VivoSeq
Neurology

Post-Operative Delirium

17

Pipeline Programs↗

4

Active Trials↗

11

Companies Involved↗

Post-Operative Delirium is an emerging landscape with 17 programs across 11 companies. The most active players are Takeda, Eisai, Xenon Pharmaceuticals Inc.. 5 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

45/100

Pipeline Velocity

15/100

Mech. Concentration

27/100

Completion Rate

89/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Takeda logo

Takeda

1 program

Phase 2Eisai logo

Eisai

1 program

Phase 2X

Xenon Pharmaceuticals Inc.

1 program

Phase 2Eli Lilly logo

Eli Lilly

1 program

Phase 2Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

ApprovedM

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

Approved

Pipeline

Programs by Phase

Analysis

Trial Status

13

clinical trials

Completed8 · 62%
Not yet recruiting3 · 23%
Terminated1 · 8%
Recruiting1 · 8%

Clinical Trials

Trial Activity

13 trials

Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery (PRECISION)
Recruiting·UUniversity Hospital, Basel, Switzerland·N/A·NCT05595954·500 enrolled
Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients
Not yet recruiting·UUniversity of British Columbia·Phase 2·NCT06648681·60 enrolled
Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial
Not yet recruiting·BBeijing Tiantan Hospital·Phase 2·NCT07695285·992 enrolled
A Dynamic Early Warning System for Postoperative Delirium After Cardiac Surgery Integrating EEG, Cerebral Oxygenation, Hemodynamic Physiology, and Clinical Risk Factors
Not yet recruiting·SSoutheast University, China·N/A·NCT07686900·200 enrolled
The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries
Completed·—·Phase 4·NCT07475156·100 enrolled
A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium
Completed·UUniversity of Colorado, Denver·Phase 3·NCT00865202·301 enrolled
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Completed·IIndiana University·Phase 4·NCT02213900·135 enrolled
Post-operative Haloperidol Versus Placebo for Prevention of Post-operative Delirium After Acute Hip Surgery
Completed·—·Phase 3·NCT00250237·220 enrolled
Ramelteon in the Prevention of Post-operative Delirium
Completed·JJohns Hopkins University·Phase 2·NCT02324153·80 enrolled
Rivastigmine Patch Effect on the Post-operative Delirium in Patients at Risk of Dementia.
Completed·—·Phase 4·NCT02413554·62 enrolled
Effect of Remimazolam Versus Propofol Anesthesia on Postoperative Delirium in Neurosurgical Patients: A Randomised, Controlled, Noninferiority Trial
Completed·SSamsung Medical Center·Preclinical·NCT06115031·696 enrolled
Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery：a Prospective, Multicenter, Randomized Controlled Trial
Completed·TTianjin Nankai Hospital·Preclinical·NCT03606941·1,100 enrolled
Namenda to Prevent Post-Operative Delirium
Terminated·UUniversity of Rochester·Phase 4·NCT00303433·30 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)