Ultane

(sevoflurane)

ApprovedSmall molecule

Sevoflurane is an inhaled anesthetic gas used to put patients to sleep during surgery and medical procedures. It helps keep patients unconscious and pain-free while doctors perform operations.[2] Ultane is currently approved and in use across 79 indications[4].[1]

Ultane is one of 1057 small molecule programs targeting Agitation. It is currently in Approved.

Indications

390

Total Trials

Active Trials

1,056

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

HypotensionUnknown status

Cesarean SectionUnknown status

DeliriumUnknown status

Neuropathic PainActive, not recruiting

HypoxemiaActive, not recruiting

Abdominal Aortic AneurysmActive, not recruiting

Liver TransplantActive, not recruiting

Drug DependenceApproved

Coronary Artery DiseaseApproved

Cerebral Arterial DiseaseApproved

HypotensionApproved

Unknown status

Cesarean SectionApproved

Unknown status

DeliriumApproved

Unknown status

Neuropathic PainApproved

Active, not recruiting

HypoxemiaApproved

Active, not recruiting

Abdominal Aortic AneurysmApproved

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

Drug DependenceApproved

Approved

Coronary Artery DiseaseApproved

Approved

Cerebral Arterial DiseaseApproved

Approved

Showing 10 of 71 indications

Competition

Competitive Landscape

348 competitors in Prostate Cancer

#DrugCompanyPhaseTrials

Zoladex

TTerSera Therapeutics LLC

Phase 3

35 2

Ultane

AbbVie

Approved

1 3

Talzenna

Pfizer

Phase 3

9 4

Tecentriq

Roche

Phase 3

8 5

Truqap

AstraZeneca

Phase 3

2 6

LHRH Agonist

Roche

Phase 3

10 7

Xaluritamig

Amgen

Phase 3

4 8

Lutetium Lu-177 PNT2002

JJonsson Comprehensive Cancer Center

Phase 3

4 9

Lhrha

Johnson & Johnson

Phase 3

2 10

Luteinizing Hormone Releasing Hormone

UUS Department of Veterans Affairs

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Total Intravenous Anesthesia

NCT06779890

Q4 2026

Phase 3Recruiting

Delirium

NCT06624592

Post-ApprovalRecruiting

Prognosis

NCT05663242

Q1 2027

N/ARecruiting

Hysterectomy

NCT07062367

Post-ApprovalRecruiting

Inhalational Anesthesia

NCT06036095

Q2 2028

N/ARecruiting

Breast Cancer

NCT04800393

Clinical

Trials by Indication[1]

Sevoflurane26 trials

Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers

Completed·TTechnical University of Munich·Phase 1·NCT02149927·20 enrolled

Propofol and Sevoflurane for Catheter-Related Bladder Discomfort

Completed·SSeoul National University Hospital·N/A·NCT02252445·82 enrolled

Propofol Versus Sevoflurane Recovery After Gynecological Surgery

Completed·NNorthwestern University·Phase 4·NCT01755234·90 enrolled

Show 23 more trials

The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung

Completed·IInonu University·N/A·NCT04645316·72 enrolled

Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification

Completed·TTanta University··NCT03726580·600 enrolled

Desflurane and Sevoflurane in Pediatrics With Elevated Liver Enzymes

Unknown status·NNational Cancer Institute, Egypt·N/A·NCT04775212·60 enrolled

Early Cardioprotective Effect of Sevoflurane

Completed·UUniversity Hospital Dubrava·Phase 4·NCT00477737·32 enrolled

Low-Flow Desflurane vs Sevoflurane: Impact on Physiology and Recoveryand Recovery Profiles in Adult ENT Surgery

Completed·HHarran University·N/A·NCT07016308·40 enrolled

Comparison of Sevoflurane and Propofol on ANI

Not yet recruiting·PPusan National University Yangsan Hospital·N/A·NCT06907823·30 enrolled

Analysis of Cisatracurium Consumption in Balanced Anesthesia With 1% Sevoflurane, and With Only Sevoflurane, Using a Closed-loop Computer Controlled System Infusion.

Completed·TTianjin Medical University General Hospital·N/A·NCT01736371·156 enrolled

Effects of Sevoflurane and Desflurane on Treg

Completed·MMahidol University·Phase 2·NCT02559297·40 enrolled

Sevoflurane and Hyperperfusion Syndrome

Unknown status·SSeoul National University Hospital·N/A·NCT02510586·152 enrolled

Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery

Completed·OOhio State University·Phase 3·NCT01219881·75 enrolled

Interest of Using the Sevoflurane in the Prevention of Newborns Pain

Completed·AAssistance Publique Hopitaux De Marseille·Phase 2/3·NCT00420693·60 enrolled

Blood Levels of Sevoflurane and Desflurane

Completed·—··NCT03015350·16 enrolled

Comparison the Effects of Etomidate and Sevoflurane During Electroconvulsive Therapy

Completed·IInonu University·Phase 4·NCT02500225·25 enrolled

Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia

Completed·XXinqiao Hospital of Chongqing·Phase 4·NCT02931877·300 enrolled

Sevoflurane and Success of External Cephalic Version (ECV)

Unknown status·KKing Saud University·Phase 4·NCT04346823·40 enrolled

The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries

Completed·UUniversity of Debrecen·Phase 4·NCT02054143·24 enrolled

Effect of Sevoflurane on Sweat Threshold in Children of Different Ages

Not yet recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·N/A·NCT07035782·100 enrolled

Effect of Head Position on MACEI of Sevoflurane in Children With Obstructive Airway

Unknown status·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·N/A·NCT03522402·38 enrolled

The Effect of Propofol or Sevoflurane on Renal Function

Completed·UUppsala University·Phase 4·NCT03336801·37 enrolled

Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Completed·RRutgers, The State University of New Jersey··NCT01219569·35 enrolled

Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapy

Completed·IInonu University·Phase 4·NCT01870219·24 enrolled

Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

Completed·CChina International Neuroscience Institution·Phase 3·NCT03841812·146 enrolled

Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS

Unknown status·—·Phase 3·NCT04530188·68 enrolled

Delirium10 trials

Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Recruiting·SSir Ganga Ram Hospital··NCT04707794·270 enrolled

Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

Withdrawn·MMoscow Regional Research and Clinical Institute (MONIKI)·Phase 4·NCT02394418

Researching the Affect of Sevoflurane in Cardiac Surgery on Delirium

Unknown status·—··NCT05365165·2 enrolled

Show 7 more trials

Epigenetics in PostOperative Pediatric Emergence Delirium

Completed·UUniversity of Sao Paulo·N/A·NCT03787849·175 enrolled

Does Optimized General Anesthesia Care Reduce Postoperative Delirium?

Terminated·UUniversity of Missouri-Columbia·N/A·NCT02604459·145 enrolled

Sevoflurane and Propofol Anesthesia on Postoperative Delirium

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT01995214·500 enrolled

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Recruiting·MMedical University of Vienna·Phase 4·NCT05990790·1,332 enrolled

Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

Recruiting·MMayo Clinic·Phase 3·NCT06624592·400 enrolled

Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium

Unknown status·CCentre Clinical, France·N/A·NCT03705728·1,000 enrolled

Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients

Recruiting·WWest China Hospital·N/A·NCT06176144·890 enrolled

Total Intravenous Anesthesia7 trials

The Effect of Total Intravenous Anesthesia and Volatile Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Laparoscopic or Robotic Assisted Gastrectomy

Completed·YYonsei University·N/A·NCT04183296·136 enrolled

Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery

Completed·TTaichung Veterans General Hospital·N/A·NCT03263078·78 enrolled

Comparison of Optic Nerve Sheath Diameter in Children Receiving Caudal Block According to Anesthetic Agents: Total Intravenous Anesthesia vs. Volatile Anesthesia

Completed·YYonsei University·N/A·NCT04415905·60 enrolled

Show 4 more trials

Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery

Unknown status·CCoordinación de Investigación en Salud, Mexico··NCT03233815·40 enrolled

Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)

Completed·SSaglik Bilimleri Universitesi·N/A·NCT06558695·52 enrolled

Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome

Recruiting·GGeorgia Tsaousi·Phase 4·NCT06779890·84 enrolled

Total Intravenous Anesthesia in Sinus Surgery

Completed·OOchsner Health System·Phase 4·NCT02578862·72 enrolled

Cardiac Surgery7 trials

Influence of Anesthetics on Clinical Outcome During Cardiac Surgery in Adults

Completed·—·N/A·NCT05693428·90 enrolled

Comparison of the Effects of Sevoflurane and Midazolam Used for the Maintenance of Anaesthesia on the Levels of Postoperative Cardiac Troponin I in Pediatric Cardiac Surgery

Unknown status·—·Phase 4·NCT01548859·50 enrolled

The Protective Effects of Sevoflurane in Pediatric Cardiac Surgery

Unknown status·XXijing Hospital·N/A·NCT01450956·100 enrolled

Show 4 more trials

A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery

Unknown status·GGolden Jubilee National Hospital·Phase 4·NCT00244283·150 enrolled

SIRS in Cyanotic and Acyanotic Children in Cardiac Surgery

Completed·—··NCT04254744·197 enrolled

Sevoflurane in Cardiac Surgery

Completed·UUniversità Vita-Salute San Raffaele·Phase 4·NCT00821262·200 enrolled

Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery

Terminated·TTriemli Hospital·N/A·NCT02407626·2 enrolled

Anesthesia6 trials

Effect of Anesthesia in Fracture Healing

Completed·—·Phase 4·NCT02621255·30 enrolled

Differences in Speed of Recovery From Anesthesia for Intraoral Surgery

Recruiting·—·N/A·NCT06275087·42 enrolled

Minimal Flow Anesthesia and Infection Risk

Active, not recruiting·—·N/A·NCT07092046·140 enrolled

Show 3 more trials

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

Completed·UUniversity of Turku·Phase 4·NCT02624401·160 enrolled

EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia

Withdrawn·MMassachusetts General Hospital·Phase 1/2·NCT02429076

Evaluation of Different Anesthesia for Uterine Curettage

Completed·NNanjing Medical University·N/A·NCT00733564·150 enrolled

108 more indications

General Anesthesia5 trials

Long-term Outcome of General Anesthesia on Dysgnosia

Unknown status·NNanjing Medical University·Phase 4·NCT01184638·10,000 enrolled

This Study Evaluated the Safety of Awake Extubation in Children at Risk for Respiratory Events Undergoing General Anesthesia.

Completed·SSelcuk University··NCT06936761·425 enrolled

The Effects of General Anesthesia on Microcirculation of Central and Peripheral Soft Tissue: a Comparison of Inhalational and Intravenous Anesthetics

Unknown status·NNational Taiwan University Hospital·N/A·NCT02530632·100 enrolled

Show 2 more trials

Glasgow Coma Scales and General Anesthesia

Completed·—·N/A·NCT03521414·45 enrolled

The Effect of General Anesthesia on the Middle Ear Pressure

Completed·—·N/A·NCT03100604·50 enrolled

Sedation4 trials

A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI

Completed·—·N/A·NCT06606899·60 enrolled

Dexmedetomidine and Propofol for Pediatric MRI Sedation

Completed·MMedical College of Wisconsin·Phase 4·NCT03513757·40 enrolled

Comparison Between Sevoflurane and Propofol for Maintenance of Sedation During ERCP

Completed·SSindh Institute of Urology and Transplantation·Phase 4·NCT05996588·86 enrolled

Show 1 more trial

Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation

Completed·RRuhr University of Bochum·N/A·NCT03860129·30 enrolled

Concentration4 trials

Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses

Completed·SSeverance Hospital·N/A·NCT02440204·68 enrolled

Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

Unknown status·UUniversity of Zurich·Phase 4·NCT00526695·10 enrolled

Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram

Completed·HHuazhong University of Science and Technology·Phase 4·NCT01662622·31 enrolled

Show 1 more trial

Automated Control of End-tidal Volatile Anesthetic Concentration

Completed·RRuhr University of Bochum·N/A·NCT02342509·63 enrolled

Oxidative Stress3 trials

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Unknown status·ZZhujiang Hospital·Phase 4·NCT02202239·60 enrolled

Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy

Recruiting·—·N/A·NCT07152912·80 enrolled

Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

Completed·TThe Third Central Clinical College of Tianjin Medical University·Phase 4·NCT02691416·60 enrolled

Liver Transplant3 trials

Anaesthetic and Pediatric Living Related Liver Transplantation

Unknown status·TTianjin First Central Hospital·N/A·NCT03024840·60 enrolled

The Effect of Inhalation Agent on the QTc Interval During Liver Transplantation: Sub Study (NCT01886664)

Completed·SSeoul National University Hospital··NCT01899248·52 enrolled

Conditioning With Volatile Anesthetics in Liver Transplantation

Completed·UUniversity of Zurich·N/A·NCT00913276·98 enrolled

Post Operative Pain3 trials

The Influence of Type of Anesthesia on Postoperative Pain

Unknown status·SSeoul National University Hospital·N/A·NCT04239794·468 enrolled

Propofol Versus Volatile Anesthesia in Post Operative Pain Management

Terminated·TThe Cleveland Clinic·N/A·NCT00712517·90 enrolled

Effects of TIVA With Propofol Versus Inhalational Anaesthesia on Postoperative Pain After Hepatectomy

Completed·TThe University of Hong Kong·Phase 4·NCT03597997·90 enrolled

Cardiopulmonary Bypass2 trials

Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

Completed·UUniversity of Zurich·N/A·NCT00924222·120 enrolled

Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit)

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT01601795·30 enrolled

Cesarean Section2 trials

Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section

Unknown status·TTao Zhang·Phase 4·NCT03149588·60 enrolled

The Effects of Different Anesthetic Techniques on QT, Corrected QT (QTc), and P Wave Dispersions in Cesarean Section

Completed·—·Phase 4·NCT03134677·90 enrolled

Nausea and vomiting2 trials

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia

Completed·RRWTH Aachen University·Phase 4·NCT00793663·220 enrolled

Intraocular Pressure2 trials

The Effect of Different Sevoflurane Concentrations on Intraocular Pressure in Patients Undergoing Ocular Surgery Under General Anesthesia

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01575626·30 enrolled

Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery

Completed·—·N/A·NCT07033442·60 enrolled

Intravenous2 trials

Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00988520·38 enrolled

The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep

Completed·YYanchao Yang·N/A·NCT04123249·74 enrolled

General Anesthetics2 trials

The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects

Completed·MMassachusetts General Hospital·Phase 4·NCT01557920·18 enrolled

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

Recruiting·PPeking University First Hospital··NCT05210764·366 enrolled

Breast Cancer2 trials

The Impact of Inhalation vs Total Intravenous Anesthesia on the Immune Status and Mortality in Patients Undergoing Breast Cancer Surgery: a Prospective Double-Blind Randomized Clinical Trial.

Recruiting·MMoscow Clinical Scientific Center·N/A·NCT04800393·130 enrolled

Anesthesia and Circulating Tumor Cells in Breast Cancer

Completed·UUniversity of Zurich·Phase 4·NCT02005770·221 enrolled

Coronary Artery Bypass2 trials

Xenon in Off-pump Coronary Artery Bypass Graft Surgery

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT01757106·42 enrolled

Inhaled Sevoflurane Compared to Intravenous Sedation Post Coronary Artery Bypass Grafting

Completed·KKarolinska Institutet·Phase 1/2·NCT00484575·100 enrolled

Inflammation2 trials

Inflammation After One Lung Ventilation

Completed·UUniversity Medical Centre Ljubljana·Phase 1·NCT02188407·40 enrolled

Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT02166853·50 enrolled

Preconditioning2 trials

Effect of Propofol on Cardioprotective Role of Remote Ischemic Preconditioning (RIPC)

Completed·SSeoul National University Hospital·N/A·NCT02932722·51 enrolled

Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R

Withdrawn·NNegovsky Reanimatology Research Institute·Phase 4·NCT04287842

General Anaesthesia2 trials

Cardiovascular Safety of Xenon in General Anaesthesia, in Patient With Cardiovascular Risk in Non Cardiac Surgery

Completed·AAir Liquide Santé International·Phase 3·NCT01120405·600 enrolled

Sevoflurane vs. Isoflurane for Low-Flow General Anaesthesia for Abdominal Surgery

Completed·—·N/A·NCT00521612·82 enrolled

Inflammatory Response2 trials

Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB

Completed·IInstituto Dante Pazzanese de Cardiologia··NCT02672345·100 enrolled

Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents

Completed·HHospital General Universitario Gregorio Marañon·Phase 4·NCT02168751·180 enrolled

Analgesic2 trials

The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02609802·77 enrolled

Comparison of Analgesic Effect of Volatile Anesthetics

Completed·KKangbuk Samsung Hospital·Phase 3·NCT02830243·90 enrolled

Elderly Patients2 trials

Optimization of Desflurane in Elderly Patients

Completed·—·Phase 1/2·NCT01700907·20 enrolled

Remifentanil for Smooth Emergence in Elderly Patients

Completed·—·Phase 4·NCT02334046·47 enrolled

Complication2 trials

Airway Complications After LMA in Children

Completed·—·N/A·NCT03553082·135 enrolled

Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery

Completed·SSecond Affiliated Hospital of Nanchang University·N/A·NCT05527314·110 enrolled

Tics2 trials

Role of Volatile Anesthetics for Hepatic Protection

Completed·UUniversity of Zurich·N/A·NCT00516711

Comparison of Effect of Equi-MAC Anesthetics on PSI

Completed·KKangbuk Samsung Hospital·N/A·NCT03587779·74 enrolled

Post Operative Cognitive Dysfunction2 trials

Long Term Postoperative Cognitive Dysfunction in the Elderly Patients

Unknown status·PPusan National University Yangsan Hospital·Phase 4·NCT02301676·190 enrolled

The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients

Completed·—·N/A·NCT06353516·154 enrolled

Postoperative Cognitive Dysfunction (POCD)1 trial

Dexmedetomidine and Postoperative Cognitive Dysfunction (POCD)

Completed·UUdayana University·Phase 4·NCT06371638·112 enrolled

Myocardial Protection1 trial

Myocardial Protection and Anesthetic Agents

Completed·—·Phase 4·NCT02405689·60 enrolled

Prognosis1 trial

The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action

Recruiting·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT05663242·300 enrolled

Laryngeal Mask Airway1 trial

Desflurane in Children With Laryngeal Mask Airway

Completed·SSeoul National University Hospital·N/A·NCT02470442·200 enrolled

Hysterectomy1 trial

Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

Recruiting·TTanta University·N/A·NCT07062367·90 enrolled

Nitrous Oxide1 trial

Global Warming Impact of Nitrous Oxide

Completed·SSir Ganga Ram Hospital·Phase 4·NCT05430750·102 enrolled

Congenital Heart Disease1 trial

Propofol vs Sevoflurane in Cyanotic Congenital Heart Disease

Completed·—·Phase 4·NCT04125550·34 enrolled

Strabismus1 trial

Propofol Versus Sevoflurane Anesthesia in Pediatric Strabismus Surgery: Feasibility of BIS Monitoring

Completed·SSameh Fathy·N/A·NCT04485117·100 enrolled

Cardiac Arrest1 trial

SEVOflurane Inhalation in CARdiac Arrest Resuscitated Patients Treated With Therapeutic Hypothermia

Completed·UUniversity Hospital, Clermont-Ferrand·N/A·NCT02201134·20 enrolled

Colorectal Cancer1 trial

The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

Unknown status·GGuizhi Du··NCT03193710·260 enrolled

Colon Cancer1 trial

Anesthesia and Cancer Study: Colon Cancer

Active, not recruiting·SSeoul National University Hospital·N/A·NCT04259398·797 enrolled

Percutaneous Coronary Intervention1 trial

Sevoflurane and Percutaneous Coronary Intervention by Stent

Terminated·IInstituto Dante Pazzanese de Cardiologia·Phase 4·NCT02671084·701 enrolled

Pediatric Patients1 trial

Sevoflurane and Laryngeal Reflex Responses in Pediatric Patients

Terminated·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT00665418·40 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Remimazolam in OPCAB Surgery

Unknown status·—·N/A·NCT05396690·94 enrolled

Aesthetic1 trial

Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery

Completed·UUniversity Medical Centre Ljubljana·Phase 1·NCT02229201·40 enrolled

Ultrasound1 trial

Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block

Unknown status·TTanta University·N/A·NCT05543109·85 enrolled

Aortic Valve Replacement1 trial

Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults

Completed·—·Phase 3·NCT05696509·75 enrolled

Ischemia1 trial

Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins

Completed·UUS Department of Veterans Affairs·N/A·NCT00995670·59 enrolled

Quality of Recovery1 trial

Quality of Recovery of Remimazolam Versus Sevoflurane in Transurethral Bladder Resection.

Completed·KKangbuk Samsung Hospital·N/A·NCT05356091·36 enrolled

Endometrial Cancer1 trial

Regional Anesthesia and Endometrial Cancer Recurrence

Withdrawn·TThe Cleveland Clinic·Phase 3·NCT00531349

Children1 trial

Namsos Anaesthesia Children Outcome Study

Completed·HHelse Nord-Trøndelag HF·N/A·NCT04292457·761 enrolled

Neuromuscular Block1 trial

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

Unknown status·UUniversity of Florence·Phase 4·NCT02698969·58 enrolled

Oxygenation1 trial

The Effect of Anesthesia on Cerebral Oxygenation

Completed·KKaradeniz Technical University··NCT04760262·30 enrolled

Arteriosclerosis Obliterans1 trial

Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Completed·TTao Zhang·Phase 4·NCT02107170·68 enrolled

Vomiting1 trial

Heart Rate Variability and Postoperative Nausea Vomiting

Completed·—··NCT04514211·40 enrolled

Surgical Stress Response1 trial

Intravenous Anesthesia by Targeted Controlled Infusion Versus Inhalational Anesthesia on the Surgical Stress Response

Active, not recruiting·—·Phase 4·NCT06024733·90 enrolled

Carotid Endarterectomy1 trial

The Effects of Anaesthesia on Cerebral Oxygenation and Cognitive Function in Carotid Endarterectomy

Completed·NNorthern State Medical University·N/A·NCT02771418·40 enrolled

Renal Transplant1 trial

Volatile Anesthetic Protection Of Renal Transplants 2

Completed·UUniversity Medical Center Groningen·Phase 4·NCT02727296·488 enrolled

Tracheal Intubation1 trial

Endotracheal Intubation With Sevoflurane in Surgical Pediatric Patients

Completed·UUniversity of Sulaimani·N/A·NCT02429323·100 enrolled

Dilation and Evacuation1 trial

Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures

Completed·OOregon Health and Science University·Phase 4·NCT01048658·160 enrolled

Laparoscopic Cholecystectomy1 trial

Pain After Laparoscopic Cholecystectomy

Completed·—·N/A·NCT00983918·80 enrolled

Ventilation1 trial

Nebulized Epoprostenol (FLOLAN) and Phenylephrine on One Lung Ventilation (OLV)

Completed·UUniversity Health Network, Toronto·Phase 4·NCT02748265·8 enrolled

Hemodynamic1 trial

Hemodynamics for Equi-MAC Anesthesia

Completed·KKangbuk Samsung Hospital·N/A·NCT03570164·70 enrolled

Injury1 trial

Anesthetics to Prevent Lung Injury in Cardiac Surgery

Completed·—·Phase 1/2·NCT02918877·51 enrolled

Closed-Loop1 trial

Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System

Unknown status·TTianjin Medical University General Hospital··NCT02364934·240 enrolled

Ketorolac1 trial

An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Completed·—·Phase 2·NCT04646967·100 enrolled

Heart Failure1 trial

Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation

Unknown status·HHeidelberg University··NCT04934410·50 enrolled

Terminated·Dd sessler·N/A·NCT01001585·55 enrolled

Vasodilation1 trial

Vasodilation Effect of Inhalational Anesthetics

Completed·NNanjing Medical University·N/A·NCT00815269·300 enrolled

Gynecologic Surgery1 trial

Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Laparoscopic Gynecologic Surgery

Unknown status·OObstetrics & Gynecology Hospital of Fudan University·Phase 1·NCT03498235·110 enrolled

Colonoscopy1 trial

Inhaled Sevofluran vs Endovenous Propofol for Colonoscopy

Completed·CCentro Medico Docente la Trinidad·N/A·NCT03818048·32 enrolled

PONV1 trial

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

Completed·—·Phase 4·NCT02809378·150 enrolled

Botulinum Toxin1 trial

Sevoflurane and Propofol for Botulinum Toxin Injection

Withdrawn·YYeungnam University College of Medicine·N/A·NCT05505123

Preoperative1 trial

The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery

Completed·IInje University·N/A·NCT02916407·56 enrolled

Postoperative Recovery1 trial

The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery

Completed·MMedical University of Vienna·Phase 4·NCT05331027·190 enrolled

Acute Kidney Injury1 trial

Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery

Withdrawn·TTokyo Medical and Dental University·Phase 4·NCT02174575

Mastectomy1 trial

The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap

Completed·YYonsei University·N/A·NCT05136508·50 enrolled

Treatment Resistant Depression1 trial

Sevoflurane for Treatment-Resistant Depression

Unknown status·SShanghai First Maternity and Infant Hospital·N/A·NCT05008939·15 enrolled

Ischemia Reperfusion Injury1 trial

Sevoflurane Protective Effect on Ischemia Reperfusion Injury in Microvascular Surgery

Completed·RRegina Elena Cancer Institute·N/A·NCT01972230·128 enrolled

Ventricular Tachycardia1 trial

Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

Completed·—·N/A·NCT02419547·11 enrolled

Age1 trial

Comparison of PRS According to Inhalation Agent During LDLT

Completed·SSeoul National University Hospital·Phase 4·NCT01886664·70 enrolled

Renal Transplant Recipient1 trial

Comparison Between Target-controlled Infusion of Propofol and Sevoflurane as Maintenance of Anesthesia to Hemodynamic Profile of Renal Transplant Recipient

Completed·IIndonesia University·N/A·NCT03214653·23 enrolled

Cognition1 trial

Sevoflurane's Effect on Neurocognition Study

Completed·KKeith M Vogt·Phase 1·NCT06044740·42 enrolled

Inhalational Anesthesia1 trial

Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study

Recruiting·OOregon Health and Science University·Phase 4·NCT06036095·260 enrolled

COVID-191 trial

AnaConDa-therapy in COVID-19 Patients

Terminated·JJeroen Bosch Ziekenhuis··NCT05586126·42 enrolled

Abdominal Aortic Aneurysm1 trial

Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery

Completed·SSykehuset i Vestfold HF·Phase 4·NCT00538421·193 enrolled

Hypospadias1 trial

Sevoflurane and Intravenous Anesthesia in Hypospadias Repair

Unknown status·—·N/A·NCT06396468·90 enrolled

Inguinal hernia1 trial

Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial

Unknown status·TTanta University·N/A·NCT05442905·60 enrolled

Remimazolam1 trial

Remimazolam Phase II Cardiac Anesthesia Study

Completed·PPaion UK Ltd.·Phase 2·NCT01937767·90 enrolled

Endovascular Thrombectomy1 trial

General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

Completed·UUniversity of Saskatchewan··NCT02639806·34 enrolled

Pediatric Anesthesia1 trial

Bispectral Index to Guide Intubation in Pediatric Anesthesia

Completed·UUniversity of Liege·N/A·NCT02806596·60 enrolled

Agitation1 trial

Melatonin for Pediatric Emergence Agitation

Completed·MMenoufia University·Phase 4·NCT05223010·117 enrolled

Knee Arthroplasty1 trial

Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane

Completed·UUniversity of Sao Paulo General Hospital·N/A·NCT03379103·30 enrolled

Pulmonary Function1 trial

Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Unknown status·IIstanbul University·N/A·NCT02709863·90 enrolled

Headache1 trial

Maintenance of Anaesthesia With Sevoflurane Versus Propofol and the Occurrence of Postoperative Headache.

Unknown status·—·N/A·NCT03789370·130 enrolled

Hypotension1 trial

Vasopressin to Prevent Hypotension During Beach Chair Surgery

Completed·—··NCT01687894·74 enrolled

Adult1 trial

A Study of Danavorexton in Anesthetized Adults

Completed· Takeda logo

Takeda·Phase 1·NCT05025397·28 enrolled

Regional Anesthesia1 trial

Regional Anesthesia Versus General Anesthesia

Completed·IIRCCS Azienda Ospedaliero-Universitaria di Bologna·N/A·NCT03830086·28 enrolled

Neuropathic Pain1 trial

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

Completed·VVA Pittsburgh Healthcare System·Phase 4·NCT02527083·10 enrolled

Intraoperative Bleeding1 trial

Intraoperative Bleeding During Endoscopic Sinus Surgery

Completed·UUniversity of Chicago·N/A·NCT01014728·33 enrolled

Third Molar Surgery1 trial

Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery

Completed·TThe University of Hong Kong·Phase 4·NCT03058341·96 enrolled

Muscle Relaxant1 trial

The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02467595·75 enrolled

Hepatocellular Carcinoma1 trial

Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients

Unknown status·TThe University of Hong Kong·N/A·NCT04601961·220 enrolled

Surgery1 trial

Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery

Completed·KKonkuk University Medical Center·Phase 4·NCT02136979·2 enrolled

Hepatic Function1 trial

Effect of Desflurane Versus Sevoflurane With Recent Bio-markers on Renal and Hepatic Functions

Completed·TTheodor Bilharz Research Institute··NCT05027191·70 enrolled

Retinopathy of Prematurity1 trial

Anesthesia for Retinopathy of Prematurity

Completed·TTC Erciyes University·Phase 4·NCT01955135·60 enrolled

Postoperative Sleep Quality1 trial

Postoperative Sleep Quality of Patients Anesthesia With Propofol or Sevoflurane Undergoing Thyroidectomy

Completed·—·Phase 4·NCT02146976·124 enrolled

Intravenous Anesthesia1 trial

Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study

Recruiting·UUniversity of Kansas Medical Center·Phase 2·NCT06017141·80 enrolled

Renal Transplantation1 trial

Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT00337051·120 enrolled

Depth of Anesthesia1 trial

End Tidal Anesthetic Concentration in Different Anesthesia Techniques Where Depth of Anesthesia Adjusted With Entropy

Completed·IIstanbul University·N/A·NCT04203290·44 enrolled

Postoperative Analgesia1 trial

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT03135795·100 enrolled

Unspecified4 trials

Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia

Completed·—·N/A·NCT03816072·66 enrolled

Ultrasonography for Prediction of Difficult Intubation and Prediction of Endotracheal Tube Size

Unknown status·IIstanbul University·N/A·NCT03013036·150 enrolled

Evaluation of Micropore"s SpiraLith Absorbents

Completed·RRutgers, The State University of New Jersey··NCT02550470·186 enrolled

Show 1 more trial

Three Anaesthesic Method in Electroconvulsive Theraphy

Completed·IInonu University·Phase 4·NCT01759589·39 enrolled

Regulatory

FDA Approval Timeline[5]

Jun 7, 1995

ULTANE

NDA NDA020478

Jul 2, 1997

ULTANE

NDA NDA020478

Dec 23, 1997

ULTANE

NDA NDA020478

Aug 6, 1998

ULTANE

NDA NDA020478

Jun 16, 2000

ULTANE

NDA NDA020478

Mar 14, 2001

ULTANE

NDA NDA020478

Mar 30, 2001

ULTANE

NDA NDA020478

Aug 9, 2001

ULTANE

NDA NDA020478

Sep 28, 2001

ULTANE

NDA NDA020478

May 24, 2002

ULTANE

NDA NDA020478

Dec 11, 2002

ULTANE

NDA NDA020478

Jun 27, 2003

ULTANE

NDA NDA020478

Jun 21, 2005

ULTANE

NDA NDA020478

Jun 27, 2006

ULTANE

NDA NDA020478

Jan 21, 2010

ULTANE

NDA NDA020478

Aug 16, 2012

ULTANE

NDA NDA020478

Aug 16, 2012

ULTANE

NDA NDA020478

Mar 11, 2014

ULTANE

NDA NDA020478

Mar 11, 2014

ULTANE

NDA NDA020478

Oct 26, 2015

ULTANE

NDA NDA020478

Apr 27, 2017

ULTANE

NDA NDA020478

Mar 1, 2022

ULTANE

NDA NDA020478

Mar 1, 2022

ULTANE

NDA NDA020478

Mar 1, 2022

ULTANE

NDA NDA020478

Mar 1, 2022

ULTANE

NDA NDA020478

May 19, 2022

ULTANE

NDA NDA020478

Nov 1, 2022

ULTANE

NDA NDA020478

Feb 3, 2025

ULTANE

NDA NDA020478

Sources

References

[1]
ClinicalTrials.gov — 390 trial records for sevoflurane. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ultane drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — sevoflurane compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for sevoflurane. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020478). U.S. Food & Drug Administration.
[6]
SEC EDGAR — AbbVie company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glycine Receptor (alpha-1/beta) Positive Modulator; Potassium Channel Subfamily K Member 10 Opener; Potassium Channel Subfamily K Member 18 Opener; Potassium Channel Subfamily K Member 2 Opener; Potassium Channel Subfamily K Member 3 Opener; Potassium Channel Subfamily K Member 9 Opener; GABA-a Receptor; Anion Channel Positive Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AbbVie

Ultane

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Q2 2028

Trials by Indication[1]

Sevoflurane26 trials

Delirium10 trials

Total Intravenous Anesthesia7 trials

Cardiac Surgery7 trials

Anesthesia6 trials

General Anesthesia5 trials

Sedation4 trials

Concentration4 trials

Oxidative Stress3 trials

Liver Transplant3 trials

Post Operative Pain3 trials

Cardiopulmonary Bypass2 trials

Cesarean Section2 trials

Nausea and vomiting2 trials

Intraocular Pressure2 trials

Intravenous2 trials

General Anesthetics2 trials

Breast Cancer2 trials

Coronary Artery Bypass2 trials

Inflammation2 trials

Preconditioning2 trials

General Anaesthesia2 trials

Inflammatory Response2 trials

Analgesic2 trials

Elderly Patients2 trials

Complication2 trials

Tics2 trials

Post Operative Cognitive Dysfunction2 trials

Postoperative Cognitive Dysfunction (POCD)1 trial

Myocardial Protection1 trial

Prognosis1 trial

Laryngeal Mask Airway1 trial

Hysterectomy1 trial

Nitrous Oxide1 trial

Congenital Heart Disease1 trial

Strabismus1 trial

Cardiac Arrest1 trial

Colorectal Cancer1 trial

Colon Cancer1 trial

Percutaneous Coronary Intervention1 trial

Pediatric Patients1 trial

Safety and Efficacy1 trial

Aesthetic1 trial

Ultrasound1 trial

Aortic Valve Replacement1 trial

Ischemia1 trial

Quality of Recovery1 trial

Endometrial Cancer1 trial

Children1 trial

Neuromuscular Block1 trial

Oxygenation1 trial

Arteriosclerosis Obliterans1 trial

Vomiting1 trial

Surgical Stress Response1 trial

Carotid Endarterectomy1 trial

Renal Transplant1 trial

Tracheal Intubation1 trial

Dilation and Evacuation1 trial

Laparoscopic Cholecystectomy1 trial

Ventilation1 trial

Hemodynamic1 trial

Injury1 trial

Closed-Loop1 trial

Ketorolac1 trial

Heart Failure1 trial

Perioperative Period1 trial

Cardiac1 trial

Mechanical Ventilation1 trial

Mitochondrial Disease1 trial

Vasodilation1 trial

Gynecologic Surgery1 trial