Insulin

Phase 3Small molecule

Merck & Co.

Insulin is one of 557 small molecule programs targeting Hyperglycemia. It is currently in Phase 3.

Indications

304

Total Trials

Active Trials

556

Competitors

Pipeline

Status by Indication[3][1]

Indication

HyperglycemiaUnknown status

Metabolic SyndromeActive, not recruiting

Diabetic KetoacidosisActive, not recruiting

Neuropathic PainActive, not recruiting

Diabetic FootActive, not recruiting

NeuropathyActive, not recruiting

Impaired Glucose ToleranceActive, not recruiting

AneurysmActive, not recruiting

Kidney TransplantActive, not recruiting

SepsisActive, not recruiting

HyperglycemiaPhase 3

Unknown status

Metabolic SyndromePreclinical

Active, not recruiting

Diabetic KetoacidosisPreclinical

Active, not recruiting

Neuropathic PainPreclinical

Active, not recruiting

Diabetic FootPreclinical

Active, not recruiting

NeuropathyPreclinical

Active, not recruiting

Impaired Glucose TolerancePreclinical

Active, not recruiting

AneurysmPreclinical

Active, not recruiting

Kidney TransplantPreclinical

Active, not recruiting

SepsisPreclinical

Active, not recruiting

Showing 10 of 24 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Insulin

Merck & Co.

Phase 3

1 2

Lexiscan

Astellas

Preclinical

1 3

Zolymbus

AbbVie

Preclinical

1 4

Blenoxane

Bristol-Myers Squibb

Preclinical

1 5

Duragesic-100

CCephalon

Preclinical

2 6

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 7

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 8

Acupan

YYonsei University

Preclinical

1 9

Vfend

PPrism Pharmaceuticals

Rilvegostomig

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Critically Ill Patients

NCT03510078

Phase 3Active, not recruiting

Critically Ill Patients

NCT03665207

N/AActive, not recruiting

Metabolic Syndrome

NCT02653092

Phase 1Recruiting

Glaucoma

NCT05206877

Q2 2027

Post-ApprovalRecruiting

Metformin

NCT06781775

Post-ApprovalNot yet recruiting

Type 1 Diabetes

NCT07293715

Clinical

Trials by Indication[1]

Type 2 Diabetes Mellitus19 trials

A Study To Assess GW677954 Used In Combination With Insulin In Subjects Who Have Type 2 Diabetes Mellitus

Terminated· GSK logo

GSK·Phase 2·NCT00437164·1 enrolled

Autologous Stem Cell and Hyperbaric Oxygen Therapy in Type 2 Diabetes Mellitus

Completed·RRodolfo Alejandro·Phase 1/2·NCT01786707·2 enrolled

Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT03170544·69 enrolled

Show 16 more trials

Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery

Completed·IImperial College London·N/A·NCT01257087·35 enrolled

Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT02036515·464 enrolled

Cardiovascular Outcomes in Participants With Type 2 Diabetes Mellitus (T2DM)

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT03249506·25,358 enrolled

Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT04029480·166 enrolled

Study of TAK-559 in Treating Subjects With Type 2 Diabetes Mellitus

Terminated· Takeda logo

Takeda·Phase 3·NCT00762190·348 enrolled

Preservation of Beta-cell Function in Type 2 Diabetes Mellitus

Completed·UUniversity of Texas Southwestern Medical Center·N/A·NCT00232583·58 enrolled

A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT03492580·714,582 enrolled

Effects of Sitagliptin on Type 2 Diabetes Mellitus Patients on Treatment With Metformin and Insulin

Completed·—·Phase 4·NCT01341717·440 enrolled

A Study of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus With Chronic Kidney Disease or Kidney Failure on Dialysis (MK-3102-019)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01698775·213 enrolled

Research on Human Insulin rDNA Safety and Efficacy in Patients With Type 2 Diabetes Mellitus

Completed·GGetz Pharma·Phase 4·NCT05161741·238 enrolled

Efficacy and Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 4·NCT02220920·146 enrolled

MSC and MC in Type 2 Diabetes Mellitus

Completed·FFuzhou General Hospital·Phase 1/2·NCT01719640·22 enrolled

Efficacy of Pioglitazone and Insulin in Treating Subjects With Type 2 Diabetes Mellitus and Renal Failure.

Completed· Takeda logo

Takeda·Phase 2·NCT00770640·40 enrolled

Study to Evaluate the Safety and Efficacy of Oral Insulin Formulation in Type 2 Diabetes Mellitus Subjects

Completed·RRoger New·Phase 2·NCT06473662·153 enrolled

A Study to Test MK-0941 in Adults With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Insulin (MK-0941-018)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00824616·68 enrolled

Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT02906709·184 enrolled

Type 1 Diabetes18 trials

Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes

Withdrawn·UUniversity of Virginia·Phase 1·NCT04133922

Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02855307·37 enrolled

Glycemic Variations During the Menstrual Cycle in Women With Type 1 Diabetes

Recruiting·IInstitut de Recherches Cliniques de Montreal··NCT05258292·86 enrolled

Show 15 more trials

Glucagon Response to Prandial Insulin Administration in Persons With Type 1 Diabetes

Terminated·WWashington University School of Medicine·Phase 1/2·NCT04079881·1 enrolled

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02846831·36 enrolled

Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00127634·385 enrolled

Efficacy and Safety of Inhaled Insulin Compared With Subcutaneous Human Insulin Therapy in Adults With Type 1 Diabetes

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00137046·582 enrolled

The Diabetes Prevention Trial of Type 1 Diabetes (DPT-1)

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00004984·711 enrolled

Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00356109·494 enrolled

Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02416765·15 enrolled

Role of Exenatide in Type 1 Diabetes

Completed·MMontefiore Medical Center·Phase 2·NCT00456300·11 enrolled

Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)

Not yet recruiting·OOhio State University·Phase 4·NCT07293715·44 enrolled

The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes

Unknown status·NNanjing Medical University·Phase 4·NCT02307695·184 enrolled

Novel Therapy to Preserve Beta Cell Function in New Onset Type 1 Diabetes

Terminated·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT00837759·7 enrolled

Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes

Withdrawn·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02490098

Closed-loop Control of Postprandial Glucose Levels After Meals With Different Macronutrients Content in Adults With Type 1 Diabetes

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02774876·15 enrolled

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 5 Days in Adults With Type 1 Diabetes

Withdrawn·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02488616

Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes

Completed·UUniversity of Minnesota·Phase 1·NCT02866435·27 enrolled

Type 2 Diabetes17 trials

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 24 Hours in Adults With Type 2 Diabetes Under Intensive Insulin Therapy

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02490085·15 enrolled

A Concordance Study Comparing Insulin Treatments in Patients With Type 2 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00330473·1,019 enrolled

Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulin

Unknown status·—··NCT04034524·20,000 enrolled

Show 14 more trials

Effects of Hypoglycemic Drugs on Testosterone Levels in Type 2 Diabetes Patients

Completed·MMajianhua·Phase 4·NCT03982238·74 enrolled

The Effect of Type 2 Diabetes and Dietary Regulation on VLDL1-and VLDL2-triglyceride Metabolism

Completed·UUniversity of Aarhus··NCT01564550·30 enrolled

Efficacy and Safety of Liraglutide in Combination With Insulin Therapy Compared to Insulin Alone in Japanese Subjects With Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk·Phase 3·NCT01572740·257 enrolled

Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·N/A·NCT03180281·135 enrolled

Study of Human Insulin Inhalation Powder in Patients With Type 2 Diabetes

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00325364·415 enrolled

Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes

Completed·TThe University of Texas Health Science Center, Houston·N/A·NCT00678080·25 enrolled

Efficacy and Safety of Inhaled Insulin Compared With Subcutaneous Human Insulin Therapy in Adults With Type 2 Diabetes

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00136916·635 enrolled

Oral Insulin: A Comparison With Subcutaneous Regular Human Insulin in Patients With Type 2 Diabetes

Completed·PProfil Institut für Stoffwechselforschung GmbH·Phase 1·NCT00982254·10 enrolled

The Effects of Hypoglycaemia in People With Type 2 Diabetes

Completed·UUniversity of Hull·N/A·NCT02205996·18 enrolled

Efficacy and Safety Study of Teneligliptin (MP-513) in Combination With Insulin in Patients With Type 2 Diabetes

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 4·NCT02081599·148 enrolled

Nephropathy In Type 2 Diabetes and Cardio-renal Events

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00535925·850 enrolled

Observational Study Describing Conditions for Intensification of Insulin Therapy in Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk··NCT00712478·114 enrolled

Effects of PN2034 in Insulin-Dependent Patients With Type 2 Diabetes

Completed·WWellstat Therapeutics·Phase 2·NCT00110864·90 enrolled

Efficacy and Safety Study of Alogliptin and Insulin in the Treatment of Type 2 Diabetes.

Completed· Takeda logo

Takeda·Phase 3·NCT00286429·390 enrolled

Hyperglycemia11 trials

Dipeptidyl Peptidase-4 Inhibitor (DPP4i) for the Control of Hyperglycemia in Patients With COVID-19

Completed·HHospital Regional de Alta Especialidad del Bajio·Phase 3·NCT04542213·70 enrolled

Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

Completed·UUniversity of Virginia·Phase 1·NCT03520569·15 enrolled

Insulin Therapy for Postreperfusion Hyperglycemia

Recruiting·SSeoul National University Hospital·Phase 4·NCT03152890·20 enrolled

Show 8 more trials

Hyperglycemia in a Coronary Intensive Care Unit

Completed·—·N/A·NCT00984737

Control of Hyperglycemia After Cardiac Surgery: CHyCS Trial

Terminated·UUniversity of Sao Paulo·Phase 3·NCT02574156·500 enrolled

Exenatide for Stress Hyperglycemia

Completed·—·Phase 2/3·NCT01969149·110 enrolled

Hyperglycemia in Renal Transplantation

Completed·UUniversity of California, San Francisco·N/A·NCT01643382·60 enrolled

ß-Cell Function and Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients With Moderate Hyperglycemia

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT01717911·160 enrolled

Comparison of 2 Hyperglycemia-correction Scales in Hospitalized Patients

Completed·—·Phase 4·NCT05752929·116 enrolled

The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia

Unknown status·GGuangdong Provincial People's Hospital·Phase 4·NCT02806999·200 enrolled

Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly

Completed· Novartis logo

Novartis·Phase 4·NCT02060383·249 enrolled

Gestational Diabetes10 trials

Metformin Versus Insulin in Gestational Diabetes

Completed·TTurku University Hospital·Phase 4·NCT01240785·221 enrolled

Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT00835861·31 enrolled

Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus

Terminated·WWomen and Infants Hospital of Rhode Island·Phase 3·NCT03651531·1 enrolled

Show 7 more trials

Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes

Withdrawn·—·Phase 4·NCT00160485

Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes (START 2)

Recruiting·TThomas Jefferson University·N/A·NCT06419803·430 enrolled

Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus

Completed·UUniversity of Oulu·Phase 2/3·NCT01087866·97 enrolled

Maternal Weight Gain in Gestational Diabetes Controlled by Metformin Versus Insulin

Completed·—·Phase 3·NCT03841591·124 enrolled

Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study

Unknown status·FFirst Affiliated Hospital, Sun Yat-Sen University·N/A·NCT01833559·3 enrolled

Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country

Unknown status·—·Phase 2/3·NCT01855763·300 enrolled

A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS

Completed·UUniversity of Edinburgh·Phase 3·NCT02080377·23 enrolled

87 more indications

Type 1 Diabetes Mellitus5 trials

Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus

Completed·MMontefiore Medical Center·Phase 4·NCT00442767·8 enrolled

Safety and Efficacy of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes Mellitus.

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00063128·119 enrolled

Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus

Completed· GSK logo

GSK·Phase 2·NCT02284009·67 enrolled

Show 2 more trials

Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00419562·560 enrolled

A Study for Patients With Type 1 Diabetes Mellitus

Completed· Eli Lilly logo

Eli Lilly·Phase 2/3·NCT00447213·70 enrolled

Heart Failure3 trials

Dapagliflozin in Diabetic Patients (Type 2) With Decompensated Heart Failure

Completed·—·Phase 4·NCT04385589·100 enrolled

The Effect of Hyperglycemia on LV Function and Exercise Capacity in Diabetics With and Without Heart Failure.

Completed·UUniversity of Aarhus·Phase 2·NCT01071772·18 enrolled

Effects of Metformin in Heart Failure Patients

Withdrawn·MMaya Guglin·N/A·NCT02694289

Autoimmune Diabetes3 trials

Safety Study and Therapeutic Effects of Umbilical Cord Blood Treg on Autoimmune Diabetes

Unknown status·SSecond Xiangya Hospital of Central South University·Phase 1/2·NCT02932826·40 enrolled

Safety and Efficacy of Umbilical Cord Blood Regulatory T Cells Plus Liraglutide on Autoimmune Diabetes

Unknown status·SSecond Xiangya Hospital of Central South University·Phase 1/2·NCT03011021·40 enrolled

GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)

Completed·TTechnical University of Munich·Phase 2·NCT03364868·1,050 enrolled

Cystic Fibrosis3 trials

Study on the Efficacy of Slow Release Insulin in Cystic Fibrosis Patients With Glucide Intolerance and Clinical Decay

Unknown status·FFondazione per la ricerca sulla Fibrosi Cistica·Phase 3·NCT00687466·70 enrolled

Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis

Terminated·NNational Center for Research Resources (NCRR)··NCT00014768·36 enrolled

Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes

Completed·JJagdeesh Ullal·Phase 4·NCT04533646·13 enrolled

Outcome3 trials

Normoglycemia and Neurological Outcome

Terminated·UUniversity of Louisville·Phase 4·NCT01137773·56 enrolled

Clinical and Angiographic Outcomes With Hyperglycemic Control Post PCI

Completed·HHamilton Health Sciences Corporation·N/A·NCT00412126·240 enrolled

To Evaluate Clinical Outcome and Injection Compliance of Scilin

Completed· Bayer logo

Bayer··NCT01588639·2,683 enrolled

Pregnancy3 trials

Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy

Completed·SSt. Luke's-Roosevelt Hospital Center·N/A·NCT01837680·105 enrolled

Effect of Adding Metformin to Insulin Therapy on Pregnancy Outcomes in Women With Uncontrolled Type I Diabetes.

Completed·KKasr El Aini Hospital·Phase 4·NCT03928340·80 enrolled

Diabetes in Pregnancy and Pregnancy Outcomes

Completed·TTarumanagara University··NCT03602846·45 enrolled

Diabetes Mellitus3 trials

To Estimate the Percentage of Children and Adolescents in Tunisia With Acceptably Controlled Diabetes Mellitus Type 1

Completed· Novo Nordisk logo

Novo Nordisk··NCT01493388·402 enrolled

Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation

Completed·NNorthwell Health·Phase 1·NCT04742023·40 enrolled

Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus

Unknown status·SSecond Xiangya Hospital of Central South University·Phase 4·NCT03011008·20 enrolled

Growth Hormone Deficiency2 trials

Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency

Completed·AAEterna Zentaris·Phase 3·NCT02558829·157 enrolled

A Study of GS3-007a for Oral Suspension in the Diagnosis of Adult Growth Hormone Deficiency (AGHD)

Not yet recruiting· Changchun GeneScience Pharmaceutical Co., Ltd. logo

Changchun GeneScience Pharmaceutical Co., Ltd.·Phase 2·NCT07259564·120 enrolled

Lip2 trials

Regional Lipolysis Insulin Regulation

Recruiting·MMayo Clinic·Phase 1·NCT06392854·48 enrolled

The Effect of Intranasal Insulin on Hepatic and Intestinal Triglyceride-rich Lipoprotein Production

Completed·UUniversity Health Network, Toronto·Phase 2/3·NCT03141827·9 enrolled

Obesity2 trials

Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle

Completed·UUniversity of Nottingham·N/A·NCT02305069·26 enrolled

Natriuretic Peptides and Metabolic Risk in Obesity

Withdrawn·VVanderbilt University Medical Center·Phase 1·NCT02642523

CLE2 trials

Myocellular Signalling in Skeletal Muscle

Completed·UUniversity of Copenhagen·N/A·NCT03203317·8 enrolled

Plasma Triglyceride Extraction by The Muscle

Completed·MMayo Clinic·Phase 1·NCT01860911·33 enrolled

Closed-Loop2 trials

Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation - Part 2

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02798250·11 enrolled

Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation

Completed·IInstitut de Recherches Cliniques de Montreal·Phase 2·NCT02626936·10 enrolled

COVID-192 trials

Can Intensive Insulin Therapy Improve Outcomes of COVID-19 Patients

Completed·—·Phase 1·NCT05441631·436 enrolled

Intranasal Insulin for COVID-19-related Smell Loss

Completed·—·Phase 3·NCT05461365·27 enrolled

Diabetic Foot2 trials

Topical Insulin Dressing on Management of Diabetic Foot Ulcers

Completed·—·N/A·NCT07432581·30 enrolled

Intensive Versus Conventional Glycemic Control in Diabetic Foot Ulcer Healing

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·N/A·NCT03740581·50 enrolled

Type 2 Diabetic Patients2 trials

Gastric Modulator (TANTALUS® System) Versus Insulin Treatment in Obese Type 2 Diabetic Patients - a Randomized Control Trial

Unknown status·—·Phase 3·NCT00975533·24 enrolled

A Study to Evaluate the Effect of Nasal Insulin on Postprandial Glycemic Control in Type 2 Diabetic Patients

Completed·NNastech Pharmaceutical Company, Inc.·Phase 2·NCT00624767·18 enrolled

Impaired glucose tolerance2 trials

Effect of Metformin on Disease Progression in Patients With Cryptogenic Cirrhosis (NASH-related Cirrhosis) With Diabetes or Impaired Glucose Tolerance or Insulin Resistance

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02234440·86 enrolled

Use of the Insulin Pump in Cystic Fibrosis Patients With Impaired Glucose Tolerance or CFRD and in Type 1 Diabetes Patients.

Withdrawn·UUniversity of Texas Southwestern Medical Center·N/A·NCT00287456

Critically Ill Patients2 trials

Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients

Recruiting·RRabin Medical Center·N/A·NCT03510078·600 enrolled

Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients

Active, not recruiting·KKU Leuven·Phase 3·NCT03665207·9,230 enrolled

Congestive Heart Failure2 trials

Intensive Glycemic Control for Congestive Heart Failure Exacerbation

Completed·KKathleen Dungan·Phase 2·NCT00812253·74 enrolled

Glycemic Control and Variability for Congestive Heart Failure Exacerbation

Completed·KKathleen Dungan·Phase 1/2·NCT00812487·75 enrolled

Beta-cell Function2 trials

Effects of Cofrogliptin on Beta-Cell Function in LADA Patients

Not yet recruiting·SSecond Xiangya Hospital of Central South University·N/A·NCT07460336·84 enrolled

Intervention to Preserve Beta-Cell Function in GAD Ab-Positive Diabetes

Completed·TTokyo Study Group·N/A·NCT00232375·42 enrolled

Liver Transplant2 trials

Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion During Liver Transplantation

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·N/A·NCT05589441·100 enrolled

Study of Glycemic Control on Liver Transplantation Outcomes

Completed·NNorthwestern University·Phase 4·NCT01211730·164 enrolled

Hypoglycemia2 trials

Mechanisms for Restoration of Hypoglycemia Awareness

Completed·YYale University·Phase 1·NCT03738852·55 enrolled

Liver Glycogen and Hypoglycemia in Humans

Active, not recruiting·JJason Winnick·Phase 1·NCT03241706·40 enrolled

ARDS1 trial

Early Insulin and Development of ARDS

Completed·—·Phase 2·NCT00605696·18 enrolled

Vascular Function1 trial

INSUlin Regimens and VASCular Functions

Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT01022658·42 enrolled

Hyaluronic Acid1 trial

Insulin Versus Hyaluronic Acid in Management of Periodontal Defects

Unknown status·OOctober University for Modern Sciences and Arts·Phase 3·NCT05746676·30 enrolled

Metabolism1 trial

A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism

Completed·IIndiana University·N/A·NCT02563834·18 enrolled

Angiogenesis1 trial

Effects of Local Insulin on Wound Angiogenesis

Unknown status·HHospital Central "Dr. Ignacio Morones Prieto"·Phase 3·NCT02396888·20 enrolled

Oral1 trial

Study of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic Agents

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00099333·49 enrolled

Prospective1 trial

Diabetes in the Elderly: Prospective Study

Completed·GGuillermo Umpierrez·Phase 4·NCT01131052·150 enrolled

Renal Transplantation1 trial

Linagliptin in Post-renal Transplantation

Completed·UUniversidad de Guanajuato··NCT03970668·28 enrolled

Central Nervous System1 trial

Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose

Completed·YYale University·Phase 1·NCT03469492·8 enrolled

Sepsis1 trial

Hyperinsulinemic Therapy in Sepsis

Unknown status·Ppeter metrakos·N/A·NCT01244178·15 enrolled

Completed· Takeda logo

Takeda·Phase 1·NCT01311076·37 enrolled

Hemodynamic1 trial

Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters

Completed·MMedical University of Vienna·N/A·NCT00431665·9 enrolled

Tics1 trial

A Crossover Study Assessing the Pharmacokinetics, Pharmacodynamics, and Safety of Recombinant Human Insulin

Completed·BBaxter Healthcare Corporation·Phase 1·NCT00358553

Rheumatoid Arthritis1 trial

ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients

Unknown status·—·N/A·NCT03394131·90 enrolled

Pediatric1 trial

Heart And Lung Failure - Pediatric INsulin Titration Trial

Completed·—·Phase 3·NCT01565941·713 enrolled

Metformin1 trial

GDM: Insulin with or Without Metformin?

Recruiting·UUniversity of Virginia·Phase 4·NCT06781775·130 enrolled

Major Non-cardiac Surgery1 trial

The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT Trial))

Terminated·Dd sessler·N/A·NCT00995501·381 enrolled

Hormonal Response1 trial

To Evaluate the Hormonal Response to Low Blood Sugar After a Single Oral Dose of AZD1656 Suspension

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT00790153·12 enrolled

Cardiac Surgery1 trial

SPECS: Safe Pediatric Euglycemia in Cardiac Surgery

Completed·—·N/A·NCT00443599·989 enrolled

Fusion Rate1 trial

Flat and Circadian Insulin Infusion Rates in Continuous Subcutaneous Insulin Infusion

Completed·IImperial College London·N/A·NCT04267770·17 enrolled

Clinical Trial1 trial

A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With COPD

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00138671·105 enrolled

Asthma1 trial

A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With Asthma

Completed· Pfizer logo

Pfizer·Phase 3·NCT00139659·288 enrolled

AIN1 trial

The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)

Completed·UUniversity of Southern California·Phase 2/3·NCT01767909·240 enrolled

POI1 trial

Pre-POINT-Early Study

Completed·TTechnical University of Munich·Phase 2·NCT02547519·44 enrolled

Open-Angle Glaucoma1 trial

Safety of Topical Insulin Drops for Open-angle Glaucoma

Active, not recruiting·—·Phase 1·NCT04118920·18 enrolled

Safety and Efficacy1 trial

Safety And Efficacy Of Exubera Compared With Subcutaneous Human Insulin Therapy In Children And Adolescents

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00479258·2 enrolled

Glaucoma1 trial

Topical Insulin for Glaucoma

Recruiting·SStanford University·Phase 1·NCT05206877·52 enrolled

Inflammatory Mediators1 trial

Effects of Topical Insulin on Levels of Tear Inflammatory Mediators

Unknown status·UUniversiti Kebangsaan Malaysia Medical Centre·Phase 1·NCT04877210·60 enrolled

Trial1 trial

SNIFF - Combo INI+EMPA Trial

Completed·WWake Forest University Health Sciences·Phase 2·NCT05081219·47 enrolled

Age1 trial

Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3

Completed·—··NCT04820010·20 enrolled

GLP-11 trial

Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle

Completed·UUniversity of Nottingham·N/A·NCT02370745·40 enrolled

Treatment1 trial

Treatment Use of Generex Oral-lyn™ in Patients With Diabetes

No longer available·GGenerex Biotechnology Corp.··NCT00948493

Hepatitis1 trial

A Pilot Study to Assess the Safety of Oral Insulin in Patients With Nonalcolholic Steatohepatitis (NASH)

Completed·OOramed, Ltd.·Phase 2·NCT02653300·10 enrolled

Insulin resistance1 trial

Investigating the Insulin Resistance in Individuals With Type 2 Diabetes

Recruiting·—·N/A·NCT06428968·30 enrolled

Cognitive Function1 trial

Effect of Single Dose Intranasal Insulin On Cognitive Function

Completed·UUniversity of Massachusetts, Worcester·Phase 4·NCT00646581·30 enrolled

Neuropathy1 trial

Ultrasonographic Insulin Versus Dexamethasone Injection With Local Anestheticss in Diabetic Patients With Mild to Moderate Median Nerve Entrapement Neuropathy .

Unknown status·MMinia University·N/A·NCT04781751·150 enrolled

Diabetic Ketoacidosis1 trial

Subcutaneous Aspart Insulin to Treat Diabetic Ketoacidosis (DKA) and Beta-Hydroxybutyrate Testing in DKA

Completed·RRush University Medical Center·N/A·NCT00920725·50 enrolled

Percutaneous Coronary Intervention (PCI)1 trial

Intravenous Insulin in Patients With Diabetes After Percutaneous Coronary Intervention (PCI)

Terminated·HHospital de Clinicas de Porto Alegre·N/A·NCT00967642·70 enrolled

Acute Pancreatitis1 trial

Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis

Unknown status·UUniversity Medical Centre Ljubljana·Phase 4·NCT05487833·30 enrolled

Wound Healing1 trial

Topical Insulin for Postoperative Wound Healing

Active, not recruiting·—·N/A·NCT06400082·74 enrolled

Acute Myocardial Infarction1 trial

Impact of Tight Glycaemic Control in Acute Myocardial Infarction

Terminated·MMelbourne Health·Phase 4·NCT00237471·40 enrolled

Function1 trial

High Dose Insulin Therapy to Improve Liver Function

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT01271140·5 enrolled

Vasoconstriction1 trial

Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction

Completed·UUniversity of Missouri-Columbia·Phase 1·NCT05244694·28 enrolled

Empagliflozin1 trial

Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT03429543·175 enrolled

Adult1 trial

Insulin Modulation of fMRI Connectivity in Healthy Adults

Withdrawn·UUniversity of Pittsburgh·Phase 1·NCT02982551

Phase II1 trial

Phase II Study of Safety and Feasibility of Intensive Blood Glucose Control With Insulin on Acute Medical Wards

Completed·SSt George's, University of London·Phase 2·NCT00764556·20 enrolled

Insulin Secretion1 trial

Effect of LY2189265 on Insulin Secretion in Response to Intravenous Glucose

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01300260·32 enrolled

Parkinson's Disease1 trial

The Effect of Intranasal Insulin on Motor and Non-motor Symptoms in Parkinson's Disease Patients

Completed·Ddr.dargahi·Phase 2·NCT04687878·28 enrolled

Intensive Care Unit1 trial

Glucontrol Study: Comparing the Effects of Two Glucose Control Regimens by Insulin in Intensive Care Unit Patients

Completed·UUniversity of Liege·N/A·NCT00107601·3,500 enrolled

Diabetes1 trial

PK/PD Study of Intranasal Insulin in Type I Diabetes

Unknown status·—·Phase 1·NCT01201278·20 enrolled

Humans1 trial

Intra-Arterial Microdosing: Proof-of-Concept in Humans

Completed·—·Phase 1·NCT02304211·10 enrolled

Kidney Transplant1 trial

Effects of Empagliflozin in Reducing Oxidative Stress After Kidney Transplantation

Completed·SShahid Beheshti University of Medical Sciences·N/A·NCT04918407·40 enrolled

Erectile Dysfunction1 trial

Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients

Completed·—·Phase 4·NCT01468519·20 enrolled

Diabetic Retinopathy1 trial

The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp

Completed·MMedical University of Vienna·Phase 2·NCT00814008·64 enrolled

Neurosurgical Patients1 trial

Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT00505505·800 enrolled

Effectiveness1 trial

Study of Effectiveness of Liraglutide Added to High Dose Insulin in Type II Diabetics

Completed·MMountain Diabetes and Endocrine Center·Phase 4·NCT01654120·37 enrolled

T1DM1 trial

Triple Therapy in T1DM

Active, not recruiting·SState University of New York at Buffalo·Phase 2/3·NCT03899402·78 enrolled

Metabolic Syndrome1 trial

Reprometabolic Syndrome Mediates Subfertility in Obesity

Active, not recruiting·UUniversity of Colorado, Denver·N/A·NCT02653092·84 enrolled

Memory1 trial

Mechanisms of Insulin Facilitation of Memory

Completed·UUniversity of Texas at Austin·N/A·NCT01145482·12 enrolled

Ischemic stroke1 trial

Efficacy and Safety of Continuous Intravenous Versus Usual Subcutaneous Insulin in Acute Ischemic Stroke

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 2/3·NCT00472381·180 enrolled

Physical Activity1 trial

Initial Testing of the Diabeloop Algorithm in T1D Patients on Pump Therapy Over the Prandial Period and Physical Activity.

Completed·CCentre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète·Phase 3·NCT01754181·18 enrolled

Local Anesthetic1 trial

Effect of Ultrasonographic Guided Insulin Injection With Dexamethasone and Local Anesthetic Mixture in Diabetic Patients With Mild to Moderate Carpal Tunnel .

Unknown status·MMinia University·N/A·NCT04781777·250 enrolled

Intravenous Administration1 trial

A Study of MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT02012166·18 enrolled

Unspecified9 trials

Januvia Re-examination Study (MK-0431-181)

Completed· Merck & Co. logo

Merck & Co.··NCT01062048·3,483 enrolled

Short-Term Intensive Insulin Therapy Induction of Long-term Glycemic Control

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT00506194·60 enrolled

Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose

Completed·UUniversity of Aarhus·N/A·NCT01919788·9 enrolled

Show 6 more trials

Effect of Dual-wave Insulin Bolus on Postprandial Glycaemia

Completed·—·N/A·NCT03179280·10 enrolled

Topical Insulin Versus Autologous Serum After Corneal Surgeries

Unknown status·—·Phase 1·NCT05331859·250 enrolled

SNIFF - 3-Week Aptar CPS Device

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT05006599

Performance Evaluation of Blood Glucose Monitoring Systems

Completed·IIKFE Institute for Clinical Research and Development·Phase 4·NCT01504620·106 enrolled

Fr1da Insulin Intervention

Completed·TTechnical University of Munich·Phase 2·NCT02620072·220 enrolled

Physiologic Response to Glucagon at Varying Insulin Levels

Completed·LLegacy Health System·N/A·NCT01483651·11 enrolled

Sources

References

[1]
ClinicalTrials.gov — 304 trial records for Insulin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Insulin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Insulin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Merck & Co.

Insulin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q2 2027

Trials by Indication[1]

Type 2 Diabetes Mellitus19 trials

Type 1 Diabetes18 trials

Type 2 Diabetes17 trials

Hyperglycemia11 trials

Gestational Diabetes10 trials

Type 1 Diabetes Mellitus5 trials

Heart Failure3 trials

Autoimmune Diabetes3 trials

Cystic Fibrosis3 trials

Outcome3 trials

Pregnancy3 trials

Diabetes Mellitus3 trials

Growth Hormone Deficiency2 trials

Lip2 trials

Obesity2 trials

CLE2 trials

Closed-Loop2 trials

COVID-192 trials

Diabetic Foot2 trials

Type 2 Diabetic Patients2 trials

Impaired glucose tolerance2 trials

Critically Ill Patients2 trials

Congestive Heart Failure2 trials

Beta-cell Function2 trials

Liver Transplant2 trials

Hypoglycemia2 trials

ARDS1 trial

Vascular Function1 trial

Hyaluronic Acid1 trial

Metabolism1 trial

Angiogenesis1 trial

Oral1 trial

Prospective1 trial

Renal Transplantation1 trial

Central Nervous System1 trial

Sepsis1 trial

Insulin Sensitivity1 trial

Hypertriglyceridemia1 trial

LAM1 trial

Hemodynamic1 trial

Tics1 trial

Rheumatoid Arthritis1 trial

Pediatric1 trial

Metformin1 trial

Major Non-cardiac Surgery1 trial

Hormonal Response1 trial

Cardiac Surgery1 trial

Fusion Rate1 trial

Clinical Trial1 trial

Asthma1 trial

AIN1 trial

POI1 trial

Open-Angle Glaucoma1 trial

Safety and Efficacy1 trial

Glaucoma1 trial

Inflammatory Mediators1 trial

Trial1 trial

Age1 trial

GLP-11 trial

Treatment1 trial

Hepatitis1 trial

Insulin resistance1 trial

Cognitive Function1 trial

Neuropathy1 trial

Diabetic Ketoacidosis1 trial

Percutaneous Coronary Intervention (PCI)1 trial

Acute Pancreatitis1 trial

Wound Healing1 trial

Acute Myocardial Infarction1 trial

Function1 trial

Vasoconstriction1 trial

Empagliflozin1 trial

Adult1 trial