VivoSeq
Other

Liver Transplant

278

Pipeline Programs↗

50

Active Trials↗

80

Companies Involved↗

Liver Transplant is a highly competitive landscape with 278 programs across 80 companies. The most active players are Enzon Pharmaceuticals, Inc., Kenvue Brands, Parkedale. 72 therapies are approved with 54 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

86/100

Pipeline Velocity

45/100

Mech. Concentration

5/100

Completion Rate

77/100

Attrition Rate

14/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

E

Enzon Pharmaceuticals, Inc.

1 program

Phase 1K

Kenvue Brands

1 program

Phase 1P

Parkedale

1 program

Phase 1J

Jiangsu Topcel-KH Pharmaceutical Co., Ltd.

1 program

Phase 1Johnson & Johnson Pharmaceutical Research & Development, L.L.C. logo

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

1 program

Phase 1E

Elpiscience Biopharma, Ltd.

1 program

Phase 1

Pipeline

Programs by Phase

Preclinical62

Valganciclovir

Engelhard Arzneimittel GmbH & Co.KG

Ganciclovir

Exela Pharma Sciences, LLC.

Lenvatinib

Eisai

Tislelizumab

BeiGene

Norepinephrine

General Hospital of Ningxia Medical University

Phase 123

Mannitol

B. Braun Medical Inc.

Acetaminophen

Kenvue Brands

Multistem

Healios K.K.

Diphenhydramine

Parkedale

Eculizumab

AstraZeneca

Phase 267

Aldesleukin

Iovance Biotherapeutics, Inc.

Semaglutide

Novo Nordisk

Fenofibrate

Jagotec

Resmetirom

Madrigal Pharmaceuticals

Boceprevir

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 354

Basiliximab

Novartis

Mycophenolate Sodium

Novartis

Patisiran

Alnylam Pharmaceuticals

Mycophenolic Acid

Novartis

Ribavirin

Conrado Roberto Hoffmann Filho

Approved72

Atezolizumab

Roche

Azathioprine

Legacy Health System

Ketamine

Aultman Health Foundation

Mycophenolate Mofetil

Roche

Cyclosporine

Novartis

Analysis

Modality Breakdown

90%

Small molecule

276 of 306 classified programs — the dominant modality here.

10%ALL OTHERSMonoclonal antibody103%Cell therapy72%Vaccine41%Protein / enzyme3<1%RNA therapy3<1%Peptide2<1%Other1<1%

Small molecule leads; the ring shows all 306 classified programs, each share of the total. Modality classified for 100% of 354 pipeline programs.

Analysis

Trial Status

382

clinical trials

Completed191 · 50%
Unknown status85 · 22%
Terminated37 · 10%
Recruiting22 · 6%
Withdrawn18 · 5%
Not yet recruiting15 · 4%
Other14 · 4%

Clinical Trials

Trial Activity

382 trials

MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation
Recruiting·UUniversity of Rome Tor Vergata·N/A·NCT06130046·300 enrolled
Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial
Recruiting·RRenJi Hospital·N/A·NCT07157631·1,546 enrolled
Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
Recruiting·IInstitute of Liver and Biliary Sciences, India·Phase 2/3·NCT06418893·60 enrolled
EVR and EPO for Liver Transplant Tolerance
Recruiting·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT06832189·20 enrolled
Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant
Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT07059494·40 enrolled
Effect of Perioperative Oral Rifaximin on Early Graft Dysfunction in Adult Living Donor Liver Transplant
Recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06743464·100 enrolled
Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant
Recruiting·VVirginia Commonwealth University·Phase 2·NCT05424003·50 enrolled
Prospective, Multicenter Clinical Study of Prolonged-release Tacrolimus in Stable Pediatric Liver Transplant Recipients
Recruiting·RRenJi Hospital·N/A·NCT06183892·80 enrolled
Reducing Pain With Methadone and Ketamine in Liver Transplant
Recruiting·LLahey Clinic·Phase 4·NCT06868589·50 enrolled
Portal Inflow Modulation Prior to Liver Transplantation in Patients With Increased Risk of Intraoperative Blood Loss
Recruiting·MMedical University of Warsaw·N/A·NCT07111221·104 enrolled
Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Safety in Liver Transplant Patients
Recruiting·CChiesi Hungary Ltd.·N/A·NCT05744635·110 enrolled
Extended-Release Tacrolimus Following Liver Transplantation
Recruiting·UUniversity of Alberta·Phase 4·NCT05242315·94 enrolled
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
Recruiting·UUniversity Hospital, Toulouse·N/A·NCT06749405·56 enrolled
Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations
Recruiting·UUniversity of British Columbia·Phase 4·NCT05089604·124 enrolled
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
Recruiting·RRennes University Hospital·Phase 4·NCT06535945·400 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)