Journavx

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Total Knee ArthroplastyPeripheral NeuropathyTotal Hip ArthroplastyNeuralgiaRib Fracture

275 competitors in Total Knee Arthroplasty

#DrugCompanyPhaseTrials

1

Journavx

Vertex Pharmaceuticals

Approved

12

Cymbalta

Alnylam Pharmaceuticals

Preclinical

53

Lyrica

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

74

Xarelto

WWim Janssens

Preclinical

55

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

46

Sufenta

LLeaf Vertical Inc.

Preclinical

37

EXPAREL

Pacira Pharmaceuticals, Inc

Preclinical

78

Nucynta

CCollegium Pharmaceutical, Inc.

Preclinical

29

Xylocaine

MMEDRx USA, Inc.

Preclinical

210

Epsom Salt

FFresenius Kabi Oncology Ltd.

Preclinical

1Show 16 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Peripheral Neuropathy4 trials

Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN)

Completed·Vertex Pharmaceuticals·Phase 2·NCT05660538·194 enrolled

Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)

Active, not recruiting·Vertex Pharmaceuticals·Phase 3·NCT06696443·455 enrolled

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

Recruiting·Vertex Pharmaceuticals·Phase 3·NCT07231419·734 enrolled

Show 1 more trial

Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy

Recruiting·Vertex Pharmaceuticals·Phase 3·NCT06628908·1,100 enrolled

Pain3 trials

RCT: Suzetrigine vs Norco for Post-op Pain

Not yet recruiting·JJacob Lensing·Phase 4·NCT07195669·76 enrolled

A Phase 1, Open-label Drug-drug Interaction Study to Evaluate the Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Subjects

Active, not recruiting·Vertex Pharmaceuticals·Phase 1·NCT07570069·18 enrolled

The Role of NaV1.8 in Human Pain Models - a Randomized, Placebo-controlled Crossover Microdosing Trial

Completed·MMedical University of Vienna·Phase 1·NCT07511400·67 enrolled

Effectiveness3 trials

A Single-arm Study to Evaluate Safety and Effectiveness of VX-548 for Acute Pain

Completed·Vertex Pharmaceuticals·Phase 3·NCT05661734·258 enrolled

A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries

Completed·Vertex Pharmaceuticals·Phase 4·NCT06887972·100 enrolled

A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries

Completed·Vertex Pharmaceuticals·Phase 4·NCT06887959·47 enrolled

Efficacy and Safety2 trials

Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty

Completed·Vertex Pharmaceuticals·Phase 3·NCT05558410·1,118 enrolled

This is a Study Evaluating the Efficacy and Safety of LTG-001 for Acute Pain After Surgical Removal of Impacted Third Molars

Completed·LLatigo Biotherapeutics·Phase 2·NCT06774625·250 enrolled

Pain Control1 trial

Evaluating Suzetrigine for Pain Control Following TKA

Not yet recruiting·AAdventHealth·Phase 3·NCT07357376·210 enrolled

11 more indications

Total Hip Arthroplasty1 trial

Suzetrigine in Total Hip Arthroplasty

Recruiting·HHospital for Special Surgery, New York·Phase 3·NCT07226700·210 enrolled

Surgery1 trial

A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine

Not yet recruiting·MMayo Clinic·Phase 4·NCT07257133·40 enrolled

Mastectomy1 trial

Suzetrigine for Non-Mastectomy Breast Surgery

Not yet recruiting·UUniversity of California, San Diego·Phase 4·NCT07463430·120 enrolled

Adult1 trial

Pharmacodynamic Study of 100mg Suzegtrigine vs Placebo in Healthy Male Adults

Completed·LLatigo Biotherapeutics·Phase 1·NCT06972212·20 enrolled

Rib Fracture1 trial

Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures

Enrolling by invitation·UUniversity of California, Irvine·Phase 4·NCT07145346·80 enrolled

Total Knee Arthroplasty1 trial

Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

Not yet recruiting·UUniversity of Louisville·Phase 4·NCT07219888·140 enrolled

Opioids1 trial

Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports

Not yet recruiting·UUniversity of California, Los Angeles·Phase 4·NCT07355166·140 enrolled

Excretion1 trial

Evaluation of the Excretion of Suzetrigine Into Breast Milk in Healthy Lactating Female Participants

Recruiting·Vertex Pharmaceuticals·Phase 1·NCT07378865·12 enrolled

Female1 trial

Evaluation of the Effect of Suzetrigine (SUZ) on the Pharmacokinetics of Oral Contraceptives in Healthy Female Participants

Completed·Vertex Pharmaceuticals·Phase 1·NCT06820307·50 enrolled

Opioid Consumption, Postoperative1 trial

Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU)

Recruiting·UUniversity of California, San Diego·Approved·NCT07672015·100 enrolled

Unspecified1 trial

A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation and Strength of Suzetrigine

Completed·Vertex Pharmaceuticals·Phase 1·NCT06336096·48 enrolled

Regulatory

FDA Approval Timeline[4]

Details

Drug Info

Patent Landscape[5]

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