VivoSeq
Other

Overdose

22

Pipeline Programs↗

4

Active Trials↗

9

Companies Involved↗

Overdose is an emerging landscape with 22 programs across 9 companies. The most active players are Egetis Therapeutics, Novartis, Arbor Pharmaceuticals, Inc.. 4 therapies are approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

48/100

Pipeline Velocity

11/100

Mech. Concentration

17/100

Completion Rate

73/100

Attrition Rate

17/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

E

Egetis Therapeutics

1 program

Phase 1Novartis logo

Novartis

1 program

Phase 1A

Arbor Pharmaceuticals, Inc.

1 program

Phase 1I

InterveXion Therapeutics, LLC

1 program

Phase 2S

Sinew Pharma Inc.

1 program

Phase 2S

Scienture

1 program

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

96%

Small molecule

23 of 24 classified programs — the dominant modality here.

4%ALL OTHERSProtein / enzyme14%

Small molecule leads; the ring shows all 24 classified programs, each share of the total. Modality classified for 100% of 24 pipeline programs.

Analysis

Trial Status

18

clinical trials

Completed8 · 44%
Recruiting4 · 22%
Terminated3 · 17%
Unknown status3 · 17%

Clinical Trials

Trial Activity

18 trials

To Evaluate the Efficacy and Safety of TYNADOTE® in the Treatment of Acetaminophen Overdose
Recruiting·SSinew Pharma Inc.·Phase 2·NCT05557448·24 enrolled
Naltrexone for Overdose Prevention
Recruiting·UUniversity of California, San Francisco·Phase 2/3·NCT06633900·100 enrolled
A Universal Primary Care Based Pilot Intervention to Reduce Youth Overdose Risk
Recruiting·BBoston Medical Center·Preclinical·NCT07022717·24 enrolled
Kentucky Women's Justice Community Overdose Innovation Network - Phase II
Recruiting·—·Preclinical·NCT07179614·300 enrolled
PP100-01 (Calmangafodipir) for Overdose of Paracetamol
Completed·EEgetis Therapeutics·Phase 1·NCT03177395·24 enrolled
An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses
Completed·JJohns Hopkins Bloomberg School of Public Health·N/A·NCT04212364·614 enrolled
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
Completed·UUniversity of Cincinnati·N/A·NCT02922959·80 enrolled
Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose
Completed·IIsfahan University of Medical Sciences·Phase 2·NCT01293058·100 enrolled
Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate
Completed·National Cancer Institute (NCI)·N/A·NCT00018967·10 enrolled
Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose
Completed·UUniversity of Aarhus·Phase 1·NCT03679442·16 enrolled
Project OOPEN: Opioid Overdose Prevention, Education and Intervention
Completed·UUniversity of Washington·Phase 4·NCT01788306·256 enrolled
Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the Hospital
Completed·NNorwegian University of Science and Technology·Phase 3·NCT03518021·286 enrolled
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
Terminated·—·Phase 2·NCT05517668·29 enrolled
Virginia Opioid Overdose Treatment InitiatVE
Terminated·VVirginia Commonwealth University·Phase 3·NCT03818399·19 enrolled
Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose
Terminated·IInterveXion Therapeutics, LLC·Phase 2·NCT04715230·20 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)