Cyklokapron

(tranexamic acid)

ApprovedSmall molecule

Tranexamic acid is used to reduce excessive bleeding, such as heavy menstrual bleeding or bleeding after surgery or dental procedures. It works by helping blood clots stay in place longer.[2] Cyklokapron is currently approved and in use across 109 indications[4].[1]

Cyklokapron is one of 1114 small molecule programs targeting Total Hip Arthroplasty. It is currently in Approved.

109

Indications

554

Total Trials

Active Trials

1,113

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Total Hip ArthroplastyUnknown status

HemoptysisCompleted

Total Knee ArthroplastyUnknown status

Placenta AccretaApproved

Cirrhosis of LiverApproved

ScoliosisApproved

Skin NeoplasmApproved

ShockApproved

OsteoarthritisApproved

Septic ShockApproved

Total Hip ArthroplastyApproved

Unknown status

HemoptysisPhase 3

Completed

Total Knee ArthroplastyApproved

Unknown status

Placenta AccretaApproved

Approved

Cirrhosis of LiverApproved

Approved

ScoliosisApproved

Approved

Skin NeoplasmApproved

Approved

ShockApproved

Approved

OsteoarthritisApproved

Approved

Septic ShockApproved

Approved

Showing 10 of 106 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Cyklokapron

Zolymbus

1 3

Blenoxane

Bristol-Myers Squibb

Preclinical

1 4

Duragesic-100

CCephalon

Preclinical

2 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 6

Spravato

WWim Janssens

Preclinical

2 7

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 8

Acupan

YYonsei University

Preclinical

1 9

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 10

Vfend

PPrism Pharmaceuticals

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1/2Not yet recruiting

Postoperative Blood Loss

NCT06983886

Q4 2026

Post-ApprovalRecruiting

Tranexamic Acid

NCT05345613

N/AActive, not recruiting

Bariatric Surgery

NCT07401394

Recruiting

Pregnancy

NCT04146376

Not yet recruiting

Von Willebrand Disease

NCT07410130

Post-ApprovalRecruiting

Cardiac Surgery

NCT06109155

Clinical

Trials by Indication[1]

Tranexamic Acid60 trials

Tranexamic Acid for the Prevention of Blood Loss in High Risk Delivered Women

Completed·HHawler Medical University·N/A·NCT04201951·196 enrolled

Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy

Completed·—·N/A·NCT06145191·1,013 enrolled

Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery

Completed·NNYU Langone Health·Phase 4·NCT00958581·177 enrolled

Show 57 more trials

Evaluation of Laser and Tranexamic Acid in Treatment of Melasma

Unknown status·—·Phase 2/3·NCT04599205·40 enrolled

Impact of Topical Tranexamic Acid on Pre- and Post-operative Hemoglobin/Hematocrit

Completed·UUniversity of Cincinnati·Phase 1·NCT05357079·94 enrolled

Use of Tranexamic Acid in Facial Fillers

Withdrawn·UUniversity of Wisconsin, Madison·Phase 4·NCT04373603

Tranexamic Acid During Excisional Burn Surgery

Recruiting·MMaasstad Hospital·Phase 3·NCT05507983·96 enrolled

Tranexamic Acid Infusion During Elective Spine Surgery

Enrolling by invitation·—·Phase 4·NCT04312880·65 enrolled

Tranexamic Acid for Craniofacial Surgery

Terminated·UUniversity of Pittsburgh·Phase 4·NCT00722436·20 enrolled

Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement

Completed·MMayo Clinic·Phase 2·NCT03182751·128 enrolled

Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction

Terminated·UUniversity of Kansas Medical Center·Phase 4·NCT04347122·12 enrolled

Tranexamic Acid in Adherent Placenta (TAP)

Withdrawn·—·Phase 3·NCT02329756

Efficacy of Tranexamic Acid Reducing Blood Loss During Maxillofacial Trauma Surgery

Completed·NNishtar Medical University·Phase 2·NCT07392034·60 enrolled

Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.

Unknown status·KKafrelsheikh University·N/A·NCT04367155·200 enrolled

Tranexamic Acid in Cyanotic Heart Defects

Completed·—·Phase 2·NCT03244423·120 enrolled

Oral Melatonin Versus Oral Tranexamic Acid in the Management of Melasma

Enrolling by invitation·HHina Malik·Phase 2·NCT07169383·160 enrolled

Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects

Completed·OOregon Health and Science University·Phase 4·NCT06000423·65 enrolled

Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery

Completed·—·N/A·NCT01258010·99 enrolled

Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients

Withdrawn·UUniversity of Alabama at Birmingham·Phase 2·NCT04338126

A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02561923·158 enrolled

Comparison of Chitosan, Ankaferd and Tranexamic Acid in Dental Extraction in Liver Pre-Transplant Children

Completed·—·Phase 1·NCT06457360·39 enrolled

Intravenous vs. Topical Tranexamic Acid in Revision THA (VITALITY-X)

Unknown status·MMount Sinai Hospital, Canada·Phase 4·NCT02938962·160 enrolled

Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid

Completed·UUniversity of Missouri-Columbia·N/A·NCT02051686·88 enrolled

Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA

Unknown status·UUniversidade do Vale do Sapucai·N/A·NCT04696224·90 enrolled

Use of Tranexamic Acid in Reduction Mammoplasty

Completed·MMontefiore Medical Center·Phase 4·NCT04947514·98 enrolled

Tranexamic Acid in Proximal Humeral Fractures

Unknown status·—·Phase 4·NCT05437822·40 enrolled

Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy

Recruiting·—·N/A·NCT04811313·400 enrolled

Tranexamic Acid and Blood Clots in Knee Surgery

Completed·UUniversity of New Mexico··NCT02867163·25 enrolled

Tranexamic Acid During Colonic Endoscopic Resection Procedures

Recruiting·—·Phase 4·NCT05345613·200 enrolled

Intravenous Tranexamic Acid Versus Pericervical Tourniquet To Decrease Blood Loss In Trans-Abdominal Myomectomy

Unknown status·—·Phase 3·NCT02733952·70 enrolled

Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations

Unknown status·—·Phase 4·NCT04537533·90 enrolled

Tranexamic Acid and Pediatric Adenotonsillectomy

Completed·IIrmandade Santa Casa de Misericórdia de Porto Alegre·Phase 4·NCT01228136·95 enrolled

Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.

Completed·—·N/A·NCT05517590·102 enrolled

Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid

Recruiting·—·Phase 1/2·NCT06997796·24 enrolled

Topical Tranexamic Acid Application in Rhinoplasty

Completed·—·Phase 4·NCT05326139·50 enrolled

Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma

Completed·—·Phase 1·NCT05884151·60 enrolled

Tranexamic Acid in Percutaneous Nephrolithotomy

Completed·HHaseki Training and Research Hospital·N/A·NCT05947435·75 enrolled

Tranexamic Acid in Pregnancies With Vaginal Bleeding

Completed·HHawler Medical University·N/A·NCT03632824·139 enrolled

Prophylactic Tranexamic Acid During Minimally Invasive Myomectomies

Unknown status·—·Phase 3·NCT04311073·50 enrolled

Effect of Tranexamic Acid on Blood Loss After High Tibial Osteotomy

Unknown status·TThe Catholic University of Korea·N/A·NCT04653623·40 enrolled

Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements

Unknown status·IInstituto Mexicano del Seguro Social·Phase 3·NCT05855590·20 enrolled

The Effect of Tranexamic Acid in Total Blood Loss During Proximal Femoral Nailing

Completed·HHaseki Training and Research Hospital··NCT05359172·100 enrolled

The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery

Completed·WWake Forest University Health Sciences·Phase 3·NCT02684851·87 enrolled

Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.

Completed·—·Phase 1·NCT02319915·14 enrolled

Tranexamic Acid in Breast Esthetic Surgery.

Completed·PPoznan University of Medical Sciences·Phase 4·NCT05945680·60 enrolled

Tranexamic Acid to Reduce Blood Loss in Spine Surgery

Recruiting·—·Phase 2/3·NCT02314988·252 enrolled

Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and Hemagglutinase

Unknown status·—·Phase 1·NCT06149091·300 enrolled

Low vs. Very Low Dose of Prophylactic Tranexamic Acid for Bleeding Reduction During Rhinoplasty

Unknown status·BBartłomiej Wódarski·Phase 4·NCT03070847·50 enrolled

The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients

Recruiting·SStanford University·Phase 2·NCT03552705·50 enrolled

The Use of Tranexamic Acid to Reduce Perioperative Blood Loss During High Risk Spine Fusion Surgery

Completed·NNorthwestern University·Phase 2·NCT01728636·61 enrolled

Intravenous Tranexamic Acid Versus IV Carbetocin in Abdominal Myomectomy

Unknown status·—·Phase 4·NCT04357015·153 enrolled

Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Skin Type IV - V

Completed·IIndonesia University·N/A·NCT05236569·34 enrolled

The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery

Recruiting·MMontefiore Medical Center·Phase 4·NCT06450392·150 enrolled

Does Intravenous Tranexamic Acid Reduce Blood Loss During Vaginectomy?

Unknown status·MMount Sinai Hospital, Canada·Phase 3·NCT03216083·30 enrolled

Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement

Completed·HHospital for Special Surgery, New York·Phase 4·NCT02540226·76 enrolled

Use of Tranexamic Acid in Blepharoplasties

Withdrawn·NNorthwestern University·Phase 3·NCT04724772

Topical Tranexamic Acid (TXA) in Joint Arthroplasty

Completed·TThe Hawkins Foundation·Phase 4·NCT01937559·188 enrolled

Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid

Recruiting·EEgymedicalpedia·N/A·NCT06522984·45 enrolled

Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma

Active, not recruiting·TThammasat University·Phase 4·NCT07034560·75 enrolled

Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation

Unknown status·—·N/A·NCT05841251·80 enrolled

Total Knee Arthroplasty9 trials

Intravenous Versus Topical Administration of Low Dose Epinephrine Plus Combined Administration of Intravenous and Topical Tranexamic Acid (TXA)for Primary Total Knee Arthroplasty

Unknown status·SSouthwest Hospital, China·N/A·NCT02860221·210 enrolled

Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical

Completed·HHospital for Special Surgery, New York·Phase 4·NCT01940523·640 enrolled

Tranexamic Acid for Unilateral Total Knee Arthroplasty

Completed·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 3·NCT01594671·150 enrolled

Show 6 more trials

Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients

Unknown status·SSeoul National University Hospital·Phase 4·NCT03109652·144 enrolled

Intra-articular Tranexamic Acid in the Reduction of Blood Transfusions in Primary Total Hip and Total Knee Arthroplasty

Completed·OOrthopaedic Innovation Centre·Phase 2·NCT02393963·140 enrolled

The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty

Completed·XXijing Hospital·Phase 4·NCT02504125·120 enrolled

Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty

Recruiting·—·Phase 2·NCT06479161·80 enrolled

Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial

Completed·IIsfahan University of Medical Sciences·N/A·NCT02327117·90 enrolled

Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty

Completed·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 3·NCT01306370·172 enrolled

Total Hip Arthroplasty8 trials

Study Comparing Topical Versus Intravenous Tranexamic Acid in Anterior Total Hip Arthroplasty

Unknown status·—·Phase 4·NCT03359525·114 enrolled

Role of Topical Tranexamic Acid in Total Hip Arthroplasty

Terminated·NNorthwell Health·Phase 2·NCT01866943·41 enrolled

The Effect of Tranexamic Acid for Total Hip Arthroplasty

Unknown status·TTC Erciyes University·Phase 4·NCT02094066·60 enrolled

Show 5 more trials

The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT01622946·80 enrolled

Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty

Completed·SShanghai Jiao Tong University School of Medicine·Phase 3·NCT02312440·173 enrolled

Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty

Unknown status·TThe First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine·N/A·NCT01260818·100 enrolled

Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty

Completed·—·Phase 4·NCT02747615·60 enrolled

Noninferiority Oral Tranexamic Acid vs Intravenous Administration in Total Hip Arthroplasty

Completed·UUniversity of Liege·Phase 4·NCT04691362·230 enrolled

Cardiac Surgery6 trials

A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery

Completed·MMayo Clinic·Phase 3·NCT00588133·20 enrolled

Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

Completed·LLoma Linda University·N/A·NCT01248104·100 enrolled

The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery

Recruiting·TTaichung Veterans General Hospital·Phase 4·NCT06109155·150 enrolled

Show 3 more trials

Dose-ranging Study of Two Doses of Tranexamic Acid During Cardiac Surgery

Completed·HHopital Foch·Phase 4·NCT00809393·600 enrolled

Phase II Study to Compare MDCO-2010 vs Placebo and Tranexamic Acid in Patients Undergoing Cardiac Surgery

Terminated· Novartis logo

Novartis·Phase 2·NCT01530399·44 enrolled

Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery

Unknown status·SSHI Jia·Phase 4·NCT03838328·360 enrolled

Hip Fracture6 trials

Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures

Terminated·YYale University·Phase 4·NCT02908516·6 enrolled

Effect of Early Administration of TXA in Adult Hip Fractures

Recruiting·AAscension Health·Phase 2/3·NCT05047133·170 enrolled

Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients

Completed·—·Phase 4·NCT03211286·129 enrolled

Show 3 more trials

Tranexamic Acid Use in Acute Hip Fractures

Completed·CCarilion Clinic·Phase 4·NCT02947529·113 enrolled

The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures

Withdrawn·HHospital for Special Surgery, New York·Phase 4·NCT01940536

Blood Loss After Early TXA in Hip Fractures.

Unknown status·—·Phase 1·NCT04488367·120 enrolled

80 more indications

Functional Endoscopic Sinus Surgery5 trials

Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score

Recruiting·—·Phase 1·NCT06725732·90 enrolled

Tranexamic Acid in Functional Endoscopic Sinus Surgery

Completed·—·Phase 4·NCT05686005·159 enrolled

Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial

Unknown status·—·Phase 3·NCT03965767·120 enrolled

Show 2 more trials

The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery

Withdrawn·UUniversity of Calgary·N/A·NCT00671281·74 enrolled

Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery

Completed·UUniversity of Alberta·N/A·NCT01111669·28 enrolled

Caesarean Section4 trials

Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section

Completed·UUniversity of Zimbabwe·Phase 3·NCT03463993·506 enrolled

Efficacy of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section

Unknown status·—·Phase 1/2·NCT02350179·100 enrolled

Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section

Completed·TTalkha Central Hospital·Phase 4·NCT02780245·100 enrolled

Show 1 more trial

Topical Tranexamic Acid in Caesarean Section

Unknown status·UUnknown Sponsor·Phase 3·NCT02492087·84 enrolled

Ovarian Cancer3 trials

Tranexamic Acid in Surgery of Advanced Ovarian Cancer

Completed·—·Phase 4·NCT00740116·100 enrolled

Efficacy and Safety of Tranexamic Acid in Cytoreductive Surgery for Ovarian Cancer

Completed·JJun Zhang·N/A·NCT04360629·151 enrolled

Comparison of Single-Dose Tranexamic Acid Vs. Placebo in Ovarian Cancer Surgery

Completed·SSheikh Zayed Medical College·N/A·NCT06879353·372 enrolled

Hemorrhage3 trials

Impact of Inhaled Tranexamic Acid in Pulmonary Hemorrhage in Pediatric Intensive Care Unit

Completed·TTanta University·N/A·NCT07481682·100 enrolled

Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial

Unknown status·KKwong Wah Hospital·Phase 3·NCT03044184·220 enrolled

The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial

Active, not recruiting·SSunnybrook Health Sciences Centre·Phase 3·NCT02261415·1,386 enrolled

Postoperative Blood Loss3 trials

Effect of Tranexamic Acid on Reducing Postoperative Blood Loss in Cervical Laminoplasty

Completed·—·N/A·NCT01027546·40 enrolled

DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery

Terminated·PPopulation Health Research Institute·Phase 3·NCT03954314·3,242 enrolled

The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic Surgery

Not yet recruiting·RRamathibodi Hospital·Phase 1/2·NCT06983886·25 enrolled

Hematoma3 trials

Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma

Recruiting·—·Phase 3·NCT03582293·554 enrolled

Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2

Unknown status·UUnity Health Toronto·Phase 2·NCT04898712·90 enrolled

Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma

Unknown status·UUnity Health Toronto·Phase 3·NCT03280212·60 enrolled

Prevention2 trials

Postoperative Bleeding Prevention in Massive Bone Tumour Resection

Terminated·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 3·NCT02153593·56 enrolled

Prevention of Postpartum Haemorrhage

Unknown status·—·N/A·NCT04463966·100 enrolled

Postpartum Hemorrhage2 trials

Carbetocin Versus Buccal Misoprostol Plus IV Tranexamic Acid for Prevention of Postpartum Hemorrhage at Cesarean Section

Completed·—·N/A·NCT03710317·400 enrolled

Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section

Completed·MMansoura University·Phase 2/3·NCT03351686·140 enrolled

Surgery2 trials

TXA Study in Major Oncologic Surgery

Completed·CCorewell Health West·N/A·NCT01980355·76 enrolled

TXA Study in Major Burn Surgery

Terminated·CCorewell Health West·N/A·NCT02753816·25 enrolled

Spinal Fusion2 trials

Efficacy and Safety of Tranexamic Acid in Spinal Fusion Surgery

Terminated·EExela Pharma Sciences, LLC.·Phase 3·NCT03425799·5 enrolled

TXA in Spinal Fusion

Completed·—·Phase 2·NCT04272606·123 enrolled

Thrombocytopenia2 trials

A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia

Terminated·MMeghan McCormick·Phase 1/2·NCT03806556·11 enrolled

American Trial Using Tranexamic Acid in Thrombocytopenia

Completed·UUniversity of Washington·Phase 3·NCT02578901·330 enrolled

Head Injury2 trials

Clinical Randomisation of an Antifibrinolytic in Significant Head Injury

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT01402882·12,737 enrolled

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

Recruiting·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT04521881·5,000 enrolled

Intracerebral Hemorrhage2 trials

Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist

Completed·UUniversity Hospital, Basel, Switzerland·Phase 2/3·NCT02866838·64 enrolled

Precision Use of TXA in Intracerebral Hemorrhage

Recruiting·TThe University of Hong Kong·N/A·NCT07365150·70 enrolled

Upper Gastrointestinal Bleeding2 trials

Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT03023189·500 enrolled

Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT04788121·160 enrolled

Cesarean Section2 trials

The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women

Completed·—·N/A·NCT03820206·160 enrolled

Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section

Not yet recruiting·—·Phase 3·NCT06010368·150 enrolled

Bleeding2 trials

The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

Completed·SSt. Olavs Hospital·Phase 4·NCT01964781·30 enrolled

Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery

Unknown status·—·Phase 2·NCT03112135·90 enrolled

Meningioma2 trials

The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection

Completed·—·N/A·NCT04595786·228 enrolled

Tranexamic Acid Reduce Blood Loss in Meningioma Resection

Unknown status·—·Phase 4·NCT04386642·44 enrolled

Shoulder Arthroscopy2 trials

The Effect of Tranexamic Acid (TXA) on Visualization During Shoulder Arthroscopy

Unknown status·RRothman Institute Orthopaedics·Phase 3·NCT04610164·200 enrolled

The Effect of Intravenous Tranexamic Acid and Interscalene Block Applied on Shoulder Arthroscopy

Unknown status·—·N/A·NCT04419246·60 enrolled

Vaginal Delivery2 trials

Use of Tranexamic Acid After Vaginal Delivery with Episiotomy a RCT Placebo Control Trail

Completed·—·Phase 4·NCT05448456·150 enrolled

Tranexamic Acid for Preventing Postpartum Haemorrhage Following a Vaginal Delivery

Completed·UUniversity Hospital, Angers·Phase 3·NCT02302456·4,079 enrolled

Perioperative Bleeding2 trials

Tranexamic Acid Versus Placebo for Blood to Reduce Perioperative Bleeding Post-liver Resection

Completed·SSunnybrook Health Sciences Centre·Phase 3·NCT01651182·24 enrolled

Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery

Completed·UUniversity Hospital, Lille·Phase 3·NCT02702128·157 enrolled

Blood Loss2 trials

Reducing Blood Loss Using Tisseel in TKA

Unknown status·—·Phase 4·NCT03310060·100 enrolled

Treatment of Copper Intra Uterine Device Associated Heavy Menstrual Blood Loss

Unknown status·—·Phase 3·NCT03139422·140 enrolled

Caesarean Delivery2 trials

Prophylactic Tranexamic Acid To Reduce Blood Loss During Caesarean Delivery.

Recruiting·—·N/A·NCT06604325·300 enrolled

Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Caesarean Delivery

Terminated·UUniversity Hospital, Lille·Phase 4·NCT02797119·225 enrolled

Non-Opioid Pain Management1 trial

Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

Terminated·NNYU Langone Health·Phase 4·NCT04814433·46 enrolled

Coronary Artery Bypass1 trial

The Effect of Tranexamic Acid on Postoperative Blood Loss and Coagulation in Patients With Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; Double Blind Randomized Control Study

Completed·YYonsei University·Phase 4·NCT01067638·90 enrolled

Pilot Study1 trial

PeriOperative ISchemic Evaluation-3 Trial: A Pilot Study

Completed·MMcMaster University·Phase 3·NCT02546648·100 enrolled

Lip1 trial

Ulipristal Use in Chinese Population

Terminated·QQueen Mary Hospital, Hong Kong·Phase 4·NCT02825719·31 enrolled

Joint Replacement Surgery1 trial

Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery

Unknown status·TThe New England Baptist Hospital·Phase 3·NCT02438566·118 enrolled

Intravenous1 trial

Oral vs. Intravenous TXA Study Proposal: TJA

Completed·RRush University Medical Center·N/A·NCT02233101·167 enrolled

Sex1 trial

Use of Transexamic Acid in Hip Replacement

Unknown status·SSamsung Medical Center·Phase 3·NCT02587845·150 enrolled

Bone Sarcoma1 trial

Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient

Unknown status·SShaukat Khanum Memorial Cancer Hospital & Research Centre·Phase 1·NCT05427513·42 enrolled

Randomized1 trial

ITCH Trial: Protocol for a Randomized, Double Blind Placebo-controlled Trial

Completed·—·Phase 2/3·NCT04742205·154 enrolled

Myelodysplastic Syndromes1 trial

Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Recruiting·UUniversity of Manitoba·Phase 2·NCT06599762·75 enrolled

Mohs Micrographic Surgery1 trial

Topical Tranexamic Acid Use on Granulating Wounds Following Mohs Micrographic Surgery

Completed·UUniversity of Missouri-Columbia·Phase 1·NCT04541303·124 enrolled

ACL Reconstruction1 trial

Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA

Completed·NNYU Langone Health·Phase 4·NCT03631355·110 enrolled

Lumbar Spine Surgery1 trial

Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery

Completed·HHenry Ford Health System·Phase 4·NCT03037515·83 enrolled

Surgical1 trial

Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 2·NCT02922582·16 enrolled

Bleeding Disorder1 trial

Treatment and Management of Women With Bleeding Disorders

Completed·CCenters for Disease Control and Prevention·N/A·NCT00111215·100 enrolled

Hyperpigmentation1 trial

Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Withdrawn·WWayne State University·Phase 2/3·NCT03361345

Hereditary Hemorrhagic Telangiectasia1 trial

North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)

Completed·JJames Gossage·Phase 2·NCT01408030·123 enrolled

Trial1 trial

World Maternal Antifibrinolytic Trial_2

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT03475342·15,068 enrolled

Hereditary Angioedema1 trial

Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE)

Completed· Takeda logo

Takeda·Phase 3·NCT00500656·85 enrolled

Uterine Bleeding1 trial

Tranexamic Acid and Depot-Medroxyprogesterone Acetate for Perimenopausal Irregular Uterine Bleeding

Completed·—·N/A·NCT04710017·110 enrolled

Gastrointestinal1 trial

Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

Completed·BBayside Health·Phase 4·NCT04192435·3,300 enrolled

Blood Transfusion1 trial

The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates

Withdrawn·AAymen N Naguib··NCT01914211

Breast Reconstruction1 trial

Impact of Topical Tranexamic Acid in Breast Reconstruction

Terminated·UUniversity of California, San Francisco·Phase 4·NCT05807074·23 enrolled

Pregnancy1 trial

Von Willebrand Factor in Pregnancy (VIP) Study

Recruiting·UUniversity of Washington··NCT04146376·110 enrolled

Idiopathic Scoliosis1 trial

Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?

Completed·—·Phase 1/2·NCT01813058·120 enrolled

Growth1 trial

Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign

Unknown status·MMinistry of Science and Technology of the People´s Republic of China·Phase 2·NCT02625948·240 enrolled

Dilation and Evacuation1 trial

Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes

Recruiting·UUniversity of California, San Diego·Phase 4·NCT06820177·276 enrolled

Craniosynostosis1 trial

Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial

Completed·YYonsei University·N/A·NCT02180321·50 enrolled

Third Molar Surgery1 trial

Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery

Recruiting·—··NCT06806241·20 enrolled

Breast1 trial

Role of TXA in Patients Undergoing Breast Free Flap Reconstruction

Recruiting·UUniversity of Virginia·Phase 4·NCT06428682·100 enrolled

Von Willebrand disease1 trial

Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate

Not yet recruiting·—··NCT07410130·25 enrolled

Anemia1 trial

This is a Study to Verify if Tranexamic Acid Can Reduce the Anemia After a Femoral Shaft Fractures Surgery

Withdrawn·CChristian Candrian·Phase 4·NCT04803591

Injury1 trial

Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study

Completed·—·Phase 2·NCT02840097·31 enrolled

TED1 trial

TXA in Anticoagulated Patients Study

Terminated·NNYU Langone Health·Phase 4·NCT04560010·17 enrolled

Hysterectomy1 trial

Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy

Not yet recruiting·—·Phase 4·NCT06290596·387 enrolled

Tooth Extraction1 trial

Effect of TXA Oral Sol 5% in Patients Treated With DOACs or VKA and Undergoing a Single or Multiple Tooth Extraction

Unknown status·HHyloris Developments·Phase 3·NCT06143787·280 enrolled

Uterine Fibroid1 trial

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

Completed·—·Phase 4·NCT03317795·18 enrolled

Transurethral Resection1 trial

Safety and Efficacy of Intravenous Tranexamic Acid in Endoscopic Transurethral Resections in Urology

Completed·UUniversity Tunis El Manar·Phase 4·NCT02653261·131 enrolled

Bronchoscopy1 trial

Topical Instillation of Tranexamic Aacid in Bronchoscopy to Decrease Bleeding During Entobronchial & Transbronchial Biopsiy: a Prospective Double Blind Placebo Controlled Study

Unknown status·LLiran Levy·Phase 2·NCT02219152·120 enrolled

Coagulopathy1 trial

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Completed·MMonash University·Phase 3·NCT02187120·1,310 enrolled

Inflammatory Response1 trial

Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis

Recruiting·—·Phase 3·NCT04910464·80 enrolled

Platelet Transfusion1 trial

Platelet Transfusion Requirements in Hematopoietic Transplantation Pilot Study

Completed·OOttawa Hospital Research Institute·Phase 3·NCT02650791·100 enrolled

Femur Fracture1 trial

Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures

Unknown status·—·Phase 4·NCT02580227·100 enrolled

Mastectomy1 trial

The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy

Completed·SSt. Olavs Hospital·Phase 4·NCT02627560·202 enrolled

Menorrhagia1 trial

Efficacy and Safety Study of XP12B in Women With Menorrhagia

Completed· Ferring logo

Ferring·Phase 3·NCT00386308·196 enrolled

Post Operative Pain1 trial

Effect on Post-operative Pain of Tranexamic Acid Injection During Shoulder Surgery

Recruiting·EElsan·Phase 3·NCT05302986·220 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Intraarticular Injection of Tranexamic Acid Reduced Postoperative Hemarthrosis in Arthroscopic Anterior Cruciate Ligament Reconstruction

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT03580018·320 enrolled

Bariatric Surgery1 trial

BAR-TAX - Tranexamic Acid in Bariatric Surgery.

Active, not recruiting·—·N/A·NCT07401394·1,000 enrolled

Cesarean Delivery1 trial

Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery

Unknown status·—·N/A·NCT03741075·100 enrolled

Randomized Controlled Trial1 trial

Precise Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Bleeding: A Randomized Controlled Trial

Completed·NNational Cheng-Kung University Hospital·N/A·NCT06421389·60 enrolled

Lichen Planus1 trial

The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans

Recruiting·HHenry Ford Health System·Phase 2·NCT04233749·5 enrolled

Spinal Deformity1 trial

Tranexamic Acid Dosing in Adult Spinal Deformity Surgery

Completed·WWashington University School of Medicine·Phase 2/3·NCT02053363·64 enrolled

Total Shoulder Arthroplasty1 trial

TXA in Revision Total Shoulder Arthroplasty

Terminated·NNYU Langone Health·Phase 4·NCT04650698·19 enrolled

Brain Injury1 trial

Evaluating the Effect of Tranexamic Acid on the Clinical Outcomes in Patients With Traumatic Brain Injury

Recruiting·MMansoura University·Phase 1/2·NCT06330935·90 enrolled

Treatment1 trial

Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma

Completed·—·Phase 1·NCT05362500·54 enrolled

Freckles1 trial

Treatment of Freckles by Intradermal Tranexamic Acid Versus Q Switched KTP Laser.

Unknown status·KKasr El Aini Hospital·Phase 1·NCT03885895·30 enrolled

Knee Arthroscopy1 trial

Tranexamic Acid for Total Knee Arthroscopy

Completed·TThe Miriam Hospital·Phase 4·NCT04443920·86 enrolled

Unspecified1 trial

Intravesical Antifibrinolytic for Patients With Hematuria and Clot Retention

Completed·FFraser Health·Phase 1/2·NCT04555343·14 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 1986

CYKLOKAPRON

NDA NDA019281

Dec 30, 1986

CYKLOKAPRON

NDA NDA019280

Nov 13, 2009

LYSTEDA

NDA NDA022430

Apr 15, 2019

TRANEXAMIC ACID

NDA NDA212020

Sources

References

[1]
ClinicalTrials.gov — 554 trial records for tranexamic acid. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Cyklokapron drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — tranexamic acid compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for tranexamic acid. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA212020). U.S. Food & Drug Administration.
[6]
SEC EDGAR — J Molner company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Plasminogen Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: JJ Molner