Inderal

(Propranolol)

ApprovedSmall molecule

Propranolol is used to treat high blood pressure, angina (chest pain), and irregular heartbeats. It's also used to prevent migraines and reduce anxiety symptoms.[2] Inderal is currently approved and in use across 80 indications[4].[1]

Inderal is one of 1094 small molecule programs targeting Breast Cancer. It is currently in Approved.

Indications

230

Total Trials

Active Trials

1,093

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Breast CancerCompleted

CirrhosisCompleted

Traumatic Brain Injury (TBI) PatientsRecruiting

MemoryTerminated

Capillary HemangiomaApproved

Famililal Cerebral Cavernous MalformationsApproved

HypertensionApproved

SyncopeApproved

Alcohol DrinkingApproved

DystociaApproved

Breast CancerPhase 2

Completed

CirrhosisApproved

Completed

Traumatic Brain Injury (TBI) PatientsPhase 3

Recruiting

MemoryApproved

Terminated

Capillary HemangiomaApproved

Approved

Famililal Cerebral Cavernous MalformationsApproved

Approved

HypertensionApproved

Approved

SyncopeApproved

Approved

Alcohol DrinkingApproved

Approved

DystociaApproved

Approved

Showing 10 of 79 indications

Competition

Competitive Landscape

702 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Inderal

WWyeth-Lederle Vaccines

Approved

2 2

Adenocard

Astellas

Preclinical

2 3

Zolymbus

AbbVie

Preclinical

1 4

Lexiscan

Astellas

Preclinical

1 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 6

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 7

Tricor

JJagotec

Preclinical

1 8

Acupan

YYonsei University

Preclinical

1 9

Chantix

PPrism Pharmaceuticals

Preclinical

1 10

Duragesic

CCephalon

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Active, not recruiting

Cognitive Function

NCT01988883

Post-ApprovalNot yet recruiting

Migraine

NCT06499116

Q2 2027

Phase 2Recruiting

Gastrointestinal Tumors

NCT06775080

N/ARecruiting

Multiple Myeloma

NCT05312255

Q3 2027

Phase 3Recruiting

Post-Traumatic Stress Disorder

NCT04985344

Phase 1Recruiting

Immunotherapy

NCT05968690

Clinical

Trials by Indication[1]

Propranolol38 trials

Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

Withdrawn·UUniversity of California, Irvine·Phase 2·NCT00315913

In Vivo Specificity of KUC 7483 CL Co-administered With Bisoprolol, Propranolol, and Acipimox in Healthy Male Subjects

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02256722·12 enrolled

Burn Healing and Analgesia With Propranolol

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT00934947·45 enrolled

Show 35 more trials

Protective Effects of Propranolol in Adults

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT01902810·47 enrolled

Influence of Propranolol on Conditioned Pain Modulation

Completed·KKristian Kjær Petersen·N/A·NCT02808611·25 enrolled

Effects of Propranolol on the Encoding and Retrieval of Emotional Material After Single Dose Administration in Healthy Young Subjects

Completed·UUniversity Medicine Greifswald·Phase 1·NCT00889096·46 enrolled

Bioavailability Study of Propranolol Under Fed Conditions

Completed·PPar Pharmaceutical, Inc.·Phase 1·NCT00652600·46 enrolled

Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation

Terminated·SSt. Joseph's Hospital and Medical Center, Phoenix·Phase 2·NCT03474614·4 enrolled

Reducing Reconsolidation of Trauma Memories With Propranolol

Unknown status·—·Phase 2·NCT01349439·76 enrolled

Fenofibrate and Propranolol in Burn Patients

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT02452255·18 enrolled

A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT01298284·60 enrolled

Optimising the Propranolol Block Model

Completed· GSK logo

GSK·Phase 1·NCT00549120·18 enrolled

Efficacy of Clonidine and Propranolol in Dentistry (AAA)

Unknown status·—·Phase 2·NCT01784250·60 enrolled

Propranolol in Severely Burned Children

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT01957449·63 enrolled

Banding Versus Propranolol for Primary Prophylaxis of Variceal Bleeding

Terminated·UUniversity of Padova·Phase 3·NCT00337740·120 enrolled

Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity

Completed·—·Phase 4·NCT03309943·44 enrolled

Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices

Enrolling by invitation·XXijing Hospital·Phase 4·NCT07352228·350 enrolled

8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding

Completed·WWest China Hospital·N/A·NCT02477384·100 enrolled

Trial of Propranolol in Adults and Adolescents With ASD and Predictors of Response

Withdrawn·UUniversity of Missouri-Columbia·N/A·NCT02414451

Propranolol for Protracted Labor

Completed·CChristiana Care Health Services·Phase 1·NCT04741698·80 enrolled

Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 4·NCT00060866·24 enrolled

The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding

Unknown status·SShanghai Zhongshan Hospital·Phase 4·NCT02385422·480 enrolled

Effects on the Airway Lumen of Talsaclidine in Combination With Propranolol in Comparison to the Effects of the Monosubstances in Healthy Elderly Male Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02264093·12 enrolled

Carvedilol vs. Propranolol in Second Prophylaxis of Variceal Bleeding

Unknown status·WWest China Hospital·N/A·NCT05651789·160 enrolled

TRAUMA HELP: Healing and Analgesia With Propranolol

Withdrawn·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT01007084

A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol

Completed·MMassachusetts General Hospital·Phase 4·NCT00709735·23 enrolled

In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT03434444·57 enrolled

Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 2·NCT00093860·50 enrolled

Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding

Unknown status·KKorea University·Phase 4·NCT00965900·288 enrolled

A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol (S-HCC)

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT01451658·100 enrolled

A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03882255·52 enrolled

A Study of Lasmiditan and Propranolol in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT03270644·44 enrolled

Anabolic Steroid and Propranolol in Paediatric Burn

Unknown status·KKing Edward Medical University·N/A·NCT05805553·114 enrolled

Analysis of Atropine and Propranolol Induced Changes

Completed·NNational Institute on Aging (NIA)·Phase 1·NCT00251602·24 enrolled

Propranolol for Treatment of Cocaine Addiction - 2

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00000197

The Effects of Propranolol on Fear of Tooth or Molar Extraction

Completed·—·Phase 2/3·NCT02268357·36 enrolled

Combined Effects of Early Behavioral Intervention and Propranolol on ASD

Completed·UUniversity of Missouri-Columbia·N/A·NCT02428205·10 enrolled

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Terminated·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT00688805·40 enrolled

Migraine13 trials

Comparative Efficacy of Flunarizine and Propanolol in Pediatric Migraine

Recruiting·MMuhammad Aamir Latif·N/A·NCT07354126·44 enrolled

Zonisamide Versus Propranolol in Migraine

Recruiting·KKafrelsheikh University·Phase 3·NCT06361446·600 enrolled

Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine

Completed·HHaseki Training and Research Hospital·Phase 4·NCT02350985·73 enrolled

Show 10 more trials

Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care

Not yet recruiting·FFundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina·Phase 4·NCT06499116·460 enrolled

Comorbidity-Based Propranolol Use in Pediatric Migraine

Completed·—··NCT07103031·488 enrolled

Lacosamide Versus Propranolol in Migraine

Completed·KKafrelsheikh University·Phase 3·NCT05851781·600 enrolled

Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine

Withdrawn·UUniversity of South Alabama·N/A·NCT00777218

Effect of "Sekanjabin e Safarjali" (Quince Oxymel) in the Prevention of Migraine Attacks

Unknown status·SShiraz University of Medical Sciences·N/A·NCT02179775·45 enrolled

Valproate Versus Propranolol in Migraine

Recruiting·KKafrelsheikh University·Phase 4·NCT06485726·600 enrolled

Candesartan Versus Propranolol for Migraine Prevention

Completed·NNorwegian University of Science and Technology·Phase 2/3·NCT00884663·72 enrolled

Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine

Not yet recruiting·FFayoum University·Phase 3·NCT07147972·100 enrolled

Effectivity and Safety of GB20 Acupoint Pharmacopuncture With Lidocaine 2% on Migraine Patients

Completed·IIndonesia University·N/A·NCT07067853·30 enrolled

Propranolol for Pediatric Migraine: A Prospective Clinical Study

Completed·—·N/A·NCT07180043·178 enrolled

Hemangioma11 trials

The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma

Completed·SSeoul National University Hospital·Phase 4·NCT01908972·34 enrolled

Off Label Use of Propranolol for Infancy Hemangiomas

Completed·HHannover Medical School··NCT01211080·72 enrolled

Systemic Propranolol for the Treatment of Paediatric Patients With Infantile Hemangiomas

Completed·QQilu Hospital of Shandong University··NCT04651049·128 enrolled

Show 8 more trials

Low-Dose Propranolol and Bleomycin for Infantile Hemangioma (IH)

Completed·WWuhan Integrated Traditional Chinese and Western Medicine Hospital·N/A·NCT07104526·260 enrolled

Nadolol Versus Propranolol in Children With Infantile Hemangiomas

Completed·TThe Hospital for Sick Children·Phase 3·NCT02505971·74 enrolled

Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma

Completed·WWest China Hospital·Phase 3·NCT02342275·377 enrolled

Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma

Completed·UUniversity of Sao Paulo·Phase 2·NCT01072045·50 enrolled

Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas

Terminated·NNancy Bauman·Phase 2·NCT00967226·19 enrolled

Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)

Terminated·SSeattle Children's Hospital·Phase 2·NCT01074437·9 enrolled

Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT03237637·60 enrolled

Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo

Completed·PPierre Fabre Dermatology·Phase 2·NCT01512173·82 enrolled

Brain Injury7 trials

Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status

Unknown status·HHamad Medical Corporation·Phase 4·NCT04508244·771 enrolled

Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury

Recruiting·MMansoura University·Phase 1/2·NCT06836856·100 enrolled

Beta Blocker Effects in Traumatic Brain Injury

Completed·MMenoufia University·Phase 4·NCT05195996·40 enrolled

Show 4 more trials

Beta Blockade in in Traumatic Brain Injury

Completed·UUniversity of Tennessee·Phase 4·NCT02957331·26 enrolled

Propranolol for the Treatment of Traumatic Brain Injury

Unknown status·LLondon Health Sciences Centre·Phase 1·NCT06262061·50 enrolled

Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury

Unknown status·MMinia University·Phase 1·NCT04833218·90 enrolled

Early Propranolol After Traumatic Brain Injury: Phase II

Terminated·—·Phase 2·NCT01202110·10 enrolled

Retinopathy of Prematurity5 trials

Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity

Recruiting·UUniversity of Zurich·Phase 2·NCT03083431·276 enrolled

Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants

Unknown status·HHuiqing Sun·N/A·NCT02977000·100 enrolled

Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity

Completed·MMeyer Children's Hospital IRCCS·Phase 2/3·NCT01079715·52 enrolled

Show 2 more trials

Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study

Completed·RRambam Health Care Campus·Phase 1/2·NCT01238471·20 enrolled

a Prospective Cohort Study for Propranolol Treatment in Retinopathy of Prematurity

Unknown status·GGuangdong Women and Children Hospital·Phase 2·NCT03038295·100 enrolled

97 more indications

Post-Traumatic Stress Disorder5 trials

Propranolol in Post Traumatic Stress Disorder

Completed·UUniversity Hospital, Toulouse·Phase 2·NCT00465608·20 enrolled

Effect of Propranolol on Preventing Posttraumatic Stress Disorder

Completed·MMassachusetts General Hospital·Phase 4·NCT00158262·43 enrolled

Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence

Not yet recruiting·UUniversity Hospital, Tours·Phase 2·NCT07452978·34 enrolled

Show 2 more trials

Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol

Recruiting·UUniversity Hospital, Toulouse·Phase 3·NCT04985344·92 enrolled

Testing a Novel Therapeutic Strategy for Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder

Unknown status·CCentre for Addiction and Mental Health·Phase 2·NCT05692271·48 enrolled

Memory5 trials

Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

Recruiting·MMassachusetts General Hospital·Phase 4·NCT05853627·80 enrolled

The Use of Propranolol to Block Memory Reconsolidation in PTSD

Terminated·WWayne State University·Phase 2·NCT00611871·12 enrolled

Beta-blockade Effects on Memory for Cocaine Craving

Completed·MMedical University of South Carolina·Phase 2·NCT00830362·50 enrolled

Show 2 more trials

Efficacy of Traumatic Memory Modification Using Memory Reconsolidation and Propranolol Among Adolescents With PTSD

Withdrawn·RRennes University Hospital·Phase 2·NCT04921982

PTSD Symptom Reduction by Propranolol Given After Trauma Memory Activation

Terminated·VVA Office of Research and Development·Phase 4·NCT00645450·9 enrolled

Portal Hypertension4 trials

Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension

Unknown status·UUniversidade Federal do Rio de Janeiro·Phase 2/3·NCT03720067·80 enrolled

Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH)

Completed·GGovind Ballabh Pant Hospital·Phase 3·NCT01000779·100 enrolled

HVPG-guided Laparoscopic Versus Endoscopic Therapy for Variceal Rebleeding in Portal Hypertension: A Multicenter Randomized Controlled Trial (CHESS1803)

Unknown status·NNanfang Hospital, Southern Medical University·N/A·NCT03783065·40 enrolled

Show 1 more trial

Danish Carvedilol Study in Portal Hypertension

Completed·HHvidovre University Hospital·Phase 3·NCT00493480·40 enrolled

Esophageal Varices4 trials

The Use of Propranolol for the Prevention of Worsening of Esophageal Varices in Patients With Isolated Gastric Varices

Unknown status·WWest China Hospital·N/A·NCT03171805·74 enrolled

Preventing Recurrent Bleeding After Eradication of Esophageal Varices

Unknown status·KKaohsiung Veterans General Hospital.·Phase 4·NCT02740166·212 enrolled

Beta-blockers for Prevention Of Growth Of Small Esophageal Varices In Cirrhosis: An Randomized Controlled Trial (RCT)

Completed·GGovind Ballabh Pant Hospital·N/A·NCT00772057·164 enrolled

Show 1 more trial

PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES?

Completed·FFederal University of São Paulo·Phase 4·NCT01893541·100 enrolled

Cirrhosis3 trials

8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding in Patients With Child A Cirrhosis

Unknown status·WWest China Hospital·N/A·NCT03094234·72 enrolled

Effect of Betablocker or Aldosterone Antagonist Therapy on Patients With Liver Cirrhosis

Unknown status·HHvidovre University Hospital·Phase 4·NCT00332904·22 enrolled

Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal

Completed·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 4·NCT01059396·201 enrolled

Induction of Labor3 trials

Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas

Completed·AAhmed mohamed fathy ismail·Phase 2·NCT04533841·128 enrolled

Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT03348683·240 enrolled

The Effect of Coadministration of Oral Propranolol to Oxytocin on Induction of Labor

Unknown status·—·Phase 3·NCT02702674·242 enrolled

Tremor3 trials

Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response

Completed·UUniversity of California, San Diego·Phase 4·NCT02495883·56 enrolled

A Study Comparing Propranolol and Amantadine for Reducing Tremors in People With Parkinson's Disease

Completed·MMultan Medical And Dental College·N/A·NCT07113015·220 enrolled

Propranolol and Botulinum Toxin for Essential Vocal Tremor

Completed·EEmory University·Phase 4·NCT02111369·18 enrolled

Sickle Cell Disease2 trials

Study of Propranolol as Anti-Adhesive Therapy in Sickle Cell Disease (SCD)

Completed·—·Phase 2·NCT01077921·31 enrolled

Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease

Terminated·UUniversity of Miami·Phase 1·NCT02012777·9 enrolled

Multiple Myeloma2 trials

Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

Completed·GGPCR Therapeutics, Inc.·Phase 2·NCT05561751·30 enrolled

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Recruiting·RRoswell Park Cancer Institute·N/A·NCT05312255·175 enrolled

Breast Cancer2 trials

Propranolol and Pembrolizumab for Tumor Re-sensitization and Treatment of Patients With Checkpoint Inhibitor Refractory Metastatic or Unresectable Triple Negative Breast Cancer

Not yet recruiting·EEmory University·Phase 2·NCT05741164·37 enrolled

Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Completed·—·Phase 2·NCT01847001·10 enrolled

Anxiety2 trials

Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety

Completed·NNational Institute of Mental Health (NIMH)·Phase 4·NCT02153944·142 enrolled

Oral Propranolol for Reducing Pediatric Dental Patients Anxiety

Completed·—·N/A·NCT03388957·60 enrolled

Injury2 trials

Beta Blockade in Critical Injury

Terminated·—·Phase 2·NCT00356187·15 enrolled

Controlling Hyperadrenergic Activity in Neurologic Injury

Withdrawn·JJohns Hopkins University·Phase 1/2·NCT01343329

Soft Tissue Sarcoma2 trials

Propranolol Plus Standard Radiation Therapy Before Surgery for the Treatment of Patients With Soft Tissue Sarcoma

Withdrawn·RRoswell Park Cancer Institute·Phase 1·NCT06670976

Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients

Recruiting·NNiels Junker·Phase 2·NCT05961761·80 enrolled

Angiosarcoma2 trials

Propranolol in Angiosarcoma

Completed·TThe Netherlands Cancer Institute·Phase 2·NCT04518124·14 enrolled

Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Trial by the French Sarcoma Group (GSF/GETO)

Unknown status·AAssistance Publique Hopitaux De Marseille·Phase 1/2·NCT02732678·24 enrolled

Capillary Hemangioma1 trial

Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma

Unknown status·—·Phase 4·NCT04288700·100 enrolled

Pregnancy1 trial

A Comparison Between the Effect of Oxytocin Only and Oxytocin Plus Propranolol on Induction of Labor in Term Pregnancy

Unknown status·—·N/A·NCT03533699·202 enrolled

Acute Stress Disorder1 trial

Propranolol for the Treatment of Acute Stress Disorder

Completed·NNational Institute of Mental Health (NIMH)·Phase 2·NCT00069355·50 enrolled

Wound Healing1 trial

Assessment of Mechanisms of Improved Wound Healing

Completed·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT00673309·644 enrolled

Heart1 trial

A Study of Continuous Heart Rate Monitoring in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·N/A·NCT04682184·21 enrolled

Addiction1 trial

Establishing and Eliminating Cue-drug Associations in Human Cocaine Addiction

Terminated·YYale University·Phase 1·NCT01978457·6 enrolled

Headache1 trial

Medical Therapies for Chronic Post-Traumatic Headaches

Terminated·MMadigan Army Medical Center·Phase 4·NCT00862095·64 enrolled

Heart Attack1 trial

Beta-Blocker Heart Attack Trial (BHAT)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000492

Autism Spectrum Disorder1 trial

Trial of Propranolol in Children and Youth With Autism Spectrum Disorder and Predictors of Response

Completed·UUniversity of Missouri-Columbia·Phase 1·NCT02871349·69 enrolled

Hyperthyroidism1 trial

Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT03379181·19 enrolled

Chronic Kidney Disease1 trial

Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers

Completed·UUniversity of California, San Francisco·Phase 1·NCT01087749·24 enrolled

Type 2 Diabetes1 trial

Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy

Unknown status·HHospital de Clinicas de Porto Alegre··NCT00935805·124 enrolled

Portal vein thrombosis1 trial

TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV

Unknown status·ZZaibo Jiang·Phase 3·NCT02853526·100 enrolled

Cognitive Function1 trial

Modafinil and Cognitive Function in POTS

Active, not recruiting·VVanderbilt University Medical Center·Phase 1·NCT01988883·20 enrolled

Melanoma1 trial

MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients

Unknown status·AAzienda Sanitaria di Firenze·Phase 2/3·NCT02962947·546 enrolled

Nicotine Dependence1 trial

Memory Reconsolidation Blockade as a Novel Intervention for Nicotine Dependence

Completed·MMassachusetts General Hospital·Phase 3·NCT00916721·113 enrolled

Hypotensive Anesthesia1 trial

Efficacy of Ivabradine Versus Propranolol Premedication During Hypotensive Anesthesia in Endoscopic Sinus Surgery

Unknown status·—·N/A·NCT04208594·50 enrolled

Medication1 trial

Shortening Duration of Antiarrhythmic Medication for SVT in Infants

Completed·TTampere University Hospital··NCT04837261·107 enrolled

Tachycardia1 trial

Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)

Completed·SSeoul National University Hospital·Phase 4·NCT02171988·150 enrolled

Inflammation1 trial

Evaluation of Propranolol's Effect on Pain and Inflammation.

Completed·MMartin Angst·N/A·NCT01094574·10 enrolled

Fear1 trial

Brief Intervention to Reduce Fear of Public Speaking

Terminated·NNew York State Psychiatric Institute·Phase 4·NCT02790736·6 enrolled

Burn1 trial

Catecholamine Blockade Post-burn

Unknown status·SSunnybrook Health Sciences Centre·N/A·NCT01299753·80 enrolled

Gastric Cancer1 trial

Clinical Study of Propranolol Combined With Neoadjuvant Chemotherapy in Gastric Cancer

Unknown status·YYijing He·Phase 2·NCT04005365·78 enrolled

Hyperalgesia1 trial

Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol

Unknown status·PPontificia Universidad Catolica de Chile·Phase 4·NCT02934763·80 enrolled

Blood Pressure1 trial

A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline

Terminated· Otsuka logo

Otsuka·Phase 1·NCT05189977·34 enrolled

Cardiovascular1 trial

A Study in Healthy Young Men to Look at What Drives the Cardiovascular Effects After Dosing With Mirabegron.

Completed· Astellas logo

Astellas·Phase 1·NCT01284868·12 enrolled

Tislelizumab1 trial

Propranolol With Tislelizumab Plus GC in Neoadjuvant Bladder UC

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 1·NCT07353294·12 enrolled

Metastatic Melanoma1 trial

Bevacizumab vs Dacarbazine in Metastatic Melanoma

Terminated·HHaukeland University Hospital·Phase 2·NCT01705392·2 enrolled

Hepatocellular Carcinoma1 trial

Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT01970748·200 enrolled

Essential Tremor1 trial

Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor

Completed·UUniversity Medical Centre Ljubljana··NCT04692844·61 enrolled

Cerebral Cavernous Malformation1 trial

Treat_CCM: Propranolol in Familial Cerebral Cavernous Malformation

Completed· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research·Phase 2·NCT03589014·71 enrolled

Intestinal Cancer1 trial

Clinical Research on Teratment of Gastrointestinal Cancer in the Preoperative by Propranolol

Unknown status·—·Phase 1·NCT03245554·80 enrolled

Anxiety Disorder1 trial

Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders

Completed·MMassachusetts General Hospital·Phase 4·NCT01631682·186 enrolled

Atrial Fibrillation1 trial

Rate Control in Atrial Fibrillation

Completed·TTehran University of Medical Sciences·Phase 4·NCT01655303·90 enrolled

Gene Expression1 trial

Study of Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in HCT Recipients

Completed·MMedical College of Wisconsin·Phase 2·NCT02420223·25 enrolled

Ischemic stroke1 trial

Beta Blockers In Acute Ischemic Stroke

Completed·WWilhelm Haverkamp·Phase 2/3·NCT01061190·20 enrolled

Preoperative1 trial

Examining Safety, Efficacy and Feasibility of Preoperative Propranolol in Patients With PDAC.

Recruiting·ZZealand University Hospital·Phase 2·NCT06145074·30 enrolled

Opioids1 trial

Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

Completed·SStanford University·Phase 2·NCT01222091·10 enrolled

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT04074473·170 enrolled

Elective1 trial

Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI

Not yet recruiting·TTanta University·Phase 3·NCT06870370·60 enrolled

Drug1 trial

Beta-Adrenergic Modulation of Drug Cue Reactivity

Recruiting·UUniversity of Oklahoma·Phase 4·NCT05587361·80 enrolled

Metabolism1 trial

Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism

Completed·MMayo Clinic·Phase 1·NCT02467400·165 enrolled

Diabetic Retinopathy1 trial

Propranolol for Diabetic Retinopathy

Completed·UUniversity of Wisconsin, Madison·Phase 1·NCT01535495·9 enrolled

Hydrocortisone1 trial

The Effects of Propranolol, Hydrocortisone, and Morphine on Military-Relevant Performance Outcomes

Recruiting·WWalter Reed Army Institute of Research (WRAIR)·Phase 4·NCT06982183·110 enrolled

Blood Pressure Monitoring1 trial

A Study of Continuous Blood Pressure Monitoring in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·N/A·NCT05692869·24 enrolled

Cannabis Use1 trial

Nabilone in Cannabis Users With PTSD

Terminated·NNew York State Psychiatric Institute·Phase 1/2·NCT03251326·4 enrolled

Alcohol Dependence1 trial

Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence

Completed·MMedical University of South Carolina·Phase 2·NCT01055171·44 enrolled

Lymphedema1 trial

Propranolol Dose Escalation in Lymphedema in Patients

Terminated·—·Phase 2·NCT02595996·1 enrolled

Experimental1 trial

Brief Stresses Experimental Study

Terminated·DDana Bovbjerg·Phase 1·NCT03893617·239 enrolled

Adjuvant Treatment1 trial

Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study)

Completed·MMikael Lantz·Phase 4·NCT01458600·65 enrolled

Ovarian Cancer1 trial

Therapeutic Targeting of Stress Factors in Ovarian Cancer Patients

Completed·WWashington University School of Medicine·Phase 1·NCT01308944·24 enrolled

Islet Transplantation1 trial

Adrenergic System in Islet Transplantation

Active, not recruiting·UUniversity of Pennsylvania·Phase 1·NCT03079921·11 enrolled

Cancer Recurrence1 trial

Perioperative Propranolol During Prostatectomy to Decrease Cancer Recurrence

Completed·OOslo University Hospital·Phase 2·NCT05679193·40 enrolled

Low back pain1 trial

Genetic Variants Associated With Low Back Pain and Their Response to Treatment With Duloxetine or Propranolol

Terminated·MMark Ware·Phase 2·NCT03364075·10 enrolled

Stroke1 trial

Propranolol on Post Stroke Immune Status and Infection

Unknown status·TTianjin Medical University General Hospital·Phase 2·NCT05375240·45 enrolled

Craving1 trial

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

Completed·MMedical University of South Carolina·Phase 2·NCT01822587·181 enrolled

Surgical1 trial

Oral Propanolol for Surgically Inaccessible Cavernous Malformations

Unknown status·UUniversity of Virginia·Phase 1·NCT03523650·346 enrolled

Hypoglycemia1 trial

Propranolol in Treating Hypoglycemia Unawareness

Terminated·AAnu Sharma·Phase 2·NCT03161964·2 enrolled

Gastrointestinal Tumors1 trial

The Use of Propranolol in the Perioperative Period of Resectable Gastrointestinal Tumors

Recruiting·HHuashan Hospital·Phase 2·NCT06775080·40 enrolled

Sleep Apnea1 trial

Propranolol for Sleep Apnea Therapy

Completed·JJohns Hopkins University·Phase 2·NCT03049306·24 enrolled

Hemangioendothelioma1 trial

Sirolimus in the Treatment for Infantile Hepatic Hemangioendothelioma(IEEH)

Unknown status·SShanghai Children's Medical Center·Phase 4·NCT04406870·36 enrolled

Clinical Trial1 trial

Clinical Trial of Propranolol for Seasonal Affective Disorder

Completed·NNational Institute of Mental Health (NIMH)·Phase 2·NCT00016666·70 enrolled

Von Hippel-Lindau Disease1 trial

Propranolol and Von Hippel-Lindau Disease

Recruiting·AAssistance Publique - Hôpitaux de Paris·N/A·NCT05424016·85 enrolled

Cocaine Dependence1 trial

Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2

Completed·UUniversity of Pennsylvania·Phase 2·NCT00158132·199 enrolled

Epilepsy1 trial

Propranolol Adjuvant Treatment of Focal Refractory Epilepsy (PATFRE)

Not yet recruiting·XXuanwu Hospital, Beijing·Phase 1·NCT06719804·15 enrolled

Immunotherapy1 trial

Naltrexone and Propranolol Combined With Immunotherapy

Recruiting·SSarah Weiss·Phase 1·NCT05968690·12 enrolled

Fasting Conditions1 trial

Bioavailability Study of Propranolol Under Fasting Conditions

Completed·PPar Pharmaceutical, Inc.·Phase 2·NCT00653120·48 enrolled

ART1 trial

A Study of LY2216684 in Healthy Participants Receiving Albuterol or Propanolol

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01263197·48 enrolled

Stress1 trial

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

Recruiting·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT06263452·120 enrolled

Shivering1 trial

Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT01950520·47 enrolled

Asthma1 trial

Beta Blockers for the Treatment of Asthma

Completed·UUniversity of Dundee·Phase 2·NCT01074853·18 enrolled

Rehabilitation1 trial

Assessment of the Treatment of Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT00675714·1,126 enrolled

Papilloma1 trial

Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis

Withdrawn·MMassachusetts Eye and Ear Infirmary·Phase 2/3·NCT01058317

Ascites1 trial

Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04208776·140 enrolled

Induction of Labour1 trial

Effects of Oral Propranolol on Induction-Delivery Interval During Induction of Labour With Oxytocin

Not yet recruiting·FFederal Teaching Hospital Abakaliki·N/A·NCT06960850·308 enrolled

Cervical Cancer1 trial

Feasibility - Beta Adrenergic Blockade (BB) in Cervical Cancer (CX)

Terminated·MM.D. Anderson Cancer Center·N/A·NCT01902966·6 enrolled

Supraventricular tachycardia1 trial

Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia

Completed·UUniversity of British Columbia·Phase 3·NCT00390546·72 enrolled

Autism1 trial

Propranolol for Challenging Behaviors in Autism

Completed·RRutgers, The State University of New Jersey·Phase 2·NCT04047355·8 enrolled

Panic Disorder1 trial

Disruption of Memory Reconsolidating as a Treatment for Panic Disorder

Unknown status·VVU University of Amsterdam·Phase 2·NCT02631694·60 enrolled

Treatment1 trial

Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma

Unknown status·—·Phase 2·NCT04982211·150 enrolled

Unspecified3 trials

Study of Arm and Putter Movement in Golfers With Golfer's Cramp

Completed·MMayo Clinic·Phase 4·NCT02032758·38 enrolled

A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers

Completed·TTheravance Biopharma·Phase 1·NCT00687700·23 enrolled

Learning and Decision-making

Completed·MMaastricht University·N/A·NCT06014606·150 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

INDERAL

NDA NDA016418

Jan 1, 1982

PROPRANOLOL HYDROCHLORIDE

NDA NDA016419

Jan 9, 1984

INDERAL LA

NDA NDA018553

Mar 6, 1984

INDERAL LA

NDA NDA018553

Aug 9, 1984

INDERAL LA

NDA NDA018553

Oct 11, 1984

INDERAL LA

NDA NDA018553

Mar 21, 1985

INDERAL LA

NDA NDA018553

Apr 2, 1985

INDERAL LA

NDA NDA018553

Aug 20, 1985

INDERAL LA

NDA NDA018553

Nov 20, 1985

INDERAL LA

NDA NDA018553

Jan 7, 1986

INDERAL LA

NDA NDA018553

Mar 4, 1986

INDERAL LA

NDA NDA018553

May 27, 1986

INDERAL LA

NDA NDA018553

Sep 2, 1986

INDERAL LA

NDA NDA018553

Dec 12, 1986

INDERAL

NDA NDA019536

Jan 20, 1987

INDERAL LA

NDA NDA018553

Mar 18, 1987

INDERAL LA

NDA NDA018553

Mar 18, 1987

INDERAL LA

NDA NDA018553

May 25, 1988

INDERAL LA

NDA NDA018553

Aug 8, 1988

INDERAL LA

NDA NDA018553

Jan 25, 1989

INDERAL LA

NDA NDA018553

Apr 10, 1989

INDERAL LA

NDA NDA018553

Jun 5, 1989

INDERAL LA

NDA NDA018553

Jul 10, 1989

INDERAL LA

NDA NDA018553

Feb 9, 1990

INDERAL LA

NDA NDA018553

Apr 17, 1990

INDERAL LA

NDA NDA018553

Nov 7, 1997

INDERAL LA

NDA NDA018553

Aug 22, 1999

INDERAL LA

NDA NDA018553

Mar 31, 2000

INDERAL LA

NDA NDA018553

Feb 6, 2002

INDERAL LA

NDA NDA018553

Mar 12, 2003

INNOPRAN XL

NDA NDA021438

Mar 12, 2003

INNOPRAN XL

NDA NDA021438

Jun 9, 2004

INDERAL LA

NDA NDA018553

Oct 22, 2004

INNOPRAN XL

NDA NDA021438

Jan 3, 2007

INDERAL LA

NDA NDA018553

Feb 21, 2007

INDERAL LA

NDA NDA018553

Oct 31, 2007

INDERAL LA

NDA NDA018553

Jan 2, 2008

INNOPRAN XL

NDA NDA021438

Dec 30, 2009

INNOPRAN XL

NDA NDA021438

Dec 14, 2010

INNOPRAN XL

NDA NDA021438

Dec 14, 2010

INNOPRAN XL

NDA NDA021438

Mar 17, 2011

INDERAL LA

NDA NDA018553

Oct 24, 2013

INNOPRAN XL

NDA NDA021438

Nov 19, 2013

INNOPRAN XL

NDA NDA021438

Mar 14, 2014

HEMANGEOL

NDA NDA205410

Oct 22, 2015

INDERAL LA

NDA NDA018553

Dec 21, 2015

INDERAL LA

NDA NDA018553

Aug 16, 2021

INNOPRAN XL

NDA NDA021438

Nov 7, 2023

INDERAL LA

NDA NDA018553

Nov 7, 2023

INDERAL LA

NDA NDA018553

Dec 22, 2023

INNOPRAN XL

NDA NDA021438

Sources

References

[1]
ClinicalTrials.gov — 230 trial records for Propranolol. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Inderal drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Propranolol compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Propranolol. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA021438). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Inderal. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Wyeth-Lederle Vaccines company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Beta-2 Adrenergic Receptor Antagonist; Beta-1 Adrenergic Receptor Antagonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: WWyeth-Lederle Vaccines

Patent Landscape[6]

Patent Cliff

Oct 16, 2028

Earliest patent expiration — generic entry possible after this date

Patent #Expires

8338489Oct 16, 2028

8987262Oct 16, 2028

Inderal

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q2 2027

Q3 2027

Trials by Indication[1]

Propranolol38 trials

Migraine13 trials

Hemangioma11 trials

Brain Injury7 trials

Retinopathy of Prematurity5 trials

Post-Traumatic Stress Disorder5 trials

Memory5 trials

Portal Hypertension4 trials

Esophageal Varices4 trials

Cirrhosis3 trials

Induction of Labor3 trials

Tremor3 trials

Sickle Cell Disease2 trials

Multiple Myeloma2 trials

Breast Cancer2 trials

Anxiety2 trials

Injury2 trials

Soft Tissue Sarcoma2 trials

Angiosarcoma2 trials

Capillary Hemangioma1 trial

Pregnancy1 trial

Acute Stress Disorder1 trial

Wound Healing1 trial

Heart1 trial

Addiction1 trial

Headache1 trial

Heart Attack1 trial

Autism Spectrum Disorder1 trial

Hyperthyroidism1 trial

Chronic Kidney Disease1 trial

Type 2 Diabetes1 trial

Portal vein thrombosis1 trial

Cognitive Function1 trial

Melanoma1 trial

Nicotine Dependence1 trial

Hypotensive Anesthesia1 trial

Medication1 trial

Tachycardia1 trial

Inflammation1 trial

Fear1 trial

Burn1 trial

Gastric Cancer1 trial

Hyperalgesia1 trial

Blood Pressure1 trial

Cardiovascular1 trial

Tislelizumab1 trial

Metastatic Melanoma1 trial

Hepatocellular Carcinoma1 trial

Essential Tremor1 trial

Cerebral Cavernous Malformation1 trial

Intestinal Cancer1 trial

Anxiety Disorder1 trial

Atrial Fibrillation1 trial

Gene Expression1 trial

Ischemic stroke1 trial

Preoperative1 trial

Opioids1 trial

Liver Disease1 trial

RCT1 trial

Acute Kidney Injury1 trial

Elective1 trial

Drug1 trial

Metabolism1 trial

Diabetic Retinopathy1 trial

Hydrocortisone1 trial

Blood Pressure Monitoring1 trial

Cannabis Use1 trial

Alcohol Dependence1 trial

Lymphedema1 trial

Experimental1 trial

Adjuvant Treatment1 trial

Ovarian Cancer1 trial