Lipitor

(atorvastatin)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Atorvastatin is used to lower cholesterol and reduce the risk of heart disease and stroke by helping your body remove excess cholesterol from the blood.[2] Lipitor is currently approved and in use across 146 indications[4].[1]

Lipitor is one of 1994 small molecule programs targeting COVID-19. It is currently in Approved.

146

Indications

658

Total Trials

Active Trials

1,993

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

COVID-19Completed

EpilepsyEnrolling by invitation

Graves DiseaseNot yet recruiting

Insulin ResistanceActive, not recruiting

Mood DisorderActive, not recruiting

BronchiectasisActive, not recruiting

Abdominal Aortic AneurysmActive, not recruiting

CognitionActive, not recruiting

Cystic FibrosisActive, not recruiting

Hepatitis BActive, not recruiting

COVID-19Phase 3

Completed

EpilepsyPhase 1

Enrolling by invitation

Graves DiseasePhase 2

Not yet recruiting

Insulin ResistanceApproved

Active, not recruiting

Mood DisorderApproved

Active, not recruiting

BronchiectasisApproved

Active, not recruiting

Abdominal Aortic AneurysmApproved

Active, not recruiting

CognitionApproved

Active, not recruiting

Cystic FibrosisApproved

Active, not recruiting

Hepatitis BApproved

Active, not recruiting

Showing 10 of 143 indications

Competition

Competitive Landscape

332 competitors in Treatment

#DrugCompanyPhaseTrials

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

6 2

Theo-Dur

Pfizer

Preclinical

1 3

Levulan

Sun Pharmaceutical Industries, Inc.

Preclinical

1 4

Lamprene

Novartis

Preclinical

1 5

Emtriva

Gilead

Preclinical

1 6

Hivid

CConrado Roberto Hoffmann Filho

Preclinical

6 7

Foscavir

CClinigen, Inc.

Preclinical

6 8

Valium

Akero Therapeutics

Preclinical

2 9

Reminyl

WWim Janssens

Preclinical

1 10

Brevibloc

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 1Recruiting

Cardiovascular

NCT06961630

Q3 2027

Recruiting

Cardiovascular Disease

NCT06858332

Q1 2030

Post-ApprovalNot yet recruiting

Immune Checkpoint Inhibitor

NCT06785974

Q1 2042

Phase 3Recruiting

Prostate Cancer

NCT03819101

Clinical

Trials by Indication[1]

Atorvastatin41 trials

A Study Evaluating Bioequivalence of a Fixed Dose Combination Versus Individual Tablets of Bempedoic Acid, Ezetimibe, and Atorvastatin

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT07235189·58 enrolled

A Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects.

Completed· GSK logo

GSK·Phase 1·NCT01138072·14 enrolled

Study to Evaluate the Pharmacokinetic Interaction Between Fimasartan and Atorvastatin in Healthy Male Volunteers

Completed· Boryung Pharmaceutical Co., Ltd logo

Boryung Pharmaceutical Co., Ltd·Phase 1·NCT02397590·36 enrolled

Show 38 more trials

Atorvastatin Plus Ezetimibe on Coronary Plaque Progression

Unknown status·SShanghai Jiao Tong University School of Medicine·Phase 4·NCT01086020·400 enrolled

A Bioequivalence Study Of 80 Mg Atorvastatin Calcium Tablets Versus 80 Mg Lipitor® Tablets Under Fed Conditions

Completed·RRanbaxy Laboratories Limited·Phase 1·NCT01499771·80 enrolled

A Study to Compare the Pharmacokinetics of Fimasartan/Atorvastatin Combination Tablet

Completed· Boryung Pharmaceutical Co., Ltd logo

Boryung Pharmaceutical Co., Ltd·Phase 1·NCT02566187·99 enrolled

Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00166504·203 enrolled

A Pharmacokinetic Interaction Study Between TMC435, Atorvastatin and Simvastatin in Healthy Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT01689623·36 enrolled

Effects of Atorvastatin on Human Semen and Gonadal Hormones

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT02094313·17 enrolled

Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin

Completed·AAkebia Therapeutics·Phase 1·NCT03801733·134 enrolled

Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00136981·800 enrolled

PULSAR - A Prospective Study to Evaluate the Utility of Low Doses of the Statins Atorvastatin and Rosuvastatin.

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00329173·1,000 enrolled

A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects

Completed· Takeda logo

Takeda·Phase 1·NCT02093390·40 enrolled

Atorvastatin in the Recipient's Kidney Graft From a Living Donor

Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT02522117·48 enrolled

This Study Uses Ultrasound to Determine Whether Atorvastatin or Pravastatin Effects the Progression of Coronary Plaque.

Completed· Pfizer logo

Pfizer·Phase 4·NCT00380939·600 enrolled

A Formulation Screening Study of Dalcetrapib and Atorvastatin in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01363999·24 enrolled

Study to Compare the Efficacy of Pitavastatin With That of Atorvastatin in Lowering Cholesterol Levels

Completed·KKowa Research Europe·Phase 3·NCT00249249·830 enrolled

Effect of Atorvastatin on Glycemic Control in Prediabetic Patients

Completed·—··NCT02470455·75 enrolled

Comparison of Vascular Effects After Therapy With Irbesartan and Atorvastatin.

Completed·TTechnische Universität Dresden·N/A·NCT00154024

Drug Interaction Study - Assess Pharmacokinetics of Both AZD5672 and Atorvastatin

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT00722956·12 enrolled

Anti-inflammatory Effect of Atorvastatin on Graft Donor Kidney

Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT02355704·48 enrolled

STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654537·5,625 enrolled

Study of Influence of Atorvastatin on the Repolarisation Phase of Cardiomyocytes

Unknown status·MMasaryk University·N/A·NCT00520585

Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography

Unknown status·IIsfahan University of Medical Sciences·Phase 3·NCT02113540

Comparison of the Combination of Fenofibrate and Simvastatin Versus Atorvastatin

Completed·SSolvay Pharmaceuticals·Phase 3·NCT00362934·516 enrolled

The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man

Completed·RRegional Hospital Holstebro·Phase 2·NCT01214746·26 enrolled

A Study Of The Efficacy Of Atorvastatin In Lowering Cholesterol In Latin American Patients With High Cholesterol

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00645151·512 enrolled

A Study Of Pharmacokinetics, Pharmacodynamics And Safety Of Adding ETC-1002 To Atorvastatin 80 mg

Completed·EEsperion Therapeutics, Inc.·Phase 2·NCT02659397·68 enrolled

Effects of Atorvastatin in Graves' Orbitopathy (GO)

Completed·UUniversity of Pisa·Phase 2·NCT03110848·88 enrolled

Atorvastatin in Perioperative Vascular Surgery - Pilot Study

Completed·UUniversity of Campinas, Brazil·Phase 4·NCT00610545·100 enrolled

A 16 Week Comparative Study of Fenofibrate Versus Ezetimibe as Add-on Therapy to Atorvastatin

Completed·AAbbott·Phase 3·NCT00195793·174 enrolled

Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.

Completed·AAegerion Pharmaceuticals, Inc.·Phase 1·NCT02080455·32 enrolled

Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)

Completed·OOrganon and Co·Phase 3·NCT03768427·454 enrolled

Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 Weeks

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00653588

A Study Comparing The Efficacy & Safety Of Torcetrapib/Atorvastatin And Atorvastatin In Subjects With High Triglycerides

Completed· Pfizer logo

Pfizer·Phase 3·NCT00134498·160 enrolled

Carotid B-mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin.

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00134238·755 enrolled

Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions

Unknown status·—·Phase 4·NCT00640744·12 enrolled

Atorvastatin Study For The Treatment Of High Cholesterol In Patients From Thailand

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00647543·242 enrolled

Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting

Unknown status·—·Phase 4·NCT01572623·150 enrolled

Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI

Withdrawn·UUNC Lineberger Comprehensive Cancer Center·Phase 1·NCT01605344

Double Blind Atorvastatin Amlodipine Study

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00159718·360 enrolled

Hypercholesterolemia7 trials

Evaluation of Ezetimibe and Atorvastatin Coadministration Versus Atorvastatin or Rosuvastatin Monotherapy in Japanese Patients With Hypercholesterolemia (Study P06027)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00871351·125 enrolled

Efficacy And Safety Study Of Atorvastatin Versus Simvastatin In Type 2 Diabetic Subjects With Hypercholesterolemia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00141141·383 enrolled

Mercury II - Compare the Efficacy and Safety of Lipid Lowering Agents Atorvastatin and Simvastatin With Rosuvastatin in High Risk Subjects With Type IIa and IIb Hypercholesterolemia

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654407·4,875 enrolled

Show 4 more trials

Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) When Co-administered With High Dose of Atorvastatin in Patients With Primary Hypercholesterolemia

Completed· Sanofi logo

Sanofi·Phase 2·NCT01288469·92 enrolled

A Clinical Trial Study to Evaluate Efficacy and Safety of Atorvastatin in Korean Patients With Hypercholesterolemia

Completed·YYonsei University·Phase 4·NCT01081548·17 enrolled

Ezetimibe Plus Atorvastatin Versus Atorvastatin in Untreated Subjects With Primary Hypercholesterolemia and Coronary Heart Disease (P03396)

Completed·OOrganon and Co·Phase 3·NCT00650689·122 enrolled

Compare the Efficacy of Rosuvastatin to Atorvastatin in High Risk Patients With Hypercholesterolemia

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00683618·934 enrolled

Coronary Artery Disease5 trials

Effect of Atorvastatin on Fractional Flow Reserve in Coronary Artery Disease

Completed·KKeimyung University Dongsan Medical Center·Phase 3·NCT01946815·119 enrolled

Comparison of Pitavastatin With Atorvastatin in Increasing High Density Lipoprotein - Cholesterol (HDL-C) and Adiponectin in Patients With Dyslipidemia and Coronary Artery Disease (CAD)

Completed·KKumamoto University·Phase 4·NCT00861861·129 enrolled

Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa)

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT02030054·150 enrolled

Show 2 more trials

Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI

Completed·PPeking University First Hospital·Phase 4·NCT01293097·2,884 enrolled

EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)

Completed·OOrganon and Co·Phase 4·NCT00166530·367 enrolled

Safety and Efficacy5 trials

Safety and Efficacy Study Comparing ABT-335 Coadministered With Atorvastatin and Ezetimibe to Atorvastatin Coadministered With Ezetimibe in Subjects With Multiple Abnormal Lipid (Fat) Levels in the Blood

Completed·AAbbott·Phase 3·NCT00639158·543 enrolled

Safety and Efficacy of Lapaquistat Acetate Taken Alone and With Atorvastatin in Subjects With Primary Dyslipidemia

Completed· Takeda logo

Takeda·Phase 3·NCT00487994·2,130 enrolled

A Study To Evaluate The Safety And Efficacy Of Atorvastatin In Patients With Diabetes And High Cholesterol

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00645424·155 enrolled

Show 2 more trials

Study To Evaluate The Safety And Efficacy Of Torcetrapib/Atorvastatin In Subjects With Familial Hypercholerolemia

Completed· Pfizer logo

Pfizer·Phase 3·NCT00134485·400 enrolled

Evaluate Safety and Efficacy of ABT-335 in Combination With Atorvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood

Completed·AAbbott·Phase 3·NCT00300469·613 enrolled

Acute Coronary Syndrome5 trials

Comparison of Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome

Completed·QQueen's University·Phase 4·NCT00665834·18 enrolled

Effects in The ApoB/ApoA-I Ratio Using Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00296387·1,160 enrolled

Intensive Statin Therapy in PCI Patient With Acute Coronary Syndrome

Unknown status·XXijing Hospital·Phase 4·NCT01372839·300 enrolled

Show 2 more trials

Evaluation of Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia

Completed· Sanofi logo

Sanofi·Phase 4·NCT02984982·206 enrolled

Atorvastatin Pre-Treatment Study In Asian Patients With Acute Coronary Syndrome

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00728988·499 enrolled

98 more indications

Metabolic Syndrome5 trials

COMETS - Compare the Efficacy of Rosuvastatin With Atorvastatin and Placebo in the Treatment of Non-Diabetic, Non-Atheroscleric, Metabolic Syndrome Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654485·940 enrolled

ROMEO (Rosuvastatin in Metabolic syndrOme)

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00395486·258 enrolled

Ezetimibe (+) Simvastatin vs. Atorvastatin Comparative Study in DM or Metabolic Syndrome Patients (0653A-093)

Completed·OOrganon and Co·Phase 4·NCT00157924·190 enrolled

Show 2 more trials

Implications for Treatment of the Metabolic Syndrome

Completed·UUniversity Hospital Southampton NHS Foundation Trust·Phase 2·NCT00666029·40 enrolled

Prothrombotic Inflammatory Markers in Women With Metabolic Syndrome - Effect of Atorvastatin

Completed·UUniversity of Rochester·Phase 1/2·NCT01785615·116 enrolled

Heart Disease4 trials

Study On Liprimar (Atorvastatin) In Patients With Coronary Heart Disease (CHD) And High Risk Of Cardiovascular Complications

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT00993915·687 enrolled

A Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease

Completed· Pfizer logo

Pfizer·Phase 3·NCT00134173·1,100 enrolled

Ezetimibe and Atorvastatin vs. Atorvastatin in Patients Age 65 and Older at High Risk for Coronary Heart Disease (CHD)(0653-112)

Completed·OOrganon and Co·Phase 3·NCT00418834·1,053 enrolled

Show 1 more trial

Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD

Completed· Pfizer logo

Pfizer·Phase 4·NCT00159835·8,600 enrolled

Cardiovascular Disease4 trials

Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia

Recruiting· Novartis logo

Novartis··NCT06858332·2,382 enrolled

Efficacy Study of Pioglitazone and Atorvastatin Combination Therapy in Treating Subjects With Elevated Risk for Cardiovascular Disease

Completed· Takeda logo

Takeda·Phase 2·NCT00770575·148 enrolled

The Role of Statins in the Prevention of Contrast-induced Acute Kidney Injury in Patients With Cardiovascular Diseases

Completed·II.M. Sechenov First Moscow State Medical University·N/A·NCT04666389·150 enrolled

Show 1 more trial

Atorvastatin Treatment to Attenuate the Progression of Cardiovascular Disease in Hemodialysis Patients

Completed·EErcan OK·Phase 3·NCT00481364·446 enrolled

Atherosclerosis4 trials

Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT00570752·72 enrolled

Merck Carotid Atherosclerosis Trial (MK-0000-111)(COMPLETED)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00804843·100 enrolled

Effect of Atorvastatin and Lifestyle Intervention on Progression of Pre-Clinical Atherosclerosis

Unknown status·MMinistry of Science and Technology of the People´s Republic of China·N/A·NCT00723320·1,200 enrolled

Show 1 more trial

Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis

Completed·UUniversity of Florida·Phase 4·NCT00361283·108 enrolled

Treatment3 trials

Effect of Upstream Treatment With High Intensity Statin on the Outcomes of STMI Patients Treated With PPCI

Unknown status·—·Phase 3·NCT04754789·160 enrolled

Combined Effects of Non-statin Treatments on Apolipoprotein A-I Up-Regulation (CENTAUR): A Feasibility Study

Completed·UUniversity of Pennsylvania·Phase 2·NCT00728910·25 enrolled

Intensive Statin Treatment for STEMI Patients Undergoing Primary PCI

Unknown status·—·Phase 4·NCT01033058·500 enrolled

Overweight3 trials

A Study to Learn How the Study Medicine Danuglipron is Taken Up Into the Blood and If Danuglipron Changes How the Body Processes Other Study Medicines (Atorvastatin and Rosuvastatin) in Healthy Adults Who Are Overweight or Obese

Completed· Pfizer logo

Pfizer·Phase 1·NCT06567327·82 enrolled

A Study to Evaluate LY3202328 in Overweight Healthy Participants and Dyslipidemia

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT02714569·60 enrolled

Safety and Benefit of MBX-8025 With and Without Commonly Used Statins in Moderately Overweight Patients With High Cholesterol

Completed· Gilead logo

Gilead·Phase 2·NCT00701883·183 enrolled

Toxicity3 trials

Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT)

Completed·WWake Forest University Health Sciences·Phase 2·NCT01988571·279 enrolled

Differences in Atorvastatin Metabolite Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity

Completed·OOslo University Hospital·Phase 4·NCT00199745·53 enrolled

Investigations on Differences in Atorvastatin Metabolites Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity

Completed·UUniversity of Oslo School of Pharmacy·Phase 4·NCT00414531·53 enrolled

Efficacy and Safety3 trials

Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00631189·668 enrolled

Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)

Completed· Regeneron logo

Regeneron·Phase 3·NCT01730040·355 enrolled

Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654173·4,444 enrolled

Hyperlipidemia3 trials

IMPAACT P1063: Safety and Effectiveness of Atorvastatin in HIV Infected Children and Adolescents With Hyperlipidemia

Terminated·IInternational Maternal Pediatric Adolescent AIDS Clinical Trials Group·Phase 1/2·NCT00663234·28 enrolled

Safety and Efficacy of Evolocumab in Combination With Statin Therapy in Adults With Diabetes and Hyperlipidemia or Mixed Dyslipidemia

Completed· Amgen logo

Amgen·Phase 3·NCT02662569·986 enrolled

Evaluation of the Fixed-dose Combination of Irbesartan/Atorvastatin in Type 2 Diabetic Patients Diagnosed With Hyperlipidemia and Hypertension

Completed· Sanofi logo

Sanofi·Phase 4·NCT02842359·11 enrolled

Complication2 trials

Statin Drugs to Prevent Complications During Surgery

Completed·OOttawa Hospital Research Institute·N/A·NCT00967434·60 enrolled

Study of Atorvastatin Versus Placebo to Reduce Cardiopulmonary Complications After Thoracic Surgery

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT00375518·162 enrolled

Heart Failure2 trials

A Study Of The Usage Of Statins In A Community Heart Failure Population

Completed·SSt Vincent's University Hospital, Ireland·Phase 4·NCT00795912·56 enrolled

Comparison of Lipophilic Versus Hydrophilic Statins on Patients With Heart Failure

Completed·—·Phase 4·NCT03255044·85 enrolled

Hypercholesterolaemia2 trials

Treatment of Hypercholesterolaemia in South Asian Subjects (IRIS)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00654225·2,340 enrolled

Rosuvastatin Versus Atorvastatin in the Treatment of Hypercholesterolaemia in African American Subjects(ARIES)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00653744·1,700 enrolled

Diabetes Mellitus2 trials

Follow-On Study of Pitavastatin Versus Atorvastatin in Patients With Type II Diabetes Mellitus and Combined Dyslipidemia

Completed·KKowa Research Europe·Phase 3·NCT00344370·214 enrolled

Atorvastatin and LDL Profile in Non-Insulin Dependent Diabetes Mellitus

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00640549·41 enrolled

Type 2 Diabetes Mellitus2 trials

Efficacy and Safety Study of Pitavastatin Compared to atoRvastatin in Type 2 dIabeTes Mellitus With Hypercholesterolemia

Completed·JJW Pharmaceutical·Phase 4·NCT00889226·161 enrolled

Atorvastatin and Endothelial Function in Type 2 Diabetes Mellitus (ATTEND-Study)

Completed·UUniversity of Southern Denmark·Phase 4·NCT00124397·186 enrolled

Clinical Trial2 trials

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects Who Are Intolerant to Statins

Completed· Pfizer logo

Pfizer·Phase 3·NCT02135029·184 enrolled

A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)

Active, not recruiting·MMonash University·Phase 4·NCT02099123·9,971 enrolled

Atrial Fibrillation2 trials

The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation

Completed·MMayo Clinic·Phase 4·NCT00579098·125 enrolled

Does Atorvastatin Prevent Post Operative Atrial Fibrillation After Pulmonary Resection: A Randomized Clinical Study

Completed·UUniversity of Alabama at Birmingham·N/A·NCT00756886·73 enrolled

Chronic Periodontitis2 trials

Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT03745300·120 enrolled

Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT02800902·90 enrolled

Type 2 Diabetes2 trials

LIpid Lowering With Highly Potent Statins in Hyperlipidaemia With Type 2 Diabetes patiENts

Completed·LListen Trial Group·N/A·NCT01544309·1,049 enrolled

Effect of Atorvastatin on Vascular Inflammation in Type 2 Diabetes

Withdrawn·KKorea University·N/A·NCT00932048

Atherosclerotic Plaque2 trials

Assessment of Change in Atherosclerotic Plaque by Serial CCTA

Unknown status·YYonsei University··NCT03414840·400 enrolled

Evaluate the Utility of 18FDG-PET as a Tool to Quantify Atherosclerotic Plaque (MK-0000-081 AM3)(COMPLETED)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT00703261·83 enrolled

Effectiveness2 trials

To Evaluate the Safety and Effectiveness of Atorvastatin Plus a Cholinesterase Inhibitor in AD Patients.

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151502·600 enrolled

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/20 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 20 mg Tablets in Participants With High Cholesterol (MK-0653C-185 AM1)

Completed·OOrganon and Co·Phase 3·NCT01370590·406 enrolled

Proteinuria2 trials

Study of Atorvastatin Dose Dependent Reduction of Proteinuria

Completed·LLaval University·Phase 4·NCT00768638·23 enrolled

Prospective Evaluation of Proteinuria and Renal Function in Non-diabetic Patients With Progressive Renal Disease

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00296400·237 enrolled

Statins2 trials

Statins Evaluation in Coronary Procedures and Revascularization Trial

Completed·HHospital do Coracao·Phase 4·NCT01448642·4,191 enrolled

Statins and CPAP in Adipose Tissue of OSA

Completed·MMayo Clinic·Phase 1/2·NCT03308578·50 enrolled

Symptomatic Intracranial Atherosclerotic Stenosis2 trials

Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 3·NCT06080256·80 enrolled

Evolocumab Added to Statin Therapy in Symptomatic Intracranial Atherosclerotic Stenosis (EAST-ICAS)

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 3·NCT05741086·80 enrolled

Tuberculosis1 trial

Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial

Withdrawn·UUniversity of Minnesota·Phase 2/3·NCT01442428

Childhood Cancer1 trial

Statin Therapy in Young Adult Survivors of Childhood Cancer

Completed·UUniversity of Minnesota·Phase 2·NCT01733953·27 enrolled

Cystic Fibrosis1 trial

A Trial of Atorvastatin as an Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis

Completed·UUniversity of Edinburgh·Phase 4·NCT01299181·60 enrolled

Hemorrhage1 trial

Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial

Completed·UUniversity of Chicago·Phase 1/2·NCT02603328·80 enrolled

Hepatitis B1 trial

Effects of Short-term Atorvastatin Treatment on Vaccination Efficacy in Nonresponder Persons to Hepatitis B Vaccine

Unknown status·NNematollah Jonaidi Jafari·Phase 4·NCT01548326·52 enrolled

Genetic Polymorphism1 trial

Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin

Completed·—·Phase 1·NCT00973986·20 enrolled

Bronchiectasis1 trial

Atorvastatin in Bronchiectasis in Patients With Pseudomonas Aeruginosa

Completed·UUniversity of Edinburgh·Phase 4·NCT01299194·32 enrolled

Interaction1 trial

Drug Interaction Statin

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02089061·26 enrolled

Immune Response1 trial

The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23

Completed·UUniversity of Florida·Phase 1·NCT02097589·33 enrolled

Cardiovascular1 trial

Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction

Recruiting·NNYU Langone Health·Phase 1·NCT06961630·50 enrolled

Inflammation1 trial

Impact of Chronic Statin Use During Surgery on Inflammation and Infection Rates

Completed·OOttawa Hospital Research Institute··NCT00967252·50 enrolled

Lip1 trial

Lipid-lowering Therapy Individualization

Completed·UUniversité Catholique de Louvain·Phase 4·NCT03604471·75 enrolled

Carotid Endarterectomy1 trial

Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes

Completed·—·Phase 3·NCT02850081·31 enrolled

Prostate Cancer1 trial

Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer

Recruiting·GGustave Roussy, Cancer Campus, Grand Paris·Phase 3·NCT03819101·1,210 enrolled

Orthopedic Surgery1 trial

Risk Factor Control Before Orthopedic Surgery

Terminated·NNYU Langone Health·Phase 4·NCT01837069·198 enrolled

Insulin resistance1 trial

Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling

Completed·SStanford University·Phase 4·NCT02437084·115 enrolled

Overweight or Obese1 trial

A Study to Evaluate the Drug-drug Interactions (DDIs) of IBI362 With Metformin, Warfarin, Atorvastatin, Digoxin in Overweight or Obese Subjects

Completed· Innovent Biologics (Suzhou) Co. Ltd. logo

Innovent Biologics (Suzhou) Co. Ltd.·Phase 1·NCT05815680·48 enrolled

Pulmonary Hypertension1 trial

Atorvastatin in Pulmonary Hypertension

Completed·—·Phase 2·NCT00615823·220 enrolled

Coronary Artery Bypass1 trial

Efficacy of Different Perioperative Statin Regimens on the Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events

Completed·—·Phase 4·NCT02706860·94 enrolled

Combination Therapy1 trial

Study of Atorvastatin/Fenofibrate (LCP-AtorFen) Combination Therapy in Dyslipidemia

Completed·VVeloxis Pharmaceuticals·Phase 2·NCT00504829·220 enrolled

Metabolism1 trial

Regulation of Lipoprotein Metabolism in Obese Men

Completed·TThe University of Western Australia·Phase 3·NCT00392717·48 enrolled

Prevention1 trial

Efficacy of Statins In Prevention of CIN

Terminated·UUniversity of Oklahoma·N/A·NCT01071993·21 enrolled

Type 1 Diabetes1 trial

Treatment Effects of Atorvastatin on Hemostasis and Skin Microcirculation in Patients With Type 1 Diabetes

Completed·KKarolinska Institutet·Phase 4·NCT01497912·20 enrolled

Hypertension1 trial

Comparing Amlodipine/Atorvastatin Co-Administration To Amlodipine Alone In Patients With Hypertension And Dyslipidemia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00174330·330 enrolled

Midazolam1 trial

Effects of Statins on the Pharmacokinetics for Midazolam in Healthy Volunteers

Completed·HHamamatsu University·N/A·NCT00716846·11 enrolled

Imaging1 trial

CRESTOR Athero Imaging Head to Head IVUS Study

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00620542·2,333 enrolled

Vaccine Response1 trial

Systems Biological Assessment of Statin Effect on Vaccine Responses

Completed·EEmory University·Phase 4·NCT06024096·63 enrolled

COVID-191 trial

HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID)

Unknown status·—·Phase 3·NCT04801940·2,631 enrolled

Alcoholic Fatty Liver Disease1 trial

Assessment of Endothelial Function in Patients With Non Alcoholic Fatty Liver Disease and the Impact of Statin Treatment

Withdrawn·SSheba Medical Center·N/A·NCT01987310

Cardiotoxicity1 trial

STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)

Completed·MMassachusetts General Hospital·Phase 2·NCT02943590·300 enrolled

Chronic Kidney Disease1 trial

Effect of Pitavastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease

Completed·—·Phase 4·NCT02863185·45 enrolled

Cardiovascular Events1 trial

Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD

Completed·RResverlogix Corp·Phase 3·NCT02586155·2,425 enrolled

Chronic Asthma1 trial

Trial to Evaluate the Effect of Statins on Asthma Control of Patients With Chronic Asthma

Completed·UUniversity of Glasgow·Phase 2/3·NCT00126048·54 enrolled

Acute Kidney Injury1 trial

Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)

Completed·CCentro Cardiopatici Toscani·Phase 4·NCT01870804·760 enrolled

Plaque1 trial

CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction

Terminated·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 4·NCT02740699·79 enrolled

Diastolic Heart Failure1 trial

The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure

Completed·SSt Vincent's University Hospital, Ireland·N/A·NCT00505336·43 enrolled

Statin1 trial

KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts

Recruiting·MMikko Niemi·Phase 1·NCT06469450·15 enrolled

LDL-cholesterol1 trial

A Swiss Study With Atorvastatin in Hyperlipidemic Patients Measuring LDL-Cholesterol

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00136942·370 enrolled

Drug Interactions1 trial

Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers

Completed·GGalmed Pharmaceuticals Ltd·Phase 1·NCT03760848·15 enrolled

Diffuse Scleroderma1 trial

Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma

Completed·RRobyn T. Domsic, MD, MPH·Phase 2·NCT02370784·24 enrolled

Oxidative Stress1 trial

Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01322711·60 enrolled

Familial Hypercholesterolemia1 trial

8-Week PK/PD Atorvastatin Study In Children And Adolescents With Heterozygous Familial Hypercholesterolemia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 1·NCT00739999·39 enrolled

Platelet Reactivity1 trial

Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01567774·100 enrolled

Nasopharyngeal Carcinoma1 trial

Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis

Suspended·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT02022293·324 enrolled

Dialysis Patients1 trial

Salusin-alpha - a New Factor in the Pathogenesis of Lipid Abnormalities in Hemodialysis Patients

Completed·PPoznan University of Medical Sciences·Phase 4·NCT01448174·310 enrolled

Vascular Function1 trial

The Effect of Statin Use on Vascular Function in Hypertensive Subjects

Terminated·JJohns Hopkins University·Phase 4·NCT00181181·24 enrolled

Hypertriglyceridemia1 trial

Evaluation of Efficacy and Safety of Omacor, Co-Administered With Atorvastatin, in Subjects With Hypertriglyceridemia

Completed· GSK logo

GSK·Phase 3·NCT00435045·245 enrolled

Abdominal Surgery1 trial

Study To Check The Analgesic And Anti-Inflammatory Effects Of Atorvastatin In Patients Undergoing Abdominal Surgery

Unknown status·—·Phase 3·NCT00902967·40 enrolled

Breast Cancer1 trial

STOP Heart Disease in Breast Cancer Survivors Trial

Terminated·—·Phase 2·NCT02674204·2 enrolled

Septic Shock1 trial

Study the Impact of Statins in Septic Shock

Completed·SSanjay Gandhi Postgraduate Institute of Medical Sciences·N/A·NCT02681653·40 enrolled

Psoriasis1 trial

Influence of Atorvastatin on Psoriasis Severity and Endothelial Function

Withdrawn·Sshmuel fuchs·Phase 3·NCT01527097

Essential Hypertension1 trial

Efficacy and Safety of HL-040XC in Essential Hypertension and Hyperlipidemia

Completed·HHanAll BioPharma Co., Ltd.·Phase 3·NCT01541943·356 enrolled

Necrosis1 trial

Effects of Short Term, High Dose Atorvastatin Therapy on Periprocedural Myonecrosis and Platelet Inhibition After Percutaneous Coronary Intervention (PCI)

Terminated·IIndiana University School of Medicine·N/A·NCT00979940·60 enrolled

Blood Pressure1 trial

Effects of Atorvastatin on Blood Pressure and Urinary Albumin Excretion

Completed·—·N/A·NCT01126684·50 enrolled

Gastrointestinal1 trial

Effect of Liraglutide on Gastrointestinal Absorption of Several Drugs and Potential Influence of Liraglutide on Intragastric pH

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT01518166·70 enrolled

Elderly Patients1 trial

Effect of Atorvastatin Versus Rosuvastatin Intensive Statin Regimens on Chinese Elderly Patients Undergoing PCI

Unknown status·—·Phase 4·NCT01646307·1,000 enrolled

Myalgia1 trial

Study of the Safety and Tolerability Associated With PPD10558 Versus Atorvastatin in Patients Previously Intolerant to Statins Due to Statin-associated Myalgia (SAM)

Completed·FFuriex Pharmaceuticals, Inc·Phase 2·NCT01279590·282 enrolled

Hematoma1 trial

The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders

Unknown status·OOriental Neurosurgery Evidence-Based-Study Team·Phase 2·NCT02192320·60 enrolled

Abnormal Glucose Metabolism1 trial

Comparison of Atorvastatin and Pitavastatin on the Effect of HbA1c in AMI Patients With Abnormal Glucose Metabolism

Unknown status·—·Phase 4·NCT04945122·900 enrolled

Non-Alcoholic Steatohepatitis1 trial

Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis

Unknown status·TTehran University of Medical Sciences·Phase 2·NCT01617772·440 enrolled

Endothelial Function1 trial

Statins and Endothelial Function in Patients With Coarctation of the Aorta

Terminated·UUniversity of California, San Francisco·Phase 4·NCT00767572·12 enrolled

Ischemia1 trial

Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers

Completed·KKarolinska Institutet·Phase 1·NCT02286544·36 enrolled

Endothelial Dysfunction1 trial

Effect of a Fibrate and a Statin on Endothelial Dysfunction

Terminated·—·N/A·NCT00491400·28 enrolled

Cholesterol1 trial

A Study in People With High Cholesterol

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00133380·300 enrolled

Function1 trial

Effect of Chronic Statin and Viagra Therapy in Persons With Endothelial Cell Dysfunction

Withdrawn·MMayo Clinic·N/A·NCT00587379

Nephropathy1 trial

Atorvastatin Effect on Contrast Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention

Completed·MMohamed Abdelfatah·Phase 4·NCT04375787·200 enrolled

Pediatric1 trial

Bioequivalence Study Of Pediatric Appropriate Formulation

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 1·NCT00758004·76 enrolled

Immune Thrombocytopenia1 trial

The Combination of Atorvastatin, Acetylcysteine and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Unknown status·PPeking University People's Hospital·Phase 1/2·NCT03460808·200 enrolled

Pulmonary Sarcoidosis1 trial

Atorvastatin to Treat Pulmonary Sarcoidosis

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00279708·55 enrolled

Immune Checkpoint Inhibitor1 trial

Statins to Prevent Immune Checkpoint Inhibitor-induced PRogression of AtherosLerosis

Not yet recruiting·EErasmus Medical Center·Phase 4·NCT06785974·140 enrolled

Coronary Spasm1 trial

The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm

Unknown status·SSamsung Medical Center·Phase 4·NCT01674686·200 enrolled

Mood Disorder1 trial

Anti-inflmmation Treatment in Mood Disorder and Deep Learning Prediction Model

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT04685642·180 enrolled

Nephrotic Syndrome1 trial

Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome

Terminated·GGloria Vega·Phase 2·NCT03004001·3 enrolled

Optical Coherence Tomography1 trial

Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography (OCT) Combined With Intravascular Ultrasound (IVUS)

Completed·HHarbin Medical University·Phase 4·NCT01023607·120 enrolled

Unspecified3 trials

A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels

Completed· Pfizer logo

Pfizer·Phase 4·NCT00327691·8,600 enrolled

Pemvidutide (ALT-801) DDI Study in Healthy Volunteers

Completed· Altimmune logo

Altimmune·Phase 1·NCT04972396·40 enrolled

Diazoxide Choline Controlled-Release Tablet (DCCR) for Very High Triglycerides

Withdrawn·EEssentialis, Inc.·Phase 3·NCT00973271

Regulatory

FDA Approval Timeline[5]

Dec 17, 1996

LIPITOR

NDA NDA020702

Jul 18, 1997

LIPITOR

NDA NDA020702

Oct 28, 1997

LIPITOR

NDA NDA020702

Nov 5, 1997

LIPITOR

NDA NDA020702

Feb 2, 1998

LIPITOR

NDA NDA020702

Feb 6, 1998

LIPITOR

NDA NDA020702

Mar 23, 1998

LIPITOR

NDA NDA020702

Apr 29, 1998

LIPITOR

NDA NDA020702

Jun 3, 1998

LIPITOR

NDA NDA020702

Jun 25, 1998

LIPITOR

NDA NDA020702

Jul 10, 1998

LIPITOR

NDA NDA020702

Jul 10, 1998

LIPITOR

NDA NDA020702

Aug 4, 1998

LIPITOR

NDA NDA020702

Aug 28, 1998

LIPITOR

NDA NDA020702

Dec 1, 1999

LIPITOR

NDA NDA020702

Dec 2, 1999

LIPITOR

NDA NDA020702

Dec 22, 1999

LIPITOR

NDA NDA020702

Apr 7, 2000

LIPITOR

NDA NDA020702

Nov 14, 2000

LIPITOR

NDA NDA020702

Jun 8, 2001

LIPITOR

NDA NDA020702

Nov 20, 2001

LIPITOR

NDA NDA020702

Dec 27, 2001

LIPITOR

NDA NDA020702

Dec 27, 2001

LIPITOR

NDA NDA020702

Apr 8, 2002

LIPITOR

NDA NDA020702

Apr 22, 2002

LIPITOR

NDA NDA020702

Apr 22, 2002

LIPITOR

NDA NDA020702

Jul 2, 2002

LIPITOR

NDA NDA020702

Oct 18, 2002

LIPITOR

NDA NDA020702

May 12, 2003

LIPITOR

NDA NDA020702

Sep 29, 2003

LIPITOR

NDA NDA020702

May 24, 2004

LIPITOR

NDA NDA020702

Jul 30, 2004

LIPITOR

NDA NDA020702

Sep 21, 2005

LIPITOR

NDA NDA020702

Oct 11, 2005

LIPITOR

NDA NDA020702

Jun 23, 2006

LIPITOR

NDA NDA020702

Aug 7, 2006

LIPITOR

NDA NDA020702

Jan 16, 2007

LIPITOR

NDA NDA020702

Mar 2, 2007

LIPITOR

NDA NDA020702

Sep 26, 2007

LIPITOR

NDA NDA020702

Mar 27, 2009

LIPITOR

NDA NDA020702

Jun 17, 2009

LIPITOR

NDA NDA020702

Feb 28, 2012

LIPITOR

NDA NDA020702

Oct 31, 2012

LIPITOR

NDA NDA020702

Oct 31, 2012

LIPITOR

NDA NDA020702

Nov 30, 2012

LIPITOR

NDA NDA020702

May 21, 2014

LIPITOR

NDA NDA020702

Mar 11, 2015

LIPITOR

NDA NDA020702

Jun 23, 2017

LIPITOR

NDA NDA020702

Jun 23, 2017

LIPITOR

NDA NDA020702

Aug 10, 2018

LIPITOR

NDA NDA020702

Apr 12, 2019

LIPITOR

NDA NDA020702

Nov 27, 2019

LIPITOR

NDA NDA020702

Sep 25, 2020

LIPITOR

NDA NDA020702

Nov 16, 2020

LIPITOR

NDA NDA020702

Dec 7, 2022

LIPITOR

NDA NDA020702

Feb 1, 2023

ATORVALIQ

NDA NDA213260

Apr 2, 2024

LIPITOR

NDA NDA020702

Sources

References

[1]
ClinicalTrials.gov — 658 trial records for atorvastatin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Lipitor drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — atorvastatin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for atorvastatin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020702). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Lipitor. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: HMG-Coa Reductase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Patent Landscape[6]

Patent Cliff

Jun 7, 2037

Earliest patent expiration — generic entry possible after this date

Patent #Expires

11654106Jun 7, 2037

11925704Jun 7, 2037

12370136Jun 7, 2037

12168069Jun 7, 2037

11369567Jun 7, 2037

1 more patents

12599553Jun 7, 2037