VivoSeq
Rare Disease

Hypothalamic Obesity

14

Pipeline Programs

5

Active Trials

9

Companies Involved

Hypothalamic Obesity is an emerging landscape with 14 programs across 9 companies. The most active players are Novo Nordisk, BioMarin Pharmaceutical, EMD Serono. 2 therapies are approved with 4 more in late-stage development.

Pipeline Metrics

Competitive Density

43/100

Pipeline Velocity

11/100

Mech. Concentration

14/100

Completion Rate

90/100

Attrition Rate

6/100

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Programs by Phase

Modality Breakdown

73%

Small molecule

11 of 15 classified programs — the dominant modality here.

27%ALL OTHERSPeptide320%Protein / enzyme17%

Small molecule leads; the ring shows all 15 classified programs, each share of the total. Modality classified for 100% of 15 pipeline programs.

Trial Status

16

clinical trials

Completed9 · 56%
Recruiting2 · 13%
Active, not recruiting2 · 13%
Unknown status1 · 6%
Enrolling by invitation1 · 6%
Withdrawn1 · 6%

Trial Activity

16 trials

A Trial of Setmelanotide in Acquired Hypothalamic Obesity
Active, not recruiting·Rhythm Pharmaceuticals logoRhythm Pharmaceuticals·Phase 3·NCT05774756·120 enrolled
SETMELANOTIDE-RM: Setmelanotide in Rare Obesity
Active, not recruiting·Rhythm Pharmaceuticals logoRhythm Pharmaceuticals·Phase 3·NCT04580342·155 enrolled
Effects of Exenatide on Hypothalamic Obesity
Completed··Phase 1/2·NCT01061775·19 enrolled
Pediatric Hypothalamic Obesity
Completed·Novartis logoNovartis·Phase 4·NCT00076362·60 enrolled
Intranasal Oxytocin in Hypothalamic Obesity
Completed·SShana McCormack, MD·Phase 2·NCT02849743·18 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)