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Psychiatry/Insomnia

Insomnia

29

Pipeline Programs↗

90

Active Trials↗

45

Companies Involved↗

Insomnia is an emerging landscape with 29 programs across 45 companies. The most active players are Nanjing Chia-tai Tianqing Pharmaceutical, Vanda Pharmaceuticals. 5 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

65/100

Pipeline Velocity

68/100

Mech. Concentration

25/100

Completion Rate

90/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Nanjing Chia-tai Tianqing Pharmaceutical

1 program

Vanda Pharmaceuticals

1 program

Pipeline

Programs by Phase

Preclinical15

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Obeticholic Acid

Intercept Pharmaceuticals

Midazolam

Conrado Roberto Hoffmann Filho

Ciprofol

Haisco Pharmaceutical Group Co., Ltd.

Sertraline

Viatris Specialty LLC

Phase 13

Qingxin Jiaotai Decoction

Fohow Pharmaceutical Group

Inhaled Melatonin (100 Μg)

Woolcock Institute of Medical Research

Diprivan

Fresenius

Phase 26

Apstzd 1

Apsen Farmaceutica S.A.

Apstzd 2

Apsen Farmaceutica S.A.

Apstzd 4

Apsen Farmaceutica S.A.

Single Agent Therapy

Theodore Brasky PhD

AB-Free Kava

University of Florida

Phase 35

Tasimelteon

Vanda Pharmaceuticals

SM-1

Sequential Medicine Ltd

Cannabidiol

Jazz Pharmaceuticals

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Estazolam 1

Abbott

Approved

No programs

Analysis

Trial Status

367

clinical trials

Completed225 · 61%

Recruiting49 · 13%

Not yet recruiting27 · 7%

Unknown status25 · 7%

Terminated15 · 4%

Withdrawn11 · 3%

Other15 · 4%

Clinical Trials

Trial Activity

367 trials

The Effect of Different rTMS Intervention on Acute Experimental Muscular Pain in Individuals Comorbid With Insomnia: a Pilot RCT

Recruiting·TThe Hong Kong Polytechnic University·Preclinical·NCT07827677·30 enrolled

The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise Induced Muscular Pain: a Case Control Study

Recruiting·TThe Hong Kong Polytechnic University·N/A·NCT07827664·80 enrolled

A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia Disorder: a Randomised Placebo-controlled Cross-over Study.

Recruiting·WWoolcock Institute of Medical Research·Phase 2·NCT06823752·20 enrolled

Blue-blocking Glasses for Treating Evening Activation and Sleep Disorders in Child and Adolescent Psychiatry - a Pilot Trans-diagnostic Randomized Controlled Trial.

Recruiting·—·Preclinical·NCT07433491·40 enrolled

The Impact of Acute Pain on Sleep Parameters in the Insomnia Population and Healthy Controls: a Case-control Study

Recruiting·TThe Hong Kong Polytechnic University·N/A·NCT07826650·80 enrolled

Sequential Multiple Assignment Randomized Trial Comparing Commonly Prescribed and Over the Counter Medications for the Treatment of Insomnia in Adults

Recruiting·UUniversity of Pennsylvania·Approved·NCT07542756·1,200 enrolled

Sleep as a Mechanism of Change in Alcohol Use Outcomes Among Heavy-Drinking Adults

Recruiting·UUniversity of Missouri-Columbia·Preclinical·NCT06286774·256 enrolled

A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)

Recruiting·MMassachusetts General Hospital·Preclinical·NCT06375265·50 enrolled

Digital Cognitive Behavioral Treatment of Insomnia in Youth: An RCT Examining Feasibility, Acceptability, and Efficacy of NiteCAPP Jr

Recruiting·UUniversity of South Florida·Preclinical·NCT07091149·40 enrolled

Uptake, Acceptability, and Effectiveness of Internet-Delivered Cognitive Behavioural Therapy for Public Safety Personnel With Self-Reported Sleep Difficulties

Recruiting·UUniversity of Regina·Preclinical·NCT07021183·60 enrolled

Effects of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Physically Active Participants With Insomnia Complaints: a Randomized Clinical Trial

Recruiting·Federal University of Jatai·Preclinical·NCT07607444·50 enrolled

Piloting an Insomnia Treatment in Patients With Ulcerative Colitis

Recruiting·DDartmouth-Hitchcock Medical Center·Preclinical·NCT07428629·20 enrolled

A Multicenter, Single-arm, Prospective Clinical Investigation to Observe the Long-term Safety and Efficacy of the Digital Medical Device 'BELL-001' in Patients Diagnosed With Insomnia

Recruiting·BBell International Laboratories·Preclinical·NCT07582809·40 enrolled

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Suvorexant for the Treatment of Insomnia in Participants With Opioid Use Disorder

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06655883·300 enrolled

Changes in Intravenous Anesthetic Drug Dosage in Insomnia Patients Undergoing Digestive Endoscopy: Study Protocol for a Prospective Cohort Study

Recruiting·BBeijing Tiantan Hospital·N/A·NCT06376760·3,360 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)