VivoSeq
Psychiatry

PTSD

3

Pipeline Programs↗

18

Active Trials↗

6

Companies Involved↗

PTSD is an early-stage landscape with 3 programs across 6 companies. The most active players are Lykos Therapeutics, Honeybrains Biotech LLC, Eli Lilly. 1 therapy is approved.

Intelligence

Pipeline Metrics

Competitive Density

38/100

Pipeline Velocity

30/100

Mech. Concentration

100/100

Completion Rate

81/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

L

Lykos Therapeutics

1 program

Phase 2H

Honeybrains Biotech LLC

1 program

Phase 2Eli Lilly logo

Eli Lilly

1 program

Phase 2Pfizer logo

Pfizer

1 program

ApprovedT

Tonix Pharmaceuticals, Inc.

0 programs

PreclinicalH

HB BioTech, LLC

0 programs

Preclinical

Pipeline

Programs by Phase

Preclinical
No programs
Phase 1
No programs
Phase 22

HB-1

Honeybrains Biotech LLC

Intranasal Insulin

University Health Network, Toronto

Phase 3
No programs
Approved1

Rimegepant

Pfizer

Analysis

Trial Status

41

clinical trials

Completed17 · 41%
Recruiting13 · 32%
Unknown status2 · 5%
Terminated2 · 5%
Enrolling by invitation2 · 5%
Not yet recruiting2 · 5%
Other3 · 7%

Clinical Trials

Trial Activity

41 trials

Computational Assessment of GABA Receptor Modulation in PTSD
Recruiting·VVA Office of Research and Development·Phase 4·NCT06852469·150 enrolled
MDMA-Assisted CBCT for PTSD vs CBCT RCT
Recruiting·RRemedy·Phase 2·NCT06044675·60 enrolled
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
Recruiting·MMassachusetts General Hospital·Phase 2·NCT07079761·96 enrolled
Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD
Recruiting·—·Phase 2·NCT04468360·256 enrolled
Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 Events
Recruiting·SSheba Medical Center·Phase 2·NCT07469098·168 enrolled
Dose Optimization of MDMA-Assisted Therapy for PTSD
Recruiting·—·Phase 2·NCT06418178·60 enrolled
Safety and Efficacy of Cannabidiol (CBD) for Symptoms of Post-Traumatic Stress Disorder (PTSD) in Adults Using Liquid StructureTM Formulation (NantheiaTM ATL5).
Recruiting·UUniversity of Nebraska·Phase 2·NCT05269459·180 enrolled
Adolescent Injury: Intervening to Prevent Posttraumatic Stress and Substance Use Outcomes
Recruiting·RRhode Island Hospital·Preclinical·NCT07197476·92 enrolled
Safety and Efficacy of HB-1 for PTSD: A Multi-center, Randomized, Double-Blind, Placebo-Controlled Study
Recruiting·HHB BioTech, LLC·Phase 2·NCT07499440·200 enrolled
Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms
Recruiting·OOhio State University·Preclinical·NCT07680517·120 enrolled
Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder (PTSD) Treatment Outcomes in Federally Qualified Health Centers
Recruiting·UUniversity of Michigan·Preclinical·NCT05457985·430 enrolled
Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD
Recruiting·OOhio State University·Preclinical·NCT06285708·100 enrolled
Exposure by Assessment: Effects of Daily AMQ-Based EMA of an Intrusive Trauma Memory in PTSD
Recruiting·TTel Aviv University·Preclinical·NCT07658157·50 enrolled
Non-Inferiority Trial of Trauma Informed Guilt Reduction Therapy (TrIGR) for PTSD
Active, not recruiting·VVA Office of Research and Development·Preclinical·NCT05789329·160 enrolled
MDMA-Assisted Massed Exposure Therapy for PTSD
Not yet recruiting·EEmory University·Phase 2·NCT07288151·200 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)