VivoSeq
Dermatology

Lichen Planus

26

Pipeline Programs↗

3

Active Trials↗

14

Companies Involved↗

Lichen Planus is an emerging landscape with 26 programs across 14 companies. The most active players are Incyte, Novartis, Astellas. 4 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

6/100

Mech. Concentration

25/100

Completion Rate

77/100

Attrition Rate

16/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Incyte logo

Incyte

2 programs

Phase 2Novartis logo

Novartis

1 program

Phase 2Astellas logo

Astellas

1 program

Phase 2Amgen logo

Amgen

1 program

Phase 2I

Immunex

1 program

Phase 2A

Amring

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Modality Breakdown

82%

Small molecule

23 of 28 classified programs — the dominant modality here.

18%ALL OTHERSProtein / enzyme311%Monoclonal antibody27%

Small molecule leads; the ring shows all 28 classified programs, each share of the total. Modality classified for 93% of 30 pipeline programs.

Analysis

Trial Status

19

clinical trials

Completed10 · 53%
Terminated3 · 16%
Unknown status3 · 16%
Not yet recruiting2 · 11%
Recruiting1 · 5%

Clinical Trials

Trial Activity

19 trials

The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans
Recruiting·HHenry Ford Health System·Phase 2·NCT04233749·5 enrolled
Systemic Treatment Options for Generalized Lichen Planus
Not yet recruiting·SSheikh Zayed Medical College·Phase 2·NCT06739551·124 enrolled
Comparative Efficacy of Clobetasol 0.05% Versus Intralesional Triamcinolone in Treatment of Hypertrophic Lichen Planus at a Tertiary Care Hospital
Not yet recruiting·—·Approved·NCT07666620·50 enrolled
Topical Ruxolitinib Lichen Planus
Completed·—·Phase 2·NCT03697460·12 enrolled
Use of Injectable Platelet Rich Fibrin in Lichen Planus
Completed·—·N/A·NCT03265093·24 enrolled
PoC Study to Evaluate the Efficacy and Safety of Secukinumab 300 mg in Patients With Lichen Planus
Completed·Novartis logoNovartis·Phase 2·NCT04300296·111 enrolled
Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT
Completed·OOslo University Hospital·Phase 2/3·NCT01282515·40 enrolled
The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus
Completed·OOctober 6 University·Phase 2·NCT02106468·30 enrolled
Baricitinib (LY3009104) in the Treatment of Cutaneous Lichen Planus
Completed·—·Phase 2·NCT05188521·12 enrolled
Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension
Completed·WWroclaw Medical University·Phase 2·NCT04991012·30 enrolled
Glutamine With Topical Corticosteroids for Lichen Planus Treatment
Completed·—·N/A·NCT04442633·30 enrolled
Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus
Completed·IIsfahan University of Medical Sciences·Phase 2·NCT02453503·60 enrolled
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Cutaneous Lichen Planus
Completed·Incyte logoIncyte·Phase 2·NCT05593432·64 enrolled
A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus
Terminated·MMassachusetts General Hospital·Phase 2·NCT00135733·13 enrolled
Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream
Terminated·—·Phase 2·NCT00321750·14 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)