Ciprofol

Phase 3Small molecule

Haisco Pharmaceutical Group Co., Ltd.

Ciprofol is one of 165 small molecule programs targeting Insomnia. It is currently in Phase 3.

Indications

Total Trials

Active Trials

164

Competitors

Pipeline

Status by Indication[3][1]

Indication

InsomniaActive, not recruiting

Liver CancerActive, not recruiting

TonsillectomyRecruiting

Extracorporeal Membrane OxygenationNot yet recruiting

Total Intravenous AnesthesiaCompleted

ColonoscopyCompleted

Postoperative Quality of RecoveryUnknown status

IntraoperativeNot yet recruiting

Fiberoptic BronchoscopyNot yet recruiting

Hemodynamic StabilityNot yet recruiting

InsomniaPreclinical

Active, not recruiting

Liver CancerPreclinical

Active, not recruiting

TonsillectomyPhase 3

Recruiting

Extracorporeal Membrane OxygenationPhase 3

Not yet recruiting

Total Intravenous AnesthesiaPreclinical

Completed

ColonoscopyPreclinical

Completed

Postoperative Quality of RecoveryPreclinical

Unknown status

IntraoperativePhase 3

Not yet recruiting

Fiberoptic BronchoscopyPreclinical

Not yet recruiting

Hemodynamic StabilityPhase 3

Not yet recruiting

Showing 10 of 16 indications

Competition

Competitive Landscape

60 competitors in Liver Cancer

#DrugCompanyPhaseTrials

Idamycin

Blenoxane

Taxol

Opdivo

12 5

Baraclude

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Approved

1 6

Eloxatin

Teva

Phase 3

8 7

Lenvima

Eisai

Phase 3

7 8

Rapamune

PPrism Pharmaceuticals

Glucophage

Revlimid

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Approved

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Recruiting

Ciprofol

NCT07301242

Post-ApprovalNot yet recruiting

Extracorporeal Membrane Oxygenation

NCT06934811

Q1 2027

ApprovedNot yet recruiting

Intraoperative

NCT07718152

PreclinicalNot yet recruiting

Hypotension

NCT07663695

Q3 2027

PreclinicalNot yet recruiting

Brain Neoplasms

NCT07799623

Q4 2027

Post-ApprovalRecruiting

Injury

NCT07028593

Clinical

Trials by Indication[1]

Sedation6 trials

Dose Exploration of Ciprofol for Sedation in Gastrointestinal Endoscopic Diagnosis and Treatment of Obese Patients.

Unknown status·RRenJi Hospital·N/A·NCT05517408·30 enrolled

Phase III Clinical Trial Evaluating the Efficacy and Safety of Ciprofol Injection for the Induction of Sedation/Anesthesia in Subjects Undergoing Gynecological Outpatient Surgeries

Completed· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 3·NCT04958746·135 enrolled

the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People

Unknown status·SSecond Hospital of Shanxi Medical University·Phase 1·NCT06293144·70 enrolled

Show 3 more trials

Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study

Unknown status·NNanfang Hospital, Southern Medical University··NCT05971121·456 enrolled

Median Effective Dose of Ciprofol-Assisted Sedation for Elderly Patients Undergoing Knee Arthroplasty

Completed·SSecond Hospital of Shanxi Medical University·Phase 1·NCT06293131·70 enrolled

Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients With Mechanical Ventilation: A Multi-Center, Double-Blind, Randomized Controlled Trial

Completed·ZZhongda Hospital·Approved·NCT06538883·366 enrolled

Postoperative Recovery3 trials

Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery

Unknown status·XXiumei Song·Phase 4·NCT05664386·126 enrolled

Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery

Active, not recruiting·NNorthern Jiangsu People's Hospital·N/A·NCT06976996·190 enrolled

The Impact of Low-Dose Esketamine Combined With Ciprofol on the Quality of Early Postoperative Recovery Among Elderly Patients Undergoing Painless Gastroscopy

Active, not recruiting·NNorthern Jiangsu People's Hospital·N/A·NCT06617039·376 enrolled

Tracheal Intubation2 trials

Ciprofol Versus Propofol for Tracheal Intubation in ICU

Completed·SShanghai Zhongshan Hospital·Phase 4·NCT06344949·100 enrolled

The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation

Unknown status·—·Phase 4·NCT06095570·150 enrolled

Hypotension2 trials

Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·N/A·NCT06258967·160 enrolled

Comparison of the Effects of Propofol and Ciprofol on the Incidence of Post-induction Hypotension in Frail Elderly Patients Undergoing General Anesthesia

Not yet recruiting·GGeneral Hospital of Ningxia Medical University·Preclinical·NCT07663695·96 enrolled

Anesthesia Induction2 trials

Clinical Observation of Ciprofol for Anesthesia Induction

Unknown status·XXiumei Song·Phase 4·NCT05706337·90 enrolled

The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding Trial

Recruiting·HHuazhong University of Science and Technology·Approved·NCT07697404·180 enrolled

32 more indications

Ciprofol2 trials

Study on Pharmacokinetics of Single Injection of Ciprofol in Patients With Moderate to Severe Hypoproteinemia

Completed·XXie Kangjie·Phase 4·NCT06425757·36 enrolled

Population Pharmacokinetics and Pharmacodynamics of Ciprofol

Recruiting·—··NCT07301242·50 enrolled

Tonsillectomy1 trial

Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy

Recruiting·TTongji Hospital·Phase 4·NCT07118579·114 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Efficacy and Safety of Ciprofol in Laparoscopic Sleeve Gastrectomy

Completed·—·Phase 4·NCT05522998·212 enrolled

Cardiac Surgery1 trial

Safety and Effectiveness of Ciprofol in Cardiac Surgery Anesthesia

Unknown status·LLe Yu·N/A·NCT05892471·80 enrolled

Injury1 trial

Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery

Recruiting·TTongji Hospital·Phase 4·NCT07028593·1,058 enrolled

Memory1 trial

Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients

Unknown status·FFirst Affiliated Hospital of Chongqing Medical University·Phase 1·NCT05266560·390 enrolled

Mechanically Ventilated Patients1 trial

The Effect of Ciprofol on Breathing Patterns, Respiratory Drive, and Inspiratory Effort in Mechanically Ventilated Patients

Unknown status·—·N/A·NCT06287138·20 enrolled

Colonoscopy1 trial

Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy

Completed·SSichuan Provincial People's Hospital·N/A·NCT05294679·110 enrolled

Extracorporeal Membrane Oxygenation1 trial

Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients

Not yet recruiting·FFirst Affiliated Hospital of Wannan Medical College·Phase 4·NCT06934811·30 enrolled

Hysteroscopy1 trial

Ciprofol Versus Propofol in Patients Undergoing Painless Hysteroscopy

Not yet recruiting·—·N/A·NCT06413862·188 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Ciprofol Compared to Propofol for Nonintubated General Anesthesia in Patients Undergoing TAVR

Unknown status· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 4·NCT05035069·24 enrolled

Postoperative Quality of Recovery1 trial

Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery

Unknown status·XXijing Hospital·N/A·NCT05843383·280 enrolled

Concentration1 trial

The Effective Blood Concentration of Ciprofol

Recruiting·PPeking University Shenzhen Hospital··NCT07294989·101 enrolled

Anesthesia1 trial

Effect of Remazolam on Anesthesia Recovery in Patients Undergoing Fundus Surgery

Not yet recruiting·SSichuan Provincial People's Hospital·Phase 1·NCT06205719·93 enrolled

Fiberoptic Bronchoscopy1 trial

Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy

Not yet recruiting·—·N/A·NCT06531915·190 enrolled

Transcatheter Aortic Valve Replacement1 trial

Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement

Completed·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT05881291·124 enrolled

Total Intravenous Anesthesia1 trial

Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery

Completed·TTongji Hospital·N/A·NCT06735430·86 enrolled

Overweight1 trial

Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients

Completed·RRenJi Hospital·Phase 4·NCT05518929·1,090 enrolled

Propofol1 trial

A Study to Evaluate the Differences in Pharmadynamics, Pharmacokinetics, and Safety Between Ciprofol and Propofol

Completed· Haisco Pharmaceutical Group Co., Ltd. logo

Haisco Pharmaceutical Group Co., Ltd.·Phase 1·NCT04294056·18 enrolled

Hypoxia1 trial

Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP

Not yet recruiting·RRenJi Hospital·N/A·NCT06015074·136 enrolled

Liver Cancer1 trial

Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation

Unknown status·ZZhejiang Cancer Hospital·N/A·NCT06178926·80 enrolled

Insomnia1 trial

Study for Evaluating the Efficacy of Ciprofol in Patients Under Narcotic Sleep With Chronic Insomnia

Unknown status·SSichuan Provincial People's Hospital·N/A·NCT04958382·30 enrolled

Colorectal Surgery1 trial

The Effect of Different Intravenous Anesthetics on Postoperative Recovery Quality in Patients Undergoing Elective Laparoscopic Colorectal Surgery: A Single-Center, Prospective, Randomized Controlled Trial

Completed·TThe First Affiliated Hospital of Zhengzhou University·Preclinical·NCT07903389·180 enrolled

PND1 trial

Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery

Enrolling by invitation·SSecond Affiliated Hospital of Wenzhou Medical University·Approved·NCT07895407·148 enrolled

Neurocognitive Function1 trial

Comparison of the Effects of Ciprofol and Propofol on Cognitive Function After Painless Gastroenteroscopy

Completed·SSecond Affiliated Hospital of Wenzhou Medical University··NCT07887594·196 enrolled

Cholelithiasis1 trial

A Prospective, Randomized, Controlled, Single-Blind Clinical Trial Comparing the Effects of Propofol, Ciprofol, and Remimazolam on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy

Active, not recruiting·XXi'an Aerospace General Hospital·Approved·NCT07758803·114 enrolled

Completed·WWenzhou Central Hospital·Approved·NCT07744061·100 enrolled

Intraoperative1 trial

Effects of Alternating Ciprofol and Remimazolam on Intraoperative Motor and Somatosensory Evoked Potentials During Spine Surgery: A Randomized Crossover Trial

Not yet recruiting·AAffiliated 2 Hospital of Nantong University·Approved·NCT07718152·60 enrolled

Hemodynamic Stability1 trial

Ciprofol vs Propofol for Hemodynamic Stability in Patients Having General Anesthesia for Endovascular Thrombectomy After Ischemic Stroke: A Multicenter Randomized Open-label Parallel-group Trial (CONSTANCY)

Not yet recruiting·RRenJi Hospital·Approved·NCT07696208·124 enrolled

Postoperative Delirium (POD)1 trial

Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery: a Multicentre, Prospective, Single-blind, Randomized Controlled Study

Completed·WWang Tianlong·Approved·NCT06674226·225 enrolled

Sources

References

[1]
ClinicalTrials.gov — 48 trial records for Ciprofol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ciprofol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ciprofol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Haisco Pharmaceutical Group Co., Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Haisco Pharmaceutical Group Co., Ltd.

Ciprofol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q3 2027

Q4 2027

Trials by Indication[1]

Sedation6 trials

Postoperative Recovery3 trials

Tracheal Intubation2 trials

Hypotension2 trials

Anesthesia Induction2 trials

Ciprofol2 trials

Tonsillectomy1 trial

Laparoscopic Sleeve Gastrectomy1 trial

Cardiac Surgery1 trial

Injury1 trial

Memory1 trial

Mechanically Ventilated Patients1 trial

Colonoscopy1 trial

Extracorporeal Membrane Oxygenation1 trial

Hysteroscopy1 trial

Efficacy and Safety1 trial

Postoperative Quality of Recovery1 trial

Concentration1 trial

Anesthesia1 trial

Fiberoptic Bronchoscopy1 trial

Transcatheter Aortic Valve Replacement1 trial

Total Intravenous Anesthesia1 trial

Overweight1 trial

Propofol1 trial

Hypoxia1 trial

Liver Cancer1 trial

Insomnia1 trial

Colorectal Surgery1 trial

PND1 trial

Neurocognitive Function1 trial

Cholelithiasis1 trial

ERCP1 trial

Brain Neoplasms1 trial

Bronchoscopy1 trial

Intraoperative1 trial

Hemodynamic Stability1 trial

Postoperative Delirium (POD)1 trial

References

Drug Info

Quick Facts

Related News