes University·Phase 4·NCT01948336·60 enrolled

Brain Injury2 trials

Efficacy of Ketamine in Children With Severe Brain Injury for Brain Cell Protection

Withdrawn·UUniversity of Arkansas·Phase 2·NCT00556387

Ketamine in Acute Brain Injury Patients.

Recruiting·—·Phase 4·NCT05097261·100 enrolled

Nausea and vomiting2 trials

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery

Completed·YYonsei University·Phase 4·NCT01394406·50 enrolled

Double-blind2 trials

Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia

Suspended·PPharmaTher Inc.·Phase 2·NCT04912115·30 enrolled

The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients

Completed·BBayside Health·Phase 4·NCT00163969·40 enrolled

Intravenous2 trials

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

Completed·—·Phase 1·NCT06867068·73 enrolled

Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients

Unknown status·PPusan National University Yangsan Hospital·Phase 2·NCT03362073·26 enrolled

Sickle Cell Disease2 trials

Low-Dose Ketamine Infusion for Children With Sickle Cell Disease-Related Pain

Terminated·—·Phase 2·NCT00595530·3 enrolled

Ketamine Sickle Cell Disease

Withdrawn·UUniversity of South Florida·Phase 3·NCT03502421

Fentanyl2 trials

Intranasal Ketamine Versus Intranasal Fentanyl

Completed·IIsfahan University of Medical Sciences·Phase 3·NCT04414800·125 enrolled

IN Sub-Dissociative Ketamine vs IN Fentanyl

Completed·WWake Forest University Health Sciences·Phase 2·NCT02521415·87 enrolled

Cardiovascular2 trials

Cardiovascular Safety After Continuous Ketamine Infusion

Completed·UUniversidad de Antioquia··NCT03979105·300 enrolled

Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions

Completed·UUniversidad de Antioquia·N/A·NCT03525912·101 enrolled

Pilot Study2 trials

Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects

Completed·YYale University·Phase 1·NCT00700076·15 enrolled

Ketamine Pilot Study

Terminated·MMeghan Spyres·Phase 4·NCT05379179·3 enrolled

Spinal Fusion2 trials

Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients

Terminated·MMontefiore Medical Center·Phase 4·NCT02989597·10 enrolled

A Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fusion

Completed·NNYU Langone Health·Phase 2·NCT03274453·129 enrolled

Suicidal Ideation2 trials

Intranasal Ketamine for Late-Life Depression and Suicidal Ideation

Withdrawn·MMassachusetts General Hospital·Phase 4·NCT02295787

Ketamine for Mood Disorders With Suicidal Ideation

Unknown status·TThe Miriam Hospital·Phase 1·NCT04099771·20 enrolled

Cancer Pain2 trials

Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients

Terminated·UUniversity Hospital, Basel, Switzerland·Phase 3·NCT02591017·11 enrolled

Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT01326325·24 enrolled

Tonsillectomy2 trials

Peri Tonsillar Infiltration of Ketamine or Bupivacaine for Post Tonsillectomy Analgesia

Completed·SSohag University·Phase 4·NCT05341323·80 enrolled

Low Dose Ketamine as an Adjunct to Fentanyl in Outpatient Tonsillectomy

Completed·MMayo Clinic·N/A·NCT00587665·122 enrolled

Depressed1 trial

Repeated Neurocognitive Measurements in Depressed Patients

Withdrawn·JJay Fournier·Phase 1/2·NCT05991232

Severe Pain1 trial

Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain

Terminated·MMercy Health Ohio·Phase 4·NCT03959852·6 enrolled

Obsessive-Compulsive Disorder1 trial

A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder

Terminated·MMclean Hospital·Phase 2·NCT02234011·1 enrolled

Lumbar Spine Surgery1 trial

Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery

Terminated·—·Phase 2·NCT04220489·1 enrolled

Hemodynamic1 trial

Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation

Completed·SSouth East Area Health Education Center, Wilmington, NC·Phase 4·NCT03545503·428 enrolled

Status Asthmaticus1 trial

The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus

Withdrawn·—·Phase 3·NCT03338205

Acute Pain1 trial

ESKetamine Low-dose vs Ketamine Low-dose for Severe Acute Pain in Emergency Units, Comparison of PsychodyslEptic Effects

Recruiting·—·Phase 4·NCT06853041·74 enrolled

COVID-191 trial

Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19

Terminated·CCorewell Health East·Phase 2·NCT04365985·70 enrolled

Chronic pain1 trial

Lidocaine-Ketamine for Management of Chronic Pain

Unknown status·HHamilton Health Sciences Corporation·N/A·NCT03249025·72 enrolled

Radiotherapy1 trial

Ketamine Tolerance in Children After Repeated Administrations During Radiotherapy Sessions

Completed·—·Phase 4·NCT02512055·33 enrolled

Traumatology1 trial

Low Dose Ketamine Intra Nasal Traumatology

Completed·UUniversity of Monastir·Phase 2·NCT03233035·1,102 enrolled

Abuse Potential1 trial

Study in Healthy Recreational Polydrug Users to Measure the Abuse Potential of TC-5214

Withdrawn· AstraZeneca logo

AstraZeneca·Phase 1·NCT01500018

Randomized1 trial

Randomized Trial of Sedative Choice for Intubation

Completed·VVanderbilt University Medical Center·Phase 4·NCT05277896·2,367 enrolled

Bronchoscopy1 trial

Remifentanil Use in Pediatric Rigid Bronchoscopy

Completed·—·Phase 4·NCT01947114·40 enrolled

Burn Wound1 trial

Low-Dose Ketamine Infusion During Burn Wound Care

Recruiting·UUniversity of Tennessee·Phase 4·NCT06506565·140 enrolled

Preoperative1 trial

Comparing Efficacy Preoperative Nebulized: Ketamine , Mgspo4 ,and Lidocaine In Attenuating Endotracheal Sore Throat

Completed·ZZagazig University·Phase 3·NCT03729973·100 enrolled

Biomarker1 trial

Biomarker Assessment of Glutamatergic Target Engagement

Completed·NNew York State Psychiatric Institute·Phase 4·NCT02134951·65 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Hemorrhoid1 trial

Ketamine for Post-operative Analgesia in Hemorrhoidectomy

Recruiting·UUniversity of Oklahoma·Phase 4·NCT04248205·100 enrolled

Anesthesia1 trial

Ketamine Effect on Isoflurane Anesthesia

Completed·MMinia University·Phase 4·NCT03290495·30 enrolled

Colorectal Surgery1 trial

Ketamine in Colorectal Surgery

Withdrawn·MMedical College of Wisconsin·Phase 4·NCT02785003

Terminated·YYale University·Phase 2·NCT03395314·22 enrolled

Thoracic Surgery1 trial

Ketamine In Thoracic Surgery (KITS) Trial

Completed·—·Phase 2·NCT00504725·40 enrolled

Spinal Anesthesia1 trial

Prevention of Shivering Associated With Spinal Anesthesia

Unknown status·—·Phase 2/3·NCT06082076·90 enrolled

Endometriosis1 trial

Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT06951802·118 enrolled

Agitation1 trial

Nalbuphine Versus Ketamine for Prevention of Emergence Agitation After Sevoflurane in Children Undergoing Tonsillectomy

Completed·—·Phase 4·NCT05176119·90 enrolled

Bariatric Surgery1 trial

Ketamine for Pain Relief in Bariatric Surgery

Completed·SSir Ganga Ram Hospital·Phase 4·NCT03052673·76 enrolled

Sternotomy1 trial

Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT00822419·75 enrolled

Tracheal Intubation1 trial

Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT02643381·801 enrolled

Surgery1 trial

Comparison of Opioid Based and Opioid Free Anaesthesia in Transsphenoidal Surgery

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·N/A·NCT03120234·60 enrolled

Fatigue1 trial

Effect of Ketamine on Fatigue Following Cancer Therapy

Terminated·NNational Institute of Nursing Research (NINR)·Phase 1·NCT02317341·2 enrolled

MPA1 trial

Comparison of Methods to Facilitate Rapid Sequence Intubation

Completed·SSeoul National University Bundang Hospital·N/A·NCT01479751·110 enrolled

Cocaine Dependence1 trial

The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence

Terminated·NNew York State Psychiatric Institute·Phase 1/2·NCT01535937·55 enrolled

Laparoscopy1 trial

The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy

Completed·UUniversity Hospital, Lille·Phase 2/3·NCT02969733·135 enrolled

Intraoperative1 trial

Machine-learning Algorithm to Differentiate Intraoperative Ketamine Dosing Based on Electroencephalographic Density Spectrum Array Analysis

Unknown status·TTaipei Veterans General Hospital, Taiwan··NCT05256264·90 enrolled

Local Anesthetic1 trial

Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block

Completed·—·Phase 2/3·NCT03060070·90 enrolled

Injury1 trial

Ketamine for Pain Control After Severe Traumatic Injury

Completed·MMedical College of Wisconsin·N/A·NCT04274361·93 enrolled

Post-Traumatic Stress Disorder, PTSD1 trial

Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

Unknown status·SSouthern California Institute for Research and Education·Phase 1·NCT01736020·293 enrolled

Gastrectomy1 trial

Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy

Completed·NNYU Langone Health·Phase 2/3·NCT02452060·90 enrolled

Severe Depression1 trial

Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients

Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT06508710·60 enrolled

Mindfulness1 trial

Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement

Not yet recruiting·UUniversity of California, San Diego·Phase 2·NCT07369089·88 enrolled

Efficacy1 trial

Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial

Completed·HHospital Nossa Senhora da Conceicao·Phase 2/3·NCT03000413·45 enrolled

Dexamethasone1 trial

Dexamethasone & Ketamine as Adjuvants to Bupivacaine for Incisional Infiltration in Pediatric Abdominal Operations

Completed·—·N/A·NCT05190952·150 enrolled

Mucositis1 trial

Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash

Completed·AAaron Cumpston, PharmD, BCOP·Phase 2·NCT01566448·30 enrolled

External Oblique Intercostal Plane Block1 trial

Dexmedetomidine and Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain

Completed·TTanta University·N/A·NCT06331182·40 enrolled

Alcohol Withdrawal1 trial

Ketamine vs. Placebo as Adjunctive Therapies for Severe Alcohol Withdrawal

Withdrawn·UUniversity of Colorado, Denver·Phase 4·NCT02823977

Analgesic1 trial

Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption

Completed·EEgymedicalpedia·Phase 1·NCT05596669·100 enrolled

Laparoscopic1 trial

Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT00822133·75 enrolled

Stroke1 trial

Use of Transmucosal Ketamine in Post Stroke Depression

Unknown status·WWest Virginia University·Phase 1·NCT04876066·21 enrolled

Hyperalgesia1 trial

Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia

Completed·FFederal University of São Paulo·Phase 3·NCT01301079·60 enrolled

Bipolar Depression1 trial

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

Completed·BBrian Barnett·Phase 2·NCT06620042·20 enrolled

Single Dose1 trial

Single Dose Administration of Ketamine 10, 20, 40 and 80 mg and 5 mg Solution for Infusion in 15 Healthy Subjects

Completed·UUniversity Medicine Greifswald·Phase 1·NCT02494830·15 enrolled

Tooth Extraction1 trial

Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction

Completed·IiX Biopharma Ltd.·Phase 2·NCT02356965·80 enrolled

Driving1 trial

Assessment of Effect of Rapastinel on Driving Performance

Completed· AbbVie logo

AbbVie·Phase 1·NCT03814733·107 enrolled

Closed-Loop1 trial

Ketamine and Closed-Loop Anesthesia System

Terminated·HHopital Foch·Phase 3·NCT02011347·67 enrolled

Multiple Sclerosis1 trial

Ketamine for Multiple Sclerosis Fatigue

Active, not recruiting·JJohns Hopkins University·Phase 2·NCT05378100·110 enrolled

Coronary Artery Bypass1 trial

A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

Unknown status·—·Phase 4·NCT01386229·40 enrolled

Schizophrenia1 trial

Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy

Unknown status·—·Phase 4·NCT03829124·1 enrolled

Cardiac Surgery1 trial

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

Completed·SStanford University·Phase 4·NCT03861988·45 enrolled

Nerve Block1 trial

Comparison of Transversus Abdominis Plane Block and Ilioinguinal / Iliohypogastric Nerve Block

Unknown status·EErzincan University·N/A·NCT02991053·100 enrolled

Bipolar Disorder1 trial

Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder

Unknown status·MMclean Hospital··NCT05209217·20 enrolled

Delirium1 trial

Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) Patients

Terminated·EEmory University·Phase 4·NCT03040024·71 enrolled

Anxiety1 trial

The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety

Completed·—·Phase 3·NCT06310850·60 enrolled

Pediatric1 trial

Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises

Unknown status·CCameroon Baptist Convention Health·N/A·NCT02573714·160 enrolled

Intranasal Administration1 trial

To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSD

Withdrawn·AAdriana Feder·Phase 2/3·NCT02398136

Total Joint Arthroplasty1 trial

Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty

Completed·—·Phase 1·NCT04437888·200 enrolled

Abdominal Cancer Surgery1 trial

Intrathecal Ketamine, Dexmedetomidine and Both With Bupivacaine for Postoperative Abdominal Cancer Surgery Pain

Unknown status·—·Phase 2/3·NCT02455609·90 enrolled

Magnetic Resonance Imaging (MRI)1 trial

Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01046630·128 enrolled

Neuroimaging1 trial

Ketamine and Propofol NeuroImaging

Recruiting·KKeith M Vogt·Phase 1·NCT07294092·60 enrolled

Laceration1 trial

IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair

Terminated·CCorewell Health East·Phase 4·NCT03528512·5 enrolled

Aesthetic1 trial

Ketamine as an Anaesthetic Agent in Electroconvulsive Therapy (ECT)

Completed·NNorthside Clinic, Australia·Phase 4·NCT00680433·83 enrolled

Unspecified2 trials

The Dreamy Jet Study

Withdrawn·UUniversity of Wisconsin, Madison·Phase 1·NCT06919198

Study of CT001 in Healthy Volunteers

Completed·CCessatech A/S·Phase 1·NCT04807335·14 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

KETALAR

NDA NDA016812

Sources

References

[1]
ClinicalTrials.gov — 734 trial records for Ketamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ketalar drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Ketamine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Ketamine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA016812). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Aultman Health Foundation company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glutamate [NMDA] Receptor Negative Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AAultman Health Foundation

Ketalar

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q2 2027

Q1 2028

Trials by Indication[1]

Ketamine26 trials

Sedation12 trials

Depression7 trials

Major Depressive Disorder6 trials

Treatment Resistant Depression6 trials

Dexmedetomidine5 trials

Children4 trials

Treatment4 trials

Status Epilepticus3 trials

Neuropathic Pain3 trials

Midazolam3 trials

Major Depression3 trials

Postoperative Analgesia3 trials

General Anesthesia3 trials

Suicide3 trials

Chronic PTSD2 trials

Post-Traumatic Stress Disorder2 trials

Multimodal Analgesia2 trials

Post Operative Pain2 trials

Pediatric Patients2 trials

Brain Injury2 trials

Nausea and vomiting2 trials

Double-blind2 trials

Intravenous2 trials

Sickle Cell Disease2 trials

Fentanyl2 trials

Cardiovascular2 trials

Pilot Study2 trials

Spinal Fusion2 trials

Suicidal Ideation2 trials

Cancer Pain2 trials

Tonsillectomy2 trials

Depressed1 trial

Severe Pain1 trial

Obsessive-Compulsive Disorder1 trial

Lumbar Spine Surgery1 trial

Hemodynamic1 trial

Status Asthmaticus1 trial

Acute Pain1 trial

COVID-191 trial

Chronic pain1 trial

Radiotherapy1 trial

Traumatology1 trial

Abuse Potential1 trial

Randomized1 trial

Bronchoscopy1 trial

Burn Wound1 trial

Preoperative1 trial

Biomarker1 trial

Perioperative Pain Control1 trial

Hemorrhoid1 trial

Anesthesia1 trial

Colorectal Surgery1 trial

Pain1 trial

Bone Fracture1 trial

Borderline personality disorder1 trial

Thoracic Surgery1 trial

Spinal Anesthesia1 trial

Endometriosis1 trial

Agitation1 trial

Bariatric Surgery1 trial

Sternotomy1 trial

Tracheal Intubation1 trial

Surgery1 trial

Fatigue1 trial

MPA1 trial

Cocaine Dependence1 trial

Laparoscopy1 trial

Intraoperative1 trial

Local Anesthetic1 trial

Injury1 trial

Post-Traumatic Stress Disorder, PTSD1 trial