Fragmin

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

COVID-19CancerAcute Coronary SyndromeThrombocytopeniaTotal Hip ArthroplastyMPRFetal Growth RestrictionCritical Illness

317 competitors in COVID-19

#DrugCompanyPhaseTrials

1

Fragmin

Pfizer

Approved

12

Aldactone

Pfizer

Preclinical

13

Aimovig

Amgen

Preclinical

14

Nexavar

Bayer

Preclinical

15

Stivarga

Bayer

Preclinical

16

Activella

Eli Lilly

Preclinical

—7

Calciferol

Jazz Pharmaceuticals

Preclinical

—8

Angiomax

BBaxter Healthcare Corporation

Preclinical

29

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

110

Tricor

JJagotec

Preclinical

1Show 25 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Venous Thromboembolism9 trials

Apixaban for the Treatment of Venous Thromboembolism in Patients With Cancer

Completed·FFadoi Foundation, Italy·Phase 3·NCT03045406·1,170 enrolled

A Randomized Phase II Open Label Study to Compare the Safety and Efficacy of Subcutaneous Dalteparin Versus Direct Oral Anticoagulants for Cancer-associated Venous Thromboembolism

Unknown status·—·Phase 2·NCT03139487·176 enrolled

PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)

Recruiting·SSunnybrook Health Sciences Centre·Phase 3·NCT03559114·1,100 enrolled

Show 6 more trials

Dalteparin for Primary Venous Thromboembolism (VTE) Prophylaxis in Pancreatic Cancer Patients

Completed·MM.D. Anderson Cancer Center·Phase 4·NCT00966277·87 enrolled

Dalteparin Low Molecular Weight Heparin for Primary Prophylaxis of Venous Thromboembolism in Brain Tumour Patients

Completed·OOntario Clinical Oncology Group (OCOG)·Phase 3·NCT00135876·512 enrolled

Cancer Venous Thromboembolism (VTE)

Completed·Daiichi Sankyo·Phase 3·NCT02073682·1,046 enrolled

Dalteparin vs Unfractionated Heparin For The Prevention Of Venous Thromboembolism (VTE) In Hospitalized Acutely Ill Medical Patients

Terminated·Pfizer·Phase 4·NCT00445328·84 enrolled

WAVe Study - Weight Adjusted Dalteparin for Patients Over 90 kg With Acute Cancer Associated Venous Thromboembolism

Terminated·OOttawa Hospital Research Institute·Phase 2·NCT03297359·92 enrolled

Apixaban or Dalteparin in Reducing Blood Clots in Patients With Cancer Related Venous Thromboembolism

Completed·—·Phase 3·NCT02585713·300 enrolled

Pancreatic Cancer2 trials

Gemcitabine With or Without Dalteparin in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

Completed·HHull University Teaching Hospitals NHS Trust·Phase 2·NCT00462852·120 enrolled

Gemcitabine With or Without Dalteparin in Treating Patients With Unresectable or Metastatic Pancreatic Cancer

Terminated·GGary Morrow·Phase 3·NCT00031837·400 enrolled

Treatment2 trials

Evaluation of Dalteparin for Long-term (One Year) Treatment of Blood Clots in Subjects With Cancer

Completed·Pfizer·Phase 4·NCT00942968·338 enrolled

Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo

Completed·—·Phase 2·NCT01419977·34 enrolled

Lung Cancer2 trials

Dalteparin in Preventing Blood Clots in Patients With Lung Cancer

Unknown status·VVelindre NHS Trust·Phase 3·NCT00519805·2,200 enrolled

Coagulation Profile in Patients Undergoing Video Assisted Thorascopic Surgery (VATS) for Lung Cancer

Completed·TThomas Decker Christensen·Phase 4·NCT01741506·116 enrolled

Acute Coronary Syndrome2 trials

Effectiveness And Safety Of Dalteparin In Patients With Acute Coronary Syndromes Without ST Elevations In Clinical Practice

Completed·Pfizer··NCT00922766·618 enrolled

Dalteparin Versus Unfractionated Heparin In Patients With Acute Coronary Syndrome

Terminated·Pfizer·Phase 4·NCT00435487·173 enrolled

28 more indications

MPR1 trial

Alterations of Blood Clotting With the Use of Sequential Compression Devices on the Lower Limbs

Terminated·UUniversity of Parma·N/A·NCT00726570·40 enrolled

Critical Illness1 trial

Collaborative Risk-stratified Investigation in Teen Inpatients With Critical Illness: Anticoagulation With LMWH in Kids for ThromboProphylaxis (CRITICAL-Kids-TP)

Not yet recruiting·JJohns Hopkins All Children's Hospital·Phase 3·NCT06628778·802 enrolled

Low Molecular Weight Heparin1 trial

Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis

Completed·UUniversity Medical Centre Ljubljana·Phase 4·NCT01245998·68 enrolled

Ovarian Cancer1 trial

Fragmin in Ovarian Cancer: Utility on Survival (FOCUS)

Completed·OOntario Clinical Oncology Group (OCOG)·Phase 2·NCT00239980·77 enrolled

Septic Shock1 trial

Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot

Completed·UUniversity of Manitoba·Phase 2·NCT01648036·76 enrolled

Thrombocytopenia1 trial

STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis

Recruiting·TTzu-Fei Wang·Phase 4·NCT05255003·50 enrolled

COVID-191 trial

Australasian COVID-19 Trial (ASCOT) ADAptive Platform Trial

Active, not recruiting·UUniversity of Melbourne·Phase 3·NCT04483960·2,200 enrolled

Nephrotic Syndrome1 trial

Causes and Prevention of Thromboembolic Disease in Nephrotic Syndrome

Completed·UUniversity of Aarhus·Phase 1/2·NCT04850378·57 enrolled

Multiple Myeloma1 trial

Dalteparin, Lenalidomide, and Low-Dose Dexamethasone in Treating Patients With Previously Untreated Multiple Myeloma

Terminated·UUniversity of Southern California·Phase 2·NCT01518465·13 enrolled

Kidney Cancer1 trial

Dalteparin and Sunitinib Malate as First-Line Therapy in Treating Patients With Kidney Cancer That is Metastatic or Cannot Be Removed by Surgery

Completed·RRoswell Park Cancer Institute·Phase 1·NCT01061411·16 enrolled

Deep Vein Thrombosis1 trial

The Catheter Study: Central Venous Catheter Survival in Cancer Patients Using Low Molecular Weight Heparin (Dalteparin) for the Treatment of Deep Vein Thrombosis

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2·NCT00216866·70 enrolled

Anticoagulation1 trial

Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study)

Completed·—·Phase 3·NCT00786474·1,884 enrolled

Genitourinary Cancer1 trial

A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE

Active, not recruiting·AAnthos Therapeutics, Inc.·Phase 3·NCT05171075·417 enrolled

Anticoagulant1 trial

Comparative Analysis of Injectable Anticoagulants for Thromboprophylaxis Post Cancer-related Surgery

Completed·GSK··NCT01444612·4,068 enrolled

Pediatric Cancer1 trial

Fragmin for the Treatment of Acute VTE in Pediatric Cancer Patients

Completed·Pfizer·Phase 2·NCT00952380·38 enrolled

Direct Oral Anticoagulants (DOACs)1 trial

Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer

Completed·AAlliance Foundation Trials, LLC.·N/A·NCT02744092·811 enrolled

Bariatric Surgery1 trial

Venous Thromboprophylaxis in Bariatric Surgery

Completed·GGroupe Hospitalier Pitie-Salpetriere··NCT03218514·118 enrolled

Prostate Cancer1 trial

Standard Therapy With or Without Dalteparin in Treating Patients With Advanced Breast, Lung, Colorectal, or Prostate Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00003674·141 enrolled

Effectiveness1 trial

PERIOP 2 - A Safety and Effectiveness of LMWH vs Placebo Bridging Therapy for Patients on Long Term Warfarin Requiring Temporary Interruption of Warfarin.

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 3·NCT00432796·1,473 enrolled

Dialysis Patients1 trial

A New Anticoagulation Method Using Dalteparin in Quotidian and Nocturnal Home Hemodialysis Patients

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 4·NCT02607111·15 enrolled

Glioblastoma Multiforme1 trial

Dalteparin and Radiation Therapy in Treating Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00028678·45 enrolled

Prophylaxis1 trial

A Study of Dalteparin Prophylaxis in High-Risk Ambulatory Cancer Patients

Terminated·UUniversity of Rochester·Phase 3·NCT00876915·218 enrolled

Venous thrombosis1 trial

Outpatient Treatment Of Deep Venous Thrombosis Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT00041782·26 enrolled

Total Hip Arthroplasty1 trial

Preoperative Versus Postoperative Start With Thromboprophylaxis in THA (Total Hip Arthroplasty)

Completed·VVestre Viken Hospital Trust·Phase 4·NCT01714297·80 enrolled

Critically Ill Patients1 trial

Thromboprophylaxis in Critically Ill Patients

Terminated·MMedical University of Vienna·Phase 4·NCT00437697·90 enrolled

Cancer1 trial

Dalteparin in Preventing DVT in Participants With Cancer

Completed·MM.D. Anderson Cancer Center·N/A·NCT00525057·65 enrolled

Fetal Growth Restriction1 trial

LMWH to Prevent Preeclampsia and Fetal Growth Restriction

Terminated·UUniversity of Florence··NCT00260520

Thrombosis1 trial

Thromboprophylaxis in Lower Limb Immobilisation (TiLLI): a Multicentre Study Comprising Two Linked Open Label Phase III Randomised Controlled Trials Evaluating the Effectiveness and Cost Effectiveness of Different Methods of Pharmacological Prophylaxis for Patients With Temporary Lower Limb Immobilisation.

Recruiting·QQueen Mary University of London·Phase 3·NCT06370273·10,044 enrolled

Regulatory

FDA Approval Timeline[4]

Details

Drug Info

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