MS Contin

(Morphine Sulfate)

ApprovedSmall molecule

Morphine sulfate is a strong painkiller used to treat moderate to severe pain, such as pain from cancer, heart attacks, or after surgery. It can also be used to help people with severe shortness of breath.[2] MS Contin is currently approved and in use across 13 indications[4].[1]

MS Contin is one of 308 small molecule programs targeting Overdose. It is currently in Approved.

Indications

Total Trials

Active Trials

307

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

OverdoseUnknown

Abdominal PainActive, not recruiting

Knee InjuryActive, not recruiting

Pain AgnosiaActive, not recruiting

Drug DependenceUnknown

Sickle Cell DiseaseActive, not recruiting

Cesarean SectionActive, not recruiting

Inflammatory ResponseActive, not recruiting

HysterectomyActive, not recruiting

Breast CancerActive, not recruiting

OverdosePreclinical

Unknown

Abdominal PainPreclinical

Active, not recruiting

Knee InjuryPreclinical

Active, not recruiting

Pain AgnosiaPreclinical

Active, not recruiting

Drug DependencePreclinical

Unknown

Sickle Cell DiseaseApproved

Active, not recruiting

Cesarean SectionApproved

Active, not recruiting

Inflammatory ResponsePreclinical

Active, not recruiting

HysterectomyPreclinical

Active, not recruiting

Breast CancerPreclinical

Active, not recruiting

Showing 10 of 12 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

MS Contin

HHikma Pharmaceuticals LLC

Approved

2 2

Lexiscan

Astellas

Preclinical

1 3

Voltaren

Novartis

Preclinical

1 4

Zolymbus

AbbVie

Preclinical

1 5

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 6

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 7

Duragesic-100

CCephalon

Preclinical

2 8

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 9

Tricor

JJagotec

Preclinical

1 10

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalActive, not recruiting

Neonatal Abstinence Syndrome

NCT03092011

Q4 2029

Phase 3Recruiting

Abdominal Pain

NCT06160778

Clinical

Trials by Indication[1]

Morphine10 trials

Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects

Unknown status·HHopital Lariboisière·Phase 4·NCT02641301·24 enrolled

Cannabidiol, Morphine, Pain

Unknown status·WWayne State University·Phase 1·NCT04030442·40 enrolled

Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fed Conditions

Completed·AActavis Inc.·Phase 1·NCT00759356·36 enrolled

Show 7 more trials

Dose Proportionality and Food Effect of Morphine Sulfate

Completed·RRoxane Laboratories·N/A·NCT00994539·36 enrolled

Comparative Bioavailability Study of Morphine Sulfate Immediate Release and Controlled Release

Completed·RRoxane Laboratories·N/A·NCT00994383·36 enrolled

Breathlessness Exertion and Morphine Sulphate

Completed·FFlinders University·Phase 3·NCT02720822·171 enrolled

Comparison of One Morphine Sulfate Sustained-Release 200 mg Capsule With Two 100 mg KADIAN Capsules on Applesauce

Completed·AActavis Inc.·Phase 1·NCT00759954·36 enrolled

Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds

Unknown status·IInstituto Nacional de Cancer, Brazil·Phase 2·NCT05800834·106 enrolled

Bioequivalence Study of Morphine Sulfate 60 mg Extended-Release Tablets Under Fed Conditions

Completed·RRanbaxy Inc.·Phase 1·NCT01665209·24 enrolled

Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions

Completed·RRoxane Laboratories·N/A·NCT00994942·18 enrolled

Analgesic Efficacy3 trials

A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery (Study P05800)

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT00782951·11 enrolled

Analgesic Efficacy of Transmucosal Fentanyl for Breakthrough Pain Caused by Interventional Gastrostomy

Completed·—·Phase 4·NCT02869321·20 enrolled

Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)

Completed·AAntonios Likourezos·Phase 2·NCT03088826·80 enrolled

Cancer Pain3 trials

IV PCA With or Without Continuous Dose vs Oral Opioid to Maintain Analgesia for Severe Cancer Pain After Successful Titration

Completed·FFujian Cancer Hospital·Phase 3·NCT04785768·1,372 enrolled

A Study to Evaluate Buprenorphine Transdermal Patch in Chinese Subjects With Moderate to Severe Chronic Cancer Pain

Unknown status·MMundipharma (China) Pharmaceutical Co. Ltd·Phase 3·NCT03967327·194 enrolled

Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain

Completed·UUniversity Hospitals Bristol and Weston NHS Foundation Trust·Phase 4·NCT00378937·30 enrolled

Chronic pain3 trials

A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer

Withdrawn·LLabtec GmbH·Phase 2·NCT00943566

Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza

Completed· Pfizer logo

Pfizer·Phase 4·NCT00640042·1,570 enrolled

Treatment for Chronic Pain in Patients With Advanced Cancer

Completed·NNCIC Clinical Trials Group·Phase 3·NCT00003687·87 enrolled

Abdominal pain3 trials

Ketorolac for Moderate to Severe Abdominal Pain in Children

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT04528563·105 enrolled

The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision

Withdrawn·UUniversity of Texas Southwestern Medical Center·N/A·NCT00839787

Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain

Recruiting·UUniversity of Calgary·Phase 3·NCT06160778·495 enrolled

53 more indications

Cesarean Section3 trials

Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section

Completed·—·Phase 2·NCT03483870·80 enrolled

Comparison of Pruritus Incidence After Intrathecal Morphine 0.1 vs 0.2 mg in Cesarean Section

Recruiting·KKhon Kaen University·Phase 4·NCT07054775·69 enrolled

Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.

Unknown status·MMinia University·N/A·NCT04618146·60 enrolled

Buprenorphine3 trials

Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals

Unknown status·UUniversity of California, Los Angeles·N/A·NCT02136784·12 enrolled

Intravenous Buprenorphine Versus Morphine for Severe Pain in the Emergency Department

Unknown status·—·Phase 2·NCT03256487·122 enrolled

Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film

Completed·BBioDelivery Sciences International·Phase 2·NCT01871285·39 enrolled

Breast Cancer2 trials

Perioperative Analgesic Modalities for Breast Cancer Surgeries

Completed·NNational Cancer Institute, Egypt·N/A·NCT04248608·75 enrolled

Morphine for the Treatment of Pain in Patients With Breast Cancer

Completed·RRoswell Park Cancer Institute··NCT00003000·18 enrolled

Fasting Conditions2 trials

Bioequivalence Study of Morphine Sulfate 60 mg Extended-Release Tablets Under Fasting Conditions

Completed·RRanbaxy Inc.·Phase 1·NCT01665222·26 enrolled

Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fasting Conditions

Completed·AActavis Inc.·Phase 1·NCT00759759·36 enrolled

Cesarean Delivery2 trials

Intrathecal Morphine for Cesarean Delivery

Completed·—·Phase 4·NCT05069012·72 enrolled

Decreased Neuraxial Morphine After Cesarean Delivery

Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT04279054·87 enrolled

Opioid Use Disorder2 trials

Anti-suicidal Effects of Buprenorphine in Opioid Use Disorder

Withdrawn·NNew York State Psychiatric Institute·Phase 4·NCT04234516

Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy

Withdrawn·LLyndra Inc.·Phase 1·NCT05251376

Quadratus Lumborum Block2 trials

Quadratus Lumborum Block in Pediatric Patients

Completed·—·N/A·NCT03693222·40 enrolled

Ultrasound Guided Anterior Quadratus Lumborum Block

Completed·—·N/A·NCT03425162·60 enrolled

Pediatric2 trials

Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects

Completed·RRoxane Laboratories·Phase 4·NCT01322360·50 enrolled

Study of Oral Morphine Sulfate Administration in Pediatric Subjects

Completed·WWest-Ward Pharmaceutical·Phase 3·NCT03429400·51 enrolled

Efficacy and Safety2 trials

Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients

Completed·QQRxPharma Inc.·Phase 3·NCT01016808·522 enrolled

Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients

Completed·QQRxPharma Inc.·Phase 2·NCT00831051·197 enrolled

Neonatal Abstinence Syndrome2 trials

Comparison of Buprenorphine to Morphine in Treatment of Neonatal Abstinence Syndrome (NAS)

Completed·PPediatrix·Phase 2·NCT01708707·29 enrolled

Treatment of Neonatal Abstinence Syndrome With Clonidine Versus Morphine as Primary Therapy

Active, not recruiting·TThe Cooper Health System·Phase 4·NCT03092011·69 enrolled

Methadone2 trials

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Terminated·MM.D. Anderson Cancer Center·N/A·NCT00726830·1 enrolled

Epidural Methadone in Healthy Volunteers

Completed·Ssimon.haroutounian·Phase 1·NCT03525509·13 enrolled

Dexmedetomidine2 trials

Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity

Unknown status·—·Phase 1/2·NCT03024957·30 enrolled

Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.

Completed·PPontificia Universidad Catolica de Chile·Phase 4·NCT03809182·40 enrolled

Ultrasound1 trial

Ultrasound-Guided Versus Conventional Injection for Caudal Block

Completed·—·N/A·NCT03337191·134 enrolled

Liposomal Bupivacaine1 trial

Liposomal Bupivacaine in Implant Based Breast Reconstruction

Terminated·LLoma Linda University·N/A·NCT02659501·24 enrolled

Pleural effusion1 trial

Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion

Unknown status·OOxford University Hospitals NHS Trust·Phase 2·NCT00644319·320 enrolled

Adult1 trial

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01507220·2 enrolled

Hysterectomy1 trial

Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy

Completed·IInonu University·N/A·NCT04691856·66 enrolled

Perioperative Analgesia1 trial

SEQ Block for Perioperative Analgesia in Acetabular Surgery

Completed·—·Phase 3·NCT04688814·52 enrolled

Oxycodone1 trial

Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients

Completed·QQRxPharma Inc.·Phase 3·NCT01280331·375 enrolled

Sickle Cell Disease1 trial

Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease

Completed·—·Phase 4·NCT02222246·106 enrolled

Esketamine1 trial

Postoperative Analgesic Effect of Esketamine

Completed·XXuanhan County People's Hospital·N/A·NCT05582135·119 enrolled

Recurrent1 trial

A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED

Withdrawn·AAntonios Likourezos·Phase 4·NCT03529331

Fed1 trial

Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fed Conditions

Completed·AActavis Inc.·Phase 1·NCT00759915·36 enrolled

Breakthrough Pain1 trial

Inhaled Morphine Compared With Morphine By Mouth in Treating Cancer Patients With Breakthrough Pain

Completed·—·Phase 2·NCT00020618

Total Knee Arthroplasty1 trial

Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

Completed·SSeoul National University Hospital·Phase 4·NCT00901628·101 enrolled

Lumbar Disc Surgery1 trial

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery

Completed·IInonu University·N/A·NCT03437707·3 enrolled

TED1 trial

Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fasted Conditions

Completed·AActavis Inc.·Phase 1·NCT00759902·36 enrolled

Multimodal Analgesia1 trial

Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery

Completed·—·Phase 4·NCT04110665·92 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Knee Arthroplasty1 trial

Comparison of Local Anesthetic Dose in Ipack Block Performed in Knee Arthroplasty Operations

Completed·IIstanbul University·N/A·NCT05963139·112 enrolled

Pulmonary Arterial Hypertension1 trial

Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertension

Unknown status·JJohn Granton·Phase 2·NCT03401476·15 enrolled

Infusion1 trial

Comparison Between Pericapsular Nerve Group Block (PENG) and Morphine Infusion

Completed·SSuez Canal University·N/A·NCT05023473·36 enrolled

Epidural Analgesia1 trial

Thoracic Epidural Analgesia in Flail Chest

Unknown status·—·Phase 2/3·NCT03413059·40 enrolled

LAM1 trial

Effects of Anaesthesia on Inflammatory Markers

Completed·—·N/A·NCT04630938·81 enrolled

Percutaneous Coronary Intervention1 trial

Ticagrelor and Intracoronary Morphine in Patients Undergoing Primary Percutaneous Coronary Intervention

Unknown status·HHyeon-Cheol Gwon·Phase 2·NCT01738100·100 enrolled

Pancreatic Cancer1 trial

Standard Pain Control or Intrathecal Therapy in Controlling Pain in Patients With Locally Advanced, Unresectable, or Metastatic Pancreatic Cancer

Terminated·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·N/A·NCT00660348·1 enrolled

Radiofrequency Ablation1 trial

Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer

Completed·IInstitut Bergonié·Phase 2·NCT00712712·78 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

Long Thoracic Nerve Blockade for Pain Treatment After Video-Assisted Thoracoscopic Surgery

Unknown status·—·N/A·NCT03483415·60 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Opioids for Refractory Breathlessness in Chronic Obstructive Pulmonary Disease

Withdrawn·FFlinders University·Phase 3·NCT02455362

Hypoglycemia1 trial

Mechanisms of Hypoglycemia Associated Autonomic Failure

Unknown status·—·Phase 2·NCT00678145·116 enrolled

Erector Spinae Plane Block1 trial

Effectiveness of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Open Knee Surgeries

Enrolling by invitation·—·N/A·NCT06562634·40 enrolled

Post Operative Pain1 trial

Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy

Completed·NNeumentum, Inc.·Phase 3·NCT05324358·341 enrolled

Thoracic Surgery1 trial

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Recruiting·NNorthwestern University·Phase 4·NCT05351229·90 enrolled

Acetaminophen1 trial

Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen

Completed·IIsfahan University of Medical Sciences·Phase 3·NCT05630222·150 enrolled

Serratus Anterior Plane Block1 trial

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Completed·—·N/A·NCT02962024·40 enrolled

Postoperative Pain Control1 trial

Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally

Unknown status·SSohag University·Phase 2·NCT05186454·60 enrolled

Interaction1 trial

Evaluation of the Interactions of Cannabidiol (CBD) With Morphine

Recruiting·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT05143424·60 enrolled

Encephalopathy1 trial

Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)

Completed·UUniversity of Utah·Phase 2·NCT04772222·50 enrolled

Inflammatory Response1 trial

Inflammatory Responses to Acute and Chronic Opioid Exposure in Humans

Terminated·SStanford University·N/A·NCT01749826·20 enrolled

Pulmonary Fibrosis1 trial

Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough

Completed·RRoyal Brompton & Harefield NHS Foundation Trust·Phase 3·NCT04429516·44 enrolled

Arthritis1 trial

NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint

Unknown status·HHildrun Haibel·Phase 2/3·NCT02967302·112 enrolled

Anemia1 trial

Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia

Completed·—·Phase 2/3·NCT04301336·350 enrolled

Total Knee Replacement1 trial

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

Unknown status·TThe New England Baptist Hospital·Phase 3·NCT02473198·312 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 18, 1984

DURAMORPH PF

NDA NDA018565

Apr 8, 1988

MS CONTIN

NDA NDA019516

May 2, 1988

MS CONTIN

NDA NDA019516

Sep 12, 1989

MS CONTIN

NDA NDA019516

Sep 12, 1989

MS CONTIN

NDA NDA019516

Jan 16, 1990

MS CONTIN

NDA NDA019516

Apr 12, 1990

MS CONTIN

NDA NDA019516

Jul 12, 1990

MORPHINE SULFATE (AUTOINJECTOR)

NDA NDA019999

Oct 30, 1992

MORPHINE SULFATE

NDA NDA019917

Oct 30, 1992

MORPHINE SULFATE

NDA NDA019916

Nov 8, 1993

MS CONTIN

NDA NDA019516

Nov 23, 1994

ORAMORPH SR

NDA NDA019977

Jul 3, 1996

MORPHINE SULFATE

NDA NDA020631

Apr 29, 1997

MS CONTIN

NDA NDA019516

May 2, 2000

MS CONTIN

NDA NDA019516

May 2, 2000

MS CONTIN

NDA NDA019516

May 2, 2000

MS CONTIN

NDA NDA019516

May 2, 2000

MS CONTIN

NDA NDA019516

May 2, 2000

MS CONTIN

NDA NDA019516

May 12, 2000

MS CONTIN

NDA NDA019516

Jun 27, 2000

MS CONTIN

NDA NDA019516

Feb 12, 2001

MS CONTIN

NDA NDA019516

Dec 18, 2001

MS CONTIN

NDA NDA019516

Mar 20, 2002

AVINZA

NDA NDA021260

Feb 21, 2003

MS CONTIN

NDA NDA019516

Aug 6, 2003

MS CONTIN

NDA NDA019516

May 18, 2004

DEPODUR

NDA NDA021671

Apr 20, 2007

KADIAN

NDA NDA020616

May 11, 2007

MS CONTIN

NDA NDA019516

Mar 17, 2008

MORPHINE SULFATE

NDA NDA022207

Mar 17, 2008

MORPHINE SULFATE

NDA NDA022195

May 11, 2010

MS CONTIN

NDA NDA019516

Jun 23, 2011

MORPHINE SULFATE

NDA NDA201517

Nov 14, 2011

MORPHINE SULFATE

NDA NDA202515

Jul 9, 2012

MS CONTIN

NDA NDA019516

Jul 9, 2012

MS CONTIN

NDA NDA019516

Apr 15, 2013

MS CONTIN

NDA NDA019516

Oct 30, 2013

MORPHINE SULFATE

NDA NDA204223

Apr 16, 2014

MS CONTIN

NDA NDA019516

Jun 2, 2014

MS CONTIN

NDA NDA019516

Aug 19, 2014

MS CONTIN

NDA NDA019516

Oct 22, 2014

MS CONTIN

NDA NDA019516

Jun 26, 2015

MS CONTIN

NDA NDA019516

Oct 2, 2015

MORPHABOND ER

NDA NDA206544

Apr 20, 2016

MS CONTIN

NDA NDA019516

Sep 30, 2016

MS CONTIN

NDA NDA019516

Dec 16, 2016

MS CONTIN

NDA NDA019516

Jan 9, 2017

ARYMO ER

NDA NDA208603

May 26, 2017

MS CONTIN

NDA NDA019516

Sep 18, 2018

MS CONTIN

NDA NDA019516

Sep 18, 2018

MS CONTIN

NDA NDA019516

Oct 7, 2019

MS CONTIN

NDA NDA019516

Mar 4, 2021

MS CONTIN

NDA NDA019516

Dec 15, 2023

MS CONTIN

NDA NDA019516

Oct 31, 2024

MS CONTIN

NDA NDA019516

Dec 22, 2025

MS CONTIN

NDA NDA019516

Jun 18, 2026

MS CONTIN

NDA NDA019516

Sources

References

[1]
ClinicalTrials.gov — 89 trial records for Morphine Sulfate. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — MS Contin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Morphine Sulfate compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Morphine Sulfate. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA019516). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Hikma Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: HHikma Pharmaceuticals LLC

MS Contin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q4 2029

Trials by Indication[1]

Morphine10 trials

Analgesic Efficacy3 trials

Cancer Pain3 trials

Chronic pain3 trials

Abdominal pain3 trials

Cesarean Section3 trials

Buprenorphine3 trials

Breast Cancer2 trials

Fasting Conditions2 trials

Cesarean Delivery2 trials

Opioid Use Disorder2 trials

Quadratus Lumborum Block2 trials

Pediatric2 trials

Efficacy and Safety2 trials

Neonatal Abstinence Syndrome2 trials

Methadone2 trials

Dexmedetomidine2 trials

Ultrasound1 trial

Liposomal Bupivacaine1 trial

Pleural effusion1 trial

Adult1 trial

Hysterectomy1 trial

Perioperative Analgesia1 trial

Oxycodone1 trial

Sickle Cell Disease1 trial

Esketamine1 trial

Recurrent1 trial

Fed1 trial

Breakthrough Pain1 trial

Total Knee Arthroplasty1 trial

Lumbar Disc Surgery1 trial

TED1 trial

Multimodal Analgesia1 trial

Perioperative Pain Control1 trial

Knee Arthroplasty1 trial

Pulmonary Arterial Hypertension1 trial

Infusion1 trial

Epidural Analgesia1 trial

LAM1 trial

Percutaneous Coronary Intervention1 trial

Pancreatic Cancer1 trial

Radiofrequency Ablation1 trial

Video-Assisted Thoracoscopic Surgery1 trial

Chronic Obstructive Pulmonary Disease1 trial

Hypoglycemia1 trial

Erector Spinae Plane Block1 trial

Post Operative Pain1 trial

Thoracic Surgery1 trial

Acetaminophen1 trial

Serratus Anterior Plane Block1 trial

Postoperative Pain Control1 trial

Interaction1 trial

Encephalopathy1 trial

Inflammatory Response1 trial

Pulmonary Fibrosis1 trial

Arthritis1 trial

Anemia1 trial

Total Knee Replacement1 trial

FDA Approval Timeline[5]

References

Drug Info

Quick Facts

Related News