VivoSeq
Neurology

Essential Tremor

44

Pipeline Programs↗

7

Active Trials↗

22

Companies Involved↗

Essential Tremor is a moderately active landscape with 44 programs across 22 companies. The most active players are UCB, Biogen, Merz Pharmaceuticals GmbH. 5 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

58/100

Pipeline Velocity

11/100

Mech. Concentration

13/100

Completion Rate

83/100

Attrition Rate

14/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

UCB logo

UCB

1 program

Phase 1Biogen logo

Biogen

2 programs

Phase 2M

Merz Pharmaceuticals GmbH

2 programs

Phase 2Sun Pharmaceutical Industries, Inc. logo

Sun Pharmaceutical Industries, Inc.

1 program

Phase 2Neurocrine Biosciences logo

Neurocrine Biosciences

1 program

Phase 2C

Cadent Therapeutics

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical5

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Propranolol

Wyeth-Lederle Vaccines

Alcohol

Astellas

Alprazolam

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Primidone

Valeant Pharmaceuticals

Phase 11

Levetiracetam

UCB

Phase 227

Incobotulinumtoxina

Merz Pharmaceuticals GmbH

Sodium Oxybate

Jazz Pharmaceuticals

Perampanel

Catalyst Biosciences

Acamprosate

Forest Laboratories

Zonisamide

Azurity Pharmaceuticals

Phase 36

Pramipexole

Boehringer Ingelheim

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Treatments for Essential Tremor

US Department of Veterans Affairs

F-18 FPCIT

Asan Medical Center

BOTOX És

University Hospital, Clermont-Ferrand

Approved5

Pregabalin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Dronabinol

Alnylam Pharmaceuticals

Topiramate

Wim Janssens

Cannabidiol

Jazz Pharmaceuticals

Memantine

AbbVie

Analysis

Trial Status

49

clinical trials

Completed33 · 67%
Recruiting6 · 12%
Terminated4 · 8%
Withdrawn3 · 6%
Unknown status2 · 4%
Enrolling by invitation1 · 2%

Clinical Trials

Trial Activity

49 trials

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
Recruiting·TThe Cleveland Clinic·N/A·NCT06293638·55 enrolled
Proof of Concept Study on BP1.4979 Effect on Essential Tremor
Recruiting·BBioprojet·Phase 2·NCT07074002·50 enrolled
The Swedish Essential Tremor (SWEET) Trial
Recruiting·KKarolinska Institutet·N/A·NCT03832712·100 enrolled
International, Multicenter, Investigator Blinded, Randomized And Controlled Essential Tremor Trial With Staged-Bilateral FUS
Recruiting·IInSightec·Preclinical·NCT06974916·100 enrolled
Boston Scientific Registry of Deep Brain Stimulations for Treatment of Essential Tremor (ET):ET Registry
Recruiting·BBoston Scientific Corporation·N/A·NCT04032470·500 enrolled
A Phase 2b Multicenter, Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label Period to Evaluate the Efficacy and Safety of AGN-151607-DP (USAN: gemibotulinumtoxinA) for the Treatment of Upper Limb Essential Tremor in Adults
Recruiting·AbbVie logoAbbVie·Phase 2·NCT07673107·94 enrolled
Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)
Enrolling by invitation·PPraxis Precision Medicines·Phase 3·NCT06087276·1,000 enrolled
A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor
Completed·SSK Life Science, Inc.·Phase 2·NCT00524056·62 enrolled
A Pilot Clinical Trial Of Memantine for Essential Tremor
Completed·VVA Greater Los Angeles Healthcare System·Phase 4·NCT00439699·16 enrolled
Study to Evaluate SAGE-324 in Participants With Essential Tremor
Completed·Biogen logoBiogen·Phase 2·NCT05173012·146 enrolled
Pregabalin (Lyrica) for the Treatment of Essential Tremor
Completed·UUniversity of South Florida·Phase 4·NCT00584376·29 enrolled
Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor
Completed·Neurocrine Biosciences logoNeurocrine Biosciences·Phase 2·NCT04880616·31 enrolled
A Pilot Efficacy and Safety Study of ST101 in Essential Tremor
Completed·SSonexa Therapeutics, Inc.·Phase 2·NCT01332695·25 enrolled
Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor
Completed·UUniversity Hospital, Clermont-Ferrand·Phase 3·NCT02555982·120 enrolled
Octanol to Treat Essential Tremor
Completed·National Institute of Neurological Disorders and Stroke (NINDS)·Phase 2·NCT00080366·14 enrolled
Page 1 of 4

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)