Cyklokapron

(tranexamic acid)

ApprovedSmall molecule

Tranexamic acid is used to reduce excessive bleeding, such as heavy menstrual bleeding or bleeding after surgery or dental procedures. It works by helping blood clots stay in place longer.[2] Cyklokapron is currently approved and in use across 111 indications[4].[1]

Cyklokapron is one of 1104 small molecule programs targeting Hemoptysis. It is currently in Approved.

111

Indications

562

Total Trials

Active Trials

1,103

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

HemoptysisEnrolling by invitation

Placenta AccretaApproved

Cirrhosis of LiverApproved

ScoliosisApproved

Skin NeoplasmApproved

ShockApproved

OsteoarthritisApproved

Septic ShockApproved

Hematopoietic and Lymphoid Cell NeoplasmApproved

Pelvic Organ ProlapseApproved

HemoptysisApproved

Enrolling by invitation

Placenta AccretaApproved

Approved

Cirrhosis of LiverApproved

Approved

ScoliosisApproved

Approved

Skin NeoplasmApproved

Approved

ShockApproved

Approved

OsteoarthritisApproved

Approved

Septic ShockApproved

Approved

Hematopoietic and Lymphoid Cell NeoplasmApproved

Approved

Pelvic Organ ProlapseApproved

Approved

Showing 10 of 108 indications

Competition

Competitive Landscape

702 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Cyklokapron

Lexiscan

1 3

Duragesic-100

CCephalon

Preclinical

2 4

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 5

Spravato

WWim Janssens

Preclinical

2 6

Duragesic

CCephalon

Preclinical

1 7

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 8

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 9

Tc99m Sestamibi

MM.D. Anderson Cancer Center

Preclinical

2 10

Liposomal Irinotecan and Apatinib

SSecond Affiliated Hospital, School of Medicine, Zhejiang University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Recruiting

Pregnancy

NCT04146376

Not yet recruiting

Von Willebrand Disease

NCT07410130

Post-ApprovalRecruiting

Cardiac Surgery

NCT06109155

Post-ApprovalNot yet recruiting

Cesarean Section

NCT07078942

Q1 2027

Phase 3Recruiting

Inflammatory Response

NCT04910464

Q2 2027

N/ARecruiting

Total Knee Arthroplasty

NCT06208267

Clinical

Trials by Indication[1]

Tranexamic Acid44 trials

Tranexamic Acid During Cystectomy Trial (TACT)

Completed·OOttawa Hospital Research Institute·Phase 2/3·NCT01869413·354 enrolled

Tranexamic Acid During Upper GI Endoscopic Resection Procedures

Unknown status·—·Phase 4·NCT05688020·200 enrolled

Tranexamic Acid for Bleeding in Breast Surgery

Unknown status·OOttawa Hospital Research Institute·Phase 4·NCT02615366·800 enrolled

Show 41 more trials

A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02561923·158 enrolled

Comparison of Chitosan, Ankaferd and Tranexamic Acid in Dental Extraction in Liver Pre-Transplant Children

Completed·—·Phase 1·NCT06457360·39 enrolled

Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery

Completed·UUniversity Health Network, Toronto·Phase 3·NCT00444470·151 enrolled

Intravenous vs. Topical Tranexamic Acid in Revision THA (VITALITY-X)

Unknown status·MMount Sinai Hospital, Canada·Phase 4·NCT02938962·160 enrolled

Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid

Completed·UUniversity of Missouri-Columbia·N/A·NCT02051686·88 enrolled

Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA

Unknown status·UUniversidade do Vale do Sapucai·N/A·NCT04696224·90 enrolled

Use of Tranexamic Acid in Reduction Mammoplasty

Completed·MMontefiore Medical Center·Phase 4·NCT04947514·98 enrolled

Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy

Recruiting·—·N/A·NCT04811313·400 enrolled

Tranexamic Acid and Blood Clots in Knee Surgery

Completed·UUniversity of New Mexico··NCT02867163·25 enrolled

Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH

Completed·AAzienda U.S.L. 1 di Massa e Carrara·Phase 3·NCT02775773·256 enrolled

A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma.

Completed·XxjpfW·N/A·NCT03963466·30 enrolled

Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity

Completed·HHaseki Training and Research Hospital·N/A·NCT04628676·100 enrolled

Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy

Completed·—·N/A·NCT04188184·60 enrolled

Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT

Completed·MMahidol University·N/A·NCT01449552·240 enrolled

Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Tranexamic Acid on Transfusion Requirements and Surgical Bleeding in Major Spine Surgery

Completed·HHospital Universitari Vall d'Hebron Research Institute·Phase 4·NCT01136590·96 enrolled

Efficacy of Tranexamic Acid in Foot and Ankle Surgeries

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT03653429·100 enrolled

Reduction Bleeding in Laminectomy With Double Doses of Tranexamic Acid

Completed·MMahidol University·Phase 4·NCT01643135·78 enrolled

Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus

Completed·HHillerod Hospital, Denmark·Phase 4·NCT01940419·332 enrolled

Impact of Tranexamic Acid Use in Percutaneous Nephrolithotomy

Unknown status·UUniversity of Sao Paulo·Phase 4·NCT02966236·192 enrolled

Tranexamic Acid in Proximal Humeral Fractures

Unknown status·—·Phase 4·NCT05437822·40 enrolled

Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction

Terminated·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT03413891·222 enrolled

Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study

Completed·UUniversity of California, San Francisco·Phase 4·NCT02806024·14 enrolled

Tranexamic Acid During Colonic Endoscopic Resection Procedures

Recruiting·—·Phase 4·NCT05345613·200 enrolled

Intravenous Tranexamic Acid Versus Pericervical Tourniquet To Decrease Blood Loss In Trans-Abdominal Myomectomy

Unknown status·—·Phase 3·NCT02733952·70 enrolled

Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations

Unknown status·—·Phase 4·NCT04537533·90 enrolled

Tranexamic Acid and Pediatric Adenotonsillectomy

Completed·IIrmandade Santa Casa de Misericórdia de Porto Alegre·Phase 4·NCT01228136·95 enrolled

Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.

Completed·—·N/A·NCT05517590·102 enrolled

Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid

Recruiting·—·Phase 1/2·NCT06997796·24 enrolled

Topical Tranexamic Acid Application in Rhinoplasty

Completed·—·Phase 4·NCT05326139·50 enrolled

Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma

Completed·—·Phase 1·NCT05884151·60 enrolled

Tranexamic Acid in Percutaneous Nephrolithotomy

Completed·HHaseki Training and Research Hospital·N/A·NCT05947435·75 enrolled

Tranexamic Acid in Pregnancies With Vaginal Bleeding

Completed·HHawler Medical University·N/A·NCT03632824·139 enrolled

Prophylactic Tranexamic Acid During Minimally Invasive Myomectomies

Unknown status·—·Phase 3·NCT04311073·50 enrolled

Effect of Tranexamic Acid on Blood Loss After High Tibial Osteotomy

Unknown status·TThe Catholic University of Korea·N/A·NCT04653623·40 enrolled

Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements

Unknown status·IInstituto Mexicano del Seguro Social·Phase 3·NCT05855590·20 enrolled

The Effect of Tranexamic Acid in Total Blood Loss During Proximal Femoral Nailing

Completed·HHaseki Training and Research Hospital··NCT05359172·100 enrolled

The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery

Completed·WWake Forest University Health Sciences·Phase 3·NCT02684851·87 enrolled

Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.

Completed·—·Phase 1·NCT02319915·14 enrolled

Evaluation of Intraarticular Tranexamic Acid to Reduction of Total Blood Loss Following Knee-Arthroplasty

Completed·HHvidovre University Hospital·Phase 4·NCT02427412·60 enrolled

Tranexamic Acid vs Vasopressin in Placenta Previa Trial

Not yet recruiting·—·Phase 3·NCT07423156·58 enrolled

Tranexamic Acid in Abdominoplasty.

Completed·PPoznan University of Medical Sciences·Phase 4·NCT06086444·60 enrolled

Total Knee Arthroplasty12 trials

Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty

Unknown status·UUniversity of Sao Paulo General Hospital·Phase 4·NCT02152917·45 enrolled

Alteration of Thrombelastography and Coagulation Function in Patients Undergoing Total Knee Arthroplasty With Intra-articular Tranexamic Acid Administration

Unknown status·RRenJi Hospital··NCT05490160·54 enrolled

Epsilon Aminocaproic Acid Vs. Tranexamic Acid Vs. Placebo for Prevention of Blood Loss in Total Knee Arthroplasty

Unknown status·—·N/A·NCT01527968·54 enrolled

Show 9 more trials

Intra-articular Tranexamic Acid in the Reduction of Blood Transfusions in Primary Total Hip and Total Knee Arthroplasty

Completed·OOrthopaedic Innovation Centre·Phase 2·NCT02393963·140 enrolled

Clinical Trial Comparing Tranexamic Acid (TXA) With Aquamantys Sealer in Total Knee Arthroplasty (TKA)

Completed·—·Phase 4·NCT02374398·127 enrolled

Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty

Unknown status·SSeoul National University Hospital·Phase 1·NCT02286973·264 enrolled

The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty

Completed·XXijing Hospital·Phase 4·NCT02504125·120 enrolled

Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

Completed·HHenry Ford Health System·Phase 2·NCT01370460·101 enrolled

The Immunomodulatory Effect of Antrifibrinolytic (Tranexamic Acid) in Total Knee Arthroplasty

Unknown status·—·N/A·NCT03795649·80 enrolled

Application of Iced Normal Saline Combined With Cocktail Perfusion in Total Knee Arthroplasty

Completed·YYantai Yuhuangding Hospital·N/A·NCT05204056·60 enrolled

Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial

Completed·IIsfahan University of Medical Sciences·N/A·NCT02327117·90 enrolled

Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty

Recruiting·SSt. Mary's Research Center, Canada·N/A·NCT06208267·210 enrolled

Hip Fracture9 trials

HiFIT Study : Hip Fracture: Iron and Tranexamic Acid

Terminated·UUniversity Hospital, Angers·Phase 3·NCT02972294·419 enrolled

Effects of Tranexamic Acid on Blood Loss and Transfusion Requirement Following Hip Fracture

Unknown status·RRothman Institute Orthopaedics·N/A·NCT02738073

Study of the Effect of Tranexamic Acid Administered to Patients With Hip Fractures. Can Blood Loss be Reduced?

Terminated·HHvidovre University Hospital·N/A·NCT01535781·72 enrolled

Show 6 more trials

Clinical Trial to Assess the Efficacy of Tranexamic Acid in Reducing Blood Loss in Hip Fracture Patients.

Unknown status·—·Phase 4·NCT05489185·644 enrolled

Tranexamic Acid in Hip Fracture Patients

Unknown status·—·N/A·NCT01326403·60 enrolled

Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures

Terminated·YYale University·Phase 4·NCT02908516·6 enrolled

Effect of Early Administration of TXA in Adult Hip Fractures

Recruiting·AAscension Health·Phase 2/3·NCT05047133·170 enrolled

Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients

Completed·—·Phase 4·NCT03211286·129 enrolled

Tranexamic Acid Use in Acute Hip Fractures

Completed·CCarilion Clinic·Phase 4·NCT02947529·113 enrolled

Cesarean Section8 trials

Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section

Completed·—·N/A·NCT06060327·440 enrolled

Sublingual Misoprostol With or Without Intravenous Tranexamic Acid During Hemorrhagic Cesarean Section

Unknown status·—·N/A·NCT03774706·150 enrolled

The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women

Completed·—·N/A·NCT03820206·160 enrolled

Show 5 more trials

Tranexamic Acid Use in Elective Cesarean Section for Women With Placenta Previa

Completed·—·Phase 3·NCT03060889·86 enrolled

Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section

Not yet recruiting·—·Phase 4·NCT07078942·98 enrolled

Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa

Completed·MMedical Research Council·Phase 1/2·NCT02688127·52 enrolled

Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section

Not yet recruiting·—·Phase 3·NCT06010368·150 enrolled

Effectiveness of Intravenous Tranexamic Acid in Reducing Blood Loss During and After Cesarean Section

Unknown status·—·Phase 4·NCT02279186·200 enrolled

Cardiac Surgery7 trials

Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

Completed·LLoma Linda University·N/A·NCT01248104·100 enrolled

Tranexamic Acid in Pediatric Cardiac Surgery

Completed·OOkayama University·N/A·NCT00994994·160 enrolled

A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery

Completed·MMayo Clinic·Phase 3·NCT00588133·20 enrolled

Show 4 more trials

The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery

Recruiting·TTaichung Veterans General Hospital·Phase 4·NCT06109155·150 enrolled

Dose-ranging Study of Two Doses of Tranexamic Acid During Cardiac Surgery

Completed·HHopital Foch·Phase 4·NCT00809393·600 enrolled

Phase II Study to Compare MDCO-2010 vs Placebo and Tranexamic Acid in Patients Undergoing Cardiac Surgery

Terminated· Novartis logo

Novartis·Phase 2·NCT01530399·44 enrolled

Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery

Unknown status·SSHI Jia·Phase 4·NCT03838328·360 enrolled

84 more indications

Total Hip Arthroplasty6 trials

Role of Topical Tranexamic Acid in Total Hip Arthroplasty

Terminated·NNorthwell Health·Phase 2·NCT01866943·41 enrolled

The Effect of Tranexamic Acid for Total Hip Arthroplasty

Unknown status·TTC Erciyes University·Phase 4·NCT02094066·60 enrolled

The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT01622946·80 enrolled

Show 3 more trials

Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty

Completed·SShanghai Jiao Tong University School of Medicine·Phase 3·NCT02312440·173 enrolled

Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty

Unknown status·TThe First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine·N/A·NCT01260818·100 enrolled

Goal-directed vs Preemptive Tranexamic Acid Administration in Total Hip Arthroplasty

Unknown status·KKonkuk University Medical Center·N/A·NCT05956769·84 enrolled

Hemorrhage5 trials

Tranexamic Acid Per Inhalation for Treatment of Pulmonary Hemorrhage in Pediatric Patients

Completed·—··NCT03676023·20 enrolled

Impact of Inhaled Tranexamic Acid in Pulmonary Hemorrhage in Pediatric Intensive Care Unit

Completed·TTanta University·N/A·NCT07481682·100 enrolled

Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial

Unknown status·KKwong Wah Hospital·Phase 3·NCT03044184·220 enrolled

Show 2 more trials

Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care.

Completed·BBanc de Sang i Teixits·Phase 1/2·NCT03780894·79 enrolled

Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery

Completed·UUniversity of Texas Southwestern Medical Center·Phase 2/3·NCT03856164·110 enrolled

Blood Transfusion3 trials

Efficacy Comparison of Topical and Intravenous Tranexamic Acid to Reduce the Number of Blood Transfusions in TKA

Completed·HHospital Universitario La Paz·Phase 3·NCT01881568·79 enrolled

Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery?

Completed·MMayo Clinic·Phase 4·NCT01714336·138 enrolled

The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates

Withdrawn·AAymen N Naguib··NCT01914211

Postpartum Hemorrhage3 trials

Trends in the Administration of Tranexamic Acid for Postpartum Hemorrhage

Recruiting·MMahidol University··NCT07278037·648 enrolled

Tranexamic Acid in the Prevention of Postpartum Hemorrhage in Elective Caesarean Section

Completed·KKK Women's and Children's Hospital·Phase 3·NCT04427618·200 enrolled

Postpartum Hemorrhage Reduction With Oral Tranexamic Acid: a Clinical Trial

Recruiting·KKarolinska Institutet·Phase 4·NCT06025916·1,000 enrolled

Trial3 trials

World Maternal Antifibrinolytic Trial_2

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT03475342·15,068 enrolled

World Maternal Antifibrinolytic Trial

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00872469·20,060 enrolled

PeriOperative ISchemic Evaluation-3 Trial

Completed·PPopulation Health Research Institute·Phase 3·NCT03505723·9,535 enrolled

Bleeding3 trials

The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

Completed·SSt. Olavs Hospital·Phase 4·NCT01964781·30 enrolled

Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery

Unknown status·—·Phase 2·NCT03112135·90 enrolled

Reducing Post Operative Bleeding Following Cabg

Completed·UUniversity of Malaya·N/A·NCT01600599·40 enrolled

Hyperpigmentation2 trials

Tranexamic Acid vs Fractional CO2 Laser in Post-acne Hyperpigmentation

Unknown status·—·N/A·NCT03765021·25 enrolled

Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Withdrawn·WWayne State University·Phase 2/3·NCT03361345

Hemoptysis2 trials

Efficacy of Tranexamic Acid in Hemoptysis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT02781597·66 enrolled

The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis

Unknown status·MMeir Medical Center·Phase 3·NCT01496196·100 enrolled

Hysterectomy2 trials

Do Patients Who Received Tranexamic Acid in Vaginal Hysterectomy Loose Les Blood, Comparing to Patients Who Did Not?

Recruiting·WWolfson Medical Center·N/A·NCT05921071·80 enrolled

Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy

Not yet recruiting·—·Phase 4·NCT06290596·387 enrolled

Total Knee Replacement2 trials

The Efficacy and Safety of Using Tranexamic Acid by Different Means to Reduce Blood Loss During Total Knee Replacement

Completed·XXijing Hospital·Phase 4·NCT02117128·150 enrolled

Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement

Completed·MMahidol University·N/A·NCT01850394·152 enrolled

Heavy Menstrual Bleeding2 trials

Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding

Completed· Ferring logo

Ferring·Phase 4·NCT01190150·20 enrolled

Efficacy of Calcium Dobesilate Versus Tranexamic Acid for Treating Heavy Menstrual Bleeding

Not yet recruiting·UUniversity of Health Sciences Lahore·N/A·NCT06763094·100 enrolled

Ovarian Cancer2 trials

Tranexamic Acid in Surgery of Advanced Ovarian Cancer

Completed·—·Phase 4·NCT00740116·100 enrolled

Efficacy and Safety of Tranexamic Acid in Cytoreductive Surgery for Ovarian Cancer

Completed·JJun Zhang·N/A·NCT04360629·151 enrolled

Upper Gastrointestinal Bleeding2 trials

Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT03023189·500 enrolled

Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT04788121·160 enrolled

Coronary Artery Bypass2 trials

Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery

Completed·UUniversity of Saskatchewan·Phase 3·NCT01519245·44 enrolled

Tranexamic Acid, Hemorrhage and Transfusions After Combined Aortic Valve Replacement and Coronary Artery Bypass Surgery.

Completed·SSt. Olavs Hospital·N/A·NCT00375466·63 enrolled

Epistaxis2 trials

Tranexamic Acid Dosage for Topical Treatment of Anterior Epistaxis

Completed·—·Phase 4·NCT06183918·152 enrolled

Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis

Completed·KKecioren Education and Training Hospital·Phase 4·NCT03360045·135 enrolled

Total Joint Arthroplasty2 trials

Safety of Topical Tranexamic Acid in Total Joint Arthroplasty in High Risk Patients

Withdrawn·—·Phase 4·NCT02644473

Tranexamic Acid Dosing for Total Joint Arthroplasty

Completed·—·Phase 4·NCT02584725·84 enrolled

Growth2 trials

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Completed·NNeuroscience Trials Australia·Phase 2·NCT01702636·100 enrolled

Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign

Unknown status·MMinistry of Science and Technology of the People´s Republic of China·Phase 2·NCT02625948·240 enrolled

Blood Loss2 trials

Determination of Blood Loss After CS

Unknown status·—·Phase 1·NCT04549012·130 enrolled

Reducing Blood Loss Using Tisseel in TKA

Unknown status·—·Phase 4·NCT03310060·100 enrolled

Postoperative Blood Loss2 trials

Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery

Completed·PPopulation Health Research Institute·Phase 4·NCT03376061·97 enrolled

Effect of Tranexamic Acid on Reducing Postoperative Blood Loss in Cervical Laminoplasty

Completed·—·N/A·NCT01027546·40 enrolled

Vaginal Delivery2 trials

Prophylactic Tranexamic Acid Use After Vaginal Delivery

Completed·—·N/A·NCT05429580·480 enrolled

Use of Tranexamic Acid After Vaginal Delivery with Episiotomy a RCT Placebo Control Trail

Completed·—·Phase 4·NCT05448456·150 enrolled

Meningioma2 trials

The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection

Completed·—·N/A·NCT04595786·228 enrolled

Tranexamic Acid Reduce Blood Loss in Meningioma Resection

Unknown status·—·Phase 4·NCT04386642·44 enrolled

Shoulder Arthroscopy2 trials

The Effect of Tranexamic Acid (TXA) on Visualization During Shoulder Arthroscopy

Unknown status·RRothman Institute Orthopaedics·Phase 3·NCT04610164·200 enrolled

The Effect of Intravenous Tranexamic Acid and Interscalene Block Applied on Shoulder Arthroscopy

Unknown status·—·N/A·NCT04419246·60 enrolled

Perioperative Bleeding2 trials

Tranexamic Acid Versus Placebo for Blood to Reduce Perioperative Bleeding Post-liver Resection

Completed·SSunnybrook Health Sciences Centre·Phase 3·NCT01651182·24 enrolled

Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery

Completed·UUniversity Hospital, Lille·Phase 3·NCT02702128·157 enrolled

Functional Endoscopic Sinus Surgery2 trials

Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial

Unknown status·—·Phase 3·NCT03965767·120 enrolled

The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery

Withdrawn·UUniversity of Calgary·N/A·NCT00671281·74 enrolled

HAE1 trial

Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00375258·20,211 enrolled

Menorrhagia1 trial

Oral Tranexamic Acid Versus Diosmin for Treatment of Menorrhagia in Women Using Copper IUD

Unknown status·—·Phase 1/2·NCT02616731·100 enrolled

Orthopedic Surgery1 trial

Tranexamic Acid in Major Orthopedic Surgery: Comparison of 3 Dosage Regimen

Unknown status·—··NCT03573245·210 enrolled

Efficacy1 trial

A Study to Evaluate the Safety, Tolerability and Efficacy of LB1148 for Subjects Undergoing Elective Bowel Resection

Completed·—·Phase 1·NCT04100447·11 enrolled

Hematoma1 trial

Tranexamic Acid in Chronic Subdural Hematomas

Unknown status·—·Phase 2/3·NCT02568124·130 enrolled

Cirrhosis1 trial

Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04489108·600 enrolled

ACL Reconstruction1 trial

Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA

Completed·NNYU Langone Health·Phase 4·NCT03631355·110 enrolled

Dexmedetomidine1 trial

Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries

Completed·ZZagazig University·N/A·NCT06587620·78 enrolled

Unknown status·SSeoul National University Hospital·N/A·NCT06091891·84 enrolled

Bariatric Surgery1 trial

Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery

Terminated·SSheba Medical Center·Phase 3·NCT03085394·152 enrolled

Urologic Surgery1 trial

Tranexamic Acid in Urologic Surgery

Completed·UUniversità Vita-Salute San Raffaele·Phase 4·NCT00670345

Intracerebral Hemorrhage1 trial

Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist

Completed·UUniversity Hospital, Basel, Switzerland·Phase 2/3·NCT02866838·64 enrolled

Bleeding Disorder1 trial

Treatment and Management of Women With Bleeding Disorders

Completed·CCenters for Disease Control and Prevention·N/A·NCT00111215·100 enrolled

Thrombocytopenia1 trial

American Trial Using Tranexamic Acid in Thrombocytopenia

Completed·UUniversity of Washington·Phase 3·NCT02578901·330 enrolled

Hereditary Hemorrhagic Telangiectasia1 trial

North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)

Completed·JJames Gossage·Phase 2·NCT01408030·123 enrolled

Intraoperative Bleeding1 trial

Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid

Completed·EEsbjerg Hospital - University Hospital of Southern Denmark·Phase 4·NCT02229292·104 enrolled

Cesarean Delivery1 trial

Blood Loss During Cesarean Delivery in Placenta Previa Patients

Completed·—·Phase 4·NCT05340205·81 enrolled

Hereditary Angioedema1 trial

Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE)

Completed· Takeda logo

Takeda·Phase 3·NCT00500656·85 enrolled

Uterine Bleeding1 trial

Tranexamic Acid and Depot-Medroxyprogesterone Acetate for Perimenopausal Irregular Uterine Bleeding

Completed·—·N/A·NCT04710017·110 enrolled

Lumbar Spine Surgery1 trial

Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery

Completed·HHenry Ford Health System·Phase 4·NCT03037515·83 enrolled

Breast Reconstruction1 trial

Impact of Topical Tranexamic Acid in Breast Reconstruction

Terminated·UUniversity of California, San Francisco·Phase 4·NCT05807074·23 enrolled

Pregnancy1 trial

Von Willebrand Factor in Pregnancy (VIP) Study

Recruiting·UUniversity of Washington··NCT04146376·110 enrolled

Cutaneous Squamous Cell Carcinoma1 trial

Window of Opportunity Study of Topical Tranexamic Acid for Cutaneous Squamous Cell Carcinoma

Withdrawn·UUniversity of Florida·Phase 2·NCT06644079

Prevention1 trial

Prevention of Postoperative Bleeding in Subcapital Femoral Fractures

Completed·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 3·NCT02150720·161 enrolled

Safety and Efficacy1 trial

Evaluation of the Safety and Efficacy of the Second Dose of Tranexamic Acid

Completed·HHamad Medical Corporation·Phase 3·NCT03846973·220 enrolled

Brain Injury1 trial

Tranexamic Acid for Preventing Progressive Intracranial Haemorrhage in Traumatic Brain Injury

Completed·KKhon Kaen University·Phase 3·NCT00755209·238 enrolled

Surgical1 trial

Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 2·NCT02922582·16 enrolled

Abdominal Aortic Aneurysm1 trial

Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms

Completed·SSaskatchewan Health Authority - Regina Area·Phase 3·NCT02125890·9 enrolled

Randomized Controlled Trial1 trial

Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial

Completed·SSt. Louis Joint Replacement Institute·Phase 1·NCT06920264·165 enrolled

Stroke1 trial

STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

Completed·NNeuroscience Trials Australia·Phase 2·NCT03385928·201 enrolled

Local Infiltration1 trial

Anti-fibrinolytic and Anti-inflammatory Effects of Local Infiltration of Tranexamic Acid in Patients With Calcaneal Fractures

Completed·HHebei Medical University Third Hospital·N/A·NCT05598086·113 enrolled

Mastectomy1 trial

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage

Withdrawn·NNorthwestern University·Phase 2·NCT05554211

Intravitreal Injections1 trial

Topical Tranexamic Acid After Intravitreal Injections

Unknown status·RRambam Health Care Campus·N/A·NCT04400916·100 enrolled

Platelet Aggregation1 trial

Tranexamic Acid Effect on Platelet Aggregation Following Infant Cardiopulmonary Bypass

Withdrawn·EEmory University·Phase 4·NCT02122679

Pilot Study1 trial

A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery

Completed·WWake Forest University Health Sciences·Phase 4·NCT02656472·22 enrolled

Osteogenesis Imperfecta1 trial

Tranexamic Acid During Telescoping Nail Application In Osteogenesis Imperfecta

Completed·—·N/A·NCT05321199·20 enrolled

Subarachnoid Hemorrhage1 trial

Ultra-early Tranexamic Acid After Subarachnoid Hemorrhage.

Completed·—·Phase 2/3·NCT02684812·955 enrolled

Gastrointestinal1 trial

Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

Completed·BBayside Health·Phase 4·NCT04192435·3,300 enrolled

Idiopathic Scoliosis1 trial

Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?

Completed·—·Phase 1/2·NCT01813058·120 enrolled

Dilation and Evacuation1 trial

Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes

Recruiting·UUniversity of California, San Diego·Phase 4·NCT06820177·276 enrolled

Craniosynostosis1 trial

Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial

Completed·YYonsei University·N/A·NCT02180321·50 enrolled

Third Molar Surgery1 trial

Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery

Recruiting·—··NCT06806241·20 enrolled

Breast1 trial

Role of TXA in Patients Undergoing Breast Free Flap Reconstruction

Recruiting·UUniversity of Virginia·Phase 4·NCT06428682·100 enrolled

Von Willebrand disease1 trial

Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate

Not yet recruiting·—··NCT07410130·25 enrolled

Anemia1 trial

This is a Study to Verify if Tranexamic Acid Can Reduce the Anemia After a Femoral Shaft Fractures Surgery

Withdrawn·CChristian Candrian·Phase 4·NCT04803591

After Cardiac Surgery1 trial

Tranexamic Acid Dose and Confusion After Cardiac Surgery

Unknown status·PPapworth Hospital NHS Foundation Trust··NCT05966012·5,000 enrolled

Injury1 trial

Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study

Completed·—·Phase 2·NCT02840097·31 enrolled

TED1 trial

TXA in Anticoagulated Patients Study

Terminated·NNYU Langone Health·Phase 4·NCT04560010·17 enrolled

Tooth Extraction1 trial

Effect of TXA Oral Sol 5% in Patients Treated With DOACs or VKA and Undergoing a Single or Multiple Tooth Extraction

Unknown status·HHyloris Developments·Phase 3·NCT06143787·280 enrolled

Uterine Fibroid1 trial

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

Completed·—·Phase 4·NCT03317795·18 enrolled

Transurethral Resection1 trial

Safety and Efficacy of Intravenous Tranexamic Acid in Endoscopic Transurethral Resections in Urology

Completed·UUniversity Tunis El Manar·Phase 4·NCT02653261·131 enrolled

Bronchoscopy1 trial

Topical Instillation of Tranexamic Aacid in Bronchoscopy to Decrease Bleeding During Entobronchial & Transbronchial Biopsiy: a Prospective Double Blind Placebo Controlled Study

Unknown status·LLiran Levy·Phase 2·NCT02219152·120 enrolled

Coagulopathy1 trial

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Completed·MMonash University·Phase 3·NCT02187120·1,310 enrolled

Caesarean Section1 trial

Efficacy of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section

Unknown status·—·Phase 1/2·NCT02350179·100 enrolled

Inflammatory Response1 trial

Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis

Recruiting·—·Phase 3·NCT04910464·80 enrolled

Platelet Transfusion1 trial

Platelet Transfusion Requirements in Hematopoietic Transplantation Pilot Study

Completed·OOttawa Hospital Research Institute·Phase 3·NCT02650791·100 enrolled

Joint Replacement Surgery1 trial

Tranexamic Acid Dosing for Major Joint Replacement Surgery

Completed·SSunnybrook Health Sciences Centre·Phase 2·NCT05075200·21 enrolled

Unspecified2 trials

Intravesical Antifibrinolytic for Patients With Hematuria and Clot Retention

Completed·FFraser Health·Phase 1/2·NCT04555343·14 enrolled

TXA in the EMS on the Helicopter and the Ambulance

Unknown status·UUniversity of Zurich·Phase 4·NCT02354885·50 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 1986

CYKLOKAPRON

NDA NDA019281

Dec 30, 1986

CYKLOKAPRON

NDA NDA019280

Nov 7, 1994

CYKLOKAPRON

NDA NDA019281

Nov 7, 1994

CYKLOKAPRON

NDA NDA019281

Jul 24, 1996

CYKLOKAPRON

NDA NDA019281

Jul 24, 1996

CYKLOKAPRON

NDA NDA019281

Jul 24, 1996

CYKLOKAPRON

NDA NDA019281

Jul 24, 1996

CYKLOKAPRON

NDA NDA019281

Jul 24, 1996

CYKLOKAPRON

NDA NDA019281

Dec 5, 1996

CYKLOKAPRON

NDA NDA019281

Sep 9, 1999

CYKLOKAPRON

NDA NDA019281

Nov 15, 1999

CYKLOKAPRON

NDA NDA019281

Apr 28, 2000

CYKLOKAPRON

NDA NDA019281

Mar 27, 2001

CYKLOKAPRON

NDA NDA019281

Jul 31, 2001

CYKLOKAPRON

NDA NDA019281

Oct 31, 2001

CYKLOKAPRON

NDA NDA019281

Nov 2, 2001

CYKLOKAPRON

NDA NDA019281

Nov 2, 2001

CYKLOKAPRON

NDA NDA019281

Apr 16, 2002

CYKLOKAPRON

NDA NDA019281

May 15, 2002

CYKLOKAPRON

NDA NDA019281

Dec 22, 2008

CYKLOKAPRON

NDA NDA019281

Jan 28, 2009

CYKLOKAPRON

NDA NDA019281

Nov 13, 2009

LYSTEDA

NDA NDA022430

Jan 25, 2011

CYKLOKAPRON

NDA NDA019281

May 10, 2013

CYKLOKAPRON

NDA NDA019281

Dec 15, 2014

CYKLOKAPRON

NDA NDA019281

Apr 17, 2015

CYKLOKAPRON

NDA NDA019281

Jun 1, 2015

CYKLOKAPRON

NDA NDA019281

Oct 20, 2015

CYKLOKAPRON

NDA NDA019281

Feb 1, 2016

CYKLOKAPRON

NDA NDA019281

Aug 1, 2016

CYKLOKAPRON

NDA NDA019281

Nov 3, 2016

CYKLOKAPRON

NDA NDA019281

Nov 21, 2017

CYKLOKAPRON

NDA NDA019281

Apr 15, 2019

TRANEXAMIC ACID

NDA NDA212020

Jun 7, 2020

CYKLOKAPRON

NDA NDA019281

Feb 4, 2021

CYKLOKAPRON

NDA NDA019281

Aug 29, 2025

CYKLOKAPRON

NDA NDA019281

Sources

References

[1]
ClinicalTrials.gov — 562 trial records for tranexamic acid. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Cyklokapron drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — tranexamic acid compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for tranexamic acid. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA019281). U.S. Food & Drug Administration.
[6]
SEC EDGAR — J Molner company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Plasminogen Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: JJ Molner

Cyklokapron

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Trials by Indication[1]

Tranexamic Acid44 trials

Total Knee Arthroplasty12 trials

Hip Fracture9 trials

Cesarean Section8 trials

Cardiac Surgery7 trials

Total Hip Arthroplasty6 trials

Hemorrhage5 trials

Blood Transfusion3 trials

Postpartum Hemorrhage3 trials

Trial3 trials

Bleeding3 trials

Hyperpigmentation2 trials

Hemoptysis2 trials

Hysterectomy2 trials

Total Knee Replacement2 trials

Heavy Menstrual Bleeding2 trials

Ovarian Cancer2 trials

Upper Gastrointestinal Bleeding2 trials

Coronary Artery Bypass2 trials

Epistaxis2 trials

Total Joint Arthroplasty2 trials

Growth2 trials

Blood Loss2 trials

Postoperative Blood Loss2 trials

Vaginal Delivery2 trials

Meningioma2 trials

Shoulder Arthroscopy2 trials

Perioperative Bleeding2 trials

Functional Endoscopic Sinus Surgery2 trials

HAE1 trial

Menorrhagia1 trial

Orthopedic Surgery1 trial

Efficacy1 trial

Hematoma1 trial

Cirrhosis1 trial

ACL Reconstruction1 trial

Dexmedetomidine1 trial

COVID-191 trial

Lung Cancer1 trial

Scoliosis1 trial

Bariatric Surgery1 trial

Urologic Surgery1 trial

Intracerebral Hemorrhage1 trial

Bleeding Disorder1 trial

Thrombocytopenia1 trial

Hereditary Hemorrhagic Telangiectasia1 trial

Intraoperative Bleeding1 trial

Cesarean Delivery1 trial

Hereditary Angioedema1 trial

Uterine Bleeding1 trial

Lumbar Spine Surgery1 trial

Breast Reconstruction1 trial

Pregnancy1 trial

Cutaneous Squamous Cell Carcinoma1 trial

Prevention1 trial

Safety and Efficacy1 trial

Brain Injury1 trial

Surgical1 trial

Abdominal Aortic Aneurysm1 trial

Randomized Controlled Trial1 trial

Stroke1 trial

Local Infiltration1 trial

Mastectomy1 trial

Intravitreal Injections1 trial

Platelet Aggregation1 trial

Pilot Study1 trial

Osteogenesis Imperfecta1 trial

Subarachnoid Hemorrhage1 trial

Gastrointestinal1 trial

Idiopathic Scoliosis1 trial

Dilation and Evacuation1 trial

Craniosynostosis1 trial