Xylocaine

(Lidocaine hydrochloride)

ApprovedSmall molecule

Lidocaine is a numbing medication used to block pain and discomfort during medical procedures or to relieve pain from minor skin conditions like insect bites or mouth sores.[2] Xylocaine is currently approved and in use across 42 indications[4].[1]

Xylocaine is one of 896 small molecule programs targeting Plantar Fasciitis. It is currently in Approved.

Indications

Total Trials

Active Trials

895

Competitors

Pipeline

Status by Indication[4][1]

Indication

Plantar FasciitisActive, not recruiting

Ventral HerniaActive, not recruiting

Progressive Bulbar PalsyActive, not recruiting

Myofascial Pain SyndromeActive, not recruiting

Neuropathic PainActive, not recruiting

Cerebral PalsyActive, not recruiting

DysphagiaActive, not recruiting

Cerebral Small Vessel DiseaseActive, not recruiting

Migraine DisorderApproved

Carpal Tunnel SyndromeActive, not recruiting

Plantar FasciitisPreclinical

Active, not recruiting

Ventral HerniaPhase 3

Active, not recruiting

Progressive Bulbar PalsyPreclinical

Active, not recruiting

Myofascial Pain SyndromeApproved

Active, not recruiting

Neuropathic PainPreclinical

Active, not recruiting

Cerebral PalsyPreclinical

Active, not recruiting

DysphagiaPreclinical

Active, not recruiting

Cerebral Small Vessel DiseasePreclinical

Active, not recruiting

Migraine DisorderApproved

Approved

Carpal Tunnel SyndromePreclinical

Active, not recruiting

Showing 10 of 39 indications

Competition

Competitive Landscape

1399 competitors in Prostate Cancer

#DrugCompanyPhaseTrials

Xylocaine

CCitius Pharmaceuticals, Inc.

Approved

77 2

Novantrone

Pfizer

Preclinical

5 3

Trexall

Alnylam Pharmaceuticals

Preclinical

—4

Jatenzo

GGrupo Espanol de Tumores Neuroendocrinos

Preclinical

2 5

Viagra

VViatris Specialty LLC

Preclinical

1 6

Duragesic

CCephalon

Preclinical

1 7

Ranexa

MMenarini International Operations Luxembourg SA

Preclinical

1 8

Prednisone/prednisolone

Roche

Preclinical

3 9

Triptorelin Pamoate

Ipsen

Preclinical

2 10

Osmitrol

BB. Braun Medical Inc.

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 2Recruiting

Headaches Associated With Subarachnoid Hemorrhage (SAH)

NCT07054801

Q4 2028

Phase 1Recruiting

Anesthesia

NCT04992572

Clinical

Trials by Indication[1]

Lidocaine5 trials

Pharmacokinetics of Lidocaine in Healthy Adults

Completed·NNicole K Brogden·Phase 4·NCT03310970·23 enrolled

Adding Lidocaine to Custodiol Mixture

Recruiting·FFayoum University Hospital·Phase 4·NCT07205757·70 enrolled

Efficacy of Lidocaine and Xylometazoline Intranasal Spray in Anesthetizing Maxillary Teeth

Completed·—·Phase 1·NCT04732104·60 enrolled

Show 2 more trials

Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

Terminated·GGil Yosipovitch·Phase 2·NCT03096444·13 enrolled

Lidocaine Before Esophageal Manometry and Ambulatory pH Monitoring

Completed·—·Phase 2/3·NCT03967197·304 enrolled

Dysphagia5 trials

The Effectiveness of Stellate Ganglion Block in Managing Dysphagia in Patients With Medullary Infarction

Not yet recruiting·—·N/A·NCT06301698·80 enrolled

A Nerve Block Therapy for Bulbar Palsy Pharyngeal Dysphagia

Completed·BBabujinaya Cela·N/A·NCT06347250·122 enrolled

Effect of Stellate Nerve Block in Dysphagia

Completed·CCopka Sonpashan·N/A·NCT06335316·122 enrolled

Show 2 more trials

Lidocaine Injection: A Nove Block Therapy for Stroke-related Dysphagia

Completed·MMuhammad·N/A·NCT06301737·65 enrolled

Effect of Stellate Ganglion Block on Pharyngeal Dysphagia After Cerebralvascular Accident

Completed·ZZeng Changhao·N/A·NCT06249464·65 enrolled

Carpal Tunnel Syndrome3 trials

Efficacy of Combined Ultrasound Guided Steroid Injection and Splinting in Patients With Carpal Tunnel Syndrome

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT02708693·52 enrolled

Comparison of Ultrasound-guided Corticosteroid Injection Versus Corticosteroid Injection and Hydrodissection for Carpal Tunnel Syndrome

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT04346030·60 enrolled

Corticosteroid Injection in Carpal Tunnel Syndrome

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT03072290·56 enrolled

Cerebral Small Vessel Disease3 trials

Investigation of Potential Mechanisms in Stellate Ganglion Block in Individuals With Cerebral Small Vessel Disease

Not yet recruiting·—·N/A·NCT06301711·80 enrolled

Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319495·80 enrolled

Exploration of Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease

Completed·ZZeng Changhao·N/A·NCT06226415·84 enrolled

Stellate Ganglion Block3 trials

Stellate Ganglion Block in Bulbar Palsy

Completed·CCopka Sonpashan·N/A·NCT06319534·124 enrolled

Effectiveness of Stellate Ganglion Block in Individuals With Parkinson's Disease

Not yet recruiting·MMuhammad·N/A·NCT06301724·80 enrolled

Effectiveness of Stellate Ganglion Block in Patients Diagnosed With Parkinson's Disease

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319625·80 enrolled

48 more indications

Gastroesophageal Reflux Disease3 trials

Stellate Ganglion Block on Gastroesophageal Reflux Disease

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319521·80 enrolled

Impact of Glossopharyngeal Nerve Block on Swallowing Difficulties Caused by Gastroesophageal Reflux Disease

Not yet recruiting·CCopka Sonpashan·N/A·NCT06328205·80 enrolled

Effect of Lidocaine Block on Gastroesophageal Reflux Disease

Not yet recruiting·MMuhammad·N/A·NCT06304142·80 enrolled

General Anesthesia3 trials

the Effect of Opioid-free General Anesthesia

Completed·TThe Catholic University of Korea·N/A·NCT04409964·78 enrolled

Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery

Completed·MMiodrag Filipovic, Prof. Dr. med.·Phase 3·NCT03667001·140 enrolled

Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia

Unknown status·TTang-Du Hospital·Phase 4·NCT02141737·272 enrolled

Lidocaine Infusion2 trials

Lidocaine Infusion On Hysteroscopic Media Versus Oral Diclofinac For Pain Relief During Outpatient Hysteroscopy

Unknown status·—·N/A·NCT03298646·44 enrolled

Lidocaine Infusion in Hystroscopy

Completed·—·Phase 2·NCT03825016·44 enrolled

Brain Injury2 trials

Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319638·100 enrolled

Effect of Lidocaine Block in Traumatic Brain Injury

Not yet recruiting·MMuhammad·N/A·NCT06304116·80 enrolled

Safety and Efficacy2 trials

Pilot Study About Safety and Efficacy of Atomized Intrapleural Lidocaine During Pleuroscopy

Withdrawn·LLahey Clinic·N/A·NCT00693043

To Explore the Safety and Efficacy of Intravenous Infusion of Different Doses of Lidocaine in Patients

Unknown status·WWest China Hospital·N/A·NCT05369650·120 enrolled

Adhesive Capsulitis2 trials

Is Combined Steroid and Sodium Hyaluronate Hydrodilatation More Effective Than Isolated Steroid Hydrodilatation in Treating Patients With Adhesive Capsulitis

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT05861570·84 enrolled

Steroid Injection for Adhesive Capsulitis

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT04364425·80 enrolled

Cerebral Palsy2 trials

Efficacy of Lidocaine Block in Children With Cerebral Palsy and Dysphagia

Not yet recruiting·MMuhammad·N/A·NCT06304090·80 enrolled

Stellate Ganglion Block in Cerebral Palsy

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319508·80 enrolled

Obstructive Sleep Apnea2 trials

Effectiveness of Stellate Ganglion Block for the Treatment of Obstructive Sleep Apnea

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319612·80 enrolled

Stellate Ganglion Block in Obstructive Sleep Apnea

Recruiting·ZZeng Changhao·N/A·NCT06249490·80 enrolled

Neuropathy1 trial

Lidocaine for Oxaliplatin-induced Neuropathy

Completed·WWashington University School of Medicine·Phase 1/2·NCT03254394·26 enrolled

Hysterectomy1 trial

Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy

Unknown status·—·Phase 4·NCT03394001·80 enrolled

Bunion1 trial

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

Completed·CConcentric Analgesics·Phase 2·NCT03885596·36 enrolled

Myofascial Pain Syndrome1 trial

Using Saline for Myofascial Pain Syndromes (USAMPS)

Terminated·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02120261·51 enrolled

Fractures1 trial

Pain Alleviation of Forearm Fractures

Completed·—·N/A·NCT03377907·66 enrolled

Headache1 trial

Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment Phase 1

Completed·TThe Cooper Health System·Phase 1·NCT06462781·10 enrolled

Dexamethasone1 trial

Evaluation of the Effect of Adding Dexamethasone to 2% Lidocaine

Completed·JJamia Millia Islamia·N/A·NCT05361291·124 enrolled

Virtual Reality1 trial

Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Adult Patients for Pain Control During Spinal Injections (SI)

Withdrawn·—·Phase 2·NCT03787147

Migraine1 trial

Comparison of Great Occipital Nerve and Supraorbital Nerve Blockade Methods at Treatment of Acute Migraine Attack in the Emergency Department

Completed·—·Phase 4·NCT04491474·128 enrolled

Alcohol Consumption1 trial

Effect of Alcohol Consumption on the Success Rates

Unknown status·JJamia Millia Islamia·N/A·NCT06201871·70 enrolled

Spine Surgery1 trial

Inter-semispinal Plane Block and Cervical Spine Surgery

Completed·YYasser S Mostafa, MD·N/A·NCT06003933·50 enrolled

Acute Postoperative Pain1 trial

the Effect of Dexmedetomidine and Licodaine on Acute Postoperative Pain in Gynecological Laparoscopy

Withdrawn·TThe Catholic University of Korea·N/A·NCT04906889

Postoperative Analgesia1 trial

Intravenous Lidocaine for Perioperative and Postoperative Analgesia

Unknown status·RRajmonda Nallbani-Komoni·Phase 4·NCT03921567·520 enrolled

Perioperative Pain Management1 trial

Perioperative Pain Management for Lumbar Spine Surgery

Completed·—·N/A·NCT06662318·75 enrolled

Liposomal Bupivacaine1 trial

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

Recruiting·UUniversity of Kansas Medical Center·Phase 4·NCT03854344·75 enrolled

Pancreatic Cancer1 trial

Lidocaine Infusion in Pancreatic Cancer

Recruiting·UUniversity of Illinois at Chicago·Phase 1·NCT04048278·46 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of the Application of Local Anaesthetic in Spray to Repair of 1st- 2nd Perineal Lacerations

Completed·AAzienda Sanitaria-Universitaria Integrata di Udine·Phase 3·NCT05201313·136 enrolled

Insomnia1 trial

The Effect of Stellate Ganglion Block on Insomnia Patients

Recruiting·ZZeng Changhao·N/A·NCT06255730·50 enrolled

Tic Disorder1 trial

Stellate Ganglion Block in Children With Autistic Disorder

Not yet recruiting·CCopka Sonpashan·N/A·NCT06319599·80 enrolled

Rehabilitation1 trial

Intra-articular Injection Versus Normal Rehabilitation Therapy on Temporomandibular Joint Dysfunction

Not yet recruiting·CCopka Sonpashan·N/A·NCT06328998·80 enrolled

Ischemic stroke1 trial

Efficacy of Stellate Ganglion Block in Dysphagic Patients With Bulbar Palsy After Ischemic Stroke

Withdrawn·ZZeng Changhao·N/A·NCT06225076

Observational Study1 trial

Multicentre Observational Study on the Wound Pain Relief Properties of ORTODERMINA®

Completed·SSOFAR S.p.A.··NCT03720119·78 enrolled

Tramadol1 trial

Use of Tramadol Intraligamentary Injections

Completed·JJamia Millia Islamia·N/A·NCT05538052·105 enrolled

Drooling1 trial

Effect of Stellate Ganglion Block on Drooling in Parkinson's Syndrome

Not yet recruiting·BBabujinaya Cela·N/A·NCT06370195·100 enrolled

Knee Pain1 trial

Effect of Knee Pain on Walking Biomechanics

Completed·TThe Cleveland Clinic·Phase 4·NCT05670236·55 enrolled

Post Operative Sore Throat1 trial

Effect of Lidocaine on Hemodynamic Response and Postoperative Sore Throat

Completed·—·N/A·NCT06122324·100 enrolled

Outcome1 trial

Impacts of Intermittent Fasting on Energy Balance and Associated Health Outcomes

Completed·—·N/A·NCT02498002·54 enrolled

Laryngeal Mask Airway1 trial

Effect of Nebulized Lidocaine on the Quality of Laryngeal Mask Airway Insertion

Unknown status·—·N/A·NCT03361397·80 enrolled

Autism Spectrum Disorder1 trial

Effectiveness of Lidocaine Injection on Stellate Ganglion in Pediatric Patients With Autism Spectrum Disorder

Not yet recruiting·MMuhammad·N/A·NCT06301685·80 enrolled

Chronic pain1 trial

Intravenous Lidocaine on Chronic Pain in Patients Undergoing Hepatectomy

Recruiting·WWest China Hospital·Phase 2·NCT05492669·260 enrolled

Hypertension1 trial

Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension

Unknown status·AAhmed Mohamed ELbadawy·Phase 1·NCT03566329·90 enrolled

Laparoscopic Cholecystectomy1 trial

Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia

Unknown status·FFederal University of São Paulo·Phase 4·NCT02953210·40 enrolled

Ventral Hernia1 trial

Systemic Lidocaine Infusion for Pain Control in Ventral Hernia

Withdrawn·CCarilion Clinic·Phase 3·NCT03484650

Bariatric Surgery1 trial

Intraoperative Lidocaine and Combined With Ketamine on Opioid After Bariatric Surgery

Completed·MMahidol University·Phase 4·NCT04524130·87 enrolled

Anxiety1 trial

A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia.

Completed·RRiyadh Elm University·N/A·NCT04585061·31 enrolled

Hemorrhoid1 trial

Safety and Efficacy of Hydrocortisone and Lidocaine Treatment of Grade I and II Hemorrhoids

Completed·CCitius Pharmaceuticals, Inc.·Phase 2·NCT02689856·211 enrolled

Pancreatitis1 trial

Topical Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis

Completed·—·N/A·NCT00953199·506 enrolled

Intravenous Lidocaine1 trial

Efficacy of Intravenous Lidocaine on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy

Completed·WWest China Hospital·N/A·NCT04295330·260 enrolled

Anesthesia1 trial

Study Comparing Local/ MAC Anesthesia in Lumbar Decompression

Recruiting·SStanford University·Phase 1·NCT04992572·100 enrolled

Headaches Associated With Subarachnoid Hemorrhage (SAH)1 trial

Intra-arterial Lidocaine and Methylprednisolone Injection Into the Middle Meningeal Artery For Treatment of Headache Associated With Subarachnoid Hemorrhage

Recruiting·DDaniel Raper, MBBS·Phase 2·NCT07054801·25 enrolled

Sources

References

[1]
ClinicalTrials.gov — 77 trial records for Lidocaine hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Xylocaine drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Lidocaine hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Lidocaine hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Citius Pharmaceuticals, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: CCitius Pharmaceuticals, Inc.

Xylocaine

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q4 2028

Trials by Indication[1]

Lidocaine5 trials

Dysphagia5 trials

Carpal Tunnel Syndrome3 trials

Cerebral Small Vessel Disease3 trials

Stellate Ganglion Block3 trials

Gastroesophageal Reflux Disease3 trials

General Anesthesia3 trials

Lidocaine Infusion2 trials

Brain Injury2 trials

Safety and Efficacy2 trials

Adhesive Capsulitis2 trials

Cerebral Palsy2 trials

Obstructive Sleep Apnea2 trials

Neuropathy1 trial

Hysterectomy1 trial

Bunion1 trial

Myofascial Pain Syndrome1 trial

Fractures1 trial

Headache1 trial

Dexamethasone1 trial

Virtual Reality1 trial

Migraine1 trial

Alcohol Consumption1 trial

Spine Surgery1 trial

Acute Postoperative Pain1 trial

Postoperative Analgesia1 trial

Perioperative Pain Management1 trial

Liposomal Bupivacaine1 trial

Pancreatic Cancer1 trial

Efficacy and Safety1 trial

Insomnia1 trial

Tic Disorder1 trial

Rehabilitation1 trial

Ischemic stroke1 trial

Observational Study1 trial

Tramadol1 trial

Drooling1 trial

Knee Pain1 trial

Post Operative Sore Throat1 trial

Outcome1 trial

Laryngeal Mask Airway1 trial

Autism Spectrum Disorder1 trial

Chronic pain1 trial

Hypertension1 trial

Laparoscopic Cholecystectomy1 trial

Ventral Hernia1 trial

Bariatric Surgery1 trial

Anxiety1 trial

Hemorrhoid1 trial

Pancreatitis1 trial

Intravenous Lidocaine1 trial

Anesthesia1 trial

Headaches Associated With Subarachnoid Hemorrhage (SAH)1 trial

References

Drug Info

Quick Facts

Related News