Insulin

ApprovedSmall molecule

Merck & Co.

Insulin is one of 1121 small molecule programs targeting Insulin resistance. It is currently in Approved.

Indications

297

Total Trials

Active Trials

1,120

Competitors

Pipeline

Status by Indication[3][1]

Indication

Insulin ResistanceActive, not recruiting

Acute PancreatitisActive, not recruiting

Metabolic SyndromeActive, not recruiting

Diabetic KetoacidosisActive, not recruiting

Neuropathic PainActive, not recruiting

Wound HealingActive, not recruiting

Erectile DysfunctionActive, not recruiting

Carpal Tunnel SyndromeActive, not recruiting

Liver TransplantActive, not recruiting

ToxicityActive, not recruiting

Insulin ResistancePreclinical

Active, not recruiting

Acute PancreatitisApproved

Active, not recruiting

Metabolic SyndromePreclinical

Active, not recruiting

Diabetic KetoacidosisPreclinical

Active, not recruiting

Neuropathic PainPreclinical

Active, not recruiting

Wound HealingPreclinical

Active, not recruiting

Erectile DysfunctionApproved

Active, not recruiting

Carpal Tunnel SyndromePhase 1

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

ToxicityApproved

Active, not recruiting

Showing 10 of 47 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Insulin

Merck & Co.

Approved

1 2

Tecentriq

Roche

Preclinical

36 3

Adriamycin

GGynecologic Oncology Group

Preclinical

87 4

Gemzar

GGynecologic Oncology Group

Preclinical

22 5

Lexiscan

Astellas

Preclinical

1 6

Adenocard

Astellas

Preclinical

1 7

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 8

Tricor

JJagotec

Preclinical

1 9

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 10

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ARecruiting

Breast Cancer

NCT05010356

Q4 2026

Post-ApprovalActive, not recruiting

Gestational Diabetes

NCT03527537

N/ARecruiting

Critically Ill Patients

NCT03510078

Phase 3Active, not recruiting

Critically Ill Patients

NCT03665207

Phase 1Recruiting

Glaucoma

NCT05206877

Q2 2027

Post-ApprovalRecruiting

Metformin

NCT06781775

Clinical

Trials by Indication[1]

Type 1 Diabetes17 trials

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes

Withdrawn·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02846857

Impact of a Diabetes Camp on Glycemic Control Among Children and Adolescents Living With Type 1 Diabetes in Cameroon

Completed·YYaounde Central Hospital·N/A·NCT02632032·46 enrolled

Prevention of Mild-to-moderate Hypoglycemia in Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·N/A·NCT04876079·30 enrolled

Show 14 more trials

Role of Exenatide in Type 1 Diabetes

Completed·MMontefiore Medical Center·Phase 2·NCT00456300·11 enrolled

Novel Therapy to Preserve Beta Cell Function in New Onset Type 1 Diabetes

Terminated·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT00837759·7 enrolled

Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)

Not yet recruiting·OOhio State University·Phase 4·NCT07293715·44 enrolled

The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes

Unknown status·NNanjing Medical University·Phase 4·NCT02307695·184 enrolled

Glycemic Variations During the Menstrual Cycle in Women With Type 1 Diabetes

Recruiting·IInstitut de Recherches Cliniques de Montreal··NCT05258292·86 enrolled

A Trial to Investigate Hyperglycemic and Hypoglycemic Excursions in Subjects With Type 1 Diabetes

Completed·AAbvance Therapeutics·Phase 1·NCT04712266·15 enrolled

Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes

Recruiting·MMostafa Bahaa·Phase 2·NCT06762314·105 enrolled

Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00356109·494 enrolled

Closed-loop Control of Postprandial Glucose Levels After Meals With Different Macronutrients Content in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02774876·15 enrolled

Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes

Withdrawn·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02490098

Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes

Withdrawn·UUniversity of Virginia·Phase 1·NCT04133922

Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02855307·37 enrolled

Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02416765·15 enrolled

Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00127634·385 enrolled

Type 2 Diabetes16 trials

A Prospective, Multicenter, Randomized, Open-label Study of 12 Week Duration to Evaluate the Effect of VILDagliptin Added to Insulin on Glycaemic Control in haemoDIALyzed Patients With Type 2 Diabetes: Probe Analysis of CGM

Completed·UUniversity Hospital, Strasbourg, France·Phase 4·NCT02176681·70 enrolled

Effects of PN2034 in Insulin-Dependent Patients With Type 2 Diabetes

Completed·WWellstat Therapeutics·Phase 2·NCT00110864·90 enrolled

Nephropathy In Type 2 Diabetes and Cardio-renal Events

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00535925·850 enrolled

Show 13 more trials

A Concordance Study Comparing Insulin Treatments in Patients With Type 2 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00330473·1,019 enrolled

Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulin

Unknown status·—··NCT04034524·20,000 enrolled

The Effect of Type 2 Diabetes and Dietary Regulation on VLDL1-and VLDL2-triglyceride Metabolism

Completed·UUniversity of Aarhus··NCT01564550·30 enrolled

Efficacy and Safety of Repaglinide Combined With Insulin in Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk·Phase 4·NCT01720303·159 enrolled

Efficacy and Safety Study of Teneligliptin (MP-513) in Combination With Insulin in Patients With Type 2 Diabetes

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 4·NCT02081599·148 enrolled

Observational Study Describing Conditions for Intensification of Insulin Therapy in Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk··NCT00712478·114 enrolled

Effects of Hypoglycemic Drugs on Testosterone Levels in Type 2 Diabetes Patients

Completed·MMajianhua·Phase 4·NCT03982238·74 enrolled

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 24 Hours in Adults With Type 2 Diabetes Under Intensive Insulin Therapy

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02490085·15 enrolled

Efficacy and Safety of Liraglutide in Combination With Insulin Therapy Compared to Insulin Alone in Japanese Subjects With Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk·Phase 3·NCT01572740·257 enrolled

Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·N/A·NCT03180281·135 enrolled

Effect of Glycemic Variability on Autonomic Tone in Hospitalized Patients With Type 2 Diabetes

Completed·KKathleen Dungan·Phase 4·NCT01409239·42 enrolled

Study of Human Insulin Inhalation Powder in Patients With Type 2 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00325364·415 enrolled

Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes

Completed·TThe University of Texas Health Science Center, Houston·N/A·NCT00678080·25 enrolled

Type 2 Diabetes Mellitus14 trials

A Study of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus With Chronic Kidney Disease or Kidney Failure on Dialysis (MK-3102-019)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01698775·213 enrolled

Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)··NCT00445627·82 enrolled

MSC and MC in Type 2 Diabetes Mellitus

Completed·FFuzhou General Hospital·Phase 1/2·NCT01719640·22 enrolled

Show 11 more trials

Efficacy and Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 4·NCT02220920·146 enrolled

Efficacy of Pioglitazone and Insulin in Treating Subjects With Type 2 Diabetes Mellitus and Renal Failure.

Completed· Takeda logo

Takeda·Phase 2·NCT00770640·40 enrolled

Autologous Stem Cell and Hyperbaric Oxygen Therapy in Type 2 Diabetes Mellitus

Completed·RRodolfo Alejandro·Phase 1/2·NCT01786707·2 enrolled

Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT02036515·464 enrolled

Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT04029480·166 enrolled

Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT02906709·184 enrolled

Effects of Sitagliptin on Type 2 Diabetes Mellitus Patients on Treatment With Metformin and Insulin

Completed·—·Phase 4·NCT01341717·440 enrolled

A Study To Assess GW677954 Used In Combination With Insulin In Subjects Who Have Type 2 Diabetes Mellitus

Terminated· GSK logo

GSK·Phase 2·NCT00437164·1 enrolled

Long-Term Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 4·NCT02622113·139 enrolled

A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT03492580·714,582 enrolled

Study to Evaluate the Safety and Efficacy of Oral Insulin Formulation in Type 2 Diabetes Mellitus Subjects

Completed·RRoger New·Phase 2·NCT06473662·153 enrolled

Hyperglycemia13 trials

Intensive Insulin Therapy as Therapeutic Strategy for Non-diabetic Hyperglycemia After Surgery in ICU

Completed·TTanta University·N/A·NCT04554615·86 enrolled

Hyperglycemia in Renal Transplantation

Completed·UUniversity of California, San Francisco·N/A·NCT01643382·60 enrolled

Dipeptidyl Peptidase-4 Inhibitor (DPP4i) for the Control of Hyperglycemia in Patients With COVID-19

Completed·HHospital Regional de Alta Especialidad del Bajio·Phase 3·NCT04542213·70 enrolled

Show 10 more trials

Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

Completed·UUniversity of Virginia·Phase 1·NCT03520569·15 enrolled

Insulin Therapy for Postreperfusion Hyperglycemia

Recruiting·SSeoul National University Hospital·Phase 4·NCT03152890·20 enrolled

The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia

Unknown status·GGuangdong Provincial People's Hospital·Phase 4·NCT02806999·200 enrolled

Control of Hyperglycemia After Cardiac Surgery: CHyCS Trial

Terminated·UUniversity of Sao Paulo·Phase 3·NCT02574156·500 enrolled

ß-Cell Function and Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients With Moderate Hyperglycemia

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT01717911·160 enrolled

Comparison of 2 Hyperglycemia-correction Scales in Hospitalized Patients

Completed·—·Phase 4·NCT05752929·116 enrolled

Hyperglycemia in a Coronary Intensive Care Unit

Completed·—·N/A·NCT00984737

Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly

Completed· Novartis logo

Novartis·Phase 4·NCT02060383·249 enrolled

Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia

Completed·—·Phase 4·NCT01269047·37 enrolled

Prospective Study of Personalized Approach to Inpatient Patients With Hyperglycemia

Completed·HH. Lee Moffitt Cancer Center and Research Institute·Phase 1·NCT03904199·9 enrolled

Gestational Diabetes11 trials

Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus

Completed·SServices Institute of Medical Sciences, Pakistan·Phase 3·NCT03320694·278 enrolled

Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes

Recruiting·TThomas Jefferson University·N/A·NCT06419777·430 enrolled

Gestational Diabetes and Pharmacotherapy (GAP)

Active, not recruiting·MMedical College of Wisconsin·Phase 4·NCT03527537·416 enrolled

Show 8 more trials

Late Metabolic Effects of Metformin Therapy in Gestational Diabetes

Completed·TTurku University Hospital··NCT02417090·173 enrolled

Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes

Withdrawn·—·Phase 4·NCT00160485

Metformin Versus Insulin in Gestational Diabetes

Completed·TTurku University Hospital·Phase 4·NCT01240785·221 enrolled

Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT00835861·31 enrolled

A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS

Completed·UUniversity of Edinburgh·Phase 3·NCT02080377·23 enrolled

Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus

Completed·UUniversity of Oulu·Phase 2/3·NCT01087866·97 enrolled

Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country

Unknown status·—·Phase 2/3·NCT01855763·300 enrolled

Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus

Terminated·WWomen and Infants Hospital of Rhode Island·Phase 3·NCT03651531·1 enrolled

82 more indications

Type 1 Diabetes Mellitus7 trials

Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus

Completed·—·Phase 2·NCT03111433·49 enrolled

Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus

Completed·—·Phase 4·NCT01235819·20 enrolled

Safety and Efficacy of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes Mellitus.

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00063128·119 enrolled

Show 4 more trials

A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Single Dose of SAR438544 in Comparison to Glucagon in Type 1 Diabetes Mellitus Patients Under Induced Hypoglycemia

Withdrawn· Sanofi logo

Sanofi·Phase 1·NCT02635243

Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus

Completed·MMontefiore Medical Center·Phase 4·NCT00442767·8 enrolled

Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00419562·560 enrolled

A Study for Patients With Type 1 Diabetes Mellitus

Completed· Eli Lilly logo

Eli Lilly·Phase 2/3·NCT00447213·70 enrolled

Diabetes Mellitus5 trials

Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus

Unknown status·SSecond Xiangya Hospital of Central South University·Phase 4·NCT03011008·20 enrolled

Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)

Completed·VVA Office of Research and Development·Phase 3·NCT00032487·1,791 enrolled

To Estimate the Percentage of Children and Adolescents in Tunisia With Acceptably Controlled Diabetes Mellitus Type 1

Completed· Novo Nordisk logo

Novo Nordisk··NCT01493388·402 enrolled

Show 2 more trials

Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation

Completed·NNorthwell Health·Phase 1·NCT04742023·40 enrolled

Liraglutide or Insulin in Real Life Usage in Patients With Diabetes Mellitus Type 2

Completed· Novo Nordisk logo

Novo Nordisk··NCT01484262·1,344 enrolled

ESS5 trials

Study of Nasal Insulin to Fight Forgetfulness - Device Study

Completed·WWake Forest University Health Sciences·Phase 2·NCT03857321·20 enrolled

Aggressive Versus Moderate Glycemic Control in Diabetic Coronary Bypass Patients

Completed·AAmerican Heart Association·Phase 1·NCT00576394·108 enrolled

French Observational Survey to Assess Hypoglycaemia in Insulin-treated Diabetic Patients

Completed· Novo Nordisk logo

Novo Nordisk··NCT01628341·4,424 enrolled

Show 2 more trials

Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)

Completed·WWake Forest University Health Sciences·Phase 2·NCT01595646·37 enrolled

The Suppression of Toll Like Receptors by Insulin

Completed·UUniversity at Buffalo·N/A·NCT01151605·30 enrolled

Treatment3 trials

A Study to Evaluate a Potassium Normalization Treatment Regimen Including Sodium Zirconium Cyclosilicate (ZS) Among Patients With S-K ≥5.8

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT03337477·70 enrolled

Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy.

Withdrawn·UUniversity of Alberta·Phase 2/3·NCT05321251

Effect of 13-Week Treatment With Vildagliptin as Add-On Therapy to Improve Glucose Variability in Type II Diabetes

Terminated· Novartis logo

Novartis·Phase 4·NCT01862263·191 enrolled

Acute Myocardial Infarction3 trials

Intensive Insulin Therapy in Non-diabetic Patients With Acute Myocardial Infarction and Hyperglycaemia

Completed·HHospital Clinic of Barcelona·Phase 4·NCT00362778·28 enrolled

Tight Glycemic Control Increases Cardiac Stem Cells During Acute Myocardial Infarction

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00863629·65 enrolled

Impact of Tight Glycaemic Control in Acute Myocardial Infarction

Terminated·MMelbourne Health·Phase 4·NCT00237471·40 enrolled

Cystic Fibrosis3 trials

Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis

Terminated·NNational Center for Research Resources (NCRR)··NCT00014768·36 enrolled

Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes

Completed·JJagdeesh Ullal·Phase 4·NCT04533646·13 enrolled

Study on the Efficacy of Slow Release Insulin in Cystic Fibrosis Patients With Glucide Intolerance and Clinical Decay

Unknown status·FFondazione per la ricerca sulla Fibrosi Cistica·Phase 3·NCT00687466·70 enrolled

Autoimmune Diabetes3 trials

Safety Study and Therapeutic Effects of Umbilical Cord Blood Treg on Autoimmune Diabetes

Unknown status·SSecond Xiangya Hospital of Central South University·Phase 1/2·NCT02932826·40 enrolled

Protective Effects of Sitagliptin on β Cell Function in Patients With Adult-onset Latent Autoimmune Diabetes (LADA)

Completed·EEuropean Foundation for the Study of Diabetes·Phase 1/2·NCT01159847·30 enrolled

GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)

Completed·TTechnical University of Munich·Phase 2·NCT03364868·1,050 enrolled

Critically Ill Patients2 trials

Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients

Active, not recruiting·KKU Leuven·Phase 3·NCT03665207·9,230 enrolled

Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients

Recruiting·RRabin Medical Center·N/A·NCT03510078·600 enrolled

Hypoglycemia2 trials

Insulin-based Strategies to Prevent Hypoglycemia During Exercise

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT03349489·20 enrolled

Mechanisms for Restoration of Hypoglycemia Awareness

Completed·YYale University·Phase 1·NCT03738852·55 enrolled

Renal Transplantation2 trials

IV Insulin Protocol in Diabetes and Renal Transplantation

Completed·MMedical University of South Carolina·N/A·NCT00609986·104 enrolled

Linagliptin in Post-renal Transplantation

Completed·UUniversidad de Guanajuato··NCT03970668·28 enrolled

Wound Healing2 trials

Topical Insulin for Postoperative Wound Healing

Active, not recruiting·—·N/A·NCT06400082·74 enrolled

Effect of Insulin on Wound Healing-A Randomized Controlled Trial

Unknown status·MMinistry of Health, Bahrain·Phase 4·NCT04390815·30 enrolled

Beta-cell Function2 trials

Effects of Cofrogliptin on Beta-Cell Function in LADA Patients

Not yet recruiting·SSecond Xiangya Hospital of Central South University·N/A·NCT07460336·84 enrolled

Intervention to Preserve Beta-Cell Function in GAD Ab-Positive Diabetes

Completed·TTokyo Study Group·N/A·NCT00232375·42 enrolled

Insulin Secretion2 trials

Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion

Withdrawn·MMayo Clinic·Phase 4·NCT03998709

Effect of LY2189265 on Insulin Secretion in Response to Intravenous Glucose

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01300260·32 enrolled

Liver Transplant2 trials

Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion During Liver Transplantation

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·N/A·NCT05589441·100 enrolled

Study of Glycemic Control on Liver Transplantation Outcomes

Completed·NNorthwestern University·Phase 4·NCT01211730·164 enrolled

Intensive Care Unit2 trials

Glucontrol Study: Comparing the Effects of Two Glucose Control Regimens by Insulin in Intensive Care Unit Patients

Completed·UUniversity of Liege·N/A·NCT00107601·3,500 enrolled

Comparing Two Ways of Controlling Blood Sugar With Insulin in Patients Admitted to the Intensive Care Unit

Completed·MMayo Clinic·N/A·NCT00166491·238 enrolled

Diabetes2 trials

PK/PD Study of Intranasal Insulin in Type I Diabetes

Unknown status·—·Phase 1·NCT01201278·20 enrolled

How to be Safe With Alcoholic Drinks in Diabetes

Withdrawn·KKinderkrankenhaus auf der Bult·N/A·NCT02518022

Clinical Trial2 trials

Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye

Completed·BBarbara Burgos Blasco·Phase 4·NCT05692739·116 enrolled

A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With COPD

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00138671·105 enrolled

Pregnancy2 trials

Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy

Completed·—·Phase 4·NCT05479214·150 enrolled

Effect of Adding Metformin to Insulin Therapy on Pregnancy Outcomes in Women With Uncontrolled Type I Diabetes.

Completed·KKasr El Aini Hospital·Phase 4·NCT03928340·80 enrolled

Metabolism2 trials

A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism

Completed·IIndiana University·N/A·NCT02563834·18 enrolled

Insulin on Post Burn Hypermetabolism

Completed·UUnited States Army Institute of Surgical Research·N/A·NCT00137254·14 enrolled

Growth Hormone Deficiency2 trials

Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency

Completed·AAEterna Zentaris·Phase 3·NCT02558829·157 enrolled

A Study of GS3-007a for Oral Suspension in the Diagnosis of Adult Growth Hormone Deficiency (AGHD)

Not yet recruiting· Changchun GeneScience Pharmaceutical Co., Ltd. logo

Changchun GeneScience Pharmaceutical Co., Ltd.·Phase 2·NCT07259564·120 enrolled

Lip2 trials

Regional Lipolysis Insulin Regulation

Recruiting·MMayo Clinic·Phase 1·NCT06392854·48 enrolled

The Effect of Intranasal Insulin on Hepatic and Intestinal Triglyceride-rich Lipoprotein Production

Completed·UUniversity Health Network, Toronto·Phase 2/3·NCT03141827·9 enrolled

Diabetic Foot2 trials

Topical Insulin Dressing on Management of Diabetic Foot Ulcers

Completed·—·N/A·NCT07432581·30 enrolled

Intensive Versus Conventional Glycemic Control in Diabetic Foot Ulcer Healing

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·N/A·NCT03740581·50 enrolled

Heart Failure2 trials

The Effect of Hyperglycemia on LV Function and Exercise Capacity in Diabetics With and Without Heart Failure.

Completed·UUniversity of Aarhus·Phase 2·NCT01071772·18 enrolled

Dapagliflozin in Diabetic Patients (Type 2) With Decompensated Heart Failure

Completed·—·Phase 4·NCT04385589·100 enrolled

AIN2 trials

Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia

Completed·NNorthwestern University·Phase 1·NCT00993057·120 enrolled

The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)

Completed·UUniversity of Southern California·Phase 2/3·NCT01767909·240 enrolled

Outcome2 trials

Clinical and Angiographic Outcomes With Hyperglycemic Control Post PCI

Completed·HHamilton Health Sciences Corporation·N/A·NCT00412126·240 enrolled

To Evaluate Clinical Outcome and Injection Compliance of Scilin

Completed· Bayer logo

Bayer··NCT01588639·2,683 enrolled

Metformin2 trials

GDM: Insulin with or Without Metformin?

Recruiting·UUniversity of Virginia·Phase 4·NCT06781775·130 enrolled

Comparative Effects of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta

Completed·UUniversity of Karachi·N/A·NCT04907708·156 enrolled

Stroke1 trial

SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points

Completed·UUniversity of Glasgow·Phase 2·NCT00124826·45 enrolled

Acute Pancreatitis1 trial

Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis

Unknown status·UUniversity Medical Centre Ljubljana·Phase 4·NCT05487833·30 enrolled

Low Birth Weight1 trial

Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion

Unknown status·NNational Center for Research Resources (NCRR)·N/A·NCT00005889·96 enrolled

Breast Cancer1 trial

Insulin Sensitivity After Breast Cancer

Recruiting·UUniversity of Copenhagen·N/A·NCT05010356·24 enrolled

Stent Restenosis1 trial

Tight Glycemic Control During Angioplasty Revascularization Reduces Coronary Stent Restenosis

Completed·UUniversity of Campania Luigi Vanvitelli·N/A·NCT01016509·200 enrolled

Observational Study1 trial

Observational Study of Drug Naive Diabetes Receiving Insulin Therapy

Unknown status·TThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School··NCT03710811·150 enrolled

Hypertriglyceridemia1 trial

Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis

Unknown status·PPeking Union Medical College Hospital·Phase 4·NCT03342807·220 enrolled

Completed·UUniversity of Missouri-Columbia·Phase 1·NCT05244694·28 enrolled

Erectile Dysfunction1 trial

Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients

Completed·—·Phase 4·NCT01468519·20 enrolled

Closed-Loop1 trial

Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02626936·10 enrolled

Empagliflozin1 trial

Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT03429543·175 enrolled

Adult1 trial

Insulin Modulation of fMRI Connectivity in Healthy Adults

Withdrawn·UUniversity of Pittsburgh·Phase 1·NCT02982551

Neuropathic Pain1 trial

Clinical Study on the Improvement of Diabetic Neuropathic Pain by Liraglutide

Unknown status·FFudan University·N/A·NCT04137328·60 enrolled

Hyaluronic Acid1 trial

Insulin Versus Hyaluronic Acid in Management of Periodontal Defects

Unknown status·OOctober University for Modern Sciences and Arts·Phase 3·NCT05746676·30 enrolled

Efficacy and Safety1 trial

Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients

Completed· Novartis logo

Novartis·Phase 4·NCT02002221·156 enrolled

Dapagliflozin1 trial

The Potential of Dapagliflozin Plus Exenatide in Obese Insulin-resistant Patients

Terminated·UUniversitätsklinikum Hamburg-Eppendorf·Phase 3·NCT03419624·13 enrolled

Angiogenesis1 trial

Effects of Local Insulin on Wound Angiogenesis

Unknown status·HHospital Central "Dr. Ignacio Morones Prieto"·Phase 3·NCT02396888·20 enrolled

Oral1 trial

Study of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic Agents

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00099333·49 enrolled

Infusion1 trial

Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation

Completed·TTemple University·Phase 4·NCT00779701·27 enrolled

COVID-191 trial

Can Intensive Insulin Therapy Improve Outcomes of COVID-19 Patients

Completed·—·Phase 1·NCT05441631·436 enrolled

Memory1 trial

Mechanisms of Insulin Facilitation of Memory

Completed·UUniversity of Texas at Austin·N/A·NCT01145482·12 enrolled

Ischemic stroke1 trial

Efficacy and Safety of Continuous Intravenous Versus Usual Subcutaneous Insulin in Acute Ischemic Stroke

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 2/3·NCT00472381·180 enrolled

Local Anesthetic1 trial

Effect of Ultrasonographic Guided Insulin Injection With Dexamethasone and Local Anesthetic Mixture in Diabetic Patients With Mild to Moderate Carpal Tunnel .

Unknown status·MMinia University·N/A·NCT04781777·250 enrolled

Intravenous Administration1 trial

A Study of MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT02012166·18 enrolled

Phase II1 trial

Phase II Study of Safety and Feasibility of Intensive Blood Glucose Control With Insulin on Acute Medical Wards

Completed·SSt George's, University of London·Phase 2·NCT00764556·20 enrolled

Parkinson's Disease1 trial

The Effect of Intranasal Insulin on Motor and Non-motor Symptoms in Parkinson's Disease Patients

Completed·Ddr.dargahi·Phase 2·NCT04687878·28 enrolled

Impaired glucose tolerance1 trial

Use of the Insulin Pump in Cystic Fibrosis Patients With Impaired Glucose Tolerance or CFRD and in Type 1 Diabetes Patients.

Withdrawn·UUniversity of Texas Southwestern Medical Center·N/A·NCT00287456

Safety and Efficacy1 trial

Safety And Efficacy Of Exubera Compared With Subcutaneous Human Insulin Therapy In Children And Adolescents

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00479258·2 enrolled

Humans1 trial

Intra-Arterial Microdosing: Proof-of-Concept in Humans

Completed·—·Phase 1·NCT02304211·10 enrolled

Obesity1 trial

Natriuretic Peptides and Metabolic Risk in Obesity

Withdrawn·VVanderbilt University Medical Center·Phase 1·NCT02642523

Prospective1 trial

Diabetes in the Elderly: Prospective Study

Completed·GGuillermo Umpierrez·Phase 4·NCT01131052·150 enrolled

ARDS1 trial

Early Insulin and Development of ARDS

Completed·—·Phase 2·NCT00605696·18 enrolled

Vascular Function1 trial

INSUlin Regimens and VASCular Functions

Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT01022658·42 enrolled

Carpal Tunnel Syndrome1 trial

Combined Effect of Insulin and Sodium Hyaluronate Injection Guided by Ultrasound in Carpal Tunnel Syndrome

Unknown status·—·Phase 1·NCT04142411·90 enrolled

Diabetic Retinopathy1 trial

The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp

Completed·MMedical University of Vienna·Phase 2·NCT00814008·64 enrolled

Intensive Care Units1 trial

Blood Glucose Management in Intensive Care Units

Unknown status·FFrench Society for Intensive Care··NCT05775770·525 enrolled

Multiple Sclerosis1 trial

Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis

Completed·JJohns Hopkins University·Phase 1/2·NCT02988401·105 enrolled

Type 1 Diabetic1 trial

Insulin Exposure and Glucose Response to Meals in Type 1 Diabetic Subjects Administered Two Different Insulin Regimens Compared to the Endogenous Insulin Exposure and Glucose Response to Meals In Healthy Adult Controls

Completed·VVanderbilt University·N/A·NCT00927524·24 enrolled

Combination Therapy1 trial

Study of Combination Therapy With SYR-322

Completed· Takeda logo

Takeda·Phase 3·NCT01521962·67 enrolled

Major Non-cardiac Surgery1 trial

The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT Trial))

Terminated·Dd sessler·N/A·NCT00995501·381 enrolled

Trial1 trial

TOFO Insulin Combination Trial

Completed· Sanofi logo

Sanofi·Phase 4·NCT02201004·211 enrolled

Hormonal Response1 trial

To Evaluate the Hormonal Response to Low Blood Sugar After a Single Oral Dose of AZD1656 Suspension

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT00790153·12 enrolled

Cardiac Surgery1 trial

SPECS: Safe Pediatric Euglycemia in Cardiac Surgery

Completed·—·N/A·NCT00443599·989 enrolled

Hepatitis1 trial

A Pilot Study to Assess the Safety of Oral Insulin in Patients With Nonalcolholic Steatohepatitis (NASH)

Completed·OOramed, Ltd.·Phase 2·NCT02653300·10 enrolled

Fusion Rate1 trial

Flat and Circadian Insulin Infusion Rates in Continuous Subcutaneous Insulin Infusion

Completed·IImperial College London·N/A·NCT04267770·17 enrolled

Insulin resistance1 trial

Investigating the Insulin Resistance in Individuals With Type 2 Diabetes

Recruiting·—·N/A·NCT06428968·30 enrolled

Cognitive Function1 trial

Effect of Single Dose Intranasal Insulin On Cognitive Function

Completed·UUniversity of Massachusetts, Worcester·Phase 4·NCT00646581·30 enrolled

Diabetic Ketoacidosis1 trial

Subcutaneous Aspart Insulin to Treat Diabetic Ketoacidosis (DKA) and Beta-Hydroxybutyrate Testing in DKA

Completed·RRush University Medical Center·N/A·NCT00920725·50 enrolled

Asthma1 trial

A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With Asthma

Completed· Pfizer logo

Pfizer·Phase 3·NCT00139659·288 enrolled

Neurosurgical Patients1 trial

Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT00505505·800 enrolled

Glaucoma1 trial

Topical Insulin for Glaucoma

Recruiting·SStanford University·Phase 1·NCT05206877·52 enrolled

Congestive Heart Failure1 trial

Glycemic Control and Variability for Congestive Heart Failure Exacerbation

Completed·KKathleen Dungan·Phase 1/2·NCT00812487·75 enrolled

POI1 trial

Pre-POINT-Early Study

Completed·TTechnical University of Munich·Phase 2·NCT02547519·44 enrolled

Unspecified7 trials

Physiologic Response to Glucagon at Varying Insulin Levels

Completed·LLegacy Health System·N/A·NCT01483651·11 enrolled

Short-Term Intensive Insulin Therapy Induction of Long-term Glycemic Control

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT00506194·60 enrolled

Januvia Re-examination Study (MK-0431-181)

Completed· Merck & Co. logo

Merck & Co.··NCT01062048·3,483 enrolled

Show 4 more trials

Effects of Glucagon Administration on Energy Expenditure

Completed·—·Phase 1·NCT02237053·6 enrolled

SNIFF - 3-Week Aptar CPS Device

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT05006599

Fr1da Insulin Intervention

Completed·TTechnical University of Munich·Phase 2·NCT02620072·220 enrolled

Performance Evaluation of Blood Glucose Monitoring Systems

Completed·IIKFE Institute for Clinical Research and Development·Phase 4·NCT01504620·106 enrolled

Sources

References

[1]
ClinicalTrials.gov — 297 trial records for Insulin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Insulin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Insulin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Merck & Co.

Insulin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2027

Trials by Indication[1]

Type 1 Diabetes17 trials

Type 2 Diabetes16 trials

Type 2 Diabetes Mellitus14 trials

Hyperglycemia13 trials

Gestational Diabetes11 trials

Type 1 Diabetes Mellitus7 trials

Diabetes Mellitus5 trials

ESS5 trials

Treatment3 trials

Acute Myocardial Infarction3 trials

Cystic Fibrosis3 trials

Autoimmune Diabetes3 trials

Critically Ill Patients2 trials

Hypoglycemia2 trials

Renal Transplantation2 trials

Wound Healing2 trials

Beta-cell Function2 trials

Insulin Secretion2 trials

Liver Transplant2 trials

Intensive Care Unit2 trials

Diabetes2 trials

Clinical Trial2 trials

Pregnancy2 trials

Metabolism2 trials

Growth Hormone Deficiency2 trials

Lip2 trials

Diabetic Foot2 trials

Heart Failure2 trials

AIN2 trials

Outcome2 trials

Metformin2 trials

Stroke1 trial

Acute Pancreatitis1 trial

Low Birth Weight1 trial

Breast Cancer1 trial

Stent Restenosis1 trial

Observational Study1 trial

Hypertriglyceridemia1 trial

Function1 trial

Kidney Transplant1 trial

Vasoconstriction1 trial

Erectile Dysfunction1 trial

Closed-Loop1 trial

Empagliflozin1 trial

Adult1 trial

Neuropathic Pain1 trial

Hyaluronic Acid1 trial

Efficacy and Safety1 trial

Dapagliflozin1 trial

Angiogenesis1 trial

Oral1 trial

Infusion1 trial

COVID-191 trial

Memory1 trial

Ischemic stroke1 trial

Local Anesthetic1 trial

Intravenous Administration1 trial

Phase II1 trial

Parkinson's Disease1 trial

Impaired glucose tolerance1 trial

Safety and Efficacy1 trial

Humans1 trial

Obesity1 trial

Prospective1 trial

ARDS1 trial

Vascular Function1 trial

Carpal Tunnel Syndrome1 trial

Diabetic Retinopathy1 trial

Intensive Care Units1 trial

Multiple Sclerosis1 trial

Type 1 Diabetic1 trial

Combination Therapy1 trial