Ultane

(sevoflurane)

ApprovedSmall molecule

Sevoflurane is an inhaled anesthetic gas used to put patients to sleep during surgery and medical procedures. It helps keep patients unconscious and pain-free while doctors perform operations.[2] Ultane is currently approved and in use across 83 indications[4].[1]

Ultane is one of 1234 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

386

Total Trials

Active Trials

1,233

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Coronary Artery DiseaseApproved

Nephrogenic Diabetes InsipidusActive, not recruiting

Neuropathic PainActive, not recruiting

Cardiac ArrestActive, not recruiting

Ischemia Reperfusion InjuryApproved

Aortic CoarctationActive, not recruiting

Cerebral Arterial DiseaseApproved

Cerebral PalsyActive, not recruiting

HypoxemiaActive, not recruiting

Alcohol-Related DisordersApproved

Coronary Artery DiseaseApproved

Approved

Nephrogenic Diabetes InsipidusPreclinical

Active, not recruiting

Neuropathic PainApproved

Active, not recruiting

Cardiac ArrestPreclinical

Active, not recruiting

Ischemia Reperfusion InjuryApproved

Approved

Aortic CoarctationPhase 2

Active, not recruiting

Cerebral Arterial DiseaseApproved

Approved

Cerebral PalsyPreclinical

Active, not recruiting

HypoxemiaApproved

Active, not recruiting

Alcohol-Related DisordersApproved

Approved

Showing 10 of 73 indications

Competition

Competitive Landscape

2829 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Ultane

AbbVie

Approved

3 2

Halaven

Eisai

Preclinical

38 3

Tykerb

GSK

Preclinical

80 4

Adriamycin

GGynecologic Oncology Group

Preclinical

87 5

Avastin

BBio-Thera Solutions

Preclinical

153 6

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 7

Prolia

Amgen

Preclinical

14 8

Gemzar

GGynecologic Oncology Group

Preclinical

22 9

Blenoxane

Bristol-Myers Squibb

Preclinical

1 10

Voltaren

Novartis

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ANot yet recruiting

Laparoscopic Cholecystectomy

NCT07440758

Recruiting

Delirium

NCT04707794

Post-ApprovalRecruiting

Total Intravenous Anesthesia

NCT06779890

Q4 2026

N/ANot yet recruiting

Total Intravenous Anesthesia

NCT07271459

Phase 3Recruiting

Delirium

NCT06624592

Post-ApprovalRecruiting

Prognosis

NCT05663242

Clinical

Trials by Indication[1]

Sevoflurane24 trials

Interest of Using the Sevoflurane in the Prevention of Newborns Pain

Completed·AAssistance Publique Hopitaux De Marseille·Phase 2/3·NCT00420693·60 enrolled

Does Sevoflurane Cause Genomic Damage

Unknown status·JJubilee Mission Medical College and Research Institute·Phase 4·NCT03109119·30 enrolled

Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.

Completed·UUniversity of Chile·N/A·NCT03772054·16 enrolled

Show 21 more trials

Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00559468·52 enrolled

Sevoflurane Wash in Method Using Conventional Flows Versus Low Flows of 0.5L

Completed·—··NCT06209112·48 enrolled

Propofol Versus Sevoflurane During FESS

Unknown status·AAlgemeen Ziekenhuis Maria Middelares·Phase 4·NCT04619160·60 enrolled

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Completed·UUppsala University·Phase 4·NCT01975064·5,774 enrolled

Sevoflurane, Propofol and Desflurane on POD/POCD

Unknown status·SShanghai 10th People's Hospital··NCT03326960·300 enrolled

To Compare Effect of Sevoflurane Versus Desflurane on the Return of Swallowing Reflexes in the Elderly

Completed·UUniversity of Malaya·Phase 4·NCT01833676·51 enrolled

Tolerance to Sevoflurane in Children Undergoing Repeated Drug Exposure

Completed·UUniversity of Chile··NCT04188782·24 enrolled

Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium

Completed·MMaharashtra University of Health Sciences·Phase 4·NCT02785653·60 enrolled

Sevoflurane in Subarachnoidal Haemorrhage

Withdrawn·UUniversity of Zurich·Phase 2·NCT02946437

Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia

Completed·XXinqiao Hospital of Chongqing·Phase 4·NCT02931877·300 enrolled

Effect of Sevoflurane on Sweat Threshold in Children of Different Ages

Not yet recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·N/A·NCT07035782·100 enrolled

Sevoflurane and Success of External Cephalic Version (ECV)

Unknown status·KKing Saud University·Phase 4·NCT04346823·40 enrolled

The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries

Completed·UUniversity of Debrecen·Phase 4·NCT02054143·24 enrolled

A Study Comparing Sevoflurane and Propofol in Patients Undergoing Endobronchial Ultrasound Guided Needle Aspiration

Completed·SSaglik Bilimleri Universitesi··NCT07338578·102 enrolled

Low-Flow Desflurane vs Sevoflurane: Impact on Physiology and Recoveryand Recovery Profiles in Adult ENT Surgery

Completed·HHarran University·N/A·NCT07016308·40 enrolled

Sevoflurane and Hyperperfusion Syndrome

Unknown status·SSeoul National University Hospital·N/A·NCT02510586·152 enrolled

Propofol and Sevoflurane for Catheter-Related Bladder Discomfort

Completed·SSeoul National University Hospital·N/A·NCT02252445·82 enrolled

Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Completed·SSeoul National University Hospital·N/A·NCT02096224·108 enrolled

The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung

Completed·IInonu University·N/A·NCT04645316·72 enrolled

Propofol or Sevoflurane Anesthesia in Egyptian Patients

Completed·RRehab Werida·N/A·NCT05289349·44 enrolled

Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification

Completed·TTanta University··NCT03726580·600 enrolled

Delirium9 trials

Sevoflurane and Propofol Anesthesia on Postoperative Delirium

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT01995214·500 enrolled

Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia

Completed·UUniversity of British Columbia·N/A·NCT00885443·112 enrolled

Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

Recruiting·MMayo Clinic·Phase 3·NCT06624592·400 enrolled

Show 6 more trials

Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium

Unknown status·CCentre Clinical, France·N/A·NCT03705728·1,000 enrolled

Post Extubation Delirium and End-tidal Sevoflurane Concentration

Completed·—·N/A·NCT02489734·109 enrolled

Does Optimized General Anesthesia Care Reduce Postoperative Delirium?

Terminated·UUniversity of Missouri-Columbia·N/A·NCT02604459·145 enrolled

Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium

Completed·PPeking University First Hospital·N/A·NCT02662257·1,228 enrolled

Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Recruiting·SSir Ganga Ram Hospital··NCT04707794·270 enrolled

Comparison of Emergence Delirium: Remimazolam vs Sevoflurane Anesthesia

Unknown status·SSecond Affiliated Hospital of Wenzhou Medical University·Phase 4·NCT06214117·90 enrolled

Anesthesia9 trials

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

Terminated·SState University of New York at Buffalo·Phase 4·NCT02111447·6 enrolled

Impact of Anesthesia Maintenance Methods on Long-term Survival

Completed·PPeking University First Hospital·N/A·NCT02660411·1,228 enrolled

Effects of Anesthesia on Immunity in Cancer

Completed·MMeshalkin Research Institute of Pathology of Circulation·Phase 4·NCT03514550·20 enrolled

Show 6 more trials

EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia

Withdrawn·MMassachusetts General Hospital·Phase 1/2·NCT02429076

Effect of Anesthesia in Fracture Healing

Completed·—·Phase 4·NCT02621255·30 enrolled

Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02872389·90 enrolled

Ventilatory Effect on Speed of Anesthesia Under Various Inhaled Anesthetics

Completed·—·N/A·NCT01171833·36 enrolled

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

Completed·UUniversity of Turku·Phase 4·NCT02624401·160 enrolled

Minimal Flow Anesthesia and Infection Risk

Active, not recruiting·—·N/A·NCT07092046·140 enrolled

Total Intravenous Anesthesia7 trials

Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)

Completed·SSaglik Bilimleri Universitesi·N/A·NCT06558695·52 enrolled

Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers

Not yet recruiting·—·N/A·NCT07271459·40 enrolled

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Robotic-assisted Laparoscopic Radical Prostatectomy Under Sevoflurane, Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Completed·YYonsei University·N/A·NCT03539003·69 enrolled

Show 4 more trials

The Effect of Total Intravenous Anesthesia and Volatile Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Laparoscopic or Robotic Assisted Gastrectomy

Completed·YYonsei University·N/A·NCT04183296·136 enrolled

Total Intravenous Anesthesia in Sinus Surgery

Completed·OOchsner Health System·Phase 4·NCT02578862·72 enrolled

Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome

Recruiting·GGeorgia Tsaousi·Phase 4·NCT06779890·84 enrolled

Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors

Recruiting·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT05331911·500 enrolled

Agitation6 trials

Emergence Agitation Between Dexmedetomidine and Sevoflurane Anesthesia

Completed·—·N/A·NCT06482125·121 enrolled

Scalp Nerve Block on Emergence Agitation

Completed·—·Phase 4·NCT02428283·44 enrolled

Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery

Completed·—·Phase 4·NCT01878656·144 enrolled

Show 3 more trials

The Effects of Three Different Anesthetic Methods on Postoperative Agitation

Enrolling by invitation·IInonu University·N/A·NCT07304206·3 enrolled

Melatonin for Pediatric Emergence Agitation

Completed·MMenoufia University·Phase 4·NCT05223010·117 enrolled

Emergence Agitation Between Sevoflurane and Desflurane in Pediatric

Completed·PPrince of Songkla University·N/A·NCT01235143·136 enrolled

105 more indications

Concentration6 trials

Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram

Completed·HHuazhong University of Science and Technology·Phase 4·NCT01662622·31 enrolled

Automated Control of End-tidal Volatile Anesthetic Concentration

Completed·RRuhr University of Bochum·N/A·NCT02342509·63 enrolled

A Pilot Study to Investigate Plasma Bupivacaine Concentrations in Children Receiving Total Intravenous Anaesthesia and Caudal Analgesia

Completed·UUniversity of British Columbia·Phase 1/2·NCT01216007·30 enrolled

Show 3 more trials

Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children

Unknown status·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·N/A·NCT03595163·80 enrolled

Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

Unknown status·UUniversity of Zurich·Phase 4·NCT00526695·10 enrolled

Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses

Completed·SSeverance Hospital·N/A·NCT02440204·68 enrolled

Sedation5 trials

Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure

Completed·EEye & ENT Hospital of Fudan University·N/A·NCT05321160·116 enrolled

Sevoflurane- Safety in Long-term Sedation Procedures

Withdrawn·FF Javier Belda·Phase 3·NCT01802255

Comparison Between Two Types of Sedation for Elective Upper Endoscopy Procedures

Completed·UUniversity of Malaya·N/A·NCT04410211·30 enrolled

Show 2 more trials

Comparison of Sedation by Esketamine and Sevoflurane

Unknown status·EEye & ENT Hospital of Fudan University·Phase 4·NCT05011214·60 enrolled

Dexmedetomidine and Propofol for Pediatric MRI Sedation

Completed·MMedical College of Wisconsin·Phase 4·NCT03513757·40 enrolled

Tics5 trials

Inhaled Anesthetics and Myocardial Strain

Completed·UUnknown Sponsor·Phase 1·NCT03569085·26 enrolled

Effect of Anesthetics on Troponin I and С-reactive Protein

Completed·—·Phase 1·NCT05742789·255 enrolled

Role of Volatile Anesthetics for Hepatic Protection

Completed·UUniversity of Zurich·N/A·NCT00516711

Show 2 more trials

Comparison of Effect of Equi-MAC Anesthetics on PSI

Completed·KKangbuk Samsung Hospital·N/A·NCT03587779·74 enrolled

Anesthetics in Rhytidoplasty - A Comparison Study

Completed·MMercy Facial Plastic Surgery Center·N/A·NCT02410460·30 enrolled

Cardiac Surgery5 trials

Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery

Unknown status·MMansoura University·N/A·NCT04945694·80 enrolled

A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery

Unknown status·GGolden Jubilee National Hospital·Phase 4·NCT00244283·150 enrolled

Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery

Terminated·TTriemli Hospital·N/A·NCT02407626·2 enrolled

Show 2 more trials

The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery

Completed·—·Phase 1·NCT05695287·89 enrolled

The Research of the Effect of Sevoflurane on Brain-protection of Cardiac Surgery in Infants.

Unknown status·JJun Ma·N/A·NCT03366597·100 enrolled

Anesthesia Induction3 trials

Left Ventricular Diastolic Function During Anesthesia Induction

Completed·UUniversitätsklinikum Hamburg-Eppendorf··NCT03522194·200 enrolled

Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium

Completed·UUniversity of Rostock·N/A·NCT01591031·60 enrolled

Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction

Unknown status·HHenan Provincial People's Hospital·Phase 4·NCT02182648·120 enrolled

Nitrous Oxide3 trials

Evaluation of Impact of Nitrous Oxide on PONV in Breast Surgeries

Completed·TTata Memorial Hospital·N/A·NCT02736604·250 enrolled

Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG

Completed·HHuazhong University of Science and Technology·Phase 4·NCT01705743·76 enrolled

Global Warming Impact of Nitrous Oxide

Completed·SSir Ganga Ram Hospital·Phase 4·NCT05430750·102 enrolled

Coronary Artery Bypass3 trials

Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Completed·SSeoul National University Hospital·Phase 4·NCT03209193·72 enrolled

A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon

Completed·RRWTH Aachen University·Phase 3·NCT01285271·30 enrolled

Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery

Completed·AAir Liquide Santé International·Phase 3·NCT01294163·509 enrolled

General Anesthesia3 trials

The Effect of General Anesthesia on the Middle Ear Pressure

Completed·—·N/A·NCT03100604·50 enrolled

Glasgow Coma Scales and General Anesthesia

Completed·—·N/A·NCT03521414·45 enrolled

EEG Studies of Sevoflurane-Induced General Anesthesia

Completed·MMassachusetts General Hospital·Phase 2·NCT03503578·12 enrolled

Post Operative Cognitive Dysfunction2 trials

Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

Completed·SSun Yat-sen University·Phase 4·NCT01809041·684 enrolled

The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients

Completed·—·N/A·NCT06353516·154 enrolled

Laryngeal Mask Airway2 trials

Desflurane in Children With Laryngeal Mask Airway

Completed·SSeoul National University Hospital·N/A·NCT02470442·200 enrolled

Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia

Completed·RRWTH Aachen University·Phase 3·NCT02322502·352 enrolled

Oxidative Stress2 trials

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Unknown status·ZZhujiang Hospital·Phase 4·NCT02202239·60 enrolled

Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy

Recruiting·—·N/A·NCT07152912·80 enrolled

Analgesic2 trials

The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Completed·—·Phase 3·NCT03588429·90 enrolled

The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02698514·90 enrolled

Mitochondrial Disease2 trials

Anesthesia in Patients With Mitochondrial Disease

Terminated·TThe University of Texas Health Science Center, Houston·N/A·NCT02053766·19 enrolled

Anesthetic Effects in Mitochondrial Disease

Terminated·Dd sessler·N/A·NCT01001585·55 enrolled

Preconditioning2 trials

Continuous Versus Repetitive Sevoflurane Administration for Preconditioning

Completed·UUniversity Hospital Schleswig-Holstein·Phase 4·NCT00569816·50 enrolled

Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R

Withdrawn·NNegovsky Reanimatology Research Institute·Phase 4·NCT04287842

Ptosis2 trials

Anesthesia and Lymphocytes Apoptosis

Completed·RRuijin Hospital·N/A·NCT01461551·105 enrolled

Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol

Completed·UUniversity of Athens·N/A·NCT01000337·67 enrolled

Pediatric Anesthesia2 trials

Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia

Withdrawn·UUniversity Hospital, Geneva·N/A·NCT02683837

Bispectral Index to Guide Intubation in Pediatric Anesthesia

Completed·UUniversity of Liege·N/A·NCT02806596·60 enrolled

Remimazolam2 trials

Remimazolam Phase II Cardiac Anesthesia Study

Completed·PPaion UK Ltd.·Phase 2·NCT01937767·90 enrolled

Comparison of the Effect of Remimazolam With Sevoflurane on Postanesthetic Shivering

Completed·WWonkwang University Hospital··NCT05523037·74 enrolled

Inflammation2 trials

Inflammation After One Lung Ventilation

Completed·UUniversity Medical Centre Ljubljana·Phase 1·NCT02188407·40 enrolled

Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT02166853·50 enrolled

Neuromuscular Block2 trials

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

Completed·UUniversity of California, San Francisco·Phase 4·NCT01199237·107 enrolled

Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.

Completed·AAZ Sint-Jan AV·Phase 4·NCT01930747·50 enrolled

Intravenous2 trials

The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep

Completed·YYanchao Yang·N/A·NCT04123249·74 enrolled

Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00988520·38 enrolled

Intravenous Anesthesia2 trials

Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study

Recruiting·UUniversity of Kansas Medical Center·Phase 2·NCT06017141·80 enrolled

Effects of Intravenous Anesthesia and Balanced Anesthesia on Flash Visual Evoked Potentials

Unknown status·—·N/A·NCT04725032·84 enrolled

Aesthetic2 trials

A Study to Compare the Long-term Outcomes After Two Different Anaesthetics

Active, not recruiting·MMurdoch Childrens Research Institute·Phase 3·NCT03089905·450 enrolled

Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery

Completed·UUniversity Medical Centre Ljubljana·Phase 1·NCT02229201·40 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Colonoscopy1 trial

Inhaled Sevofluran vs Endovenous Propofol for Colonoscopy

Completed·CCentro Medico Docente la Trinidad·N/A·NCT03818048·32 enrolled

Strabismus1 trial

Effect of Dexmedetomedine in Subtenon's Block on Emergence Agitation in Pediatric Strabismus Surgery

Completed·SSameh Fathy·N/A·NCT04485273·100 enrolled

PONV1 trial

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

Completed·—·Phase 4·NCT02809378·150 enrolled

Unknown status·UUniversity of Patras·Phase 2/3·NCT01279499·100 enrolled

Hysterectomy1 trial

Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

Recruiting·TTanta University·N/A·NCT07062367·90 enrolled

Drug1 trial

Modeling and Application of Triple Drug Response Surface Models

Completed·TTaipei Veterans General Hospital, Taiwan··NCT03813875·100 enrolled

Propofol1 trial

Effects of Propofol on Early Recovery of Hunger After Surgery

Completed·UUniversity Hospital, Rouen·Phase 4·NCT02272166·116 enrolled

Cerebral Palsy1 trial

Popliteal Block for Postoperative Pain in Knee-ankle Soft Tissue Surgery in Cerebral Palsy

Completed·—·N/A·NCT02507700·60 enrolled

Nausea and vomiting1 trial

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Atrial Fibrillation1 trial

Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Completed·MMedical University of South Carolina·N/A·NCT02697448·135 enrolled

Digestive Cancer1 trial

Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery

Unknown status·IIuliu Hatieganu University of Medicine and Pharmacy·Phase 1·NCT04162535·40 enrolled

Liver Transplant1 trial

Anaesthetic and Pediatric Living Related Liver Transplantation

Unknown status·TTianjin First Central Hospital·N/A·NCT03024840·60 enrolled

Quality of Recovery1 trial

Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery in Obese Patients

Withdrawn·JJiangang Song·N/A·NCT05529875

Magnetic Resonance Imaging1 trial

Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging

Completed·—·N/A·NCT06832683·230 enrolled

Down syndrome1 trial

The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients

Completed·—·Phase 2·NCT02971254·39 enrolled

Conditioning1 trial

Organ Protection With Sevoflurane Postconditioning

Completed·UUniversity of Zurich·N/A·NCT00518908·125 enrolled

Hemodynamic Response1 trial

The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy

Unknown status·IInonu University·Phase 4·NCT02271555·58 enrolled

Prostate Cancer1 trial

Prothrombotic Factors and Anaesthesia in Prostate Cancer

Completed·RRegina Elena Cancer Institute·N/A·NCT01998685·200 enrolled

Sepsis1 trial

Effects of Subanesthetic Isoflurane/Sevoflurane in 60% Oxygen on Clinical In-vitro Experimental Sepsis

Unknown status·—·N/A·NCT02185118·50 enrolled

Biliary Atresia1 trial

Biliary Atresia, Hepatic Buffer Response and Sevoflurane

Completed·—··NCT02471209·25 enrolled

Lumbar Erector Spinae Plane Block1 trial

Lumbar Erector Spinae Plane Block for Back Surgery

Unknown status·DDr M. B. Breebaart·Phase 3·NCT03825198·80 enrolled

Outcome1 trial

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial

Terminated·PPeter MacCallum Cancer Centre, Australia·Phase 3·NCT04316013·254 enrolled

Intraoperative1 trial

NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane

Completed·CCiusss de L'Est de l'Île de Montréal·Phase 4·NCT04567160·60 enrolled

Nephrectomy1 trial

A Comparison of Kidney Function After Nephrectomy in Living Donors Under Sevoflurane and Desflurane Anesthesia

Completed·YYonsei University··NCT01549990·236 enrolled

Erector Spinae Block1 trial

Ultrasound Guided Erector Spinae Block vs Thoracolumbar Interfascial Plane Block

Completed·TTanta University·N/A·NCT05596227·180 enrolled

COVID-191 trial

Sevoflurane in COVID-19 ARDS (SevCov)

Completed·UUniversity of Zurich·Phase 3·NCT04355962·68 enrolled

Intelligence1 trial

Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in Children

Active, not recruiting·SSeoul National University Hospital·N/A·NCT04364945·400 enrolled

Acute Respiratory Distress Syndrome1 trial

Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection

Terminated·FFundación para la Investigación del Hospital Clínico de Valencia·Phase 4·NCT04359862·19 enrolled

Suprascapular Nerve Block1 trial

Postoperative Analgesia of Magnesium Sulfate in Suprascapular Nerve Block Following Shoulder Arthroscopy

Unknown status·MMansoura University·N/A·NCT03602469·60 enrolled

Cardiopulmonary Bypass1 trial

Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

Completed·UUniversity of Zurich·N/A·NCT00924222·120 enrolled

Myocardial Protection1 trial

Myocardial Protection and Anesthetic Agents

Completed·—·Phase 4·NCT02405689·60 enrolled

Postoperative Recovery1 trial

Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery

Completed·PPeking Union Medical College Hospital·Phase 4·NCT05822817·252 enrolled

Efficacy1 trial

Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00984633·40 enrolled

Inguinal hernia1 trial

Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial

Unknown status·TTanta University·N/A·NCT05442905·60 enrolled

Elderly Patients1 trial

Remifentanil for Smooth Emergence in Elderly Patients

Completed·—·Phase 4·NCT02334046·47 enrolled

Breast Cancer1 trial

Anesthesia and Circulating Tumor Cells in Breast Cancer

Completed·UUniversity of Zurich·Phase 4·NCT02005770·221 enrolled

Endovascular Thrombectomy1 trial

General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

Completed·UUniversity of Saskatchewan··NCT02639806·34 enrolled

Knee Arthroplasty1 trial

Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane

Completed·UUniversity of Sao Paulo General Hospital·N/A·NCT03379103·30 enrolled

Pulmonary Function1 trial

Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Unknown status·IIstanbul University·N/A·NCT02709863·90 enrolled

Respiratory Depression1 trial

Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy

Completed·UUniversity of Saskatchewan·Phase 3·NCT02987985·50 enrolled

Laryngoscopy1 trial

Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique

Completed·—·Phase 4·NCT05019560·50 enrolled

Ketorolac1 trial

Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Completed·—·Phase 1·NCT02973958·30 enrolled

Mitral Valve Repair1 trial

Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair

Completed·HHeidelberg University··NCT04865614·57 enrolled

General Anesthetics1 trial

The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children

Unknown status·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University··NCT03746340·40 enrolled

Complication1 trial

The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia

Unknown status·—·Phase 4·NCT03006250·220 enrolled

Postoperative Quality of Recovery1 trial

Postoperative Quality of Recovery After Transurethral Resection of the Bladder

Unknown status·—·N/A·NCT02534623·70 enrolled

Arteriosclerosis Obliterans1 trial

Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Completed·TTao Zhang·Phase 4·NCT02107170·68 enrolled

Thoracic Surgery1 trial

Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic Surgery

Completed·—·N/A·NCT02217319·100 enrolled

Post Operative Pain1 trial

Sevoflurane, Propofol, Postoperative Pain

Completed·TTampere University Hospital·Phase 4·NCT01437462·168 enrolled

Hemodynamic1 trial

Hemodynamics for Equi-MAC Anesthesia

Completed·KKangbuk Samsung Hospital·N/A·NCT03570164·70 enrolled

Dexmedetomidine1 trial

Dexmedetomidine Versus Sevoflurane in Children With Anticipated Difficult Intubation

Unknown status·—·Phase 2·NCT04426552·40 enrolled

Cataract1 trial

Impact of Different Modes of Ventilation With Laryngeal Mask Airway on Pediatric Cataract Surgery

Completed·SSameh Fathy·N/A·NCT04241653·150 enrolled

Randomized Controlled Trial1 trial

Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery

Completed·GGZA Ziekenhuizen Campus Sint-Augustinus·Phase 4·NCT02544282·140 enrolled

Hepatic Function1 trial

Effect of Desflurane Versus Sevoflurane With Recent Bio-markers on Renal and Hepatic Functions

Completed·TTheodor Bilharz Research Institute··NCT05027191·70 enrolled

Retinopathy of Prematurity1 trial

Anesthesia for Retinopathy of Prematurity

Completed·TTC Erciyes University·Phase 4·NCT01955135·60 enrolled

Postoperative Sleep Quality1 trial

Postoperative Sleep Quality of Patients Anesthesia With Propofol or Sevoflurane Undergoing Thyroidectomy

Completed·—·Phase 4·NCT02146976·124 enrolled

Hypotensive Anesthesia1 trial

Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation

Unknown status·MMansoura University·N/A·NCT05241054·64 enrolled

Postoperative Cognitive Dysfunction (POCD)1 trial

Dexmedetomidine and Postoperative Cognitive Dysfunction (POCD)

Completed·UUdayana University·Phase 4·NCT06371638·112 enrolled

Cancer1 trial

Anesthetic Effect on Immune Cell in Patients With Cancer

Completed·KKonkuk University Medical Center·N/A·NCT02758249·47 enrolled

Post Operative Sore Throat1 trial

Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

Unknown status·KKeimyung University Dongsan Medical Center·N/A·NCT03259672·100 enrolled

Depth of Anesthesia1 trial

End Tidal Anesthetic Concentration in Different Anesthesia Techniques Where Depth of Anesthesia Adjusted With Entropy

Completed·IIstanbul University·N/A·NCT04203290·44 enrolled

Nephrogenic Diabetes Insipidus1 trial

Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the ICU: a Retrospective Analysis

Completed·UUniversitair Ziekenhuis Brussel··NCT04939753·1,000 enrolled

Intraocular Pressure1 trial

Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery

Completed·—·N/A·NCT07033442·60 enrolled

Perioperative Period1 trial

The Effect of Sevoflurane on Airway Hyperreactivity During the Perioperative Period.

Completed·FFirst Hospital of China Medical University··NCT06694675·97 enrolled

Mechanical Ventilation1 trial

Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery

Recruiting·NNational and Kapodistrian University of Athens·N/A·NCT07304479·50 enrolled

Cardiac1 trial

Volatile Anesthetics in Cardiac Protection

Completed·UUniversità Vita-Salute San Raffaele·Phase 4·NCT00364637

MPA1 trial

Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients

Terminated·MMoscow Regional Research and Clinical Institute (MONIKI)·Phase 4·NCT02686710·10 enrolled

Aortic Coarctation1 trial

Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study

Completed·UUniversity Hospital, Ghent·Phase 2·NCT00535808·30 enrolled

Low Flow Anesthesia1 trial

1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia

Completed·KKhon Kaen University·N/A·NCT03510013·100 enrolled

Lung Cancer1 trial

Effect of Different Anesthetics on the Change of Alarmins in Lung Cancer Patients Receiving Pulmonary Lobectomy

Unknown status·TTianjin Medical University Cancer Institute and Hospital·N/A·NCT02916147·40 enrolled

Colon Cancer1 trial

Anesthesia and Cancer Study: Colon Cancer

Active, not recruiting·SSeoul National University Hospital·N/A·NCT04259398·797 enrolled

Percutaneous Coronary Intervention1 trial

Sevoflurane and Percutaneous Coronary Intervention by Stent

Terminated·IInstituto Dante Pazzanese de Cardiologia·Phase 4·NCT02671084·701 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation

Terminated·UUniversity Hospital, Montpellier·N/A·NCT03460015·16 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Remimazolam in OPCAB Surgery

Unknown status·—·N/A·NCT05396690·94 enrolled

Ultrasound1 trial

Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block

Unknown status·TTanta University·N/A·NCT05543109·85 enrolled

Aortic Valve Replacement1 trial

Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults

Completed·—·Phase 3·NCT05696509·75 enrolled

Laparoscopic Cholecystectomy1 trial

Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy

Not yet recruiting·KKayseri City Hospital·N/A·NCT07440758·70 enrolled

Brain Tumor1 trial

Influences of Propofol and Sevoflurane Anesthesia in Brain Tumor

Unknown status·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT05141877·706 enrolled

Total Knee Replacement1 trial

Total Knee Replacement TIVA With Robotic Arm Assisted

Unknown status·TThe University of Hong Kong·Phase 4·NCT04002271·180 enrolled

Unspecified2 trials

Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia

Completed·—·N/A·NCT03816072·66 enrolled

Anesthetic Techniques in EP Patients

Terminated·UUniversity of California, Los Angeles·Phase 4·NCT02664922·35 enrolled

Regulatory

FDA Approval Timeline[5]

Jun 7, 1995

ULTANE

NDA NDA020478

Sources

References

[1]
ClinicalTrials.gov — 386 trial records for sevoflurane. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ultane drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — sevoflurane compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for sevoflurane. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020478). U.S. Food & Drug Administration.
[6]
SEC EDGAR — AbbVie company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glycine Receptor (alpha-1/beta) Positive Modulator; Potassium Channel Subfamily K Member 10 Opener; Potassium Channel Subfamily K Member 18 Opener; Potassium Channel Subfamily K Member 2 Opener; Potassium Channel Subfamily K Member 3 Opener; Potassium Channel Subfamily K Member 9 Opener; GABA-a Receptor; Anion Channel Positive Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AbbVie

Ultane

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Sevoflurane24 trials

Delirium9 trials

Anesthesia9 trials

Total Intravenous Anesthesia7 trials

Agitation6 trials

Concentration6 trials

Sedation5 trials

Tics5 trials

Cardiac Surgery5 trials

Anesthesia Induction3 trials

Nitrous Oxide3 trials

Coronary Artery Bypass3 trials

General Anesthesia3 trials

Post Operative Cognitive Dysfunction2 trials

Laryngeal Mask Airway2 trials

Oxidative Stress2 trials

Analgesic2 trials

Mitochondrial Disease2 trials

Preconditioning2 trials

Ptosis2 trials

Pediatric Anesthesia2 trials

Remimazolam2 trials

Inflammation2 trials

Neuromuscular Block2 trials

Intravenous2 trials

Intravenous Anesthesia2 trials

Aesthetic2 trials

Shoulder Arthroplasty1 trial

Colonoscopy1 trial

Strabismus1 trial

PONV1 trial

Botulinum Toxin1 trial

Prognosis1 trial

Obese Patients1 trial

Hysterectomy1 trial

Drug1 trial

Propofol1 trial

Cerebral Palsy1 trial

Nausea and vomiting1 trial

Atrial Fibrillation1 trial

Digestive Cancer1 trial

Liver Transplant1 trial

Quality of Recovery1 trial

Magnetic Resonance Imaging1 trial

Down syndrome1 trial

Conditioning1 trial

Hemodynamic Response1 trial

Prostate Cancer1 trial

Sepsis1 trial

Biliary Atresia1 trial

Lumbar Erector Spinae Plane Block1 trial

Outcome1 trial

Intraoperative1 trial

Nephrectomy1 trial

Erector Spinae Block1 trial

COVID-191 trial

Intelligence1 trial

Acute Respiratory Distress Syndrome1 trial

Suprascapular Nerve Block1 trial

Cardiopulmonary Bypass1 trial

Myocardial Protection1 trial

Postoperative Recovery1 trial

Efficacy1 trial

Inguinal hernia1 trial

Elderly Patients1 trial

Breast Cancer1 trial

Endovascular Thrombectomy1 trial

Knee Arthroplasty1 trial

Pulmonary Function1 trial

Respiratory Depression1 trial

Laryngoscopy1 trial

Ketorolac1 trial

Mitral Valve Repair1 trial