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Psychiatry/Depression

Depression

71

Pipeline Programs↗

324

Active Trials↗

93

Companies Involved↗

Depression is a moderately active landscape with 71 programs across 93 companies. The most active players are Eleusis Therapeutics. 11 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

82/100

Pipeline Velocity

97/100

Mech. Concentration

17/100

Completion Rate

82/100

Attrition Rate

11/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Eleusis Therapeutics

1 program

Pipeline

Programs by Phase

Preclinical43

Midazolam Hydrochloride

Conrado Roberto Hoffmann Filho

Allopurinol

Jazz Pharmaceuticals

Nitrous Oxide-Oxygen

University Hospital, Tours

Ket10

Ibaraki Children's Hospital

Ket20

Ibaraki Children's Hospital

Phase 12

SP-624

Sirtsei Pharmaceuticals, Inc.

NRX-101

NeuroRx, Inc.

Phase 215

D-Cycloserine

Massachusetts General Hospital

Clemastine Fumarate

Novartis

Metformin

EMD Serono

Apo-Levocarb

University of British Columbia

PDC-1421

BioLite, Inc.

Phase 311

Psilocybin

COMPASS Pathways

Antidepressant Medication

Harvard Medical School (HMS and HSDM)

Ketamine Hydrochloride

Boehringer Ingelheim

Antidepressant Therapy

AbbVie

Mianserin

Hannover Medical School

Approved

No programs

Analysis

Modality Breakdown

97%

Small molecule

69 of 71 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 71 classified programs, each share of the total. Modality classified for 100% of 71 pipeline programs.

Analysis

Trial Status

1,125

clinical trials

Completed597 · 53%

Recruiting208 · 18%

Terminated88 · 8%

Unknown status74 · 7%

Not yet recruiting58 · 5%

Active, not recruiting51 · 5%

Other49 · 4%

Clinical Trials

Trial Activity

1125 trials

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT06801041·20 enrolled

Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal Depression

Recruiting·PPsychiatric University Hospital, Zurich·Preclinical·NCT07774559·60 enrolled

Single Session Personalized Aperiodic Transcranial Alternating Current Stimulation (PandA-tACS) for Antenatal Depression: A Randomized, Sham-Controlled Trial (R61 Phase)

Recruiting·UUniversity of North Carolina, Chapel Hill·Preclinical·NCT07799480·60 enrolled

A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Lumateperone for the Treatment of Major Depressive Episodes (MDEs) Associated With Bipolar I or Bipolar II Disorder (Bipolar Depression) in Pediatric Patients Aged 10 to 17 Years

Recruiting·IIntra-Cellular Therapies, Inc.·Phase 3·NCT06372964·384 enrolled

Early Life Stress and Depression: Molecular and Functional Imaging

Recruiting·MMclean Hospital·N/A·NCT04713722·160 enrolled

Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder

Recruiting·MMclean Hospital·Preclinical·NCT07593222·100 enrolled

SPARC-LI: Synaptic Plasticity Augmented Rapid Circuit Stimulation

Recruiting·MMclean Hospital·Phase 1·NCT07785102·30 enrolled

A Web-App Based Lifestyle Physical Activity Promotion Program to Improve Depressive Symptom Experience: Midlife Korean American Women

Recruiting·VVanderbilt University·Preclinical·NCT05405803·300 enrolled

The Mechanism of Action Underlying Ketamine's Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

Recruiting·National Institute of Mental Health (NIMH)·Phase 1·NCT03973268·70 enrolled

A Web-based Intervention Program for Postpartum Depression: A Feasibility and Usability Trial

Recruiting·Babes-Bolyai University·Phase 1·NCT07902141·30 enrolled

The WeACT Program for Family Caregivers of People Living With Dementia

Recruiting·UUniversity of South Florida·Preclinical·NCT07342569·40 enrolled

High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Targeting the Primary Somatosensory Cortex for Bipolar Depression in Adolescents: A Randomized Double-Blind Controlled Trial

Recruiting·JJiangsu Province Nanjing Brain Hospital·Preclinical·NCT07246044·100 enrolled

Bayesian-Optimized Dose-Finding of ATTN201 Focused Ultrasound for Behavioral Health

Recruiting·AAttune Neurosciences Inc·Preclinical·NCT07851038·300 enrolled

A Randomized, Double-blind, Placebo-controlled Trial of ALTO-207 in Adults With Treatment-resistant Depression

Recruiting·—·Phase 2·NCT07553637·178 enrolled

Characterization and Treatment of Adolescent Depression

Recruiting·National Institute of Mental Health (NIMH)·N/A·NCT03388606·4,100 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)