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Immunology/Mucositis

Mucositis

26

Pipeline Programs↗

30

Active Trials↗

32

Companies Involved↗

Mucositis is an emerging landscape with 26 programs across 32 companies. 5 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

56/100

Pipeline Velocity

42/100

Mech. Concentration

17/100

Completion Rate

80/100

Attrition Rate

13/100

Pipeline

Programs by Phase

Preclinical10

Palifermin

Swedish Orphan Biovitrum

Atorvastatin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Lyrica

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Symptomatic Treatment Only

Beni-Suef University

Mouth Wash With Morphine

University Hospital, Geneva

Phase 1

No programs

Phase 211

Rrx-001

EpicentRx, Inc.

Sancai Fengsui Decoction

Nanfang Hospital, Southern Medical University

Sodium Copper Chlorophyllin

Tata Memorial Centre

Valacyclovir

Glaxo Dba Glaxosmithkline

Hydroxychloroquine Sulfate

Jazz Pharmaceuticals

Phase 35

N-Acetylcysteine /tab

Far Eastern Memorial Hospital

Gabapentin

Viatris Specialty LLC

Dexamethasone Mouthwash

Woman's

Analgesic Agent

Alliance for Clinical Trials in Oncology

Chemotheraphy

Alliance for Clinical Trials in Oncology

Approved

No programs

Analysis

Modality Breakdown

88%

Small molecule

21 of 24 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 24 classified programs, each share of the total. Modality classified for 92% of 26 pipeline programs.

Analysis

Trial Status

202

clinical trials

Completed108 · 53%

Unknown status37 · 18%

Terminated18 · 9%

Recruiting13 · 6%

Not yet recruiting10 · 5%

Withdrawn9 · 4%

Other7 · 3%

Clinical Trials

Trial Activity

202 trials

Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy of a Copaiba-Based Mouthwash Combined With Low-Level Laser Therapy in the Prevention of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation

Recruiting·IInstituto Nacional de Cancer, Brazil·Phase 2·NCT07810530·76 enrolled

Chlorophyllin as an Adjunct for Reducing Oral Mucositis in Myeloablative Total Body Irradiation

Recruiting·TTata Memorial Centre·Phase 2·NCT07709195·17 enrolled

A Randomized Controlled Trial on Taurine's Therapeutic Effect on Acute Radiation-induced Oral Mucositis and Dermatitis

Recruiting·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·Phase 2·NCT07029178·160 enrolled

A Randomized, Open-label Study of Coconut Oil Mouth Rinse for Prophylaxis of Severe Oral Mucositis in Pediatric Patients Receiving Myeloablative Conditioning Regimens

Recruiting·WWake Forest University Health Sciences·Phase 2·NCT05441813·60 enrolled

Study for Dexamethasone Mouthwash in Lowering Episodes of Oral Mucositis Among Patients With Cancer: The SMILE Study

Recruiting·WWoman's·Approved·NCT07287826·45 enrolled

Efficacy of High-Level Laser Therapy in Managing Oral Mucositis Among Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Recruiting·—·N/A·NCT07436650·14 enrolled

Prevention and Treatment of Radiation-Induced Oral Mucositis in NPC With Houyanqing Oral Liquid

Recruiting·SSun Yat-sen University·Phase 3·NCT07311772·244 enrolled

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Recruiting·Alliance for Clinical Trials in Oncology·Phase 3·NCT06992427·228 enrolled

Traditional Chinese Medicine Preparation Alleviates Radiotherapy-induced Oral Mucositis in Head and Neck Cancer Patients.

Recruiting·WWest China Hospital·Phase 2·NCT07339774·128 enrolled

Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.

Recruiting·MMansoura University·Phase 2·NCT06354712·50 enrolled

Traditional Chinese Medicine Oral Liquids and Mouthwashes for Radiation-induced Oral Mucositis in Head and Neck Cancer Patients

Recruiting·WWest China Hospital·Phase 2·NCT07282483·118 enrolled

Hydroxychloroquine Sulfate Tablets for Radiation-induced Oral Mucositis

Recruiting·—·Phase 1/2·NCT06939582·158 enrolled

Spirulina-Derived Product Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors

Recruiting·WWest China Hospital·Phase 2·NCT07040969·70 enrolled

Evaluation of Implantoplasty in the Treatment of Peri-Implantitis: Clinical, Inflammatory, Titanium Analysis in Crevicular Fluid and Microbiological Profile

Active, not recruiting·UUniversity of Campinas, Brazil·Preclinical·NCT06884475·40 enrolled

A Randomized Placebo-Controlled Trial of Two Schedules of RRx-001 for the Attenuation of Severe Oral Mucositis in Patients Receiving Concomitant Chemoradiation for the Treatment of Locally Advanced Squamous Cell Carcinoma of the Oral Cavity or Oropharynx

Active, not recruiting·EEpicentRx, Inc.·Phase 2·NCT05966194·216 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)