Glucophage
(Metformin)ApprovedSmall molecule
EMD SeronoMetformin is used to treat type 2 diabetes by helping your body control blood sugar levels. It works by reducing the amount of sugar your liver produces and helping your body use insulin more effectively.[2] Glucophage is currently approved and in use across 196 indications[4].[1]
Glucophage is one of 2630 small molecule programs targeting Chronic Obstructive Pulmonary Disease (COPD). It is currently in Approved.
196
Indications
1,450
Total Trials
22
Active Trials
2,629
Competitors
6
FDA Applications
NDA/BLA/ANDA regulatory filings
1
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 195 indications
Competition
Competitive Landscape
706 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Glucophage
EMD SeronoApproved
Blenoxane
Bristol-Myers SquibbPreclinical
Spravato
WWim Janssens
Preclinical
Nubain
AAultman Health Foundation
Preclinical
Feraheme
AAzurity Pharmaceuticals
Preclinical
Vfend
PPrism Pharmaceuticals
Preclinical
Systemic Therapy
Bristol-Myers SquibbPreclinical
Beta Blocker
WWeill Medical College of Cornell University
Preclinical
Neoadjuvant Treatment
SShanghai Zhongshan Hospital
Preclinical
Recombinant Human Endostatin
PPeking University Third Hospital
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Type 2 Diabetes40 trials
Show 37 more trials
Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh
Not yet recruiting·—·Phase 4·NCT06449235·938 enrolled
Metformin26 trials
Show 23 more trials
Vaginal Administration of Metformin in PCOS Patients.
Unknown status·—·Phase 1·NCT02026869·200 enrolled
Effects of Metformin and Fish Oil on Treatment With Clozapine
Terminated·—·Phase 4·NCT02140788·34 enrolled
Type 2 Diabetes Mellitus15 trials
Show 12 more trials
PRKAA2 Genetic Polymorphisms and Its Susceptibility to Chinese Type 2 Diabetes Mellitus and Diabetic Nephropathy
Completed·—··NCT03155087·750 enrolled
Polycystic Ovary Syndrome9 trials
Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome
Unknown status·—·Phase 4·NCT06083935·120 enrolled
Show 6 more trials
Gestational Diabetes7 trials
Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome
Unknown status·—·Phase 2/3·NCT02802215·80 enrolled
Show 4 more trials
Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country
Unknown status·—·Phase 2/3·NCT01855763·300 enrolled
78 more indications
Insulin resistance4 trials
Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules
Completed·—·N/A·NCT03183752·28 enrolled
Interaction3 trials
PreDiabetes3 trials
Type 2 Diabetic Patients3 trials
Diabetes Mellitus3 trials
Metformin as Adjuvant to Insulin Therapy in Insulin-resistant Diabetes Mellitus With Pregnancy
Completed·—·Phase 3·NCT01915550·90 enrolled
Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment
Completed·—·Phase 4·NCT01099618·48 enrolled
COVID-192 trials
ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)
Completed·—·Phase 3·NCT06042855·3,214 enrolled
Type 1 Diabetes2 trials
Effect of Metformin in Children With Type 1 Diabetes
Completed·—·Phase 2/3·NCT04879511·80 enrolled
Prevention2 trials
Osteoarthritis2 trials
Vitamin D With Omega-3 or Metformin in Osteoarthritis
Not yet recruiting·—·N/A·NCT06328426·60 enrolled
Breast Cancer2 trials
Pregnancy2 trials
Coronary Artery Disease2 trials
Treatment2 trials
Empagliflozin2 trials
Double Blind Placebo Study of JARDIANCE® (Empagliflozin) in Prehypertensives Type II Diabetics
Unknown status·—·Phase 4·NCT01001962·1,054 enrolled
Heart Failure2 trials
Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure
Completed·—·Phase 2·NCT02810132·36 enrolled
Liraglutide2 trials
Methotrexate1 trial
MPA1 trial
Atrial Fibrillation1 trial
METFORMIN FOR ATRIAL FIBRILLATION
Unknown status·—·Phase 2·NCT05878535·770 enrolled
Beta-cell Function1 trial
Combination Therapy1 trial
Metastatic Prostate Cancer1 trial
Fasting Conditions1 trial
Coronary Artery Bypass1 trial
GLP-11 trial
Feed-Back Suppression of Meal-Induced Glucagon-like Peptide 1 (GLP-1) Secretion
Completed·—·Phase 1·NCT02749032·24 enrolled
Prostate Cancer1 trial
Diabetes1 trial
Overweight or Obese1 trial
Atherosclerotic Plaque1 trial
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
Completed·—·N/A·NCT00636766·300 enrolled
Hypogonadism1 trial
Testosterone, Metformin, or Both, for Hypogonadism in Obese Males
Completed·FFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud·Phase 3·NCT02514629·107 enrolled
Cardiovascular1 trial
Metformin And Cardiovascular Effectiveness vs SGLT2 (MACES)
Unknown status·—··NCT03627039·20,000 enrolled
Head and Neck Squamous Cell Carcinoma1 trial
Overweight1 trial
Safety and Efficacy1 trial
Obese Patients1 trial
Polycystic Ovarian Syndrome1 trial
Letrozole or Combined Clomiphene Citrate Metformin as a First Line Treatment in Women With Polycystic Ovarian Syndrome
Completed·—·N/A·NCT01679574·200 enrolled
Phase 11 trial
Wound Healing1 trial
Locally-advanced Rectal Cancer1 trial
Arthritis1 trial
Spinal Cord Injury1 trial
Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury
Not yet recruiting·—·Phase 4·NCT07272967·34 enrolled
Assisted Reproductive Technology1 trial
Blood-Brain Barrier1 trial
Role of the Blood-Brain Barrier in Stress Resilience: Investigating New Pathways Towards Pharmacological Augmentation of Stress Resilience
Not yet recruiting·LLeibniz-Institut für Resilienzforschung (LIR) gGmbH·N/A·NCT06965868·122 enrolled
In Vitro Fertilization (IVF)1 trial
Observational Study1 trial
Endometrial Cancer1 trial
Double-blind1 trial
Hyperglycemia1 trial
Herbal Medicine1 trial
Radiotherapy1 trial
Acute Myocardial Infarction1 trial
Encephalopathy1 trial
Metformin Experience on Minimal Hepatic Encephalopathy
Unknown status·FFundación Pública Andaluza para la gestión de la Investigación en Sevilla·Phase 4·NCT02470546·30 enrolled
Kidney Disease1 trial
Growth1 trial
Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children
Unknown status·—·N/A·NCT02931591·24 enrolled
Lymphoma1 trial
Psoriasis1 trial
Assessing the Efficacy and Safety of Metformin in Treatment of Moderate Psoriasis
Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT02644954·40 enrolled
Effectiveness1 trial
Oxidative Stress1 trial
Chronic Periodontitis1 trial
Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis
Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT03204071·90 enrolled
Spironolactone1 trial
Regulatory
FDA Approval Timeline[5]
Nov 5, 1998
GLUCOPHAGE
NDA NDA020357
Oct 13, 2000
GLUCOPHAGE XR
NDA NDA021202
Sep 11, 2003
RIOMET
NDA NDA021591
Apr 27, 2004
FORTAMET
NDA NDA021574
Jun 3, 2005
GLUMETZA
NDA NDA021748
Aug 29, 2019
RIOMET ER
NDA NDA212595
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Glucophage drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Metformin. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
- [7]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Mitochondrial Complex I (NADH Dehydrogenase) Inhibitor; Mitochondrial Glycerol-3-Phosphate Dehydrogenase Inhibitor[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
Patent Landscape[6]
Patent Cliff
May 1, 2035
Earliest patent expiration — generic entry possible after this date
Patent #Expires
9962336May 1, 2035