Lipitor

(atorvastatin)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Atorvastatin is used to lower cholesterol and reduce the risk of heart disease and stroke by helping your body remove excess cholesterol from the blood.[2] Lipitor is currently approved and in use across 147 indications[4].[1]

Lipitor is one of 2101 small molecule programs targeting COVID-19. It is currently in Approved.

147

Indications

650

Total Trials

Active Trials

2,100

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

COVID-19Completed

Insulin ResistanceActive, not recruiting

Mood DisorderActive, not recruiting

BronchiectasisActive, not recruiting

Abdominal Aortic AneurysmActive, not recruiting

CognitionActive, not recruiting

Cystic FibrosisActive, not recruiting

Hepatitis BActive, not recruiting

Type 1 DiabetesActive, not recruiting

Migraine DisorderApproved

COVID-19Phase 3

Completed

Insulin ResistanceApproved

Active, not recruiting

Mood DisorderApproved

Active, not recruiting

BronchiectasisApproved

Active, not recruiting

Abdominal Aortic AneurysmApproved

Active, not recruiting

CognitionApproved

Active, not recruiting

Cystic FibrosisApproved

Active, not recruiting

Hepatitis BApproved

Active, not recruiting

Type 1 DiabetesApproved

Active, not recruiting

Migraine DisorderApproved

Approved

Showing 10 of 144 indications

Competition

Competitive Landscape

350 competitors in Treatment

#DrugCompanyPhaseTrials

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

6 2

Dexilant

Takeda

Preclinical

2 3

Niclocide

Bayer

Preclinical

1 4

Theo-Dur

Pfizer

Preclinical

1 5

Foscavir

CClinigen, Inc.

Preclinical

6 6

Valium

Akero Therapeutics

Preclinical

2 7

Norpramin

VValidus Pharmaceuticals

Preclinical

1 8

Intuniv

PPromius Pharma, LLC

Preclinical

1 9

Reminyl

WWim Janssens

Preclinical

1 10

Crixivan

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 1Recruiting

Cardiovascular

NCT06961630

Q4 2027

Phase 3Recruiting

Exercise

NCT05796973

Q3 2029

Phase 2Active, not recruiting

Metastasis

NCT06157099

Q1 2030

Post-ApprovalNot yet recruiting

Immune Checkpoint Inhibitor

NCT06785974

Clinical

Trials by Indication[1]

Atorvastatin44 trials

CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events

Completed· Pfizer logo

Pfizer·Phase 4·NCT00327418·2,800 enrolled

Lipitor Trial To Study The Effect Of Torcetrpib/Atorvastatin To Atorvastatin Alone.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00137462·900 enrolled

Drug Interaction Study of MGL-3196 With Atorvastatin

Completed· Madrigal Pharmaceuticals logo

Madrigal Pharmaceuticals·Phase 1·NCT02749578·14 enrolled

Show 41 more trials

A Pre-Op Window Study Evaluating Anti-Proliferative Effects of Atorvastatin on the Endometrium

Completed·UUNC Lineberger Comprehensive Cancer Center·Phase 1·NCT02767362·24 enrolled

Atorvastatin for Preventing Occlusion and Restenosis After Intracranial Artery Stenting

Completed·JJinling Hospital, China·Phase 4·NCT01255852·100 enrolled

Drug-Drug Interaction Study Between Colchicine and Atorvastatin

Completed·MMutual Pharmaceutical Company, Inc.·Phase 1·NCT00960323·24 enrolled

Single Dose of Atorvastatin and Circulating Endothelial Microparticles

Unknown status·SSun Yat-sen University·Phase 4·NCT02023892·30 enrolled

STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTS

Completed· Pfizer logo

Pfizer·Phase 1·NCT05093205·35 enrolled

ECC5004 DDI Study With Atorvastatin, Rosuvastatin, Digoxin and Midazolam in Healthy Participants

Completed·EEccogene·Phase 1·NCT06293742·48 enrolled

A Study to Assess the Effect of ASP1585 on Pharmacokinetics of Atorvastatin in Healthy Volunteers

Completed· Astellas logo

Astellas·Phase 1·NCT01115985·24 enrolled

Atorvastatin in Myeloma

Unknown status·BBayside Health·Phase 1·NCT00164086

Relative Bioavailability of Dabigatran and Atorvastatin in Healthy Male and Female Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02171039·24 enrolled

Assessment of the Effects of Atorvastatin Therapy on Myocardial Deformation Characteristics, in Patients With STEMI

Completed·—·Phase 4·NCT02590653·200 enrolled

To Evaluate Ezetimibe Plus Atorvastatin Versus Atorvastatin in Patients With High Cholesterol Not Controlled on Atorvastatin 40 mg (0653-090)

Completed·OOrganon and Co·Phase 3·NCT00276484·579 enrolled

Randomized Placebo-Controlled Trial of Atorvastatin in HIV-Positive Patients Not on Antiretroviral Therapy

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00367458·24 enrolled

Effect of Gemcabene on the Pharmacokinetics of Atorvastatin in Healthy Volunteers

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 1·NCT02587416·20 enrolled

Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT02243098·31 enrolled

Study to Evaluate the Pharmacokinetic Interaction Between Fimasartan and Atorvastatin in Healthy Male Volunteers

Completed· Boryung Pharmaceutical Co., Ltd logo

Boryung Pharmaceutical Co., Ltd·Phase 1·NCT02397590·36 enrolled

Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00166504·203 enrolled

A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects

Completed· Takeda logo

Takeda·Phase 1·NCT02093390·40 enrolled

Effects of Atorvastatin on Human Semen and Gonadal Hormones

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT02094313·17 enrolled

A Study to Compare the Pharmacokinetics of Fimasartan/Atorvastatin Combination Tablet

Completed· Boryung Pharmaceutical Co., Ltd logo

Boryung Pharmaceutical Co., Ltd·Phase 1·NCT02566187·99 enrolled

A Formulation Screening Study of Dalcetrapib and Atorvastatin in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01363999·24 enrolled

Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00136981·800 enrolled

PULSAR - A Prospective Study to Evaluate the Utility of Low Doses of the Statins Atorvastatin and Rosuvastatin.

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00329173·1,000 enrolled

Comparison of the Combination of Fenofibrate and Simvastatin Versus Atorvastatin

Completed·SSolvay Pharmaceuticals·Phase 3·NCT00362934·516 enrolled

Atorvastatin in the Recipient's Kidney Graft From a Living Donor

Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT02522117·48 enrolled

This Study Uses Ultrasound to Determine Whether Atorvastatin or Pravastatin Effects the Progression of Coronary Plaque.

Completed· Pfizer logo

Pfizer·Phase 4·NCT00380939·600 enrolled

Anti-inflammatory Effect of Atorvastatin on Graft Donor Kidney

Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT02355704·48 enrolled

STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654537·5,625 enrolled

Study of Influence of Atorvastatin on the Repolarisation Phase of Cardiomyocytes

Unknown status·MMasaryk University·N/A·NCT00520585

A Study Of The Efficacy Of Atorvastatin In Lowering Cholesterol In Latin American Patients With High Cholesterol

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00645151·512 enrolled

A Study Of Pharmacokinetics, Pharmacodynamics And Safety Of Adding ETC-1002 To Atorvastatin 80 mg

Completed·EEsperion Therapeutics, Inc.·Phase 2·NCT02659397·68 enrolled

Effects of Atorvastatin in Graves' Orbitopathy (GO)

Completed·UUniversity of Pisa·Phase 2·NCT03110848·88 enrolled

A 16 Week Comparative Study of Fenofibrate Versus Ezetimibe as Add-on Therapy to Atorvastatin

Completed·AAbbott·Phase 3·NCT00195793·174 enrolled

Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.

Completed·AAegerion Pharmaceuticals, Inc.·Phase 1·NCT02080455·32 enrolled

Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)

Completed·OOrganon and Co·Phase 3·NCT03768427·454 enrolled

A Study Comparing The Efficacy & Safety Of Torcetrapib/Atorvastatin And Atorvastatin In Subjects With High Triglycerides

Completed· Pfizer logo

Pfizer·Phase 3·NCT00134498·160 enrolled

Atorvastatin Study For The Treatment Of High Cholesterol In Patients From Thailand

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00647543·242 enrolled

Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting

Unknown status·—·Phase 4·NCT01572623·150 enrolled

Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI

Withdrawn·UUNC Lineberger Comprehensive Cancer Center·Phase 1·NCT01605344

Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography

Unknown status·IIsfahan University of Medical Sciences·Phase 3·NCT02113540

A Bioequivalence Study Of 80 Mg Atorvastatin Calcium Tablets Versus 80 Mg Lipitor® Tablets Under Fed Conditions

Completed·RRanbaxy Laboratories Limited·Phase 1·NCT01499771·80 enrolled

A Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects.

Completed· GSK logo

GSK·Phase 1·NCT01138072·14 enrolled

Hypercholesterolemia7 trials

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)

Completed· Sanofi logo

Sanofi·Phase 3·NCT02476006·998 enrolled

A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia

Terminated· Eli Lilly logo

Eli Lilly·Phase 3·NCT02260648·149 enrolled

Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) in Patients With Primary Hypercholesterolemia on Stable Atorvastatin Therapy

Completed· Sanofi logo

Sanofi·Phase 2·NCT01288443·183 enrolled

Show 4 more trials

Coadministration of Ezetimibe and Atorvastatin in Patients With Primary Hypercholesterolemia (P05456)

Completed·OOrganon and Co·Phase 3·NCT00654095·146 enrolled

Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) in Patients With Primary Hypercholesterolemia on Stable Atorvastatin Therapy in Japan

Completed· Sanofi logo

Sanofi·Phase 2·NCT01812707·100 enrolled

Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) When Co-administered With High Dose of Atorvastatin in Patients With Primary Hypercholesterolemia

Completed· Sanofi logo

Sanofi·Phase 2·NCT01288469·92 enrolled

Ezetimibe Plus Atorvastatin Versus Atorvastatin in Untreated Subjects With Primary Hypercholesterolemia and Coronary Heart Disease (P03396)

Completed·OOrganon and Co·Phase 3·NCT00650689·122 enrolled

Atherosclerosis4 trials

The Effects of Atorvastatin in Patients With Atherosclerosis

Completed·—·Phase 3·NCT00115817·36 enrolled

Lupus Atherosclerosis Prevention Study

Completed·JJohns Hopkins University·Phase 4·NCT00120887·200 enrolled

Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis

Completed·UUniversity of Florida·Phase 4·NCT00361283·108 enrolled

Show 1 more trial

Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT00570752·72 enrolled

Efficacy and Safety4 trials

Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric Acid

Unknown status·SSang Hak Lee·N/A·NCT01974297·194 enrolled

Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00631189·668 enrolled

Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)

Completed· Regeneron logo

Regeneron·Phase 3·NCT01730040·355 enrolled

Show 1 more trial

Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654173·4,444 enrolled

Acute Coronary Syndrome3 trials

Full-dose Atorvastatin After Acute Coronary Syndrome (ACS) in Non-revascularisable Coronary Artery Disease

Terminated·SSan Filippo Neri General Hospital·Phase 3·NCT01187992·290 enrolled

Comparison of Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome

Completed·QQueen's University·Phase 4·NCT00665834·18 enrolled

Evaluation of Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia

Completed· Sanofi logo

Sanofi·Phase 4·NCT02984982·206 enrolled

113 more indications

Atherosclerotic Plaque3 trials

Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging

Unknown status·—·Phase 4·NCT00920101·30 enrolled

Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque

Completed·—·N/A·NCT00636766·300 enrolled

Assessment of Change in Atherosclerotic Plaque by Serial CCTA

Unknown status·YYonsei University··NCT03414840·400 enrolled

Type 2 Diabetes Mellitus3 trials

Statins in Patients With Type 2 Diabetes Mellitus and Previous History of Acute Coronary Syndrome

Completed·HHelwan University·N/A·NCT05306990·108 enrolled

Efficacy and Safety Study of Pitavastatin Compared to atoRvastatin in Type 2 dIabeTes Mellitus With Hypercholesterolemia

Completed·JJW Pharmaceutical·Phase 4·NCT00889226·161 enrolled

Atorvastatin and Endothelial Function in Type 2 Diabetes Mellitus (ATTEND-Study)

Completed·UUniversity of Southern Denmark·Phase 4·NCT00124397·186 enrolled

Heart Disease3 trials

Study On Liprimar (Atorvastatin) In Patients With Coronary Heart Disease (CHD) And High Risk Of Cardiovascular Complications

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT00993915·687 enrolled

Ezetimibe and Atorvastatin vs. Atorvastatin in Patients Age 65 and Older at High Risk for Coronary Heart Disease (CHD)(0653-112)

Completed·OOrganon and Co·Phase 3·NCT00418834·1,053 enrolled

Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD

Completed· Pfizer logo

Pfizer·Phase 4·NCT00159835·8,600 enrolled

Nephropathy2 trials

High Dose Atorvastatin for Preventing Contrast-induced Nephropathy

Completed·IIsfahan University of Medical Sciences·Phase 2/3·NCT02114346·250 enrolled

Atorvastatin Effect on Contrast Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention

Completed·MMohamed Abdelfatah·Phase 4·NCT04375787·200 enrolled

Effectiveness2 trials

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/40 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 40 mg Tablets in Participants With High Cholesterol (MK-0653C-190 AM1)

Completed·OOrganon and Co·Phase 3·NCT01370603·328 enrolled

To Evaluate the Safety and Effectiveness of Atorvastatin Plus a Cholinesterase Inhibitor in AD Patients.

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151502·600 enrolled

Psoriasis2 trials

Efficacy of Atorvastatin as Adjunctive Treatment for Chronic Plaque Type Psoriasis

Completed·PPhilippine Dermatological Society·Phase 2·NCT02432040·28 enrolled

Influence of Atorvastatin on Psoriasis Severity and Endothelial Function

Withdrawn·Sshmuel fuchs·Phase 3·NCT01527097

Endothelial Dysfunction2 trials

Clinical Utility of Endothelial Dysfunction in PAD

Terminated·—·Phase 1·NCT00491751·108 enrolled

Effect of a Fibrate and a Statin on Endothelial Dysfunction

Terminated·—·N/A·NCT00491400·28 enrolled

Aneurysm2 trials

Trial of Atorvastatin on the Persistent Coronary Aneurysm in Children With Kawasaki Disease

Unknown status·NNational Taiwan University Hospital·Phase 2·NCT02114099·20 enrolled

Statin Treatment for UnruptureD Intracranial anEurysms Study

Unknown status·BBeijing Neurosurgical Institute·Phase 2·NCT04149483·60 enrolled

Prostate Cancer2 trials

Atorvastatin Before Prostatectomy and Prostate Cancer

Completed·TTampere University Hospital·Phase 2·NCT01821404·160 enrolled

Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer

Recruiting·GGustave Roussy, Cancer Campus, Grand Paris·Phase 3·NCT03819101·1,210 enrolled

Hyperlipidemia2 trials

An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)

Completed·AAbbott·Phase 3·NCT00465088·199 enrolled

Evaluation of the Fixed-dose Combination of Irbesartan/Atorvastatin in Type 2 Diabetic Patients Diagnosed With Hyperlipidemia and Hypertension

Completed· Sanofi logo

Sanofi·Phase 4·NCT02842359·11 enrolled

Statins2 trials

A Study Comparing CoQ10 Levels While Taking 3 Different Statins

Completed·UUniversity of Kansas Medical Center·Phase 4·NCT01660191·134 enrolled

Statins Evaluation in Coronary Procedures and Revascularization Trial

Completed·HHospital do Coracao·Phase 4·NCT01448642·4,191 enrolled

Safety and Efficacy2 trials

Safety and Efficacy Study Comparing ABT-335 Coadministered With Atorvastatin and Ezetimibe to Atorvastatin Coadministered With Ezetimibe in Subjects With Multiple Abnormal Lipid (Fat) Levels in the Blood

Completed·AAbbott·Phase 3·NCT00639158·543 enrolled

A Study To Evaluate The Safety And Efficacy Of Atorvastatin In Patients With Diabetes And High Cholesterol

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00645424·155 enrolled

Hypercholesterolaemia2 trials

Treatment of Hypercholesterolaemia in South Asian Subjects (IRIS)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654225·2,340 enrolled

Rosuvastatin Versus Atorvastatin in the Treatment of Hypercholesterolaemia in African American Subjects(ARIES)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00653744·1,700 enrolled

Toxicity2 trials

Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT)

Completed·WWake Forest University Health Sciences·Phase 2·NCT01988571·279 enrolled

Investigations on Differences in Atorvastatin Metabolites Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity

Completed·UUniversity of Oslo School of Pharmacy·Phase 4·NCT00414531·53 enrolled

Diabetes Mellitus2 trials

Follow-On Study of Pitavastatin Versus Atorvastatin in Patients With Type II Diabetes Mellitus and Combined Dyslipidemia

Completed·KKowa Research Europe·Phase 3·NCT00344370·214 enrolled

Atorvastatin and LDL Profile in Non-Insulin Dependent Diabetes Mellitus

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00640549·41 enrolled

Clinical Trial2 trials

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects Who Are Intolerant to Statins

Completed· Pfizer logo

Pfizer·Phase 3·NCT02135029·184 enrolled

A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)

Active, not recruiting·MMonash University·Phase 4·NCT02099123·9,971 enrolled

Atrial Fibrillation2 trials

The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation

Completed·MMayo Clinic·Phase 4·NCT00579098·125 enrolled

Does Atorvastatin Prevent Post Operative Atrial Fibrillation After Pulmonary Resection: A Randomized Clinical Study

Completed·UUniversity of Alabama at Birmingham·N/A·NCT00756886·73 enrolled

Heart Failure2 trials

Comparison of Lipophilic Versus Hydrophilic Statins on Patients With Heart Failure

Completed·—·Phase 4·NCT03255044·85 enrolled

A Study Of The Usage Of Statins In A Community Heart Failure Population

Completed·SSt Vincent's University Hospital, Ireland·Phase 4·NCT00795912·56 enrolled

Treatment2 trials

Combined Effects of Non-statin Treatments on Apolipoprotein A-I Up-Regulation (CENTAUR): A Feasibility Study

Completed·UUniversity of Pennsylvania·Phase 2·NCT00728910·25 enrolled

Effect of Upstream Treatment With High Intensity Statin on the Outcomes of STMI Patients Treated With PPCI

Unknown status·—·Phase 3·NCT04754789·160 enrolled

Metabolic Syndrome2 trials

Implications for Treatment of the Metabolic Syndrome

Completed·UUniversity Hospital Southampton NHS Foundation Trust·Phase 2·NCT00666029·40 enrolled

Prothrombotic Inflammatory Markers in Women With Metabolic Syndrome - Effect of Atorvastatin

Completed·UUniversity of Rochester·Phase 1/2·NCT01785615·116 enrolled

Cardiovascular Disease2 trials

Efficacy Study of Pioglitazone and Atorvastatin Combination Therapy in Treating Subjects With Elevated Risk for Cardiovascular Disease

Completed· Takeda logo

Takeda·Phase 2·NCT00770575·148 enrolled

Atorvastatin Treatment to Attenuate the Progression of Cardiovascular Disease in Hemodialysis Patients

Completed·EErcan OK·Phase 3·NCT00481364·446 enrolled

Optical Coherence Tomography1 trial

Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography (OCT) Combined With Intravascular Ultrasound (IVUS)

Completed·HHarbin Medical University·Phase 4·NCT01023607·120 enrolled

Obesity1 trial

Clinical Study to Evaluate Antihyperlipidemic Effect of a Classical Unani Antiobesity Formulation

Completed·JJamia Hamdard University·Phase 2·NCT01332747·128 enrolled

Hormone Therapy1 trial

Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men

Withdrawn·YYale University·Phase 1·NCT04922424

Head Injury1 trial

Could Early Atorvastatin Offer Anti Inflammatory Effects Upon Brain in Traumatic Head Injury?

Completed·—·N/A·NCT04718155·30 enrolled

Kawasaki Disease1 trial

Pharmacokinetics (PK)/Safety Study of Atorvastatin in Children With Kawasaki Disease and Coronary Artery Abnormalities

Completed·UUniversity of California, San Diego·Phase 1/2·NCT01431105·34 enrolled

Rheumatoid Arthritis1 trial

Atorvastatin vs Colchicine in Decrease of Troponin I of High Sensitivity in Patients With Rheumatoid Arthritis.

Completed·HHospital Central "Dr. Ignacio Morones Prieto"·Phase 2·NCT04056039·60 enrolled

Acute Myocardial Infarction1 trial

Effects of Atorvastatin 10 mg Versus 40 mg in Eight Months Follow-up Coronary Flow Reserve and Bone Marrow Stem Cell Mobilization in Patients With Acute Myocardial Infarction

Completed·KKorea University Anam Hospital·Phase 4·NCT00536887·100 enrolled

Type 1 Diabetic1 trial

Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardioprotective Drugs

Completed·TTanta University·N/A·NCT03660293·150 enrolled

ART1 trial

A Study of LY3478045 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT04270370·72 enrolled

Carotid Plaque1 trial

Evaluation of Atorvastatin Treatment on Carotid Plaque.

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00343655·160 enrolled

Type 1 Diabetes Mellitus1 trial

Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)

Completed·—·Phase 2·NCT00529191·40 enrolled

Exercise1 trial

Measuring Oncological Value of Exercise and Statin

Recruiting·TTampere University Hospital·Phase 3·NCT05796973·240 enrolled

Pilot Study1 trial

Cerebral and Peripheral Perfusion Pilot Study

Completed·UUniversity of Wisconsin, Madison·Phase 2·NCT00751907·16 enrolled

Erectile Dysfunction1 trial

Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT03830164·14 enrolled

Aspirin1 trial

Aspirin Statins Or Both For The Reduction Of Thrombin Generation In Diabetic People

Completed·FFundacion GESICA·Phase 4·NCT00793754·30 enrolled

Mesenchymal Stem Cells1 trial

Transplantation Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells With Intensive Atorvastatin in AMI Patients

Unknown status·YYuejin Yang·Phase 2·NCT03047772·124 enrolled

Retinal Vein Occlusion1 trial

Atorvastatin for the Treatment of Retinal Vein Occlusion

Unknown status·UUniversity of Toronto·Phase 3·NCT00517257·180 enrolled

GLP-11 trial

The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion

Completed·UUniversity Hospital, Gentofte, Copenhagen·N/A·NCT03018444·15 enrolled

Diastolic Heart Failure1 trial

Effects of Statin Therapy on Vascular Properties and Outcomes in Diastolic Heart Failure Patients

Terminated·UUniversity of Wisconsin, Madison·N/A·NCT00585611·1 enrolled

Calcification1 trial

CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients

Completed·NNabi Biopharmaceuticals·Phase 4·NCT00211939·203 enrolled

Trial1 trial

LIpitor and biGuanide to Androgen Delay Trial

Withdrawn·UUniversity Health Network, Toronto·Phase 2·NCT02497638

Ischemic stroke1 trial

Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis

Unknown status·RRenJi Hospital·N/A·NCT01665235·200 enrolled

High Cardiovascular Risk1 trial

MK0653C in High Cardiovascular Risk Patients With High Cholesterol (Switch Study)(MK-0653C-162)

Completed·OOrganon and Co·Phase 3·NCT01154036·1,547 enrolled

Percutaneous Coronary Intervention (PCI)1 trial

Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention (PCI) Study 2

Unknown status·—·Phase 3·NCT01058057·200 enrolled

Cerebral Small Vessel Disease1 trial

Vasomotor Reactivity In Cerebral Small Vessel Disease And New Approach To Treat Lacunar Stroke

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00163150·128 enrolled

Non-Alcoholic Fatty Liver Disease1 trial

Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease

Unknown status·XXin Gao·Phase 4·NCT01720719·120 enrolled

Glioblastoma1 trial

Efficacy and Safety of Atorvastatin in Combination With Radiotherapy and Temozolomide in Glioblastoma

Completed·KKing Fahad Medical City·Phase 2·NCT02029573·36 enrolled

Metastasis1 trial

Atorvastatin for Preventing Disease Metastasis in Patients With Resected High-Risk Stage IIA, IIB, or IIIA Melanoma

Active, not recruiting·OOHSU Knight Cancer Institute·Phase 2·NCT06157099·150 enrolled

Bicuspid aortic valve1 trial

Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve

Completed·HHospital Universitari Vall d'Hebron Research Institute·Phase 3·NCT02679261·220 enrolled

Vitiligo1 trial

Atorvastatin in Active Vitiligo

Completed·—·Phase 2·NCT02432534·28 enrolled

Homozygous Familial Hypercholesterolemia1 trial

An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia

Completed· Sanofi logo

Sanofi·Phase 3·NCT03510715·18 enrolled

Venous thrombosis1 trial

Statins to Reduce D-dimer Levels in Patients With Venous Thrombosis

Terminated·UUniversità degli Studi dell'Insubria·Phase 2·NCT00437892·10 enrolled

Lupus Erythematosus1 trial

Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE)

Completed·LLaura Schanberg·Phase 3·NCT00065806·221 enrolled

Dual Antiplatelet Therapy1 trial

Statin and Dual Antiplatelet Therapy to Prevent Early Neurological Deterioration in Branch Atheromatous Disease

Completed·—·Phase 2·NCT04824911·376 enrolled

Platelet Inhibition1 trial

Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin

Terminated·DDr. med. Mahir Karakas·Phase 3·NCT03820466·68 enrolled

Dyslipidemia1 trial

Pharmacokinetics of Rosuvastatin and Atorvastatin in Pediatric Dyslipidemia Patients

Completed·—·Phase 1·NCT02364258·28 enrolled

Complication1 trial

Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose

Completed·HHospital do Coracao·Phase 3·NCT01543555·648 enrolled

Endometriosis1 trial

MicroRNA Activation of LOX-1 Mechanisms in Endometriosis

Terminated·PPenn State University·Phase 4·NCT05331053·6 enrolled

ST Elevation Myocardial Infarction1 trial

Efficacy of High Dose atorvaSTATIN Loading Before Primary Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction (STATIN STEMI)

Completed·YYonsei University·Phase 4·NCT00808717·170 enrolled

Renal Cell Carcinoma1 trial

Zoledronate With Atorvastatin in Renal Cell Carcinoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00490698·11 enrolled

Influenza1 trial

Statin Therapy in Acute Influenza

Completed·—·Phase 2·NCT02056340·116 enrolled

Newly Diagnosed1 trial

Atorvastatin in Management of Newly Diagnosed ITP

Unknown status·SShandong University·Phase 2/3·NCT03692754·30 enrolled

Side Effects1 trial

STATIN: Web-based Investigation of Side Effects

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 4·NCT02781064·200 enrolled

Hepatitis B1 trial

Effects of Short-term Atorvastatin Treatment on Vaccination Efficacy in Nonresponder Persons to Hepatitis B Vaccine

Unknown status·NNematollah Jonaidi Jafari·Phase 4·NCT01548326·52 enrolled

Metabolism1 trial

Regulation of Lipoprotein Metabolism in Obese Men

Completed·TThe University of Western Australia·Phase 3·NCT00392717·48 enrolled

Inflammation1 trial

Impact of Chronic Statin Use During Surgery on Inflammation and Infection Rates

Completed·OOttawa Hospital Research Institute··NCT00967252·50 enrolled

Overweight1 trial

A Study to Learn How the Study Medicine Danuglipron is Taken Up Into the Blood and If Danuglipron Changes How the Body Processes Other Study Medicines (Atorvastatin and Rosuvastatin) in Healthy Adults Who Are Overweight or Obese

Completed· Pfizer logo

Pfizer·Phase 1·NCT06567327·82 enrolled

Overweight or Obese1 trial

A Study to Evaluate the Drug-drug Interactions (DDIs) of IBI362 With Metformin, Warfarin, Atorvastatin, Digoxin in Overweight or Obese Subjects

Completed· Innovent Biologics (Suzhou) Co. Ltd. logo

Innovent Biologics (Suzhou) Co. Ltd.·Phase 1·NCT05815680·48 enrolled

Immune Response1 trial

The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23

Completed·UUniversity of Florida·Phase 1·NCT02097589·33 enrolled

Genetic Polymorphism1 trial

Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin

Completed·—·Phase 1·NCT00973986·20 enrolled

Mood Disorder1 trial

Anti-inflmmation Treatment in Mood Disorder and Deep Learning Prediction Model

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT04685642·180 enrolled

Combination Therapy1 trial

Study of Atorvastatin/Fenofibrate (LCP-AtorFen) Combination Therapy in Dyslipidemia

Completed·VVeloxis Pharmaceuticals·Phase 2·NCT00504829·220 enrolled

Type 1 Diabetes1 trial

Treatment Effects of Atorvastatin on Hemostasis and Skin Microcirculation in Patients With Type 1 Diabetes

Completed·KKarolinska Institutet·Phase 4·NCT01497912·20 enrolled

Cardiovascular1 trial

Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction

Recruiting·NNYU Langone Health·Phase 1·NCT06961630·50 enrolled

Lip1 trial

Lipid-lowering Therapy Individualization

Completed·UUniversité Catholique de Louvain·Phase 4·NCT03604471·75 enrolled

Carotid Endarterectomy1 trial

Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes

Completed·—·Phase 3·NCT02850081·31 enrolled

Orthopedic Surgery1 trial

Risk Factor Control Before Orthopedic Surgery

Terminated·NNYU Langone Health·Phase 4·NCT01837069·198 enrolled

Insulin resistance1 trial

Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling

Completed·SStanford University·Phase 4·NCT02437084·115 enrolled

Type 2 Diabetes1 trial

LIpid Lowering With Highly Potent Statins in Hyperlipidaemia With Type 2 Diabetes patiENts

Completed·LListen Trial Group·N/A·NCT01544309·1,049 enrolled

LDL-cholesterol1 trial

A Swiss Study With Atorvastatin in Hyperlipidemic Patients Measuring LDL-Cholesterol

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00136942·370 enrolled

Cardiotoxicity1 trial

STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)

Completed·MMassachusetts General Hospital·Phase 2·NCT02943590·300 enrolled

Cardiovascular Events1 trial

Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD

Completed·RResverlogix Corp·Phase 3·NCT02586155·2,425 enrolled

Acute Kidney Injury1 trial

Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)

Completed·CCentro Cardiopatici Toscani·Phase 4·NCT01870804·760 enrolled

Statin1 trial

KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts

Recruiting·MMikko Niemi·Phase 1·NCT06469450·15 enrolled

Drug Interactions1 trial

Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers

Completed·GGalmed Pharmaceuticals Ltd·Phase 1·NCT03760848·15 enrolled

Proteinuria1 trial

Study of Atorvastatin Dose Dependent Reduction of Proteinuria

Completed·LLaval University·Phase 4·NCT00768638·23 enrolled

Oxidative Stress1 trial

Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01322711·60 enrolled

Familial Hypercholesterolemia1 trial

8-Week PK/PD Atorvastatin Study In Children And Adolescents With Heterozygous Familial Hypercholesterolemia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 1·NCT00739999·39 enrolled

Platelet Reactivity1 trial

Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01567774·100 enrolled

Dialysis Patients1 trial

Salusin-alpha - a New Factor in the Pathogenesis of Lipid Abnormalities in Hemodialysis Patients

Completed·PPoznan University of Medical Sciences·Phase 4·NCT01448174·310 enrolled

Vascular Function1 trial

The Effect of Statin Use on Vascular Function in Hypertensive Subjects

Terminated·JJohns Hopkins University·Phase 4·NCT00181181·24 enrolled

Hypertriglyceridemia1 trial

Evaluation of Efficacy and Safety of Omacor, Co-Administered With Atorvastatin, in Subjects With Hypertriglyceridemia

Completed· GSK logo

GSK·Phase 3·NCT00435045·245 enrolled

Abdominal Surgery1 trial

Study To Check The Analgesic And Anti-Inflammatory Effects Of Atorvastatin In Patients Undergoing Abdominal Surgery

Unknown status·—·Phase 3·NCT00902967·40 enrolled

Breast Cancer1 trial

STOP Heart Disease in Breast Cancer Survivors Trial

Terminated·—·Phase 2·NCT02674204·2 enrolled

Septic Shock1 trial

Study the Impact of Statins in Septic Shock

Completed·SSanjay Gandhi Postgraduate Institute of Medical Sciences·N/A·NCT02681653·40 enrolled

Gastrointestinal1 trial

Effect of Liraglutide on Gastrointestinal Absorption of Several Drugs and Potential Influence of Liraglutide on Intragastric pH

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT01518166·70 enrolled

Hematoma1 trial

The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders

Unknown status·OOriental Neurosurgery Evidence-Based-Study Team·Phase 2·NCT02192320·60 enrolled

Abnormal Glucose Metabolism1 trial

Comparison of Atorvastatin and Pitavastatin on the Effect of HbA1c in AMI Patients With Abnormal Glucose Metabolism

Unknown status·—·Phase 4·NCT04945122·900 enrolled

Non-Alcoholic Steatohepatitis1 trial

Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis

Unknown status·TTehran University of Medical Sciences·Phase 2·NCT01617772·440 enrolled

Endothelial Function1 trial

Statins and Endothelial Function in Patients With Coarctation of the Aorta

Terminated·UUniversity of California, San Francisco·Phase 4·NCT00767572·12 enrolled

Ischemia1 trial

Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers

Completed·KKarolinska Institutet·Phase 1·NCT02286544·36 enrolled

Symptomatic Intracranial Atherosclerotic Stenosis1 trial

Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 3·NCT06080256·80 enrolled

Cholesterol1 trial

A Study in People With High Cholesterol

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00133380·300 enrolled

Function1 trial

Effect of Chronic Statin and Viagra Therapy in Persons With Endothelial Cell Dysfunction

Withdrawn·MMayo Clinic·N/A·NCT00587379

Coronary Artery Disease1 trial

EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)

Completed·OOrganon and Co·Phase 4·NCT00166530·367 enrolled

Immune Thrombocytopenia1 trial

The Combination of Atorvastatin, Acetylcysteine and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Unknown status·PPeking University People's Hospital·Phase 1/2·NCT03460808·200 enrolled

Pulmonary Sarcoidosis1 trial

Atorvastatin to Treat Pulmonary Sarcoidosis

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00279708·55 enrolled

Immune Checkpoint Inhibitor1 trial

Statins to Prevent Immune Checkpoint Inhibitor-induced PRogression of AtherosLerosis

Not yet recruiting·EErasmus Medical Center·Phase 4·NCT06785974·140 enrolled

Interaction1 trial

Drug Interaction Statin

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02089061·26 enrolled

Bronchiectasis1 trial

Atorvastatin in Bronchiectasis in Patients With Pseudomonas Aeruginosa

Completed·UUniversity of Edinburgh·Phase 4·NCT01299194·32 enrolled

Childhood Cancer1 trial

Statin Therapy in Young Adult Survivors of Childhood Cancer

Completed·UUniversity of Minnesota·Phase 2·NCT01733953·27 enrolled

Unspecified2 trials

A Study of LY2484595 in Japanese Subjects

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT01375075·165 enrolled

Diazoxide Choline Controlled-Release Tablet (DCCR) for Very High Triglycerides

Withdrawn·EEssentialis, Inc.·Phase 3·NCT00973271

Regulatory

FDA Approval Timeline[5]

Dec 17, 1996

LIPITOR

NDA NDA020702

Feb 1, 2023

ATORVALIQ

NDA NDA213260

Sources

References

[1]
ClinicalTrials.gov — 650 trial records for atorvastatin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Lipitor drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — atorvastatin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for atorvastatin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA213260). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Lipitor. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: HMG-Coa Reductase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Patent Landscape[6]

Patent Cliff

Jun 7, 2037

Earliest patent expiration — generic entry possible after this date

Patent #Expires

11654106Jun 7, 2037

11925704Jun 7, 2037

12370136Jun 7, 2037

12168069Jun 7, 2037

11369567Jun 7, 2037

1 more patents

12599553Jun 7, 2037