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Infectious Disease/Helicobacter Pylori Infection

Infectious Disease

Helicobacter Pylori Infection

23

Pipeline Programs↗

24

Active Trials↗

8

Companies Involved↗

Helicobacter Pylori Infection is an emerging landscape with 23 programs across 8 companies. 4 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

54/100

Pipeline Velocity

27/100

Mech. Concentration

50/100

Completion Rate

93/100

Attrition Rate

3/100

Pipeline

Programs by Phase

Preclinical17

Three Kinds of Antibiotics

Shandong University

Bismuth Amoxilillin Potassium

Kaohsiung Medical University

Omeprazole

Dexcel Pharma Technologies Ltd.

Tinidazole

Mission Pharmacal

Tetracyline

University of Medicine and Pharmacy at Ho Chi Minh City

Phase 11

Zuojin Wan

Nanjing First Hospital, Nanjing Medical University

Phase 21

Daflon

Universitaire Ziekenhuizen KU Leuven

Phase 34

Tegoprazan

Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

Bismuth Subcitrate

University Medical Centre Ljubljana

TAK-438

Takeda

Minocycline,metronidazole

Shanghai Jiao Tong University School of Medicine

Approved

No programs

Analysis

Trial Status

101

clinical trials

Completed43 · 43%

Unknown status31 · 31%

Not yet recruiting10 · 10%

Recruiting10 · 10%

Active, not recruiting2 · 2%

Withdrawn2 · 2%

Other3 · 3%

Clinical Trials

Trial Activity

101 trials

Vonoprazan-Amoxicillin Dual Sequential Therapy For Helicobacter Pylori-infected Treatment-naive Patients：A Randomized, Open-label, Parallel-controlled , Multicenter Clinical Trial

Recruiting·TThe First Affiliated Hospital with Nanjing Medical University·Approved·NCT06929962·600 enrolled

Study on the Effect of Fecal Microbiota Transplantation on Eradication of Refractory Helicobacter Pylori Infection

Recruiting·SSichuan Provincial People's Hospital·Approved·NCT07704255·10 enrolled

Application of Artificial Intelligence on the Diagnosis of Helicobacter Pylori Infection and Premalignant Gastric Lesion: A Randomized Clinical Trial

Recruiting·NNational Taiwan University Hospital·N/A·NCT05762991·6,000 enrolled

Comparison of Vonoprazan-based Versus Lansoprazole-based Triple Therapy, High Dose Dual Therapy, Bismuth and Non-bismuth Quadruple Therapy in the First-line Treatment of Helicobacter Pylori Infection

Recruiting·NNational Taiwan University Hospital·Phase 4·NCT04713670·1,200 enrolled

High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection

Recruiting·SShanghai Jiao Tong University School of Medicine·Phase 4·NCT06561698·200 enrolled

Optimization of Keverprazan-amoxicillin Dual Therapy for Eradicating Helicobacter Pylori Infection

Recruiting·—·Phase 3·NCT06734260·477 enrolled

Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection

Recruiting·TTanta University·N/A·NCT07165444·320 enrolled

Efficacy of Vonoprazan Based Dual and Triple Therapy for Patient With Helicobacter Pylori Infection

Recruiting·SSohag University·N/A·NCT07045688·150 enrolled

Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection

Recruiting·NNational Taiwan University Hospital·Phase 4·NCT05332444·450 enrolled

Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection

Recruiting·SSadat City University·Phase 1/2·NCT06546111·46 enrolled

Efficacy and Safety of Black Seed Oil With Vonoprazan Based Triple Therapy in Treatment of Helicobacter Pylori

Active, not recruiting·AAin Shams University·Phase 2·NCT05957432·90 enrolled

Lignin in Treatment of Helicobacter Pylori Infection

Active, not recruiting·ZZagazig University·Phase 3·NCT07246681·70 enrolled

Clinical Efficacy and Gut Microbiota Effects of High-Dose Single-Strain and Multi-Strain Bacillus Probiotics as Adjunctive Therapy to Bismuth Quadruple Therapy for Helicobacter Pylori Eradication: A Randomised, Double-Blind, Placebo-Controlled Trial

Not yet recruiting·AAnabio R&D·Preclinical·NCT07827170·336 enrolled

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Helicobacter Pylori-Associated Gastritis

Not yet recruiting·AAssiut University·N/A·NCT07805005·90 enrolled

Comparison of Metronidazole- and Tinidazole-Based Bismuth Quadruple Regimens for Helicobacter Pylori Eradication

Not yet recruiting·UUniversity of Medicine and Pharmacy at Ho Chi Minh City·Preclinical·NCT07746934·600 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)