Resveratrol

Phase 1Small molecule

NNational Cancer Institute (NCI)

Resveratrol is one of 143 small molecule programs targeting Eye Disease. It is currently in Phase 1.

Indications

Total Trials

Active Trials

142

Competitors

Pipeline

Status by Indication[3][1]

Indication

Eye DiseaseActive, not recruiting

Diabetic NeuropathyActive, not recruiting

WheezingActive, not recruiting

Diabetes MellitusActive, not recruiting

Primary Ovarian InsufficiencyActive, not recruiting

Type 1 DiabetesRecruiting

Eye DiseasePreclinical

Active, not recruiting

Diabetic NeuropathyPreclinical

Active, not recruiting

WheezingPreclinical

Active, not recruiting

Diabetes MellitusPreclinical

Active, not recruiting

Primary Ovarian InsufficiencyPreclinical

Active, not recruiting

Type 1 DiabetesPhase 1

Recruiting

Competition

Competitive Landscape

113 competitors in Diabetes Mellitus

#DrugCompanyPhaseTrials

Zyloprim

Tracleer

Diabeta

Atacand

IIstituto Clinico Humanitas

Approved

—5

Protonix

WWyeth-Lederle Vaccines

Micardis

Jadelle

IItalian Network for Tumor Biotherapy Foundation

Approved

—8

Inpefa

LLexicon Pharmaceuticals

Approved

—9

Brevibloc

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 3

1 10

Retatrutide

Eli Lilly

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Phase 1Recruiting

Type 1 Diabetes

NCT04449198

Clinical

Trials by Indication[1]

Metabolic Syndrome2 trials

Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome

Withdrawn·UUniversity of California, San Francisco·Phase 2·NCT00654667

Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion

Completed·UUniversity of Guadalajara·Phase 2·NCT02114892·24 enrolled

COVID-192 trials

The Anti-fibrotic Therapeutic Effects of Resveratrol for Discharged COVID-19 Patients

Unknown status·HHong Kong Baptist University·N/A·NCT04799743·30 enrolled

Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19

Terminated·—·Phase 2·NCT04400890·105 enrolled

Friedreich ataxia2 trials

A Study of Resveratrol as Treatment for Friedreich Ataxia

Completed·MMurdoch Childrens Research Institute·Phase 1/2·NCT01339884·27 enrolled

Micronised Resveratrol as a Treatment for Friedreich Ataxia

Completed·MMurdoch Childrens Research Institute·Phase 2·NCT03933163·25 enrolled

Caloric Restriction1 trial

Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years

Completed·IInCor Heart Institute·N/A·NCT01668836·48 enrolled

Heart Failure1 trial

Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function in Patients With Heart Failure

Completed·UUniversity of Alberta·Phase 2·NCT03525379·13 enrolled

32 more indications

Colon Cancer1 trial

Resveratrol for Patients With Colon Cancer

Completed·UUniversity of California, Irvine·Phase 1·NCT00256334·11 enrolled

Exercise1 trial

Resveratrol Supplementation on Exercise in Healthy Sedentary Adults

Completed·OOttawa Hospital Research Institute·Phase 2·NCT01615445·13 enrolled

Type 1 Diabetes1 trial

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Recruiting·—·Phase 1·NCT04449198·24 enrolled

Alzheimer's Disease1 trial

Resveratrol for Alzheimer's Disease

Completed·AAlzheimer's Disease Cooperative Study (ADCS)·Phase 2·NCT01504854·119 enrolled

Diabetic Nephropathy1 trial

Resveratrol's Effects in Diabetic Nephropathy

Completed·SShiraz University of Medical Sciences·Phase 1·NCT02704494·60 enrolled

Postmenopausal Women1 trial

Resveratrol in Postmenopausal Women With High Body Mass Index

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT01370889·46 enrolled

Oxidative Stress1 trial

Assessment of Antioxidant Therapy on Oxidative Stress Biomarkers in Type 2 Diabetic Patients With Neuropathy

Completed·KKhyber Medical University Peshawar·Phase 2·NCT06131918·100 enrolled

Colorectal Cancer1 trial

Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00433576·20 enrolled

Cystic Fibrosis1 trial

Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

Completed·VVirginia Commonwealth University·Phase 1·NCT04166396·8 enrolled

Cancer1 trial

UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00098969·40 enrolled

Type 2 Diabetes Mellitus1 trial

Effect of Administration of Resveratrol on Glycemic Variability in Individuals With Type 2 Diabetes Mellitus

Terminated·UUniversity of Guadalajara·Phase 2·NCT02549924·22 enrolled

Obese1 trial

Effects of High-Dose Resveratrol in Non-Diabetic Obese Males

Completed·KKhoo Teck Puat Hospital·Phase 2·NCT02247596·36 enrolled

Treatment1 trial

Resveratrol as a Preventive Treatment of OHSS

Completed·IIVI Madrid·Phase 3·NCT03446625·70 enrolled

Pancreatitis1 trial

Oral Resveratrol to Prevent Post-ERCP Pancreatitis

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 4·NCT02947932·2,700 enrolled

Older People1 trial

RESveratrol To Improve Outcomes in oldeR pEople With PAD (the RESTORE Trial)

Completed·NNorthwestern University·N/A·NCT02246660·66 enrolled

Function1 trial

Resveratrol and Exercise to Treat Functional Limitations in Late Life

Completed·UUniversity of Florida·Phase 2·NCT02523274·60 enrolled

Schizophrenia1 trial

Resveratrol, Cardiovascular Risk Markers And Cognitive Performance In Patients With Schizophrenia

Completed·FFederal University of Rio Grande do Sul·Phase 2·NCT02062190·19 enrolled

Brain Injury1 trial

Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers

Completed·UUniversity of Texas Southwestern Medical Center·Phase 1/2·NCT01321151·12 enrolled

Lip1 trial

Regulation of Intestinal and Hepatic Lipoprotein Secretion by Resveratrol

Completed·UUniversity Health Network, Toronto·Phase 2·NCT01451918·8 enrolled

Adult1 trial

Resveratrol in Healthy Adult Participants

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00721877·42 enrolled

Insulin resistance1 trial

Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans

Completed·—·Phase 2·NCT01354977·20 enrolled

Peripheral Artery Disease1 trial

Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease

Completed·NNorthwestern University·Phase 3·NCT03743636·90 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease

Completed·VVirginia Commonwealth University·Phase 1·NCT03819517·26 enrolled

Wheezing1 trial

Nasal Resveratrol and Wheezing Episodes in Preschool Children

Completed·UUniversity Of Perugia··NCT04689412·50 enrolled

Diabetes Mellitus1 trial

Effect of Resveratrol and Pharmacist Intervention on Diabetes Mellitus and Its Neuropathic Complication

Completed·UUniversity of Sulaimani·N/A·NCT05172947·120 enrolled

Osteoarthritis1 trial

Resveratrol in Knee Osteoarthritis

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT02905799·142 enrolled

Seasonal Allergic Rhinitis1 trial

Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 3·NCT02130440·100 enrolled

Primary Ovarian Insufficiency1 trial

Clinical Efficacy Analysis of Resveratrol in the Treatment of Primary Ovarian Insufficiency

Unknown status·—·N/A·NCT05410093·150 enrolled

Endometriosis1 trial

Resveratrol for Pain Due to Endometriosis

Completed·HHospital de Clinicas de Porto Alegre·Phase 4·NCT02475564·44 enrolled

Pseudoachondroplasia1 trial

Resveratrol Trial for Relief of Pain in Pseudoachondroplasia

Terminated·TThe University of Texas Health Science Center, Houston·Phase 2·NCT03866200·6 enrolled

Lymphangioleiomyomatosis1 trial

Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial

Completed·UUniversity of Cincinnati·Phase 2·NCT03253913·25 enrolled

Unspecified1 trial

Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER)

Unknown status·VVISN 17 Center of Excellence·Phase 2·NCT03665740·68 enrolled

Sources

References

[1]
ClinicalTrials.gov — 40 trial records for Resveratrol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Resveratrol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Resveratrol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — National Cancer Institute (NCI) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 1[1]
Company: NNational Cancer Institute (NCI)

Resveratrol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Trials by Indication[1]

Metabolic Syndrome2 trials

COVID-192 trials

Friedreich ataxia2 trials

Caloric Restriction1 trial

Heart Failure1 trial

Colon Cancer1 trial

Exercise1 trial

Type 1 Diabetes1 trial

Alzheimer's Disease1 trial

Diabetic Nephropathy1 trial

Postmenopausal Women1 trial

Oxidative Stress1 trial

Colorectal Cancer1 trial

Cystic Fibrosis1 trial

Cancer1 trial

Type 2 Diabetes Mellitus1 trial

Obese1 trial

Treatment1 trial

Pancreatitis1 trial

Older People1 trial

Function1 trial

Schizophrenia1 trial

Brain Injury1 trial

Lip1 trial

Adult1 trial

Insulin resistance1 trial

Peripheral Artery Disease1 trial

Chronic Obstructive Pulmonary Disease1 trial

Wheezing1 trial

Diabetes Mellitus1 trial

Osteoarthritis1 trial

Seasonal Allergic Rhinitis1 trial

Primary Ovarian Insufficiency1 trial

Endometriosis1 trial

Pseudoachondroplasia1 trial

Lymphangioleiomyomatosis1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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