Cyklokapron
(tranexamic acid)ApprovedSmall molecule
Tranexamic acid is used to reduce excessive bleeding, such as heavy menstrual bleeding or bleeding after surgery or dental procedures. It works by helping blood clots stay in place longer.[2] Cyklokapron is currently approved and in use across 109 indications[4].[1]
Cyklokapron is one of 1486 small molecule programs targeting Arthropathy. It is currently in Approved.
109
Indications
547
Total Trials
37
Active Trials
1,485
Competitors
4
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 104 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Cyklokapron
AAmring
Approved
Prolia
AmgenPreclinical
Cymbalta
Alnylam PharmaceuticalsPreclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Effexor
WWyeth-Lederle Vaccines
Preclinical
Zoladex
Luye Pharma Group Ltd.Preclinical
Apatinib Mesylate
BBukwang Pharmaceutical
Preclinical
Vit D
PPost Graduate Institute of Medical Education and Research, Chandigarh
Preclinical
Tianeptine
PfizerPreclinical
Leronlimab
CCytoDyn, Inc.
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Tranexamic Acid58 trials
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery
Completed·—·N/A·NCT01258010·99 enrolled
Show 55 more trials
Comparison of Chitosan, Ankaferd and Tranexamic Acid in Dental Extraction in Liver Pre-Transplant Children
Completed·—·Phase 1·NCT06457360·39 enrolled
Intravenous Oxytocin Versus Tranexamic Acid in Reducing Blood Loss During Abdominal Myomectomy.
Completed·—·Phase 4·NCT03892668·150 enrolled
Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy
Completed·—·N/A·NCT04188184·60 enrolled
Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations
Unknown status·—·Phase 4·NCT04537533·90 enrolled
Tranexamic Acid During Colonic Endoscopic Resection Procedures
Recruiting·—·Phase 4·NCT05345613·200 enrolled
Prophylactic Tranexamic Acid During Minimally Invasive Myomectomies
Unknown status·—·Phase 3·NCT04311073·50 enrolled
Intravenous Tranexamic Acid Versus Pericervical Tourniquet To Decrease Blood Loss In Trans-Abdominal Myomectomy
Unknown status·—·Phase 3·NCT02733952·70 enrolled
Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.
Completed·—·N/A·NCT05517590·102 enrolled
Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
Recruiting·—·Phase 1/2·NCT06997796·24 enrolled
Topical Tranexamic Acid Application in Rhinoplasty
Completed·—·Phase 4·NCT05326139·50 enrolled
Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma
Completed·—·Phase 1·NCT05884151·60 enrolled
Tranexamic Acid for Anaemia Trial
Not yet recruiting·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT06519422·4,000 enrolled
Tranexamic Acid in Patients for Caesarian Delivery.
Completed·—·N/A·NCT05759156·572 enrolled
Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma
Not yet recruiting·—·Phase 2/3·NCT07448415·42 enrolled
Intravenous Tranexamic Acid Versus IV Carbetocin in Abdominal Myomectomy
Unknown status·—·Phase 4·NCT04357015·153 enrolled
Comparative Study of Tranexamic Acid, Estrogen for Treatment AUB in DMPA Users
Unknown status·DDepartment of Medical Services Ministry of Public Health of Thailand·N/A·NCT06067217·52 enrolled
Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation
Unknown status·—·N/A·NCT05841251·80 enrolled
Antenatal Tranexamic Acid in Women With Symptomatic Placenta Previa
Unknown status·—·Phase 2/3·NCT04055194·200 enrolled
Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study
Completed·—·N/A·NCT01428713·17 enrolled
Total Knee Arthroplasty8 trials
Tranexamic Acid for Unilateral Total Knee Arthroplasty
Completed·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 3·NCT01594671·150 enrolled
Show 5 more trials
Clinical Trial Comparing Tranexamic Acid (TXA) With Aquamantys Sealer in Total Knee Arthroplasty (TKA)
Completed·—·Phase 4·NCT02374398·127 enrolled
Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty
Completed·—·Phase 4·NCT03328832·70 enrolled
Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty
Unknown status·—·Phase 4·NCT02865174·90 enrolled
Total Hip Arthroplasty6 trials
Study Comparing Topical Versus Intravenous Tranexamic Acid in Anterior Total Hip Arthroplasty
Unknown status·—·Phase 4·NCT03359525·114 enrolled
Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty
Unknown status·TThe First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine·N/A·NCT01260818·100 enrolled
Show 3 more trials
Cardiac Surgery6 trials
Hip Fracture6 trials
Clinical Trial to Assess the Efficacy of Tranexamic Acid in Reducing Blood Loss in Hip Fracture Patients.
Unknown status·—·Phase 4·NCT05489185·644 enrolled
Show 3 more trials
82 more indications
Hematoma5 trials
Show 2 more trials
Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma
Recruiting·—·Phase 3·NCT03582293·554 enrolled
Epistaxis4 trials
Randomized Controlled Trial3 trials
Prophylactic Tranexamic Acid in Low-Risk Repeat Cesarean Delivery: A Randomized Controlled Trial
Not yet recruiting·—·N/A·NCT07390799·204 enrolled
Postpartum Hemorrhage3 trials
Cesarean Section3 trials
Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida
Completed·—·Phase 3·NCT04635007·200 enrolled
The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women
Completed·—·N/A·NCT03820206·160 enrolled
Tranexamic Acid to Reduce Blood Loss in Women Having Planned Cesarean Section
Completed·—·Phase 4·NCT07013812·68 enrolled
Upper Gastrointestinal Bleeding3 trials
Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding
Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT04788121·160 enrolled
Total Shoulder Arthroplasty3 trials
Hemorrhage3 trials
Hemoptysis2 trials
Efficacy of Tranexamic Acid in Hemoptysis
Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT02781597·66 enrolled
Head Injury2 trials
Intraoperative Bleeding2 trials
Cesarean Delivery2 trials
Blood Loss During Cesarean Delivery in Placenta Previa Patients
Completed·—·Phase 4·NCT05340205·81 enrolled
Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery
Unknown status·—·N/A·NCT03741075·100 enrolled
Bariatric Surgery2 trials
BAR-TAX - Tranexamic Acid in Bariatric Surgery.
Active, not recruiting·—·N/A·NCT07401394·1,000 enrolled
Ovarian Cancer2 trials
Tranexamic Acid in Surgery of Advanced Ovarian Cancer
Completed·—·Phase 4·NCT00740116·100 enrolled
Intracerebral Hemorrhage2 trials
Brain Injury2 trials
Functional Endoscopic Sinus Surgery2 trials
Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial
Unknown status·—·Phase 3·NCT03965767·120 enrolled
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
Recruiting·—·Phase 1·NCT06725732·90 enrolled
Dilation and Evacuation2 trials
Total Knee Replacement2 trials
Tranexamic Acid in Total Knee Replacement
Completed·—·N/A·NCT03656445·180 enrolled
Anterior Cruciate Ligament Reconstruction2 trials
Caesarean Delivery2 trials
Prophylactic Tranexamic Acid To Reduce Blood Loss During Caesarean Delivery.
Recruiting·—·N/A·NCT06604325·300 enrolled
Blood Loss2 trials
Treatment of Copper Intra Uterine Device Associated Heavy Menstrual Blood Loss
Unknown status·—·Phase 3·NCT03139422·140 enrolled
Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements.
Completed·—·Phase 3·NCT05024253·48 enrolled
ACL Reconstruction1 trial
Dexmedetomidine1 trial
Myelodysplastic Syndromes1 trial
Mohs Micrographic Surgery1 trial
Liver Transplant1 trial
Surgical1 trial
Heavy Menstrual Bleeding1 trial
Postoperative Blood Loss1 trial
Vaginal Delivery1 trial
Prophylactic Tranexamic Acid Use After Vaginal Delivery
Completed·—·N/A·NCT05429580·480 enrolled
Local Infiltration1 trial
Total Joint Arthroplasty1 trial
Tranexamic Acid Dosing for Total Joint Arthroplasty
Completed·—·Phase 4·NCT02584725·84 enrolled
Craniosynostosis1 trial
Idiopathic Scoliosis1 trial
Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?
Completed·—·Phase 1/2·NCT01813058·120 enrolled
Growth1 trial
Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign
Unknown status·MMinistry of Science and Technology of the People´s Republic of China·Phase 2·NCT02625948·240 enrolled
Meningioma1 trial
Tranexamic Acid Reduce Blood Loss in Meningioma Resection
Unknown status·—·Phase 4·NCT04386642·44 enrolled
Anemia1 trial
Injury1 trial
Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
Completed·—·Phase 2·NCT02840097·31 enrolled
Hysterectomy1 trial
Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy
Not yet recruiting·—·Phase 4·NCT06290596·387 enrolled
Transurethral Resection1 trial
Bronchoscopy1 trial
Coagulopathy1 trial
Platelet Transfusion1 trial
Third Molar Surgery1 trial
Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
Recruiting·—··NCT06806241·20 enrolled
Coronary Artery Bypass1 trial
Endoscopic Sinus Surgeries1 trial
Nebulized Versus Intravenous Tranexamic Acid on Surgical Field Quality in Patients Undergoing Endoscopic Sinus Surgeries
Recruiting·—·Phase 4·NCT06777966·60 enrolled
Treatment1 trial
Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma
Completed·—·Phase 1·NCT05362500·54 enrolled
Prevention1 trial
Prevention of Postpartum Haemorrhage
Unknown status·—·N/A·NCT04463966·100 enrolled
Post Operative Pain1 trial
Gynecomastia1 trial
Different Methods of Tranexamic Acid Application in Controlling Peri Operative Bleeding in Gynecomastia Surgery
Not yet recruiting·—·Phase 1·NCT06509256·50 enrolled
Erythema1 trial
Tranexamic Acid in Treatment of Facial Erythema
Completed·—·N/A·NCT05897918·50 enrolled
Lichen Planus1 trial
Placenta Praevia1 trial
Peptic ulcer1 trial
Blood Transfusion1 trial
Major Non-cardiac Surgery1 trial
Weight loss1 trial
Surgical Field1 trial
Knee Arthroplasty1 trial
Femur Fracture1 trial
Regulatory
FDA Approval Timeline[5]
Dec 30, 1986
CYKLOKAPRON
NDA NDA019281
Dec 30, 1986
CYKLOKAPRON
NDA NDA019280
Nov 13, 2009
LYSTEDA
NDA NDA022430
Apr 15, 2019
TRANEXAMIC ACID
NDA NDA212020
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Cyklokapron drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for tranexamic acid. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]