VivoSeq
Neurology

Neuralgia

41

Pipeline Programs↗

6

Active Trials↗

31

Companies Involved↗

Neuralgia is a moderately active landscape with 41 programs across 31 companies. The most active players are Merck & Co., Vitae Pharmaceuticals Inc., an Allergan affiliate, UCB. 7 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

57/100

Pipeline Velocity

6/100

Mech. Concentration

11/100

Completion Rate

88/100

Attrition Rate

9/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Merck & Co. logo

Merck & Co.

1 program

Phase 1V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 1UCB logo

UCB

2 programs

Phase 2Pfizer logo

Pfizer

2 programs

Phase 2C

Convergence Pharmaceuticals

1 program

Phase 2Bristol-Myers Squibb logo

Bristol-Myers Squibb

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical5

Duloxetine Hydrochloride

Eli Lilly

Suzetrigine

Vertex Pharmaceuticals

Amniotic Suspension Allograft

Organogenesis

DS-5565

Daiichi Sankyo

HSK16149

Haisco Pharmaceutical Group Co., Ltd.

Phase 13

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

MK-8291

Merck & Co.

Depo-Medrol and Lidocaine

University of Calgary

Phase 220

Minocycline

Triax

Cetuximab

Imclone

Mannitol

B. Braun Medical Inc.

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Levetiracetam

UCB

Phase 36

Gabapentin

Viatris Specialty LLC

Dexamethasone

Aspen Global Incorporated

Methadone

Hikma Pharmaceuticals LLC

Valacyclovir

Glaxo Dba Glaxosmithkline

FV-100

ContraVir Pharmaceuticals, Inc.

Approved7

Duloxetine

Alnylam Pharmaceuticals

Bupivacaine

Innocoll

Capsaicin

Averitas Pharma, Inc.

Perampanel

Catalyst Biosciences

Lidocaine

MEDRx USA, Inc.

Analysis

Modality Breakdown

98%

Small molecule

45 of 46 classified programs — the dominant modality here.

2%ALL OTHERSMonoclonal antibody12%

Small molecule leads; the ring shows all 46 classified programs, each share of the total. Modality classified for 100% of 47 pipeline programs.

Analysis

Trial Status

45

clinical trials

Completed29 · 64%
Unknown status6 · 13%
Terminated4 · 9%
Recruiting3 · 7%
Active, not recruiting2 · 4%
Enrolling by invitation1 · 2%

Clinical Trials

Trial Activity

45 trials

Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia
Recruiting·UUniversity of Louisville·Phase 4·NCT06644261·40 enrolled
Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.
Recruiting·GGroupe Hospitalier Diaconesses Croix Saint-Simon·Phase 3·NCT06872437·60 enrolled
Pain Alleviation for Patients Receiving Directional Deep Brain Stimulation to Treat Neuropathic Dental Pain
Recruiting·UUniversity of British Columbia·Preclinical·NCT07671950·5 enrolled
Resolution of Pudendal Neuralgia in Chronic Pelvic Pain Using a Novel Biologic Therapy
Active, not recruiting·TThomas Jefferson University·N/A·NCT06425575·50 enrolled
Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
Active, not recruiting·NNalu Medical, Inc.·Preclinical·NCT05287373·89 enrolled
To Evaluate the Efficacy and Safety of TRD205 Tablets in the Treatment of Chronic Postoperative Neuralgia
Enrolling by invitation·BBeijing Tide Pharmaceutical Co., Ltd·Phase 2·NCT07123402·184 enrolled
Dose-Tolerability Titration Study to Evaluate The Efficacy And Safety Of Perampanel (E2007) In Patients With Post-Herpetic Neuralgia (PHN)
Completed·Eisai logoEisai·Phase 2·NCT00592774·146 enrolled
Safety/Efficacy Study of Retigabine vs. Placebo in Post-Herpetic Neuralgia (PHN)
Completed·BBausch Health Americas, Inc.·Phase 2·NCT00612105·187 enrolled
Erector Spinae Plane Block in Post-herpetic Neuralgia
Completed·TTanta University·N/A·NCT04546334·90 enrolled
Dysport in Post-Surgical Neuralgia
Completed·Ipsen logoIpsen·Phase 2·NCT03663101·16 enrolled
A Study To Compare Pregabalin/PF-00489791 Combination Versus Pregabalin Alone In Post-Herpetic Neuralgia
Completed·Pfizer logoPfizer·Phase 2·NCT00599638·72 enrolled
Methadone in Post-Herpetic Neuralgia Pain
Completed·UUniversity of Sao Paulo·Phase 3·NCT01752699·10 enrolled
Pulsed Radiofrequency vs. Steroid Injections for Occipital Neuralgia
Completed·JJohns Hopkins University·N/A·NCT01670825·81 enrolled
A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Posttraumatic Neuralgia..
Completed·AstraZeneca logoAstraZeneca·Phase 2·NCT01200524·133 enrolled
Evaluate the Efficacy and Safety of DWP05195 in Subjects With Post-Herpetic Neuralgia
Completed·Daewoong Pharmaceutical Co. LTD. logoDaewoong Pharmaceutical Co. LTD.·Phase 2·NCT01557010·140 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)