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MS Contin

(Morphine Sulfate)

ApprovedSmall molecule

Morphine sulfate is a strong painkiller used to treat moderate to severe pain, such as pain from cancer, heart attacks, or after surgery. It can also be used to help people with severe shortness of breath.[2] MS Contin is currently approved and in use across 31 indications[4].[1]

MS Contin is one of 709 small molecule programs targeting Low back pain. It is currently in Approved.

31

Indications

89

Total Trials

6

Active Trials

708

Competitors

Pipeline

Status by Indication[4][1]

Indication

Low Back PainActive, not recruiting

ArthritisActive, not recruiting

OverdoseUnknown

Pleural EffusionActive, not recruiting

Obstructive Sleep ApneaActive, not recruiting

Cancer PainActive, not recruiting

Chronic Obstructive Pulmonary DiseaseActive, not recruiting

Hallux ValgusActive, not recruiting

Pulmonary FibrosisActive, not recruiting

Chronic PainUnknown

Low Back PainPhase 1

Active, not recruiting

ArthritisPhase 2/Phase 3

Active, not recruiting

OverdosePreclinical

Unknown

Pleural EffusionPhase 2

Active, not recruiting

Obstructive Sleep ApneaPhase 3

Active, not recruiting

Cancer PainPhase 3

Active, not recruiting

Chronic Obstructive Pulmonary DiseasePhase 3

Active, not recruiting

Hallux ValgusPhase 2

Active, not recruiting

Pulmonary FibrosisPhase 3

Active, not recruiting

Chronic PainPreclinical

Unknown

Showing 10 of 30 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

MS Contin

Avastin

BBio-Thera Solutions

Megace

Bristol-Myers Squibb

Cymbalta

Alnylam Pharmaceuticals

Lexiscan

Adenocard

Voltaren

Sporanox

SSebela Pharmaceuticals Development LLC

Tricor

Avastin

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Thoracic Surgery

NCT05351229

Q4 2026

Post-ApprovalActive, not recruiting

Neonatal Abstinence Syndrome

NCT03092011

Q4 2029

Phase 3Recruiting

Abdominal Pain

NCT06160778

Clinical

Trials by Indication[1]

Morphine10 trials

Bioequivalence Study of Morphine Sulfate 60 mg Extended-Release Tablets Under Fed Conditions

Completed·RRanbaxy Inc.·Phase 1·NCT01665209·24 enrolled

Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds

Unknown status·IInstituto Nacional de Cancer, Brazil·Phase 2·NCT05800834·106 enrolled

Dose Proportionality and Food Effect of Morphine Sulfate

Completed·RRoxane Laboratories·N/A·NCT00994539·36 enrolled

Show 7 more trials

Comparative Bioavailability Study of Morphine Sulfate Immediate Release and Controlled Release

Completed·RRoxane Laboratories·N/A·NCT00994383·36 enrolled

Breathlessness Exertion and Morphine Sulphate

Completed·FFlinders University·Phase 3·NCT02720822·171 enrolled

Cannabidiol, Morphine, Pain

Unknown status·WWayne State University·Phase 1·NCT04030442·40 enrolled

Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fed Conditions

Completed·AActavis Inc.·Phase 1·NCT00759356·36 enrolled

Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects

Unknown status·HHopital Lariboisière·Phase 4·NCT02641301·24 enrolled

Comparison of One Morphine Sulfate Sustained-Release 200 mg Capsule With Two 100 mg KADIAN Capsules on Applesauce

Completed·AActavis Inc.·Phase 1·NCT00759954·36 enrolled

Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions

Completed·RRoxane Laboratories·N/A·NCT00994942·18 enrolled

Cesarean Section3 trials

Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section

Completed·—·Phase 2·NCT03483870·80 enrolled

Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.

Unknown status·MMinia University·N/A·NCT04618146·60 enrolled

Comparison of Pruritus Incidence After Intrathecal Morphine 0.1 vs 0.2 mg in Cesarean Section

Recruiting·KKhon Kaen University·Phase 4·NCT07054775·69 enrolled

Abdominal pain3 trials

The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision

Withdrawn·UUniversity of Texas Southwestern Medical Center·N/A·NCT00839787

Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain

Recruiting·UUniversity of Calgary·Phase 3·NCT06160778·495 enrolled

Ketorolac for Moderate to Severe Abdominal Pain in Children

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT04528563·105 enrolled

Buprenorphine3 trials

Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film

Completed·BBioDelivery Sciences International·Phase 2·NCT01871285·39 enrolled

Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals

Unknown status·UUniversity of California, Los Angeles·N/A·NCT02136784·12 enrolled

Intravenous Buprenorphine Versus Morphine for Severe Pain in the Emergency Department

Unknown status·—·Phase 2·NCT03256487·122 enrolled

Analgesic Efficacy3 trials

A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery (Study P05800)

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT00782951·11 enrolled

Analgesic Efficacy of Transmucosal Fentanyl for Breakthrough Pain Caused by Interventional Gastrostomy

Completed·—·Phase 4·NCT02869321·20 enrolled

Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)

Completed·AAntonios Likourezos·Phase 2·NCT03088826·80 enrolled

53 more indications

Cancer Pain3 trials

Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain

Completed·UUniversity Hospitals Bristol and Weston NHS Foundation Trust·Phase 4·NCT00378937·30 enrolled

IV PCA With or Without Continuous Dose vs Oral Opioid to Maintain Analgesia for Severe Cancer Pain After Successful Titration

Completed·FFujian Cancer Hospital·Phase 3·NCT04785768·1,372 enrolled

A Study to Evaluate Buprenorphine Transdermal Patch in Chinese Subjects With Moderate to Severe Chronic Cancer Pain

Unknown status·MMundipharma (China) Pharmaceutical Co. Ltd·Phase 3·NCT03967327·194 enrolled

Chronic pain3 trials

Treatment for Chronic Pain in Patients With Advanced Cancer

Completed·NNCIC Clinical Trials Group·Phase 3·NCT00003687·87 enrolled

Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza

Completed· Pfizer logo

Pfizer·Phase 4·NCT00640042·1,570 enrolled

A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer

Withdrawn·LLabtec GmbH·Phase 2·NCT00943566

Dexmedetomidine2 trials

Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.

Completed·PPontificia Universidad Catolica de Chile·Phase 4·NCT03809182·40 enrolled

Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity

Unknown status·—·Phase 1/2·NCT03024957·30 enrolled

Breast Cancer2 trials

Morphine for the Treatment of Pain in Patients With Breast Cancer

Completed·RRoswell Park Cancer Institute··NCT00003000·18 enrolled

Perioperative Analgesic Modalities for Breast Cancer Surgeries

Completed·NNational Cancer Institute, Egypt·N/A·NCT04248608·75 enrolled

Pediatric2 trials

Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects

Completed·RRoxane Laboratories·Phase 4·NCT01322360·50 enrolled

Study of Oral Morphine Sulfate Administration in Pediatric Subjects

Completed·WWest-Ward Pharmaceutical·Phase 3·NCT03429400·51 enrolled

Quadratus Lumborum Block2 trials

Ultrasound Guided Anterior Quadratus Lumborum Block

Completed·—·N/A·NCT03425162·60 enrolled

Quadratus Lumborum Block in Pediatric Patients

Completed·—·N/A·NCT03693222·40 enrolled

Efficacy and Safety2 trials

Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients

Completed·QQRxPharma Inc.·Phase 3·NCT01016808·522 enrolled

Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients

Completed·QQRxPharma Inc.·Phase 2·NCT00831051·197 enrolled

Methadone2 trials

Epidural Methadone in Healthy Volunteers

Completed·Ssimon.haroutounian·Phase 1·NCT03525509·13 enrolled

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Terminated·MM.D. Anderson Cancer Center·N/A·NCT00726830·1 enrolled

Neonatal Abstinence Syndrome2 trials

Comparison of Buprenorphine to Morphine in Treatment of Neonatal Abstinence Syndrome (NAS)

Completed·PPediatrix·Phase 2·NCT01708707·29 enrolled

Treatment of Neonatal Abstinence Syndrome With Clonidine Versus Morphine as Primary Therapy

Active, not recruiting·TThe Cooper Health System·Phase 4·NCT03092011·69 enrolled

Fasting Conditions2 trials

Bioequivalence Study of Morphine Sulfate 60 mg Extended-Release Tablets Under Fasting Conditions

Completed·RRanbaxy Inc.·Phase 1·NCT01665222·26 enrolled

Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fasting Conditions

Completed·AActavis Inc.·Phase 1·NCT00759759·36 enrolled

Opioid Use Disorder2 trials

Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy

Withdrawn·LLyndra Inc.·Phase 1·NCT05251376

Anti-suicidal Effects of Buprenorphine in Opioid Use Disorder

Withdrawn·NNew York State Psychiatric Institute·Phase 4·NCT04234516

Cesarean Delivery2 trials

Intrathecal Morphine for Cesarean Delivery

Completed·—·Phase 4·NCT05069012·72 enrolled

Decreased Neuraxial Morphine After Cesarean Delivery

Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT04279054·87 enrolled

Post Operative Pain1 trial

Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy

Completed·NNeumentum, Inc.·Phase 3·NCT05324358·341 enrolled

Thoracic Surgery1 trial

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Recruiting·NNorthwestern University·Phase 4·NCT05351229·90 enrolled

Inflammatory Response1 trial

Inflammatory Responses to Acute and Chronic Opioid Exposure in Humans

Terminated·SStanford University·N/A·NCT01749826·20 enrolled

Multimodal Analgesia1 trial

Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery

Completed·—·Phase 4·NCT04110665·92 enrolled

Acetaminophen1 trial

Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen

Completed·IIsfahan University of Medical Sciences·Phase 3·NCT05630222·150 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Serratus Anterior Plane Block1 trial

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Completed·—·N/A·NCT02962024·40 enrolled

Radiofrequency Ablation1 trial

Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer

Completed·IInstitut Bergonié·Phase 2·NCT00712712·78 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

Long Thoracic Nerve Blockade for Pain Treatment After Video-Assisted Thoracoscopic Surgery

Unknown status·—·N/A·NCT03483415·60 enrolled

Pulmonary Fibrosis1 trial

Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough

Completed·RRoyal Brompton & Harefield NHS Foundation Trust·Phase 3·NCT04429516·44 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Opioids for Refractory Breathlessness in Chronic Obstructive Pulmonary Disease

Withdrawn·FFlinders University·Phase 3·NCT02455362

Anemia1 trial

Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia

Completed·—·Phase 2/3·NCT04301336·350 enrolled

Hypoglycemia1 trial

Mechanisms of Hypoglycemia Associated Autonomic Failure

Unknown status·—·Phase 2·NCT00678145·116 enrolled

Erector Spinae Plane Block1 trial

Effectiveness of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Open Knee Surgeries

Enrolling by invitation·—·N/A·NCT06562634·40 enrolled

Total Knee Replacement1 trial

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

Unknown status·TThe New England Baptist Hospital·Phase 3·NCT02473198·312 enrolled

LAM1 trial

Effects of Anaesthesia on Inflammatory Markers

Completed·—·N/A·NCT04630938·81 enrolled

Lumbar Disc Surgery1 trial

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery

Completed·IInonu University·N/A·NCT03437707·3 enrolled

Interaction1 trial

Evaluation of the Interactions of Cannabidiol (CBD) With Morphine

Recruiting·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT05143424·60 enrolled

Encephalopathy1 trial

Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)

Completed·UUniversity of Utah·Phase 2·NCT04772222·50 enrolled

Arthritis1 trial

NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint

Unknown status·HHildrun Haibel·Phase 2/3·NCT02967302·112 enrolled

Ultrasound1 trial

Ultrasound-Guided Versus Conventional Injection for Caudal Block

Completed·—·N/A·NCT03337191·134 enrolled

Liposomal Bupivacaine1 trial

Liposomal Bupivacaine in Implant Based Breast Reconstruction

Terminated·LLoma Linda University·N/A·NCT02659501·24 enrolled

Pleural effusion1 trial

Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion

Unknown status·OOxford University Hospitals NHS Trust·Phase 2·NCT00644319·320 enrolled

Adult1 trial

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01507220·2 enrolled

Breakthrough Pain1 trial

Inhaled Morphine Compared With Morphine By Mouth in Treating Cancer Patients With Breakthrough Pain

Completed·—·Phase 2·NCT00020618

Total Knee Arthroplasty1 trial

Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

Completed·SSeoul National University Hospital·Phase 4·NCT00901628·101 enrolled

Hysterectomy1 trial

Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy

Completed·IInonu University·N/A·NCT04691856·66 enrolled

Perioperative Analgesia1 trial

SEQ Block for Perioperative Analgesia in Acetabular Surgery

Completed·—·Phase 3·NCT04688814·52 enrolled

Pancreatic Cancer1 trial

Standard Pain Control or Intrathecal Therapy in Controlling Pain in Patients With Locally Advanced, Unresectable, or Metastatic Pancreatic Cancer

Terminated·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·N/A·NCT00660348·1 enrolled

Oxycodone1 trial

Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients

Completed·QQRxPharma Inc.·Phase 3·NCT01280331·375 enrolled

Fed1 trial

Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fed Conditions

Completed·AActavis Inc.·Phase 1·NCT00759915·36 enrolled

Recurrent1 trial

A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED

Withdrawn·AAntonios Likourezos·Phase 4·NCT03529331

Sickle Cell Disease1 trial

Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease

Completed·—·Phase 4·NCT02222246·106 enrolled

Esketamine1 trial

Postoperative Analgesic Effect of Esketamine

Completed·XXuanhan County People's Hospital·N/A·NCT05582135·119 enrolled

TED1 trial

Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fasted Conditions

Completed·AActavis Inc.·Phase 1·NCT00759902·36 enrolled

Knee Arthroplasty1 trial

Comparison of Local Anesthetic Dose in Ipack Block Performed in Knee Arthroplasty Operations

Completed·IIstanbul University·N/A·NCT05963139·112 enrolled

Pulmonary Arterial Hypertension1 trial

Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertension

Unknown status·JJohn Granton·Phase 2·NCT03401476·15 enrolled

Infusion1 trial

Comparison Between Pericapsular Nerve Group Block (PENG) and Morphine Infusion

Completed·SSuez Canal University·N/A·NCT05023473·36 enrolled

Epidural Analgesia1 trial

Thoracic Epidural Analgesia in Flail Chest

Unknown status·—·Phase 2/3·NCT03413059·40 enrolled

Postoperative Pain Control1 trial

Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally

Unknown status·SSohag University·Phase 2·NCT05186454·60 enrolled

Percutaneous Coronary Intervention1 trial

Ticagrelor and Intracoronary Morphine in Patients Undergoing Primary Percutaneous Coronary Intervention

Unknown status·HHyeon-Cheol Gwon·Phase 2·NCT01738100·100 enrolled

Sources

References

[1]
ClinicalTrials.gov — 89 trial records for Morphine Sulfate. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — MS Contin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Morphine Sulfate compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Morphine Sulfate. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Merck & Co.

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