VivoSeq
Psychiatry

Insomnia

124

Pipeline Programs↗

40

Active Trials↗

60

Companies Involved↗

Insomnia is a highly competitive landscape with 124 programs across 60 companies. The most active players are Midnight Pharma, LLC, Biogen, Stero Biotechs Ltd.. 29 therapies are approved with 33 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

74/100

Pipeline Velocity

41/100

Mech. Concentration

14/100

Completion Rate

89/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

M

Midnight Pharma, LLC

1 program

Phase 1Biogen logo

Biogen

1 program

Phase 1S

Stero Biotechs Ltd.

1 program

Phase 1V

Valeant Pharmaceuticals

1 program

Phase 1F

Fresenius

1 program

Phase 1I

Intec Pharma Ltd.

2 programs

Phase 2

Pipeline

Programs by Phase

Preclinical19

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Melatonin

Neurim Pharmaceuticals Ltd.

Obeticholic Acid

Intercept Pharmaceuticals

Zopiclone

Taisho Pharmaceutical Co., Ltd.

Zolpidem Tartrate

Sanofi

Phase 18

LY2624803

Eli Lilly

Inhaled Melatonin (100 Μg)

Woolcock Institute of Medical Research

Almorexant

Midnight Pharma, LLC

Flurazepam

Valeant Pharmaceuticals

Propofol Injection Emulsion

Life Extension Foundation Inc.

Phase 235

Armodafinil

Nuvo Research GmbH

Pimavanserin

ACADIA Pharmaceuticals Inc.

Lisdexamfetamine Dimesylate

Takeda

Active Comparator

Moderna

HS-10506

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Phase 333

Amitriptyline

AstraZeneca

Gabapentin

Viatris Specialty LLC

Cannabidiol

Jazz Pharmaceuticals

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Tasimelteon

Vanda Pharmaceuticals

Approved29

Modafinil

Nuvo Research GmbH

Suvorexant

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Ramelteon

Takeda

Eszopiclone

Akero Therapeutics

Zolpidem

Purdue Pharma LP

Analysis

Trial Status

306

clinical trials

Completed214 · 70%
Unknown status25 · 8%
Recruiting19 · 6%
Not yet recruiting16 · 5%
Terminated15 · 5%
Withdrawn11 · 4%
Other6 · 2%

Clinical Trials

Trial Activity

306 trials

A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Pharmacokinetic Study
Recruiting·WWoolcock Institute of Medical Research·Phase 1·NCT06801379·5 enrolled
Pimavanserin for Insomnia in Veterans With PTSD
Recruiting·VVA Office of Research and Development·Phase 2·NCT05441280·60 enrolled
Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia
Recruiting·VVanda Pharmaceuticals·Phase 3·NCT06953869·420 enrolled
The Effect of Valerian on Insomnia in Menopausal Women
Recruiting·—·N/A·NCT05185219·100 enrolled
Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study)
Recruiting·—·Phase 2·NCT06983080·40 enrolled
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
Recruiting·—·Phase 4·NCT05593653·61 enrolled
Efficacy of CBT-I and Lemborexant Medication for Different Subtypes of Chronic Insomnia
Recruiting·LLaval University·N/A·NCT06779149·90 enrolled
Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA
Recruiting·UUniversity of Sao Paulo General Hospital·Phase 4·NCT06017921·60 enrolled
Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary Insomnia
Recruiting·—·N/A·NCT06996171·60 enrolled
Efficacy of Auricular Pressure Beans with Electroacupuncture and Estazolam Treating Insomnia Caused by Cancer
Recruiting·QQinghai Red Cross Hospital·Phase 3·NCT06859190·60 enrolled
Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia
Recruiting·MMilton S. Hershey Medical Center·Phase 1·NCT06281756·600 enrolled
Trazodone on NREM Sleep Stage Ⅲ in Depressed Insomniac Co-morbid Patients
Recruiting·TTongji University·Phase 4·NCT06740188·60 enrolled
The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence
Recruiting·UUniversity of Florida·Phase 2·NCT05814055·76 enrolled
Investigating the Effectiveness of E-CBTi Compared to Pharmaceutical Interventions in Treating Insomnia
Recruiting·—·N/A·NCT05125146·60 enrolled
A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Efficacy Study
Recruiting·WWoolcock Institute of Medical Research·Phase 1·NCT06802913·10 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)