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Ophthalmology/Glaucoma

Glaucoma

42

Pipeline Programs↗

86

Active Trials↗

42

Companies Involved↗

Glaucoma is a moderately active landscape with 42 programs across 42 companies. The most active players are Tarian Pharma, Santen Pharmaceutical Co., Ltd., Johnson & Johnson. 6 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

67/100

Pipeline Velocity

70/100

Mech. Concentration

29/100

Completion Rate

84/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Tarian Pharma

2 programs

Santen Pharmaceutical Co., Ltd.

1 program

Johnson & Johnson

1 program

Pipeline

Programs by Phase

Preclinical32

Triamcinolone

Bassett Healthcare

Brimonidine Tartrate

AbbVie

Lisdexamfetamine Dimesylate

Takeda

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Mannitol

B. Braun Medical Inc.

Phase 11

Insulin

Merck & Co.

Phase 23

NT-501

Neurotech Pharmaceuticals

AMDX-2011P

Amydis Inc.

Kinezodianone R Hydrochloride

Laboratoires Thea

Phase 36

Mitomycin C

Gynecologic Oncology Group

Isocapnic Oxygen

University of Maryland, Baltimore

TFC-003

Kukje Pharma

Nicotinomide

University College, London

Idose TR

Glaukos Corporation

Approved

No programs

Analysis

Trial Status

299

clinical trials

Completed138 · 46%

Unknown status48 · 16%

Recruiting43 · 14%

Not yet recruiting21 · 7%

Active, not recruiting18 · 6%

Terminated14 · 5%

Other17 · 6%

Clinical Trials

Trial Activity

299 trials

Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Recruiting·GGlaukos Corporation·Phase 2·NCT07075718·110 enrolled

Dresden Glaucoma and Treatment Study: Analysis to Assure the Quality of Follow-up and Therapy of Glaucoma Patients in a Tertiary University Hospital Glaucoma Service.

Recruiting·TTechnische Universität Dresden·N/A·NCT02959242·10,000 enrolled

A Prospective, Multicenter Clinical Study to Evaluate the Safety and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Subjects With Glaucoma

Recruiting· AbbVie logo

AbbVie·Phase 3·NCT06822738·130 enrolled

Real-World Evidence Observational Study to Evaluate the Safety of iDose® TR (Travoprost Intracameral Implant) 75 µg in an Office-Based Surgery Setting

Recruiting·GGlaukos Corporation·N/A·NCT07816692·30 enrolled

A Phase 1, Multicenter, Open-Label, Ascending-Dose and Phase 2, Randomized, Double-Masked, Sham-Controlled, Clinical Study to Evaluate the Safety and Efficacy of ASP2767 in Participants With Optic Neuropathy Due to Glaucoma

Recruiting· Astellas logo

Astellas·Preclinical·NCT07770685·156 enrolled

Longitudinal Observational Study Using Functional and Structural Optical Coherence Tomography to Diagnose and Guide Treatment of Glaucoma

Recruiting·OOregon Health and Science University·N/A·NCT01957267·249 enrolled

Impact of Home Intraocular Pressure Telemonitoring on Intraocular Pressure Control and Glaucoma Progression - A Randomized Control Trial

Recruiting·TThe University of Hong Kong·Preclinical·NCT05940623·142 enrolled

Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma

Recruiting·UUniversity Hospital, Bordeaux·Preclinical·NCT07802769·100 enrolled

Evaluation of Different Perimetric Grids to Detect Central Visual Field Defect in Glaucoma Patients With Reduce Ganglion Cell Layer Thickness Measured by Spectral Domain OCT.

Recruiting·FFondazione G.B. Bietti, IRCCS·N/A·NCT06227611·16 enrolled

The Glaucoma and Retinopathy Screening Study (GRaSS)

Recruiting·MMassachusetts Eye and Ear Infirmary·Preclinical·NCT06882356·2,000 enrolled

Long-Term Clinical Results of Ab-Interno Trabeculotomy in Glaucoma Management

Recruiting·WWuerzburg University Hospital·N/A·NCT07780916·200 enrolled

A Randomized, Double-Masked, Placebo-Controlled Phase II Clinical Trial Evaluating the Efficacy and Safety of G01 Eye Drops in the Treatment of Optic Nerve Injury Associated With Open-Angle Glaucoma

Recruiting·QQingdao WanMing BioCell Pharmaceutics Co.,Ltd.·Phase 2·NCT07777861·90 enrolled

Cross-modal Neuromodulation to Improve Balance and Cognition in Older Adults With Glaucoma: A Randomized Trial of Cerebellar Transcranial Electrical Stimulation

Recruiting·TThe Hong Kong Polytechnic University·Preclinical·NCT07771699·36 enrolled

Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Glaucoma in a Random Sample of Retinal Fundus Photograph

Recruiting·DDemocritus University of Thrace·N/A·NCT07758569·2,000 enrolled

Development of Robust Corneal Biomechanical Biomarkers for Glaucoma Using Brillouin Microscopy

Recruiting·UUniversity of Maryland, Baltimore·N/A·NCT06993597·60 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)