Xylocaine
(Lidocaine hydrochloride)Phase 3Small molecule
Lidocaine is a numbing medication used to block pain and discomfort during medical procedures or to relieve pain from minor skin conditions like insect bites or mouth sores.[1] Xylocaine is currently being investigated across 28 indications[3], with its most advanced program in Phase 3.[1]
Xylocaine is one of 528 small molecule programs targeting Gastroesophageal Reflux Disease. It is currently in Phase 3.
28
Indications
78
Total Trials
26
Active Trials
527
Competitors
Pipeline
Status by Indication[3][1]
Indication
Showing 10 of 27 indications
Competition
Competitive Landscape
348 competitors in Prostate Cancer
#DrugCompanyPhaseTrials
1Opdivo
Bristol-Myers SquibbPhase 3
Xylocaine
CCitius Pharmaceuticals, Inc.
Phase 3
Lupron
EEastern Cooperative Oncology Group
Phase 3
Nizoral
WWim Janssens
Phase 3
Lipitor
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Phase 3
Triptorelin Embonate
IpsenPhase 3
Fluciclovine
UUniversity of Utah
Phase 3
Fuzuloparib
JJiangsu HengRui Medicine Co., Ltd.
Phase 3
Rhpsma-7.3 (18f)
BBlue Earth Diagnostics
Phase 3
Trexall
Jazz PharmaceuticalsPreclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Dysphagia5 trials
The Effectiveness of Stellate Ganglion Block in Managing Dysphagia in Patients With Medullary Infarction
Not yet recruiting·—·N/A·NCT06301698·80 enrolled
Lidocaine4 trials
Efficacy of Lidocaine and Xylometazoline Intranasal Spray in Anesthetizing Maxillary Teeth
Completed·—·Phase 1·NCT04732104·60 enrolled
Show 1 more trial
Lidocaine Before Esophageal Manometry and Ambulatory pH Monitoring
Completed·—·Phase 2/3·NCT03967197·304 enrolled
Stellate Ganglion Block3 trials
General Anesthesia3 trials
Carpal Tunnel Syndrome3 trials
49 more indications
Cerebral Small Vessel Disease3 trials
Investigation of Potential Mechanisms in Stellate Ganglion Block in Individuals With Cerebral Small Vessel Disease
Not yet recruiting·—·N/A·NCT06301711·80 enrolled
Gastroesophageal Reflux Disease3 trials
Lidocaine Infusion2 trials
Lidocaine Infusion On Hysteroscopic Media Versus Oral Diclofinac For Pain Relief During Outpatient Hysteroscopy
Unknown status·—·N/A·NCT03298646·44 enrolled
Lidocaine Infusion in Hystroscopy
Completed·—·Phase 2·NCT03825016·44 enrolled
Obstructive Sleep Apnea2 trials
Safety and Efficacy2 trials
Brain Injury2 trials
Cerebral Palsy2 trials
Headaches Associated With Subarachnoid Hemorrhage (SAH)2 trials
Hysterectomy1 trial
Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy
Unknown status·—·Phase 4·NCT03394001·80 enrolled
Fractures1 trial
Pain Alleviation of Forearm Fractures
Completed·—·N/A·NCT03377907·66 enrolled
Migraine1 trial
Comparison of Great Occipital Nerve and Supraorbital Nerve Blockade Methods at Treatment of Acute Migraine Attack in the Emergency Department
Completed·—·Phase 4·NCT04491474·128 enrolled
Laparoscopic Cholecystectomy1 trial
Hemorrhoid1 trial
Post Operative Sore Throat1 trial
Effect of Lidocaine on Hemodynamic Response and Postoperative Sore Throat
Completed·—·N/A·NCT06122324·100 enrolled
Outcome1 trial
Impacts of Intermittent Fasting on Energy Balance and Associated Health Outcomes
Completed·—·N/A·NCT02498002·54 enrolled
Intravenous Lidocaine1 trial
Ischemic stroke1 trial
Observational Study1 trial
Rehabilitation1 trial
Virtual Reality1 trial
Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Adult Patients for Pain Control During Spinal Injections (SI)
Withdrawn·—·Phase 2·NCT03787147
Anxiety1 trial
Perioperative Pain Management1 trial
Perioperative Pain Management for Lumbar Spine Surgery
Completed·—·N/A·NCT06662318·75 enrolled
Bariatric Surgery1 trial
Autism Spectrum Disorder1 trial
Efficacy and Safety1 trial
Laryngeal Mask Airway1 trial
Effect of Nebulized Lidocaine on the Quality of Laryngeal Mask Airway Insertion
Unknown status·—·N/A·NCT03361397·80 enrolled
Pancreatitis1 trial
Topical Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis
Completed·—·N/A·NCT00953199·506 enrolled
Acute Postoperative Pain1 trial
CAD1 trial
Sources
References
- [1]
- [2]
- [3]Open Targets Platform — Drug–disease associations for Lidocaine hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
- [4]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Sodium Channel Alpha Subunit Blocker[2]
- Modality
- Small molecule[2]
- Highest Phase
- Phase 3[1]
- Company
- CCitius Pharmaceuticals, Inc.