Ketalar

(Ketamine)

ApprovedSmall molecule

Ketamine is used as an anesthetic to put patients to sleep during surgery and medical procedures. In recent years, it has also been used in small doses to treat severe depression and chronic pain when other treatments haven't worked.[2] Ketalar is currently approved and in use across 117 indications[4].[1]

Ketalar is one of 1220 small molecule programs targeting Treatment Resistant Depression. It is currently in Approved.

117

Indications

744

Total Trials

Active Trials

1,219

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Treatment Resistant DepressionCompleted

Major Depressive DisorderWithdrawn

Post Operative PainTerminated

Parkinson's DiseaseCompleted

Alcohol Use DisorderNot yet recruiting

KetamineTerminated

SuicidalityTerminated

IntraoperativeCompleted

Major Depressive EpisodeApproved

Treatment Resistant DepressionApproved

Completed

Major Depressive DisorderApproved

Withdrawn

Post Operative PainApproved

Terminated

Parkinson's DiseasePhase 2

Completed

Alcohol Use DisorderPhase 2

Not yet recruiting

KetamineApproved

Terminated

SuicidalityApproved

Terminated

IntraoperativeApproved

Completed

Major Depressive EpisodeApproved

Approved

Showing 10 of 112 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Ketalar

AAultman Health Foundation

Approved

3 2

Lexiscan

Astellas

Preclinical

1 3

Voltaren

Novartis

Preclinical

1 4

Zolymbus

AbbVie

Preclinical

1 5

Blenoxane

Bristol-Myers Squibb

Preclinical

1 6

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 8

Duragesic-100

CCephalon

Preclinical

2 9

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 10

Spravato

WWim Janssens

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalActive, not recruiting

Chronic Pain

NCT06317636

Phase 2Recruiting

Alcohol Use Disorder

NCT06969937

Phase 1/2Recruiting

Chronic Pain

NCT05156060

Q1 2027

N/ARecruiting

Mood Disorder

NCT02734602

Q2 2027

N/ANot yet recruiting

Breast Cancer

NCT07197684

Q3 2027

Phase 2Recruiting

Depression

NCT06559826

Clinical

Trials by Indication[1]

Ketamine16 trials

Effects of Ketamine on ERP/EEG Measures in Healthy Volunteers

Completed·EERP Biomarker Qualification Consortium·Phase 1·NCT04928703·33 enrolled

Scheduled Intranasal Ketamine

Withdrawn·SSanford Health·Phase 1·NCT05671913

A Study of Ketamine as an Antidepressant

Unknown status·TThe University of New South Wales·Phase 2·NCT01441505·42 enrolled

Show 13 more trials

Ketamine vs Hydromorphone

Completed·UUniversity of Florida·Phase 4·NCT03001843·54 enrolled

Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage

Completed·IIstanbul Training and Research Hospital·Phase 4·NCT05752110·140 enrolled

Perioperative Ketamine for Pain With Gastric Bypass

Completed·MMayo Clinic·Phase 2·NCT03448068·34 enrolled

CAP-Ketamine for Antidepressant Resistant PTSD

Completed·VVA Office of Research and Development·Phase 2·NCT02655692·163 enrolled

Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia

Unknown status·DDr Foo Li Lian·Phase 4·NCT03357055·60 enrolled

The Effect of Ketamine on Attentiveness

Completed· Johnson & Johnson Pharmaceutical Research & Development, L.L.C. logo

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 1·NCT01165294·24 enrolled

The Impact of Perioperative Ketamine Infusion on Surgical Recovery

Completed·VVanderbilt University Medical Center·Phase 4·NCT04625283·1,570 enrolled

The Role of HNKs in the Antidepressant Effect of Ketamine

Terminated·—·Phase 1·NCT03977675·8 enrolled

Ketamine in Patients Undergoing Anterior Cervical Discectomy and Fusion

Withdrawn·NNorthwestern University·Phase 4·NCT02378740

Intranasal Ketamine as a Sedative for Venipuncture

Completed·HHospital de Clinicas de Porto Alegre·Phase 2/3·NCT02929524·39 enrolled

Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Recruiting·—·Phase 1·NCT06085937·50 enrolled

Understanding Ketamine's Dissociative Effects (KD Study)

Recruiting·SStanford University·Phase 1·NCT04861051·20 enrolled

Sub-dissociative Dose Ketamine Dosing Study

Completed·LLoyola University·Phase 4·NCT03714620·98 enrolled

Treatment Resistant Depression10 trials

Intranasal Ketamine in Treatment-Resistant Depression

Completed·JJames Murrough·N/A·NCT01304147·20 enrolled

A Study of Ketamine in Patients With Treatment-resistant Depression

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01627782·68 enrolled

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

Completed·BBo Hu·Phase 2/3·NCT03113968·403 enrolled

Show 7 more trials

Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine

Withdrawn·—·Phase 2·NCT03290963

ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression

Recruiting·UUniversity of Saskatchewan·Phase 4·NCT03272698·62 enrolled

Synaptic Imaging and Network Activity in Treatment Resistant Depression

Completed·KKing's College London·N/A·NCT05870501·56 enrolled

Ketamine Plus Lithium in Treatment-Resistant Depression

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT01880593·34 enrolled

Action of Ketamine in Treatment-Resistant Depression

Completed·UUniversity of Ottawa·Phase 2/3·NCT01945047·46 enrolled

Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population

Unknown status·—·Phase 2·NCT01868802·60 enrolled

Treatment Resistant Depression (Pilot)

Completed·WWashington University School of Medicine·N/A·NCT01179009·20 enrolled

Depression9 trials

Ketamine Trial for the Treatment of Depression

Completed·TThe University of New South Wales·Phase 1·NCT02401139·10 enrolled

Naturalistic Study of Ketamine in the Treatment of Depression

Unknown status·HHospital de Clinicas de Porto Alegre··NCT05249309·90 enrolled

Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression

Completed·NNorthwell Health·Phase 4·NCT01881763·31 enrolled

Show 6 more trials

Ketamine in the Treatment of Suicidal Depression

Completed·NNew York State Psychiatric Institute·Phase 4·NCT01700829·82 enrolled

Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for Cancer

Completed·—·Phase 1·NCT02836288·4 enrolled

Ketamine and Nitroprusside for Depression

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT03102736·40 enrolled

Ketamine for Depression Relapse Prevention Following ECT

Completed·SSt Patrick's Hospital, Ireland·Phase 1·NCT02414932·6 enrolled

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT06559826·70 enrolled

Neural Circuit Effects of Ketamine in Depression

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT06213324·120 enrolled

Sedation9 trials

Intranasal Ketamine Effectiveness in Reducing Intramuscular Injection Pain Before Sedation Among Children

Completed·TTehran University of Medical Sciences·Phase 4·NCT06139380·84 enrolled

Ketamine Versus Propofol as ICU Sedation

Completed·MMenoufia University·Phase 4·NCT06243822·100 enrolled

Interscalene Nerve Block vs. Sedation for Shoulder Dislocation Reduction

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT03041506·90 enrolled

Show 6 more trials

Intranasal Ketamine Versus Intramuscular Ketamine for Procedural Sedation in Pediatric Patients

Terminated·UUniversity of Iowa·N/A·NCT01170247·3 enrolled

Sedation of Morbidly Obese for Balloon Insertion

Unknown status·MMansoura University·N/A·NCT03747094·70 enrolled

Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery

Recruiting·UUniversity Medical Centre Ljubljana·N/A·NCT07340008·60 enrolled

Ketamine-fentanyl VS Fentanyl for Analgosedation in SICU

Completed·MMahidol University·Phase 4·NCT03879564·118 enrolled

Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy

Completed·—·Phase 4·NCT06181188·66 enrolled

Comparison of the Perioperative Effects of Dexmedetomidine and Ketamine Sedation in Septorhinoplasty Operations

Completed·KKaradeniz Technical University·N/A·NCT04628559·63 enrolled

Dexmedetomidine8 trials

Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination

Completed·—·N/A·NCT07074262·114 enrolled

Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress

Completed·—·Phase 3·NCT02927379·90 enrolled

Dexmedetomidine and Ketamine in MRI

Completed·—·Phase 1·NCT02652507·22 enrolled

Show 5 more trials

The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

Completed·FFayoum University Hospital·N/A·NCT05474183·90 enrolled

Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia

Not yet recruiting·ZZagazig University·Phase 3·NCT07330375·50 enrolled

Dexmedetomidine Versus Ketamine on Laryngeal Microsurgery

Completed·—·N/A·NCT07048873·168 enrolled

Dexmedetomidine-ketamine in Femur Proximal Fracture Patients

Completed·IInje University·N/A·NCT02150759·46 enrolled

Pre-emptive Analgesia Using Nebulized Ketamine Versus Nebulized Dexmedetomidine in Endoscopic Nasal Surgeries

Recruiting·SSohag University·N/A·NCT07056582·105 enrolled

108 more indications

Intravenous6 trials

Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT03852797·33 enrolled

Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS

Completed·—·Phase 2·NCT00579085·40 enrolled

Intravenous Ketamine Effects on Functional Neuroanatomy

Withdrawn·NNeurological Associates of West Los Angeles·Phase 1·NCT04205890

Show 3 more trials

Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine

Completed·YYale University·Phase 1·NCT02289248·16 enrolled

The Effect of Intravenous Ketamine on Non Suicidal Self Injuries.

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 1/2·NCT04242914·30 enrolled

Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia

Terminated·NNantes University Hospital·Phase 3·NCT03236805·285 enrolled

Cesarean Section4 trials

Subcutaneous Wound Infiltration of Ketamine or Bupivacaine Pain Perception After Cesarean Section

Completed·HHuseyin Aksoy·Phase 1·NCT02515422·120 enrolled

Intravenous Ketamine and Postoperative Pain Following Cesarean Section.

Unknown status·—·Phase 2·NCT03018301·80 enrolled

Evaluation of the Analgesic Effect of Midazolam and Ketamine as an Additive to Intrathecal Bupivacaine in Patients Undergoing Cesarean Section

Completed·QQazvin University Of Medical Sciences·Phase 1/2·NCT01404442·90 enrolled

Show 1 more trial

Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?

Completed·NNorthwestern University·N/A·NCT00486902·188 enrolled

Major Depressive Disorder3 trials

Ketamine Infusion for Treatment-resistant Major Depressive Disorder

Completed·MMassachusetts General Hospital·N/A·NCT01582945·14 enrolled

Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder

Withdrawn·MMassachusetts General Hospital·N/A·NCT01613820

Study of Ketamine as an Antidepressant in Major Depressive Disorder

Unknown status·SShi Jinyun·Phase 1/2·NCT01573741·35 enrolled

Chronic pain3 trials

Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer

Recruiting·NNatalie Lockney·Phase 1/2·NCT05156060·64 enrolled

Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression

Active, not recruiting·SStanford University·Phase 4·NCT06317636·40 enrolled

The Effect of Perioperative Ketamine on Acute and Chronic Pain After Major Back Surgery

Completed·UUniversity Hospital, Geneva·Phase 2·NCT00618423·160 enrolled

Neuropathic Pain3 trials

Effectiveness of Ketamine in Malignant Neuropathic Pain Relief

Withdrawn·HHaukeland University Hospital·Phase 3·NCT01951911

Infusion Treatments of Chronic Peripheral Neuropathic Pain

Completed·HHacettepe University··NCT06297915·102 enrolled

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

Completed·VVA Pittsburgh Healthcare System·Phase 4·NCT02527083·10 enrolled

Alcohol Use Disorder3 trials

ACT_for Alcohol Use Disorder and Depression

Recruiting·—·N/A·NCT06620276·30 enrolled

Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder

Active, not recruiting·PPeggy C Nopoulos·Phase 2·NCT05421065·20 enrolled

Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use Disorder

Recruiting·DDr. med. Marcus Herdener·Phase 2·NCT06969937·75 enrolled

Headache3 trials

The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

Completed·UUniversity Medical Center of Southern Nevada·Phase 4·NCT02657031·54 enrolled

Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches

Recruiting·UUniversity Health Network, Toronto·Phase 3·NCT05306899·56 enrolled

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

Completed·—·Phase 3·NCT03081416·80 enrolled

Post Operative Pain3 trials

The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy

Terminated·—·Phase 4·NCT02252432·13 enrolled

Effect of Single Dose Ketamine and Magnesium on Postoperative Pain in Patients Undergoing Bariatric Surgery

Completed·MMilton S. Hershey Medical Center·N/A·NCT02334059·108 enrolled

Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty

Completed·UUniversity of Chile·N/A·NCT02450214·63 enrolled

Suicidal Ideation3 trials

Intramuscular Ketamine for Suicidal Ideation

Withdrawn·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT05105061

Intranasal Ketamine for Suicidal Ideation in Veterans

Withdrawn·BBronx Veterans Medical Research Foundation, Inc·Phase 1·NCT03788694

The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT02037503·100 enrolled

Depressive Symptoms3 trials

The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series

Withdrawn·WWashington University School of Medicine·Phase 2/3·NCT06048263

Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion

Completed·—·Phase 4·NCT06060210·110 enrolled

Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment.

Completed·IInstituto Mexicano del Seguro Social·N/A·NCT03473431·90 enrolled

Postoperative Analgesia3 trials

Magnesium and Ketamine in Postoperative Analgesia

Completed·NNational Cancer Institute, Egypt·Phase 4·NCT04111848·90 enrolled

Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH Surgery

Not yet recruiting·—·N/A·NCT07385352·54 enrolled

Topical Ketamine Versus Caudal Ketamine for Postoperative Analgesia in Children Undergoing Inguinal Herniotomy

Completed·—·Phase 2/3·NCT02462174·80 enrolled

Delirium2 trials

Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT02433041·200 enrolled

Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT)

Completed·MMedipol University·Phase 4·NCT06630364·59 enrolled

Cognition2 trials

Effects of Ketamine and Risperidone on Cognition

Completed·UUniversity of Manchester·Phase 4·NCT01140620·87 enrolled

Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers

Completed·UUniversity Hospital, Bonn·Phase 4·NCT05320991·70 enrolled

Breast Cancer2 trials

Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery

Completed·—·Phase 2·NCT04275661·60 enrolled

Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery

Not yet recruiting·—·N/A·NCT07197684·120 enrolled

Postoperative Pain Relief2 trials

Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda

Completed·UUniversity of Saskatchewan·Phase 2/3·NCT02514122·61 enrolled

The Effect of Peritonsillar Infiltration of Ketamine and Dexamethasone for Postoperative Pain Relief in Children Following Adenotonsillectomy

Unknown status·QQazvin University Of Medical Sciences·Phase 1/2·NCT01198210·160 enrolled

Bipolar Depression2 trials

Ketamine for Suicidality in Bipolar Depression

Completed·NNew York State Psychiatric Institute·Phase 1/2·NCT01944293·16 enrolled

Trial of Ketamine and Lithium Therapy in Bipolar Depression

Withdrawn·YYale University·Phase 2·NCT01768767

Pediatric2 trials

Ketamine Compared to Propofol for Pediatric GI Endoscopy

Completed·SState University of New York - Upstate Medical University··NCT00614159·34 enrolled

Importance of Integrated Pulmonary Index in Pediatric Endoscopy

Completed·MMarmara University·N/A·NCT05137574·60 enrolled

Abdominal Surgery2 trials

Ketamine Versus Propofol Effect on the Immune-mediatory Response for Abdominal Surgery

Unknown status·MMansoura University Hospital·N/A·NCT03793075·36 enrolled

Lidocaine and Ketamine in Abdominal Surgery

Terminated·TThe Cleveland Clinic·N/A·NCT00721110·64 enrolled

Major Depression2 trials

Ketamine As an Adjunctive Therapy for Major Depression (2)

Completed·UUniversity of Dublin, Trinity College·Phase 3·NCT04939649·63 enrolled

Rapid Antidepressant Effects of Ketamine in Major Depression

Completed·NNational Institute of Mental Health (NIMH)·Phase 1/2·NCT00088699·67 enrolled

Analgesia2 trials

Ketamine Effects as Preemptive Analgesia

Completed·UUniversitas Padjadjaran·Phase 2/3·NCT06040060·40 enrolled

Systemic Ketamine for the Improvement of Post-Operative Analgesia at the Alcohol-Dependent Patient

Suspended·UUniversity Hospital, Clermont-Ferrand·Phase 3·NCT00329394·56 enrolled

Bariatric Surgery2 trials

Analgesia Management in Bariatric Surgery

Completed·OOndokuz Mayıs University·N/A·NCT04836819·78 enrolled

Intraoperative Lidocaine and Combined With Ketamine on Opioid After Bariatric Surgery

Completed·MMahidol University·Phase 4·NCT04524130·87 enrolled

Anesthesia2 trials

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

Completed·UUniversity of Arkansas·Phase 4·NCT03643796·32 enrolled

Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy

Completed·UUniversity of Alberta·Phase 4·NCT02579642·48 enrolled

Septic Shock2 trials

Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock

Completed·—·Phase 3·NCT03104140·26 enrolled

Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock

Completed·—·N/A·NCT05957302·86 enrolled

Hypoventilation2 trials

Ketamine Infusion and Hypoventilation

Completed·NNorthwestern University·N/A·NCT01535976·54 enrolled

The Effect of Ketamine in the Prevention of Hypoventilation in Patients Undergoing Deep Sedation Using Propofol and Fentanyl

Withdrawn·NNorthwestern University·N/A·NCT01825083

Obsessive-Compulsive Disorder2 trials

Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)

Completed·NNew York State Psychiatric Institute·Phase 1/2·NCT02422290·5 enrolled

Intravenous Ketamine in the Treatment of Obsessive-Compulsive Disorder

Terminated·—·Phase 1/2·NCT01371110·3 enrolled

General Anaesthesia1 trial

Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

Completed·VVilnius University·Phase 4·NCT00300794·60 enrolled

Bupivacaine1 trial

Analgesic Effect of Bupivacaine Plus Ketamine Versus Bupivacaine Alone in Transversalis Fascia Plane Block

Not yet recruiting·—·Phase 1·NCT06935669·68 enrolled

Sevoflurane1 trial

Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapy

Completed·IInonu University·Phase 4·NCT01870219·24 enrolled

Schizophrenia1 trial

Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects

Completed·YYale University·Phase 1·NCT00690170·30 enrolled

Anesthesia Induction1 trial

Ketamin Plus Propofol for Anesthesia Induction

Completed·—·Phase 4·NCT04761159·112 enrolled

Thoracotomy1 trial

Prevention of Persistent Postsurgical Pain After Thoracotomy

Completed·HHospital Clinic of Barcelona·Phase 4·NCT01243801·104 enrolled

Bronchoscopy1 trial

Importance of Integrated Pulmonary Index in Pediatric Bronchoscopy

Completed·MMarmara University·N/A·NCT05137587·60 enrolled

Inflammatory Response1 trial

Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients

Recruiting·NNew Valley University·Phase 1/2·NCT06490731·2 enrolled

Alcohol Withdrawal1 trial

Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine

Withdrawn·SSanta Barbara Cottage Hospital·Phase 4·NCT03788889

Endometriosis1 trial

The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study

Terminated·NNYU Langone Health·Phase 1·NCT05229653·1 enrolled

Prostatectomy1 trial

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

Suspended·WWake Forest University Health Sciences·Phase 2/3·NCT05597878·100 enrolled

Pain Management1 trial

Geriatric Ketamine for Pain Management Study

Completed·AAntonios Likourezos·Phase 4·NCT02673372·60 enrolled

Post Operative Sore Throat1 trial

Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study

Unknown status·SSohag University··NCT05975346·80 enrolled

Head Neck Cancer1 trial

Analgesic Effects of Topical Ketamine Mouthwash in Patients Receiving Chemoradiation or Radiotherapy for Head & Neck Cancer

Completed·—·Phase 2·NCT01653327·11 enrolled

Hypospadias1 trial

Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair

Unknown status·KKafrelsheikh University·Phase 4·NCT05837000·75 enrolled

Laparoscopic Surgery1 trial

Impact of the Use of Ketamine in Laparoscopic Surgery.

Completed·UUniversidade do Porto·Phase 4·NCT03724019·127 enrolled

Aripiprazole1 trial

Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant Depression

Unknown status·UUniversity of Sao Paulo·Phase 4·NCT04234776·88 enrolled

Memory1 trial

Memory Modulation by Pain During Anesthesia

Completed·UUniversity of Pittsburgh·Phase 1·NCT02515890·32 enrolled

Hemodynamic1 trial

Laryngeal Mask Insertion Conditions And Hemodynamic Effects

Completed·LLeila mansali stambouli·N/A·NCT03257800·120 enrolled

Treatment Resistant Depression (TRD)1 trial

A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)

Completed·MMassachusetts General Hospital·Phase 4·NCT03149991·51 enrolled

Laryngeal Mask Airway1 trial

Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children

Completed·UUniversity Hospital, Mahdia·Phase 4·NCT03631875·120 enrolled

Post Cesarean Analgesia1 trial

Comparison Between Ketamine Intrathecal and iv Dexamethasone for Post Cesarean Analgesia

Not yet recruiting·—·Phase 4·NCT06408974·90 enrolled

Anxiety1 trial

The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety

Completed·—·Phase 3·NCT06310850·60 enrolled

Obstructive Sleep Apnea1 trial

Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea

Terminated·UUniversity of Alabama at Birmingham·Phase 2/3·NCT03109418·9 enrolled

Patient-Controlled Analgesia1 trial

Ketamine Patient-Controlled Analgesia for Acute Pain

Terminated·UUniversity of Cincinnati·Phase 3·NCT02062879·20 enrolled

Cardiovascular Function1 trial

The Effects of Low Dose Ketamine on Cardiovascular Function

Terminated·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT04429685·6 enrolled

Perioperative Analgesia1 trial

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

Terminated·—·Phase 3·NCT04176419·30 enrolled

Spinal Anesthesia1 trial

Nebulized vs. IV Ketamine in Preventing Shivering Post Spinal Anesthesia

Active, not recruiting·TTanta University·N/A·NCT07055828·120 enrolled

Clinical Trial1 trial

Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy

Completed·—·Phase 4·NCT02909049·100 enrolled

Opioid-induced Hyperalgesia1 trial

Effect of Ketamine on Opioid-Induced Hyperalgesia

Completed·MMassachusetts General Hospital·N/A·NCT00833755·79 enrolled

Hypersensitivity1 trial

Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity

Completed·JJacky Smith·N/A·NCT00858624·24 enrolled

Stellate Ganglion Block1 trial

Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm.

Completed·ZZagazig University·N/A·NCT06354673·205 enrolled

Hemodynamic Stability1 trial

Effect of Intravenous Ketamine Infusion for Hemodynamic Stability in Patients Undergoing Caesarean Delivery.

Completed·—·N/A·NCT05865080·126 enrolled

Post-Traumatic Stress Disorder1 trial

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

Completed·DDennis Charney·Phase 2·NCT00749203·41 enrolled

External Oblique Intercostal Plane Block1 trial

Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain

Completed·TTanta University·N/A·NCT07138781·50 enrolled

Treatment1 trial

Investigation of Antidepressant Efficacy of Oral Ketamine Treatment

Unknown status·MMedical University of Vienna·Phase 2·NCT02992496·60 enrolled

ESS1 trial

A Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Males

Completed·AAutifony Therapeutics Limited·Phase 1·NCT02935725·22 enrolled

Rib Fracture1 trial

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

Completed·MMedical College of Wisconsin·Phase 4·NCT02432456·153 enrolled

Severe Pain1 trial

Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department

Completed·AAntonios Likourezos·Phase 4·NCT01835262·90 enrolled

Vaso-occlusive Crisis1 trial

Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis

Completed·UUCSF Benioff Children's Hospital Oakland·Phase 2·NCT03296345·62 enrolled

Sickle Cell Crisis1 trial

Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department

Terminated·BBilly Sin·N/A·NCT02417298·12 enrolled

Medication1 trial

Pain Reduction With Intranasal Medications for Extremity Injuries

Completed·—·Phase 3·NCT02778880·90 enrolled

Status Epilepticus1 trial

Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)

Recruiting·SSohag University·Phase 2/3·NCT07095842·668 enrolled

Postpartum Depression1 trial

Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

Terminated·TThe University of Texas Health Science Center, Houston·Phase 2·NCT04011592·1 enrolled

Addiction1 trial

Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction

Recruiting·DDr. med. Marcus Herdener·Phase 2·NCT06125054·120 enrolled

Remifentanil1 trial

A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery

Completed·TTurkiye Yuksek Ihtisas Education and Research Hospital·Phase 4·NCT02113150·37 enrolled

Tics1 trial

Anesthetics in Rhytidoplasty - A Comparison Study

Completed·MMercy Facial Plastic Surgery Center·N/A·NCT02410460·30 enrolled

Intranasal Administration1 trial

To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSD

Withdrawn·AAdriana Feder·Phase 2/3·NCT02398136

Fentanyl1 trial

Effect of Ketamine+Propofol vs Remifentanyl+Propofol on Laryngeal Mask Insertion Conditions

Completed·—··NCT02583217·50 enrolled

Fatigue1 trial

Ketamine for Treatment of MS Fatigue

Completed·JJohns Hopkins University·Phase 1/2·NCT03500289·18 enrolled

Post Operative Cognitive Dysfunction1 trial

The Effect of Ketamine on Postoperative Cognitive Dysfunction.

Completed·—·Phase 4·NCT04321746·45 enrolled

Abuse Potential1 trial

Assessment of Abuse Potential of Rapastinel in Humans

Completed· AbbVie logo

AbbVie·Phase 1·NCT03799900·72 enrolled

Depressive Symptom1 trial

Ketamine and Postoperative Depressive Symptom-PASSION

Completed·—·Phase 2/3·NCT03086148·84 enrolled

Epidural Analgesia1 trial

Association of Intravenous Ketamine With Thoracic Epidural Analgesia: Effects on Pain and Respiratory Function Following Thoracotomy.

Terminated·AAssistance Publique Hopitaux De Marseille·N/A·NCT00726258·21 enrolled

Chronic Condition1 trial

Ketamine Treatment Plans for Chronic Conditions

Recruiting·RRIVER Foundation··NCT06038409·500 enrolled

Intravenous Administration1 trial

Axillary Approach to Brachial Plexus Blockade Using Ketamine, Regional Versus Intravenous Administration

Unknown status·NNational and Kapodistrian University of Athens·N/A·NCT05297422·81 enrolled

Brain Injury1 trial

Ketamine in Acute Brain Injury Patients.

Recruiting·—·Phase 4·NCT05097261·100 enrolled

Morbidity1 trial

Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00440102·655 enrolled

Chronic PTSD1 trial

TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD

Unknown status·TThe Cooper Health System·N/A·NCT02766192·50 enrolled

Mood Disorder1 trial

Imaging SV2A in Mood Disorders

Recruiting·YYale University·N/A·NCT02734602·130 enrolled

Spinal Surgery1 trial

Methadone and Ketamine for Spinal Surgery

Completed·EEndeavor Health·Phase 4·NCT02827526·130 enrolled

Analgesic1 trial

Evaluation of Ketamine and Multi-modal Analgesics

Withdrawn·UUniversity of Florida··NCT02815111

Laparoscopic Sleeve Gastrectomy1 trial

Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy

Not yet recruiting·IIVO JURISIC·N/A·NCT07084753·36 enrolled

Laceration1 trial

IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair

Terminated·CCorewell Health East·Phase 4·NCT03528512·5 enrolled

Tonsillectomy1 trial

Low Dose Ketamine as an Adjunct to Fentanyl in Outpatient Tonsillectomy

Completed·MMayo Clinic·N/A·NCT00587665·122 enrolled

Thoracic Surgery1 trial

Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Completed·MMahidol University·Phase 4·NCT02570230·32 enrolled

Aesthetic1 trial

Ketamine as an Anaesthetic Agent in Electroconvulsive Therapy (ECT)

Completed·NNorthside Clinic, Australia·Phase 4·NCT00680433·83 enrolled

Intraoperative1 trial

Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

Unknown status·HHallym University Kangnam Sacred Heart Hospital·Phase 4·NCT02493231·60 enrolled

Pregabalin1 trial

Pre-operative Pregabalin and Ketamine to Prevent Phantom Pain

Withdrawn·UUniversity of Texas Southwestern Medical Center·Phase 3·NCT02311777

Prevention1 trial

Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)

Completed·NNew York State Psychiatric Institute·Phase 2·NCT02062658·10 enrolled

Postoperative Sleep Quality1 trial

Comparison Of The Effects Of Melatonin Premedication And Ketamine On Postoperative Sleep Quality İn Rhinoplasty

Completed·KKonya City Hospital·Phase 4·NCT06898463·183 enrolled

Adolescent1 trial

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

Suspended·UUniversity of Wisconsin, Madison·Phase 1·NCT06378528·5 enrolled

Intravenous Lidocaine1 trial

Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

Completed·UUniversity of Lausanne Hospitals·N/A·NCT01439399·52 enrolled

Hypotension1 trial

Impact of Sub-anesthetic Dose of Ketamine on Post Spinal Hypotension in Caesarean Delivery

Completed·—·Phase 4·NCT03624166·80 enrolled

GIST1 trial

University of Iowa Interventional Psychiatry Service Patient Registry

Recruiting·MMark Niciu··NCT04480918·1,000 enrolled

Imaging1 trial

PET Imaging of mGLuR5 With Drug Challenge

Completed·YYale University·N/A·NCT01691092·79 enrolled

Acute Pain1 trial

Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department

Completed·CCarilion Clinic·Phase 4·NCT02489630·116 enrolled

Mastectomy1 trial

Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy

Completed·NNYU Langone Health·Phase 4·NCT04831736·31 enrolled

Idiopathic Scoliosis1 trial

Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis

Completed·—·Phase 4·NCT02651324·50 enrolled

S-ketamine1 trial

The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)

Unknown status·YYan Qiu·N/A·NCT04399070·150 enrolled

Cardiopulmonary Bypass1 trial

Use of Ketamine Prior to Cardiopulmonary Bypass in Children

Completed·—·Phase 2·NCT00556361·24 enrolled

Pediatric Patients1 trial

Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients

Completed·TTC Erciyes University·Phase 4·NCT02072083·60 enrolled

Unspecified1 trial

Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10

Completed·UUniversitas Sumatera Utara·N/A·NCT05648526·42 enrolled

Regulatory

FDA Approval Timeline[5]

Feb 19, 1970

KETALAR

NDA NDA016812

May 14, 1976

KETALAR

NDA NDA016812

Jan 28, 1977

KETALAR

NDA NDA016812

May 16, 1977

KETALAR

NDA NDA016812

May 16, 1977

KETALAR

NDA NDA016812

Jul 5, 1977

KETALAR

NDA NDA016812

Apr 4, 1980

KETALAR

NDA NDA016812

Apr 4, 1980

KETALAR

NDA NDA016812

Aug 18, 1980

KETALAR

NDA NDA016812

Jan 1, 1982

KETALAR

NDA NDA016812

Jun 11, 1982

KETALAR

NDA NDA016812

Feb 7, 1989

KETALAR

NDA NDA016812

Nov 29, 1994

KETALAR

NDA NDA016812

Sep 5, 1997

KETALAR

NDA NDA016812

Nov 17, 1998

KETALAR

NDA NDA016812

Mar 14, 2000

KETALAR

NDA NDA016812

Mar 29, 2000

KETALAR

NDA NDA016812

Feb 14, 2001

KETALAR

NDA NDA016812

Nov 14, 2002

KETALAR

NDA NDA016812

Mar 7, 2012

KETALAR

NDA NDA016812

Apr 27, 2017

KETALAR

NDA NDA016812

Aug 7, 2018

KETALAR

NDA NDA016812

Aug 24, 2020

KETALAR

NDA NDA016812

Jun 3, 2022

KETALAR

NDA NDA016812

Aug 23, 2022

KETALAR

NDA NDA016812

Oct 29, 2025

KETALAR

NDA NDA016812

Mar 20, 2026

KETALAR

NDA NDA016812

Mar 23, 2026

KETALAR

NDA NDA016812

Sources

References

[1]
ClinicalTrials.gov — 744 trial records for Ketamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ketalar drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Ketamine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Ketamine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA016812). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Aultman Health Foundation company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glutamate [NMDA] Receptor Negative Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AAultman Health Foundation