Prilosec

(Omeprazole)

ApprovedSmall molecule

Omeprazole reduces stomach acid to treat heartburn, acid reflux, and ulcers. It helps relieve the pain and discomfort caused by excess stomach acid.[2] Prilosec is currently approved and in use across 88 indications[4].[1]

Prilosec is one of 1613 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

274

Total Trials

Active Trials

1,612

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Coronary Artery DiseaseActive, not recruiting

GastroparesisActive, not recruiting

HIV InfectionApproved

GranulomaActive, not recruiting

DyspepsiaApproved

HypoalbuminemiaActive, not recruiting

Breast DiseaseActive, not recruiting

CysticercosisActive, not recruiting

Duodenal UlcerActive, not recruiting

Venous ThromboembolismActive, not recruiting

Coronary Artery DiseasePreclinical

Active, not recruiting

GastroparesisApproved

Active, not recruiting

HIV InfectionApproved

Approved

GranulomaPhase 2

Active, not recruiting

DyspepsiaApproved

Approved

HypoalbuminemiaApproved

Active, not recruiting

Breast DiseaseApproved

Active, not recruiting

CysticercosisPhase 3

Active, not recruiting

Duodenal UlcerPhase 3

Active, not recruiting

Venous ThromboembolismPhase 3

Active, not recruiting

Showing 10 of 85 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Prilosec

DDexcel Pharma Technologies Ltd.

Approved

4 2

Cymbalta

Alnylam Pharmaceuticals

Preclinical

3 3

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 4

Avastin

Roche

Preclinical

4 5

Zoladex

Luye Pharma Group Ltd.

Preclinical

8 6

Fentanyl Citrate

IINSYS Therapeutics Inc

Preclinical

2 7

Perflutren Lipid Microsphere

IImaRx Therapeutics

Preclinical

1 8

Iniparib

Sanofi

Preclinical

6 9

Ablavar

LLantheus Medical Imaging

Preclinical

2 10

Promestriene

UUniversity of Sao Paulo General Hospital

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Dysbiosis

NCT05517928

Q3 2027

Phase 1Recruiting

Pancreatic Cancer

NCT04930991

Clinical

Trials by Indication[1]

Interaction21 trials

Interaction of BI 425809 With Midazolam, Warfarin, Omeprazole and Digoxin

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02783040·13 enrolled

Pharmacokinetic Drug-Drug Interaction Study of Rucaparib

Completed·Ppharmaand GmbH·Phase 1·NCT02740712·17 enrolled

Voxelotor CYP and Transporter Cocktail Interaction Study

Completed· Pfizer logo

Pfizer·Phase 1·NCT05981365·44 enrolled

Show 18 more trials

Interaction Study of Clopidogrel 600/150 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects

Completed· Sanofi logo

Sanofi·Phase 1·NCT01129414·72 enrolled

Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study

Withdrawn· Takeda logo

Takeda·Phase 4·NCT02760615

A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196

Completed·AAcerta Pharma BV·Phase 1·NCT04914936·72 enrolled

Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT01517399·28 enrolled

A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02638116·20 enrolled

Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Completed·KKadmon Corporation, LLC·Phase 1·NCT03530995·73 enrolled

Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation

Completed· GSK logo

GSK·Phase 1·NCT00964106·87 enrolled

Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and Rifampin

Completed·GGuangdong Raynovent Biotech Co., Ltd·Phase 1·NCT06031454·56 enrolled

GSK1349572 Proton Pump Inhibitor Drug Interaction and Supratherapeutic Dose Study

Completed· GSK logo

GSK·Phase 1·NCT00942136·24 enrolled

A Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05852769·18 enrolled

Interaction Between Omeprazole and Gliclazide in CYP2C19 Normal/ Ultrarapid Metabolisers

Completed·UUniversity of Sarajevo·Phase 1·NCT04198948·15 enrolled

Drug-drug Interaction Study of KL1333 in Healthy Subjects

Completed·AAbliva AB·Phase 1·NCT04643249·14 enrolled

Interaction Study of Clopidogrel 300/75 mg Given Alone or With Omeprazole 80 mg 12 Hours Apart in Healthy Subjects

Completed· Sanofi logo

Sanofi·Phase 1·NCT01129388·72 enrolled

Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants

Completed·IInstitut de Recherches Internationales Servier (I.R.I.S.)·Phase 1·NCT07235748·28 enrolled

Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects

Completed· Sanofi logo

Sanofi·Phase 1·NCT01129375·72 enrolled

Study to Evaluate the Drug-drug Interaction Effect of Omeprazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants

Completed· Amgen logo

Amgen·Phase 1·NCT05581992·14 enrolled

Drug Interaction Study of CT1812 in Healthy Volunteers

Completed·CCognition Therapeutics·Phase 1·NCT03716427·16 enrolled

A Drug Interaction Study of the Effects of PPI-668 on the Pharmacokinetics of Midazolam and Omeprazole

Completed·PPresidio Pharmaceuticals, Inc.·Phase 1·NCT01786382·24 enrolled

Tics16 trials

A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants

Completed· Amgen logo

Amgen·Phase 1·NCT05599828·14 enrolled

A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT02790840·32 enrolled

Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT05635110·31 enrolled

Show 13 more trials

Compare the Pharmacokinetics of Omeprazole, Rosiglitazone, and Desipramine When Administered With Avanafil in Healthy Male Subjects

Completed·VVIVUS LLC·Phase 1·NCT01415128·60 enrolled

A Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of BMS-986205 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03936374·16 enrolled

A Study to Evaluate The Effects of Two Different Meal Types, Omeprazole And Ranitidine On Danoprevir Pharmacokinetics When Coadministered With Ritonavir in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01392755·32 enrolled

A Study to Investigate the Relative Bioavailability of 2 Different Formulations of AZD4144, the Effect of Food and Omeprazole on the Pharmacokinetics of AZD4144 in Healthy Participants

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT06948006·32 enrolled

A Study to Evaluate the Effect of an Acidic Formulation of Acalabrutinib (ACP-196), Acidic Beverage, or Grapefruit Juice on the Pharmacokinetics (PK) of ACP-196 Alone and Coadministered With Omeprazole

Completed·AAcerta Pharma BV·Phase 1·NCT04876807·36 enrolled

A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT02492776·14 enrolled

A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib

Terminated· AstraZeneca logo

AstraZeneca·Phase 1·NCT04959266·5 enrolled

Study to Assess the Pharmacodynamics/Pharmacokinetics After Repeated Dosing of D961H 10 mg and Omeprazole 10 mg in Japanese Healthy Male Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01159145·42 enrolled

Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 4·NCT01766050·45 enrolled

A Study to Compare the Relative Bioavailability of Two AG-881 Formulations and Evaluate the Effect of Food and Omeprazole on the Pharmacokinetics of AG-881

Completed·AAgios Pharmaceuticals, Inc.·Phase 1·NCT04128787·36 enrolled

Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib

Completed· Sanofi logo

Sanofi·Phase 1·NCT01539655·34 enrolled

A Study to Evaluate the Impact of Omeprazole on the Pharmacokinetics of Sotorasib Co-administered With an Acidic Beverage in Healthy Volunteers

Completed· Amgen logo

Amgen·Phase 1·NCT05497557·16 enrolled

To Evaluate the Effect of Ritonavir or Omeprazole on the Pharmacokinetics of Samatasvir (IDX719) in Healthy Participants (MK-1894-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT01813552·24 enrolled

Peptic ulcer6 trials

High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding

Completed·CCasa Sollievo della Sofferenza IRCCS·Phase 3·NCT00374101·450 enrolled

IIaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients

Completed·LLivzon Pharmaceutical Group Inc.·Phase 2·NCT03362268·180 enrolled

Oral Omeprazole in Bleeding Peptic Ulcer

Unknown status·—·Phase 1·NCT04170270·100 enrolled

Show 3 more trials

Ilaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients

Completed·LLivzon Pharmaceutical Group Inc.·Phase 3·NCT03362281·540 enrolled

Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers

Completed·SSingapore General Hospital·Phase 3·NCT00519519·126 enrolled

DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers

Terminated·DDexa Medica Group·Phase 3·NCT02262169·32 enrolled

Midazolam6 trials

A Study to Investigate the Effect of Single and Repeated Oral Doses of ACT-539313 on What the Body Does to Flurbiprofen, Omeprazole, Midazolam in Healthy Subjects

Completed· Idorsia Pharmaceuticals Ltd. logo

Idorsia Pharmaceuticals Ltd.·Phase 1·NCT05254548·22 enrolled

Effect of BI 1181181 on Midazolam, Warfarin, Omeprazole and Digoxin

Withdrawn· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02345304

A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the Body

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06494761·16 enrolled

Show 3 more trials

Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole

Completed·VVivoryon Therapeutics N.V.·Phase 1·NCT02190708·18 enrolled

Study to Assess the Effect of Co-Administration of AZD9833 on the Pharmacokinetics of Midazolam, of Omeprazole, of Celecoxib and of Dabigatran Etexilate in Healthy Postmenopausal Female Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05438303·59 enrolled

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02254148·24 enrolled

Adult6 trials

A Study to Learn if Taking BIIB141 (Omaveloxolone) Affects How Omeprazole is Processed in the Body and About BIIB141's Safety in Healthy Adults Aged 18 to 55

Completed· Biogen logo

Biogen·Phase 1·NCT07149415·22 enrolled

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT07223671·32 enrolled

A Study of ALXN1840 (Coated and Non-coated) Administered With And Without Omeprazole In Healthy Adults

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05319912·18 enrolled

Show 3 more trials

Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult Participants

Completed· Takeda logo

Takeda·Phase 1·NCT03866434·20 enrolled

A Study of ALXN1840 (Non-coated) Administered With And Without Omeprazole In Healthy Adults

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05319899·18 enrolled

Study to Determine the Effects of Multiple-dose Omeprazole on the Single-dose Pharmacokinetics of Tipranavir (TPV) Coadministered With Ritonavir (RTV) in Healthy Adult Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02253875·15 enrolled

98 more indications

Gastric3 trials

A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT02229877·18 enrolled

Investigation of Food Effect and Gastric ph Increase on the Bioavailability of Faldapravir

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT01694706·15 enrolled

Effect of Vecam 40/300 and Vecam 20/300 Compared to Omeprazole 20 mg on Gastric pH

Completed·VVecta Ltd.·Phase 1·NCT00818870·60 enrolled

Clopidogrel3 trials

Clopidogrel Proton-Pump Inhibitors Study

Withdrawn·SSheba Medical Center·Phase 4·NCT01016717

Study Evaluating Effect of Esomeprazole, Omeprazole or Lansoprazole on the Pharmacodynamics (PD) and Pharmacokinetics (PK) of Clopidogrel

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01147588·149 enrolled

Impact of Omeprazole and Fluvoxamine on Platelet Response to Clopidogrel

Completed·HHadassah Medical Organization·Phase 1·NCT01269333·15 enrolled

Esophagitis3 trials

Reflux Esophagitis Phase III Study (Maintenance Treatment)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00634114·540 enrolled

A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis Patients

Completed· Boryung Pharmaceutical Co., Ltd logo

Boryung Pharmaceutical Co., Ltd·Phase 3·NCT01499368·495 enrolled

Reflux Esophagitis Phase III Study (Initial Treatment)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00633932·602 enrolled

Drug Interactions3 trials

Drug Interactions Trial of Methoxyethyl Etomidate Hydrochloride

Completed·AAhon Pharmaceutical Co., Ltd.·Phase 1·NCT06822166·68 enrolled

A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05109390·72 enrolled

A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects

Completed·AAllist Pharmaceuticals, Inc.·Phase 1·NCT06162169·66 enrolled

Atopic Dermatitis3 trials

Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD)

Completed· Regeneron logo

Regeneron·Phase 1·NCT02647086·14 enrolled

Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis

Completed· Amgen logo

Amgen·Phase 1·NCT05891119·21 enrolled

Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4

Completed· LEO Pharma logo

LEO Pharma·Phase 1·NCT03556592·40 enrolled

Single Dose3 trials

Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subjects

Completed·NNantes University Hospital·Phase 2·NCT01136317

A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT02473627·18 enrolled

A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05932277·22 enrolled

Treatment3 trials

Four-week Omeprazole Treatment of Non-erosive Reflux Disease in a Japanese Population

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00259077·270 enrolled

A Study to Investigate the Pharmacodynamic Effect After Four-week Omeprazole Treatment of Non-erosive Reflux Disease in a Japanese Population

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00259051·40 enrolled

Treatment in Patients With Globus: Psychoeducation, Anxiolytics or Proton Pump Inhibitors

Completed·MMahidol University·Phase 3·NCT03205228·40 enrolled

Adult Subject3 trials

A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02957474·18 enrolled

Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Completed·SSpero Therapeutics·Phase 1·NCT04368585·20 enrolled

A Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokinetics of Omeprazole, Midazolam, Warfarin, Rosuvastatin, Metformin, Digoxin, and Nintedanib in Healthy Adult Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03363815·56 enrolled

Dyspepsia3 trials

Compliance With Antidepressant Medication in Treatment of Functional Dyspepsia

Completed·RRenJi Hospital·Phase 4·NCT01851863·262 enrolled

Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease

Completed·—·N/A·NCT02685150·157 enrolled

Use of Maytenus Ilicifolia in the Treatment of Dyspepsia

Terminated·CCasa Espirita Terra de Ismael·Phase 2·NCT01408849·4 enrolled

Lymphoma3 trials

A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma.

Recruiting·MMurdoch Childrens Research Institute·Phase 1·NCT06383338·10 enrolled

Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients

Completed·EEpizyme, Inc.·Phase 1·NCT03028103·32 enrolled

Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach

Unknown status·LLymphoma Trials Office·Phase 3·NCT00003617·200 enrolled

Back pain2 trials

Placebo In Chronic Back Pain - Double-Blind Randomized Control Trial

Completed·NNorthwestern University·Phase 4·NCT02013427·82 enrolled

Placebo In Chronic Back Pain (Phase 2)

Completed·AApkar Apkarian·Phase 4·NCT02986334·94 enrolled

Caffeine2 trials

Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02256813·20 enrolled

A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants

Completed· Pfizer logo

Pfizer·Phase 1·NCT05067439·26 enrolled

ART2 trials

Study of the Effect of Food and a Proton Pump Inhibitor (PPI; Omeprazole) on LOXO-305 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT05134350·10 enrolled

Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants

Completed· Roche logo

Roche·Phase 1·NCT04718181·131 enrolled

Gastric Ulcer2 trials

Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy

Completed·KKorea Otsuka International Asia Arab·Phase 4·NCT00272467·132 enrolled

Mucosta in Gastric Ulcer Treatment, Effectiveness and Safety Evaluation

Completed· Otsuka logo

Otsuka·Phase 3·NCT01150162·129 enrolled

Helicobacter Pylori Infection2 trials

The Effects of a Synbiotic Addition on Eradication Therapy of Helicobacter Pylori Infection in Children

Completed·—·N/A·NCT03165253·69 enrolled

Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients

Completed·ZZagazig University·N/A·NCT01593592·70 enrolled

Cirrhosis2 trials

Proton Pump Inhibitors and Dysbiosis in Cirrhosis

Completed·HHunter Holmes Mcguire Veteran Affairs Medical Center·N/A·NCT01458990·60 enrolled

A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·N/A·NCT05741385·4 enrolled

Oral2 trials

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ABS-1230 Given Orally Compared With Placebo in Healthy Participants Aged 18 to 55 Years

Recruiting·AActio Biosciences, Inc.·Phase 1·NCT07156201·74 enrolled

A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03058419·16 enrolled

Fed2 trials

Omeprazole Delayed Release (DR) Capsules Bioequivalence Study of Dr. Reddys Under Fed Condition

Completed·—·Phase 1·NCT01170182·54 enrolled

Bioequivalence Study of Omeprazole Magnesium 20 mg DR Capsule Under Fed Conditions

Completed·—·Phase 1·NCT01045434·62 enrolled

Intravenous2 trials

Comparison of Intravenous Omeprazole to Ranitidine on Recurrent Bleeding After Endoscopic Treatment of Bleeding Ulcer

Withdrawn·KKeio University·Phase 4·NCT00247130

Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot

Completed·FFar Eastern Memorial Hospital·Phase 4·NCT02536989·40 enrolled

Gastric Acid2 trials

CYP2C19 Genotype Predictor of Gastric Acid Suppression

Withdrawn·MMayo Clinic·Phase 1·NCT01824199

The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients With Hypersecretion of Gastric Acid

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT00001191

Gastroesophageal Reflux Disease2 trials

Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features

Terminated·—·Phase 4·NCT04028466·82 enrolled

Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity

Unknown status·BBelarusian Medical Academy of Post-Graduate Education·Phase 4·NCT02140073·60 enrolled

Rheumatoid Arthritis2 trials

A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid Arthritis

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT01636557·12 enrolled

Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4

Completed·UUnknown Sponsor·Phase 1·NCT04246762·17 enrolled

Barrett's esophagus2 trials

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus

Completed·—·Phase 1·NCT01465113·26 enrolled

Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Ablation?

Completed·MMayo Clinic·Phase 4·NCT01093755·30 enrolled

Metformin2 trials

Effect of Omeprazole on Metformin

Completed·XXijing Hospital·Phase 1·NCT01711320·20 enrolled

Impact of OCT1 on Metformin Tolerance

Completed·NNHS Tayside·Phase 4·NCT02586636·61 enrolled

Aspirin2 trials

To Compare the Gastroprotective Effects and Pharmacokinetic Profile of PA Versus Enteric-Coated Aspirin

Completed·PPOZEN·Phase 1·NCT00442052·80 enrolled

A Parallel Group Study to Compare the Gastroprotective Effects of PA 325 Versus 81 mg Enteric Coated Aspirin

Completed·PPOZEN·Phase 1·NCT00441519·80 enrolled

Fasting Conditions2 trials

Bioequivalence Study of Omeprazole Magnesium 20 mg DR Capsules Under Fasting Conditions

Completed·—·Phase 1·NCT01045642·38 enrolled

Omeprazole Delayed Release (DR) Capsules Bioequivalence Study of Dr. Reddys Under Fasting Conditions

Completed·—·Phase 1·NCT01170169·44 enrolled

Efficacy and Safety2 trials

Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease

Completed·—·Phase 3·NCT01338077·195 enrolled

Efficacy and Safety of DLBS2411 in the Management of GERD

Terminated·DDexa Medica Group·Phase 3·NCT03367195·32 enrolled

Patients With Advanced Solid Tumors2 trials

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

Completed· Novartis logo

Novartis·Phase 1·NCT01596647·39 enrolled

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT01218620·17 enrolled

Squamous Cell Carcinoma1 trial

IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity

Completed·BBrooklyn ImmunoTherapeutics, LLC·Phase 2·NCT02609386·105 enrolled

Clinical Trial1 trial

A Clinical Trial to Evaluate a High-Fat Meal and Omeprazole Enteric-coated Tablets on ASBK021

Completed·AAbbisko Therapeutics Co, Ltd·Phase 1·NCT06322706·36 enrolled

Age1 trial

Pharmacokinetic and Safety Study of Cenicriviroc and Acid Reducing Agents When Dosed Alone or in Combination

Completed·TTobira Therapeutics, Inc.·Phase 1·NCT02684799·48 enrolled

Colonization1 trial

Gastric Acid Suppression and Probiotic Colonization

Completed·SStanford University·Phase 4·NCT03327051·39 enrolled

Growth1 trial

Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis

Completed·FFaculdade de Ciências Médicas da Santa Casa de São Paulo··NCT01389401·36 enrolled

Injury1 trial

Management of Myocardial Injury After Noncardiac Surgery Trial

Completed·PPopulation Health Research Institute·Phase 3·NCT01661101·1,754 enrolled

Cardiovascular1 trial

Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout

Completed·MMenarini International Operations Luxembourg SA·Phase 4·NCT02500641·196 enrolled

Chronic Cough1 trial

Indomethacin for Refractory Chronic Cough

Unknown status·TThe First Affiliated Hospital of Guangzhou Medical University·Phase 3·NCT03662269·84 enrolled

Pilot Study1 trial

Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study

Completed·—·Phase 3·NCT01566474·80 enrolled

Baricitinib1 trial

A Study of Baricitinib and Omeprazole in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01925144·30 enrolled

Reflux1 trial

Bronchial Hyper-responsiveness in Reflux Cough

Terminated·HHull University Teaching Hospitals NHS Trust·Phase 3·NCT00668317·5 enrolled

MPA1 trial

The Impact of Proton Pump Inhibitors on the Fecal Microbiome

Completed·MMayo Clinic·Phase 1·NCT01822977·15 enrolled

Locally Advanced or Metastatic Solid Tumors1 trial

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Completed· Roche logo

Roche·Phase 1·NCT05487235·57 enrolled

Biomarkers1 trial

A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 1·NCT06378398·21 enrolled

Breast Cancer1 trial

Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)

Completed·PProvidence Health & Services·Phase 1·NCT02950259·16 enrolled

Psoriatic Arthritis1 trial

This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis

Completed· AbbVie logo

AbbVie·Phase 1·NCT02772601·21 enrolled

Randomized Controlled Trial1 trial

The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease

Completed·TTorax Medical Incorporated·Phase 4·NCT02505945·152 enrolled

Efficacy1 trial

Evaluation of GERDOFF Efficacy in Combination With Proton Pump Inhibitor

Completed·SSOFAR S.p.A.·N/A·NCT03793556·72 enrolled

Female1 trial

A Study of LY3484356 in Healthy Female Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT04840888·82 enrolled

Anemia1 trial

Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC

Unknown status·SSoroka University Medical Center·Phase 4·NCT01795794·12 enrolled

Type 2 Diabetes Mellitus1 trial

A Study to Learn How Different Amounts of PF-06954522 Are Tolerated and Act in Adults With Type 2 Diabetes Mellitus

Completed· Pfizer logo

Pfizer·Phase 1·NCT06279234·50 enrolled

Phase 11 trial

A Phase 1 Study to Examine the Pharmacodynamics of Different AZD1722 Formulations

Completed·AArdelyx·Phase 1·NCT02249936·18 enrolled

Pneumonia1 trial

Proton Pump Inhibitors and Risk of Community-acquired Pneumonia

Completed·CCanadian Network for Observational Drug Effect Studies, CNODES··NCT02555852·4,238,504 enrolled

Dysbiosis1 trial

A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

Recruiting·MMayo Clinic·N/A·NCT05517928·30 enrolled

Colorectal Cancer1 trial

Effect of G17DT in Patients With Stage II/III Colorectal Cancer

Completed·CCancer Advances Inc.·Phase 2·NCT02518373·22 enrolled

Methotrexate1 trial

Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03131973·26 enrolled

Immunodeficiency1 trial

A Study to Evaluate the Effect of Famotidine and Omeprazole on MK0518 (Raltegravir) Pharmacokinetics in Human Immunodeficiency Virus (HIV)-Infected Patients (0518-054)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT01000818·18 enrolled

Critically Ill Patients1 trial

Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.

Completed·MMenoufia University·N/A·NCT03388463·110 enrolled

Upper Gastrointestinal Bleeding1 trial

Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy

Completed·—·Phase 4·NCT00164866·638 enrolled

Semaglutide1 trial

Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT02249871·54 enrolled

Neoadjuvant Chemotherapy1 trial

Inhibiting Fatty Acid Synthase to Improve Efficacy of Neoadjuvant Chemotherapy

Completed·KKathy Miller·Phase 2·NCT02595372·42 enrolled

H Pylori Infection1 trial

High Dose Dual Therapy vs Clarithromycin Triple Therapy for Treatment Naive H Pylori Infection in an Urban Population

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT05342532·112 enrolled

Multiple Sclerosis1 trial

An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis

Completed· Biogen logo

Biogen·Phase 3·NCT01462318·133 enrolled

Ulcerative Colitis1 trial

Oral OKT3 for the Treatment of Active Ulcerative Colitis

Completed·—·Phase 1/2·NCT01287195·6 enrolled

MALT lymphoma1 trial

Antibiotic Therapy and Antacids in Patients With Malt Lymphoma of the Stomach

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002682·5 enrolled

Head and Neck Cancer1 trial

A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer

Completed·BBrooklyn ImmunoTherapeutics, LLC·Phase 2·NCT00210470·27 enrolled

TED1 trial

Effect of Repeated Doses of YF476, Omeprazole and Placebo on Stomach Acidity in Healthy Volunteers

Completed·TTrio Medicines Ltd.·Phase 1·NCT01599858·49 enrolled

Pancreatic Cancer1 trial

High Dose Omeprazole in Patients With Pancreatic Cancer

Recruiting·UUniversity of Oklahoma·Phase 1·NCT04930991·60 enrolled

Single Ascending Dose1 trial

A Study to Assess the Effects of Single Ascending Doses (SAD) of ASP8477, the Effect That Food Has on the Drug, and the Interaction Between ASP8477 and Omeprazole in Healthy Postmenopausal Females and Healthy Young Vasectomized Males

Completed· Astellas logo

Astellas·Phase 1·NCT02220777·72 enrolled

Absorption1 trial

Does Omeprazole Decrease Intestinal Calcium Absorption?

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT00582972·23 enrolled

Neuropathy1 trial

The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer Patients

Completed·AAya Mohamed Sadek Elsaid·Phase 3·NCT05680870·46 enrolled

Vulvar Intraepithelial Neoplasia1 trial

IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3

Terminated·UUniversity of Southern California·Phase 2·NCT03267680·10 enrolled

Metastatic Head and Neck Cancer1 trial

A Phase II Trial of Proton Pump Inhibitors With Chemotherapy in Patients With Metastatic Head and Neck Cancer

Withdrawn·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT02013453

Resistance1 trial

Tongue Exercises and Reflux Therapy for Upper Airway Resistance Syndrome

Withdrawn·WWest Side ENT·Phase 1·NCT00364481

Psoriasis1 trial

Pharmacokinetic Study to Evaluate the Effect of a Single Dose of Guselkumab (CNTO 1959) on CYP 450 Enzyme Activities After Subcutaneous Administration in Participants With Psoriasis

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02397382·16 enrolled

Laryngomalacia1 trial

Laryngomalacia Study

Withdrawn·—·Phase 1·NCT01782560

Impaired Renal Function1 trial

A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT01275170·49 enrolled

Hypoalbuminemia1 trial

The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia

Completed·NNational Cheng-Kung University Hospital·Phase 4·NCT01822600·91 enrolled

Elderly1 trial

GSK1325756 Relative Bioavailability Study in Healthy Elderly Subjects

Completed· GSK logo

GSK·Phase 1·NCT03457727·40 enrolled

Laryngopharyngeal Reflux1 trial

The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux

Withdrawn·LLoma Linda University·Phase 4·NCT02123498

Outcome1 trial

Omeprazole and Reflux Disease - Improvement of Clinical Outcome by Genotype-adjusted Dosing

Terminated·MMatthias Schwab·Phase 4·NCT00537732·68 enrolled

Safety and Efficacy1 trial

Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea

Completed·FForest Laboratories·Phase 3·NCT00559364·50 enrolled

Glaucoma1 trial

Evaluation of Omeprazole Effect on Glaucoma

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 1·NCT01000220

Antibiotic-resistant Bacteria1 trial

Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy

Unknown status·SStephen Harbarth·Phase 2·NCT02472600·39 enrolled

Tonsillectomy1 trial

Anti-reflux Control to Decrease Post Tonsillectomy Pain

Terminated·AAscension Health·Phase 4·NCT01777854·6 enrolled

Idiopathic Pulmonary Fibrosis1 trial

Pilot Trial Of Omeprazole in Idiopathic Pulmonary Fibrosis (IPF)

Completed·NNewcastle-upon-Tyne Hospitals NHS Trust·Phase 2·NCT02085018·45 enrolled

PK/PD1 trial

Influence of CYP2C19 Polymorphism on PK/PD of Omeprazole

Completed·SSeoul National University Hospital·Phase 1·NCT02299687·24 enrolled

Acute Coronary Syndrome1 trial

"Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER-

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT02028234·150 enrolled

EoE1 trial

EoE RCT Fluticasone and Omeprazole vs Fluticasone Alone

Unknown status·CClaire Daniels·Phase 4·NCT03781596·100 enrolled

HCV1 trial

Pharmacokinetic Study of the HCV Protease Inhibitor Bo-cePRevir and the Proton Pump Inhibitor OMeprazOle (PROMO)

Completed·RRadboud University Medical Center·Phase 1·NCT01470690·24 enrolled

Prevention1 trial

Ulcer Prevention Study in Post Gastric Bypass Patients

Completed·UUniversity of Missouri-Columbia·Phase 4·NCT00557349·40 enrolled

Helicobacter Pylori1 trial

Study of Nitazoxanide (NTZ) Based New Therapeutic Regimens for Helicobacter Pylori

Unknown status·SSherief Abd-Elsalam·Phase 3·NCT02422706·120 enrolled

Elderly Participants1 trial

A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult Participants

Completed·KKaruna Therapeutics·Phase 1·NCT06605950·78 enrolled

AML1 trial

An Open-label, DDI Study to Investigate the Effects of Amlitelimab on the PK of Selected Cytochrome P450 Substrates

Active, not recruiting· Sanofi logo

Sanofi·Phase 1·NCT06686628·23 enrolled

Gut Microbiome1 trial

Factors Influencing the Human Gut Microbiome Profile in Multi-ethnic Groups of the Singapore Community (FAMES)

Completed·—·N/A·NCT02893709·36 enrolled

Drug1 trial

Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02182336·23 enrolled

Systemic Inflammation1 trial

Effect of Proton Pump Inhibitors on Gut Microbiota and Systemic Inflammation in Older Adults

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT02844621·25 enrolled

Quality of Life1 trial

Quality of Life Validation in Laryngitis

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00641264·90 enrolled

Advanced Solid Tumors1 trial

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Completed· Pfizer logo

Pfizer·Phase 1·NCT03864042·56 enrolled

Unspecified10 trials

Effect of a Proton Pump Inhibitor on the PK of Tepotinib

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT03531762·12 enrolled

Effect of Omeprazole on PK of Fluzoparib in Healthy Male Subjects

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT04108676·16 enrolled

Effect of a Proton Pump Inhibitor on Gleevec® in Healthy Volunteers

Completed·UUniversity of Pittsburgh·Phase 1·NCT00446004·15 enrolled

Show 7 more trials

Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human

Completed·IInje University·Phase 1·NCT01570569·26 enrolled

A Two Week Nitazoxanidebased Quadruple Regimen

Unknown status·TTanta University·Phase 3·NCT02621359·100 enrolled

BAY73-4506 Probe Substrate Study

Completed· Bayer logo

Bayer·Phase 1·NCT01287598·41 enrolled

Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s

Completed·CCorcept Therapeutics·Phase 1·NCT03457597·27 enrolled

Prilosec Bioequivalence Study in Healthy Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01921920·54 enrolled

Optimal Dosing of Omeprazole in Neonates

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 2·NCT01657578·55 enrolled

Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02243553·34 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 5, 1995

PRILOSEC

NDA NDA019810

Jun 20, 2003

PRILOSEC OTC

NDA NDA021229

Dec 4, 2007

OMEPRAZOLE

NDA NDA022032

Mar 20, 2008

PRILOSEC

NDA NDA022056

Jul 5, 2017

OMEPRAZOLE

NDA NDA209400

Sources

References

[1]
ClinicalTrials.gov — 274 trial records for Omeprazole. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Prilosec drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Omeprazole compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Omeprazole. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA209400). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Prilosec. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Dexcel Pharma Technologies Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Potassium-Transporting Atpase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: DDexcel Pharma Technologies Ltd.

Patent Landscape[6]

Patent Cliff

Jan 31, 2030

Earliest patent expiration — generic entry possible after this date

Patent #Expires

12599565Jan 31, 2030

10835488Dec 8, 2036