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Neurology/Neuralgia

Neuralgia

20

Pipeline Programs↗

33

Active Trials↗

41

Companies Involved↗

Neuralgia is an emerging landscape with 20 programs across 41 companies. The most active players are Beijing Tide Pharmaceutical Co., Ltd. 2 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

54/100

Pipeline Velocity

27/100

Mech. Concentration

33/100

Completion Rate

82/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Beijing Tide Pharmaceutical Co., Ltd

1 program

Pipeline

Programs by Phase

Preclinical12

Duloxetine Hydrochloride

Jazz Pharmaceuticals

Suzetrigine

Vertex Pharmaceuticals

Amniotic Suspension Allograft

Organogenesis

DS-5565

Daiichi Sankyo

Oxycodone

Protega

Phase 11

Alloex

The Foundation for Orthopaedics and Regenerative Medicine

Phase 25

TRD205

Beijing Tide Pharmaceutical Co., Ltd

HL-1186

Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.

HL-1186 Placebo

Shanghai Huilun Pharmaceutical Co., Ltd.

Pregabalin Capsule Placebo

Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.

Y-4 Tables

Neurodawn Pharmaceutical Co., Ltd.

Phase 32

Basimglurant

Roche

Onabotulinumtoxina 100 UNT

Stanford University

Approved

No programs

Analysis

Modality Breakdown

94%

Small molecule

15 of 16 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 16 classified programs, each share of the total. Modality classified for 85% of 20 pipeline programs.

Analysis

Trial Status

156

clinical trials

Completed91 · 58%

Terminated17 · 11%

Recruiting13 · 8%

Unknown status12 · 8%

Not yet recruiting10 · 6%

Active, not recruiting8 · 5%

Other5 · 3%

Clinical Trials

Trial Activity

156 trials

Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia: A Prospective Observational Study

Recruiting·HHospital Universitari de Bellvitge·N/A·NCT06851910·20 enrolled

A Clinical Trial to Evaluate the Efficacy and Safety of HL-1186 Tablet in the Treatment of Postherpetic Neuralgia

Recruiting·SShanghai Yidian Pharmaceutical Technology Development Co., Ltd.·Phase 2·NCT07758920·200 enrolled

Decompression of Pudendal and Inferior Cluneal Nerves Using Robot-assisted Laparoscopy for Entrapment Neuralgias: Results After 1 Year of Follow-up (the X-DECO Study)

Recruiting·UUBOSGA·N/A·NCT06578767·200 enrolled

Pain Alleviation for Patients Receiving Directional Deep Brain Stimulation to Treat Neuropathic Dental Pain

Recruiting·UUniversity of British Columbia·Preclinical·NCT07671950·5 enrolled

Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia

Recruiting·UUniversity of Louisville·Phase 4·NCT06644261·40 enrolled

Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.

Recruiting·GGroupe Hospitalier Diaconesses Croix Saint-Simon·Phase 3·NCT06872437·60 enrolled

Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia

Recruiting·—·N/A·NCT06890897·174 enrolled

Pregabalin as an add-on Therapy to Carbamazepine in Trigeminal Neuralgia Patients

Recruiting·PPostgraduate Institute of Dental Sciences Rohtak·N/A·NCT06357260·50 enrolled

Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia

Recruiting·—·Phase 3·NCT06315790·80 enrolled

Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cells Exosomes for Trigeminal Neuralgia

Recruiting·TThe Foundation for Orthopaedics and Regenerative Medicine·Phase 1·NCT05152368·20 enrolled

OnabotulinumtoxinA for Trigeminal Neuralgia

Recruiting·SStanford University·Phase 4·NCT06216886·20 enrolled

Esketamine Combined Pregabalin and Duloxetine for Postherpetic Neuralgia

Recruiting·—·N/A·NCT06896994·150 enrolled

The Treatment of Postherpetic Neuralgia in the Head and Face With Superficial Needling Combined With Electroacupuncture

Recruiting·ZZhejiang Chinese Medical University·N/A·NCT06420778·124 enrolled

A Randomized, Parallel Arm, Sham-controlled, Double-blinded, Investigator-initiated Trial to Investigate the Safety and Efficacy of Percutaneous Peripheral Cryoneurolysis Therapy in Medically Refractory Trigeminal Neuralgia: a Pilot Study

Active, not recruiting·SSt. Olavs Hospital·Preclinical·NCT06213155·24 enrolled

Phase 1 Clinical Trial for MR Guided Focused Ultrasound (FUS) Thalamotomy of Central Lateral Thalamic Nucleus for the Treatment of Medication-refractory Trigeminal Neuralgia

Active, not recruiting·UUniversity of Maryland, Baltimore·Preclinical·NCT04579692·10 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)