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Neurology/Diabetic Neuropathy

Diabetic Neuropathy

15

Pipeline Programs↗

10

Active Trials↗

30

Companies Involved↗

Diabetic Neuropathy is an emerging landscape with 15 programs across 30 companies. 4 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

46/100

Pipeline Velocity

19/100

Mech. Concentration

50/100

Completion Rate

86/100

Attrition Rate

11/100

Pipeline

Programs by Phase

Preclinical10

Resveratrol

National Cancer Institute (NCI)

Cholecalciferol

Hyundai Pharmaceutical Co., LTD.

Glargine

Eli Lilly

Exenatide

AstraZeneca

Liraglutide

Novo Nordisk

Phase 1

No programs

Phase 21

Naltrexone

Teva

Phase 34

Experimental: Pregabalin XR

Brainfarma Industria Química e Farmacêutica S/A

Experimental Placebo

Brainfarma Industria Química e Farmacêutica S/A

Oral Medication

University of Michigan

Topical Medication

University of Michigan

Approved

No programs

Analysis

Modality Breakdown

80%

Small molecule

8 of 10 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 10 classified programs, each share of the total. Modality classified for 67% of 15 pipeline programs.

Analysis

Trial Status

109

clinical trials

Completed76 · 70%

Unknown status11 · 10%

Terminated7 · 6%

Withdrawn5 · 5%

Active, not recruiting4 · 4%

Not yet recruiting3 · 3%

Other3 · 3%

Clinical Trials

Trial Activity

109 trials

A Phase III, Multicenter, Randomized, Double-blind, Double-dummy, Controlled, Parallel-group, Non-inferiority Clinical Trial to Evaluate the Efficacy and Safety of Extended-release Pregabalin Tablets Compared With Immediate-release Pregabalin Tablets, in the Relief of Neuropathic Pain in Participants With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia.

Recruiting·BBrainfarma Industria Química e Farmacêutica S/A·Phase 3·NCT07712913·348 enrolled

Evaluating a Nitric Oxide Generator, Nebivolol as a Disease Modifier in Patients With Diabetic Neuropathy.

Recruiting·SSt. John's Research Institute·Phase 2/3·NCT06201611·120 enrolled

Low-Dose Naltrexone for the Treatment of Painful Diabetic Neuropathy

Recruiting·—·Phase 2·NCT04678895·35 enrolled

Effects of Blood Flow Restriction Training on Glycemic Control, Nerve Conduction, Functional Outcomes and Quality of Life in Individuals With Type 2 Diabetes Peripheral Neuropathy

Active, not recruiting·SSuperior University·Preclinical·NCT07763795·60 enrolled

A Post-Market Observational Multi-Center Study to Evaluate the Effectiveness of Repeated QUTENZA Use in Adults With Painful Diabetic Peripheral Neuropathy of the Feet

Active, not recruiting·AAveritas Pharma, Inc.·N/A·NCT06495424·144 enrolled

PDN-SENSORY: A Multi-Center Randomized Controlled Trial to Evaluate Pain and Neurological Function With 10 kHz SCS in Treatment of Painful Diabetic Neuropathy

Active, not recruiting·NNevro Corp·Preclinical·NCT05777317·143 enrolled

A Post-Market, Multicenter, Prospective, Global Clinical Study to Evaluate the Real-world Experience of Spinal Cord Stimulation That Includes 10 kHz in the Management of Chronic Intractable Pain Associated With Diabetic Neuropathy.

Active, not recruiting·NNevro Corp·Preclinical·NCT05301816·497 enrolled

Comparison of the Efficacy of Topical Lidocaine Gel Versus Oral Duloxetine in the Treatment of Painful Diabetic Peripheral Neuropathy: A Prospective Randomized Controlled Trial

Not yet recruiting·Wah Medical college , POF hospital·Approved·NCT07800468·80 enrolled

Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy (MCPAIN)

Not yet recruiting·UUniversity of Michigan·Approved·NCT07795593·600 enrolled

Effect of DLBS1033 as Adjunctive Therapy on Changes in Nerve Conduction Study Parameters, Toronto Clinical Neuropathy Score, Interleukin-8, Galectin-3, and Quality of Life in Patients With Diabetic Neuropathy

Not yet recruiting·RRS H Adam Malik·Preclinical·NCT07683598·80 enrolled

A Post-Market, Multicenter, Prospective, Randomized Clinical Trial Comparing 10 kHz Spinal Cord Stimulation (HF10™ Therapy) Combined With Conventional Medical Management to Conventional Medical Management Alone in the Treatment of Chronic, Intractable, Neuropathic Limb Pain

Completed·NNevro Corp·Preclinical·NCT03228420·430 enrolled

Comparative Analysis Between Textured Insoles and Roods Facilitatory Technique Affecting Balance in Patients With Diabetic Neuropathy

Completed·UUniversity of Faisalabad·Preclinical·NCT07712289·44 enrolled

An Evaluation of the Efficacy and Safety of E2007 in Patients With Painful Diabetic Neuropathy

Completed· Eisai logo

Eisai·Phase 2/3·NCT00505284·352 enrolled

Alpha Lipoic Acid for Treatment of Diabetic Neuropathy

Completed·—·Phase 4·NCT02439879·45 enrolled

Trazodone in Painful Diabetic Neuropathy

Completed·AAziende Chimiche Riunite Angelini Francesco S.p.A·Phase 2·NCT03202979·142 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)