VivoSeq
Other

Knee Injury

9

Pipeline Programs↗

2

Active Trials↗

4

Companies Involved↗

Knee Injury is an early-stage landscape with 9 programs across 4 companies. The most active players are Pfizer, GSK, Fresenius Kabi Oncology Ltd.. 2 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

36/100

Pipeline Velocity

11/100

Mech. Concentration

14/100

Completion Rate

83/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Pfizer logo

Pfizer

1 program

Phase 1GSK logo

GSK

2 programs

Phase 3F

Fresenius Kabi Oncology Ltd.

1 program

ApprovedMerck & Co. logo

Merck & Co.

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Modality Breakdown

90%

Small molecule

9 of 10 classified programs — the dominant modality here.

10%ALL OTHERSCell therapy110%

Small molecule leads; the ring shows all 10 classified programs, each share of the total. Modality classified for 100% of 10 pipeline programs.

Analysis

Trial Status

8

clinical trials

Completed5 · 63%
Terminated1 · 13%
Recruiting1 · 13%
Not yet recruiting1 · 13%

Clinical Trials

Trial Activity

8 trials

Losartan to Improve Outcomes After Multi-ligament Knee Injury
Recruiting·—·Phase 2·NCT06933706·90 enrolled
Quadriceps Motor Unit Adaptation to Simulated Knee Injury
Not yet recruiting·—·N/A·NCT06999057·45 enrolled
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
Completed·GSK logoGSK·Phase 3·NCT00843492·1,351 enrolled
Efficacy of Allogeneic UCMSCs for Treating Large Defects Knee Injury
Completed·—·Phase 2·NCT05016011·28 enrolled
Study to Prevent Cartilage Damage Following Acute Knee Injury.
Completed·—·Phase 1/2·NCT00332254·10 enrolled
Effects of Biofeedback Training on Knee Proprioception in Individuals With a History of Knee Injury: A Pilot Study
Completed·MMarshall University·Preclinical·NCT07691528·14 enrolled
Utilization of Rehabilitation Prior to Surgery Among Patients With Anterior-cruciate Ligament Knee Injury: a Retrospective Review of the French National Health Database (Prehab-ACL)
Completed·NNantes University Hospital·N/A·NCT05737719·864,000 enrolled
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury
Terminated·UUniversity of Calgary·Phase 1·NCT05204836·4 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)