Ritalin

(Methylphenidate)

ApprovedSmall molecule

Methylphenidate is used to treat attention-deficit/hyperactivity disorder (ADHD) and narcolepsy by helping people focus, pay attention, and stay awake. It works by stimulating the brain to improve concentration and reduce impulsive behavior.[2] Ritalin is currently approved and in use across 60 indications[4].[1]

Ritalin is one of 1109 small molecule programs targeting Childhood Cancer. It is currently in Approved.

Indications

216

Total Trials

Active Trials

1,108

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Childhood CancerActive, not recruiting

Pervasive Developmental DisorderActive, not recruiting

Methamphetamine DependenceActive, not recruiting

Nicotine DependenceApproved

Neuropathic PainActive, not recruiting

Low Back PainActive, not recruiting

Cerebral PalsyActive, not recruiting

Depressive DisorderApproved

Eating DisorderActive, not recruiting

ToxicityActive, not recruiting

Childhood CancerApproved

Active, not recruiting

Pervasive Developmental DisorderPreclinical

Active, not recruiting

Methamphetamine DependencePhase 2

Active, not recruiting

Nicotine DependenceApproved

Approved

Neuropathic PainPhase 2

Active, not recruiting

Low Back PainPhase 1

Active, not recruiting

Cerebral PalsyPhase 1

Active, not recruiting

Depressive DisorderApproved

Approved

Eating DisorderPhase 2

Active, not recruiting

ToxicityPreclinical

Active, not recruiting

Showing 10 of 58 indications

Competition

Competitive Landscape

1399 competitors in Prostate Cancer

#DrugCompanyPhaseTrials

Ritalin

Novartis

Approved

2 2

Novantrone

Pfizer

Preclinical

5 3

Trexall

Alnylam Pharmaceuticals

Preclinical

—4

Jatenzo

GGrupo Espanol de Tumores Neuroendocrinos

Preclinical

2 5

Ranexa

MMenarini International Operations Luxembourg SA

Preclinical

1 6

Viagra

VViatris Specialty LLC

Preclinical

1 7

Prednisone/prednisolone

Roche

Preclinical

3 8

Therapeutic Hydrocortisone

EEastern Cooperative Oncology Group

Preclinical

9 9

Xylocaine

CCitius Pharmaceuticals, Inc.

Preclinical

—10

Osmitrol

BB. Braun Medical Inc.

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Recruiting

Low Back Pain

NCT06355414

N/ARecruiting

Toxicity

NCT05761756

Not yet recruiting

ADHD

NCT05600881

Phase 1Active, not recruiting

Drug

NCT05978167

Phase 2Active, not recruiting

Prostate Cancer

NCT01410942

Q4 2026

Phase 2/3Active, not recruiting

Prostate Cancer

NCT03772834

Clinical

Trials by Indication[1]

Attention Deficit Hyperactivity Disorder27 trials

Unknown status·FFar Eastern Memorial Hospital··NCT01130467·150 enrolled

Pharmacokinetics of Two Extended-Release Formulations of Methylphenidate in Children With Attention Deficit Hyperactivity Disorder (ADHD)

Completed·UUniversity Hospital Freiburg·Phase 1/2·NCT00772161·24 enrolled

Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep Difficulties

Unknown status·—·Phase 4·NCT01393574·46 enrolled

Show 24 more trials

Treating Young Children With Attention Deficit Hyperactivity Disorder

Not yet recruiting·—·Phase 4·NCT07300956·370 enrolled

Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00015223

Medication Strategies for Treating Aggressive Behavior in Youth With Attention Deficit Hyperactivity Disorder

Completed·SStony Brook University·Phase 4·NCT00228046·40 enrolled

Long Acting Stimulant Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Young Children

Completed·UUniversity of Nebraska·Phase 4·NCT00754208·7 enrolled

Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT00183391·232 enrolled

Response Variability in Children With Attention Deficit Hyperactivity Disorder (ADHD)

Completed·—·Phase 4·NCT01238822·96 enrolled

Gene-environment Interactions and Brain Functional Connectivity in Attention Deficit Hyperactivity Disorder

Completed·SSeoul National University·N/A·NCT01912352·83 enrolled

Methylphenidate for Attention Deficit Hyperactivity Disorder and Autism in Children

Completed·TThe University of Texas Health Science Center, Houston·Phase 2/3·NCT00178503·24 enrolled

Single Versus Combination Medication Treatment for Children With Attention Deficit Hyperactivity Disorder

Completed·UUniversity of California, Los Angeles·Phase 4·NCT00429273·212 enrolled

Effectiveness of a Personalized Neurofeedback Training Device (ADHD@Home) in Attention-Deficit/Hyperactivity Disorder

Unknown status·MMensia Technologies SA·Phase 1/2·NCT02778360·179 enrolled

Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)

Completed·UUniversity of Cincinnati·Phase 3·NCT00264797·303 enrolled

Methylphenidate for Treating Attention Deficit Hyperactivity Disorder in Children With Both ADHD and Epilepsy

Completed·—·Phase 4·NCT00323947·33 enrolled

Biomarker Validation in Motor System Physiology in Attention Deficit Hyperactivity Disorder

Recruiting·—·Phase 4·NCT04421248·214 enrolled

Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1

Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT00061087·115 enrolled

Methylphenidate Treatment Response Study of Genetic Polymorphism in Attention Deficit Hyperactivity Disorder(ADHD)

Unknown status·SSeoul National University Hospital·Phase 4·NCT00862108·50 enrolled

Train Your Brain and Exercise Your Heart? Advancing the Treatment for Attention Deficit Hyperactivity Disorder (ADHD)

Completed·RR. van Mourik·Phase 2/3·NCT01363544·112 enrolled

Attention-deficit/Hyperactivity Disorder Translational Center for Identifying Biomarkers

Unknown status·—·Phase 4·NCT02623114·400 enrolled

The Effect of Methylphenidate Versus Placebo on State Anxiety in Children With Attention Deficit Hyperactivity Disorder.

Unknown status·SShalvata Mental Health Center·N/A·NCT01798459·30 enrolled

Treatment of Attention Deficit Hyperactivity Disorder in Preschool-Age Children (PATS)

Completed·NNew York State Psychiatric Institute·Phase 3·NCT00018863·165 enrolled

Psychostimulants Effects on Brain Functional Connectivity in Youth With Attention Deficit Hyperactivity Disorder

Unknown status·SSheba Medical Center·N/A·NCT02318017·75 enrolled

Methylphendidate Treatment of Cocaine Dependent Patients With Attention Deficit Hyperactivity Disorder - 3

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00015054·20 enrolled

Clonidine in Attention Deficit Hyperactivity Disorder (ADHD) in Children

Completed·UUniversity of Cincinnati·Phase 3·NCT00031395·122 enrolled

The Effect of Methylphenidate on Decision-making Ability of Attention Deficit Hyperactivity Disorder (ADHD) Adults

Completed·SShalvata Mental Health Center·Phase 1·NCT01040702·58 enrolled

The Effect of Methylphenidate on Primary Enuresis in Children With Attention Deficit Hyperactivity Disorder

Unknown status·MMeir Medical Center··NCT02699528·50 enrolled

Fatigue8 trials

MethylphenIdate for Fatigue in Haematological Cancer

Unknown status·HHenrik Frederiksen·Phase 3·NCT03218254·150 enrolled

Trial of a Sustained Release Methylphenidate in the Treatment of Fatigue in Cancer Patients

Terminated·MM.D. Anderson Cancer Center·Phase 3·NCT00516269·42 enrolled

The Role of the Brain in Mental and Physical Fatigue

Recruiting·VVrije Universiteit Brussel·Phase 3·NCT05880342·62 enrolled

Show 5 more trials

Methylphenidate and a Nursing Telephone Intervention for Fatigue

Completed·MM.D. Anderson Cancer Center·Phase 2/3·NCT00424099·197 enrolled

Methylphenidate for Cancer-Related Fatigue

Terminated·—·Phase 1·NCT01164956·3 enrolled

Patient Controlled Methylphenidate for Cancer Related Fatigue: A Double Blind, Randomized, Placebo Controlled Trial

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT05041946·112 enrolled

Patient Controlled Administration of Methylphenidate for Cancer Related Fatigue - PRN Methylphenidate

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT02361125·31 enrolled

A Study of Cancer Related Fatigue in Patients With Metastatic Cancer Receiving Anti-PD1 Immunotherapy

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 3·NCT03525873·212 enrolled

ADHD7 trials

Large-scale Brain Organization During Cognitive Control in ADHD

Completed·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT04349917·37 enrolled

Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT03781752·500 enrolled

Endocrine Disrupting Chemicals and Hormones in ADHD

Unknown status·—··NCT04970303·240 enrolled

Show 4 more trials

Effect of Pycnogenol® on ADHD

Completed·NNina Hermans·Phase 3·NCT02700685·88 enrolled

Added Value of the Oculomotor and Cognitive Examination in the Management of Patients With ADHD

Unknown status·—·N/A·NCT03411434·90 enrolled

Towards an Understanding of the Mechanism of Action of Methylphenidate in ADHD

Not yet recruiting·UUniversity of Dublin, Trinity College··NCT05600881·35 enrolled

Neuroendocrine Substrates, Candidate Genes and Endophenotypes in ADHD

Unknown status·—··NCT02392169·300 enrolled

Children6 trials

The Relationship Between CES1 Genotype and Methylphenidate Response in Children With ADHD - INDICES Work Package 6

Completed·—··NCT04366609·207 enrolled

The Effects of Methylphenidate and Non-invasive Brain Stimulation on Inhibitory Control in Children With ADHD

Completed·—·N/A·NCT04964427·26 enrolled

Cognitive Remediation in ADHD Children : Comparison Between Three Therapeutic Strategies : Cognitive Remediation With a Virtual Classroom Software and Methylphenidate and Supportive Psychotherapy

Completed·UUniversity Hospital, Bordeaux·N/A·NCT01821170·51 enrolled

Show 3 more trials

Effects of Evening Dose of Immediate Release Methylphenidate on Sleep in Children With ADHD

Terminated·MMilton S. Hershey Medical Center·Phase 4·NCT02638168·3 enrolled

EAA/Therapy for Treating Children With ADHD

Unknown status·SSamsung Medical Center·N/A·NCT02482649·46 enrolled

The Effects of Long-acting Methylphenidate on Academic Activity and Related Constructs in Children With ADHD

Completed·VVU University of Amsterdam·Phase 4·NCT02501798·61 enrolled

Dementia6 trials

Improving Function, Quality of Life, Glycemia in Diabetics With Dementia

Withdrawn·UUniversity of Nebraska·Phase 4·NCT00792662

Apathy in Dementia Methylphenidate Trial (ADMET)

Completed·JJohns Hopkins Bloomberg School of Public Health·Phase 2·NCT01117181·60 enrolled

Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia

Recruiting·SSunnybrook Health Sciences Centre·Phase 2·NCT07279740·12 enrolled

Show 3 more trials

Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia.

Terminated·SSt. Louis University·Phase 4·NCT01825577·14 enrolled

Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study

Completed·VVA Office of Research and Development·Phase 4·NCT00495820·60 enrolled

Apathy in Dementia Methylphenidate Trial 2

Completed·JJohns Hopkins Bloomberg School of Public Health·Phase 3·NCT02346201·200 enrolled

92 more indications

Treatment6 trials

Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints

Recruiting·VVA Office of Research and Development·Phase 4·NCT05776056·70 enrolled

Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

Enrolling by invitation·UUniversity of California, Davis·Phase 1·NCT05301361·68 enrolled

Treatments for Fathers With ADHD and Their At-Risk Children (Fathers Too)

Completed·SSeattle Children's Hospital·Phase 4·NCT02675400·19 enrolled

Show 3 more trials

Stimulant Drug Treatment of Attention-Deficit Hyperactivity Disorder (AD/HD), Inattentive Type

Completed·IIcahn School of Medicine at Mount Sinai·N/A·NCT00824317·25 enrolled

Methylphenidate for the Treatment of Acute Mania

Completed·MMichael Kluge·Phase 3·NCT01541605·42 enrolled

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT03781765·44 enrolled

Attention5 trials

Assessing Cognitive Performance Among Adults With Attention Disorders Working on Treadmill

Unknown status·—·Phase 2/3·NCT05243186·30 enrolled

Early Interventions in Children With Attention Deficit/Hyperactivity Disorder

Completed·UUniversity of Sao Paulo·Phase 4·NCT02807870·153 enrolled

Methylphenidate in Adults With Attention Deficit/Hyperactivity Disorder

Recruiting·HHospital de Clinicas de Porto Alegre·Phase 4·NCT02951754·600 enrolled

Show 2 more trials

Interventions for Children With Attention and Reading Disorders

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT01133847·222 enrolled

Methylphenidate and Driving Ability in Adult Patients With Attention-Deficit Hyperactivity Disorder

Completed·UUtrecht Institute for Pharmaceutical Sciences·Phase 4·NCT00223561·18 enrolled

Attention Deficit Disorder5 trials

Treatment of Patients With Alcoholism and Attention Deficit Disorder

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 4·NCT00261872·100 enrolled

Virtual Reality a Novel Screening and Treatment Aid in Attention Deficit Disorder

Completed·SShaare Zedek Medical Center·Phase 2·NCT00364702·40 enrolled

Effectiveness of Methylphenidate Late Formula to Reduce Cannabis Use in Young Cannabis-Related Patients and Attention Deficit Disorder Hyperactivity

Terminated·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT03481959·3 enrolled

Show 2 more trials

Further Studies of Attention Deficit Disorder - Residual Type (RT)

Completed·UUniversity of Utah·Phase 3·NCT00693212·116 enrolled

The Characteristics of Prepulse Inhibition in Children and Adolescents Suffering From Attention Deficit Disorder

Unknown status·HHaEmek Medical Center, Israel··NCT02344784·46 enrolled

Adult5 trials

A Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults

Completed·MMassachusetts General Hospital·Phase 4·NCT00302458·44 enrolled

Effects of Ritalin on Postural Stability of Old Adults

Completed·SSoroka University Medical Center·N/A·NCT00817960·30 enrolled

A Double Blind Crossover Study on the Effect of MPH on Decision-making Ability of Adults With BPD Compared to Adults With ADHD and Healthy Adults

Unknown status·SShalvata Mental Health Center·N/A·NCT01426984·20 enrolled

Show 2 more trials

A Double Blind Crossover Study on the Effect of Methylphenidate on Decision-making Ability of Adults With ADHD Compared to Healthy Adults

Unknown status·SShalvata Mental Health Center·N/A·NCT01124032·30 enrolled

Methylphenidate in Healthy Young Adults

Unknown status·SShaare Zedek Medical Center·Phase 4·NCT00815841·50 enrolled

AIN4 trials

Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 1·NCT03326245·25 enrolled

Novel Cross-Species Neurophysiological Assays of Reward and Cognitive Domains

Completed·MMclean Hospital··NCT02855229·222 enrolled

Studying the Role of Brain Molecules for Decision Making

Completed·UUniversity of Zurich·N/A·NCT04384562·160 enrolled

Show 1 more trial

Stimulant Effects on Brain Activity

Completed·TThe Hospital for Sick Children·Phase 1·NCT02453698·19 enrolled

Parkinson's Disease4 trials

Methylphenidate and Parkinson's Disease

Completed·OOregon Health and Science University·Phase 2·NCT00359723·13 enrolled

Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease

Completed·UUniversity of Cincinnati·Phase 4·NCT00526630·23 enrolled

TAME-PD - Physical Therapy, Atomoxetine and, Methylphenidate, to Enhance Gait and Balance in Parkinson's Disease

Completed·HHubert Fernandez·Phase 1·NCT02879136·23 enrolled

Show 1 more trial

The Effect of Methylphenidate on Non-motor Symptoms and Postural Control in Parkinson's Disease.

Terminated·LLaval University·Phase 4·NCT01244269·6 enrolled

Cognition4 trials

Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression

Completed·UUniversity of California, Los Angeles·Phase 4·NCT00602290·181 enrolled

Dopaminergic Modulation of Cognition and Psychomotor Function

Completed·MMaastricht University Medical Center·N/A·NCT01218425·20 enrolled

Control of Cognition (Naltrexone, Methylphenidate, and ADHD Study (NMAS))

Completed·UUniversity of Michigan·Phase 4·NCT01993108·23 enrolled

Show 1 more trial

Effects of MDMA and Methylphenidate on Social Cognition

Completed·UUniversity Hospital, Basel, Switzerland·Phase 1·NCT01616407·30 enrolled

Brain Injury4 trials

Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population

Completed·—·Phase 2·NCT02227056·34 enrolled

Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery

Completed·NNational Center for Research Resources (NCRR)·Phase 4·NCT00035139

The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain)

Completed·IImperial College London·Phase 4·NCT02015949·40 enrolled

Show 1 more trial

Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)

Completed·—·N/A·NCT00453921·76 enrolled

Adolescent3 trials

Methylphenidate vs. Risperidone for the Treatment of Children and Adolescents With ADHD and Disruptive Disorders

Terminated·SSheba Medical Center·Phase 4·NCT02063945·5 enrolled

Multimodal Brain Imaging of Methylphenidate in Children and Adolescents With ADHD

Withdrawn·JJohns Hopkins University·Phase 4·NCT06077669

The Role of Adverse Environment Factors, Family Functioning and Parental Psychopathology in the Response to Treatment With Methylphenidate in Children and Adolescents With Attention Deficit/Hyperactivity Disorder

Completed·FFederal University of Rio Grande do Sul·Phase 4·NCT00773916·130 enrolled

Anxiety3 trials

Treatment of Youth With ADHD and Anxiety

Completed·NNational Institute of Mental Health (NIMH)·N/A·NCT00012584·120 enrolled

Effects of Methylphenidate (Ritalin®) on the Neural Basis of Anxiety

Completed·UUniversity of California, San Diego·Phase 1·NCT02021214·24 enrolled

Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety

Completed·NNational Institute of Mental Health (NIMH)·Phase 4·NCT02153944·142 enrolled

Medication3 trials

Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance

Completed·RRegion Västmanland·Phase 4·NCT02477280·39 enrolled

Effects of Commonly Used Medications on Mood and Choice

Completed·JJohns Hopkins University·Phase 1·NCT03652740·25 enrolled

Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the QbTest

Completed·RRegion Västmanland·Phase 4·NCT02473185·40 enrolled

Cognitive impairment3 trials

The Effects of Methylphenidate on the Cognitive Function of Older People With Mild Cognitive Impairment

Terminated·MMeir Medical Center·N/A·NCT02180529·16 enrolled

A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.

Completed·MMassachusetts General Hospital·Phase 4·NCT03811847·11 enrolled

Symptomatic Treatment of Vascular Cognitive Impairment

Unknown status·AAmsterdam UMC, location VUmc·Phase 2/3·NCT02098824·30 enrolled

Stroke3 trials

The Effect of Methylphenidate on Motor Learning in Stroke Patients

Terminated·UUniversity of Aarhus·Phase 4·NCT00396058·13 enrolled

Neurobiological Principles Applied to the Rehabilitation of Stroke Patients

Completed·EEmory University·N/A·NCT00715520·33 enrolled

Methylphenidate for Ptsd and Stroke Veterans

Completed·VVA Office of Research and Development·Phase 1/2·NCT04885257·20 enrolled

Age2 trials

Language & Cognitive Control

Completed·DDonders Centre for Cognitive Neuroimaging·N/A·NCT05272397·36 enrolled

Sensitivity of Project: EVO Monitor Cognitive Measurements to Pharmacological Agents

Completed·AAkili Interactive Labs, Inc.·N/A·NCT02822937·18 enrolled

Executive Function2 trials

Differences by Sex and Genotype in the Effects of Stress on Executive Functions

Recruiting·UUniversity of British Columbia·Phase 1·NCT04273880·146 enrolled

Effects of Atx and Oros-mph on Executive Functions

Completed·TTC Erciyes University·Phase 4·NCT02352051·43 enrolled

Multiple Sclerosis2 trials

Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis

Completed·JJohns Hopkins University·Phase 3·NCT03185065·141 enrolled

Methylphenidate as Treatment Option of Fatigue in Multiple Sclerosis

Unknown status·MMedical University of Vienna·Phase 2·NCT01879202·96 enrolled

Biomarkers2 trials

Multi Neuro-functional Biomarkers for Monitoring the Effects of Treatments in ADHD Children

Unknown status·IIRCCS Eugenio Medea·Phase 4·NCT04272021·20 enrolled

Metabolic Mechanisms of the Electrophysiological Biomarkers for Response to Methylphenidate Treatment in Children With ADHD

Recruiting·NNational Taiwan University Hospital··NCT06073470·160 enrolled

Cocaine Dependence2 trials

Psychopharmacology for Cocaine Dependence - Buspirone

Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT01267292·50 enrolled

Methylphenidate-Duloxetine Combinations for Cocaine Dependence

Completed·UUniversity of Kentucky·Phase 1·NCT02700711·13 enrolled

Apathy2 trials

Apathy Associated With Alzheimer's Disease

Completed·SSunnybrook Health Sciences Centre·Phase 4·NCT00254033·40 enrolled

Methylphenidate for Apathy in Veterans With Parkinson's Disease

Not yet recruiting·—·Phase 2·NCT05669170·60 enrolled

Metabolism2 trials

Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype

Completed·—·Phase 4·NCT02135263·44 enrolled

Impact of CES1 Genotype on Metabolism of Methylphenidate

Completed·—·Phase 4·NCT02147535·78 enrolled

Palliative Care2 trials

Methylphenidate for Depressed Cancer Patients Receiving Palliative Care

Completed·UUS Department of Veterans Affairs·N/A·NCT00129467·47 enrolled

Ritalin: Antiasthenic Effect of Methylphenidate (Ritalin) in Palliative Care in Cancer Patients

Terminated·UUniversity Hospital, Grenoble·Phase 3·NCT00273741·39 enrolled

Chronic2 trials

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

Terminated·UUniformed Services University of the Health Sciences·Phase 2·NCT02148783·11 enrolled

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

Completed·UUniversity of Pennsylvania·Phase 2·NCT02225106·11 enrolled

Prostate Cancer2 trials

Multimodal Therapy for the Treatment of Fatigue in Patients With Prostate Cancer Receiving Radiotherapy With Androgen Deprivation Therapy

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT01410942·175 enrolled

Methylphenidate and Exercise in Reducing Cancer-Related Fatigue in Patients With Prostate Cancer

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2/3·NCT03772834·200 enrolled

Childhood Cancer2 trials

Learning Impairments Among Survivors of Childhood Cancer

Completed·SSt. Jude Children's Research Hospital·Phase 4·NCT00576472·469 enrolled

Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors

Terminated·UUniversity of Minnesota·N/A·NCT01100658·1 enrolled

Methamphetamine1 trial

Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]

Completed·CCraig Rush·Phase 1·NCT04178993·8 enrolled

Humans1 trial

Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study

Completed·UUniversity Hospital, Basel, Switzerland·Phase 1·NCT01951508·24 enrolled

Electroencephalography1 trial

Acute Effect of Three Neuroactive Drugs Measured by Magnetoencephalography (MEG), Electroencephalography (EEG) and the Synchronous Neural Interaction Test

Completed·OOrasi Medical, Inc.·N/A·NCT00972985·15 enrolled

Substance Use Disorder1 trial

Impact of Attention Deficit/Hyperactivity Disorder and Substance Use Disorder on Motorcycle Traffic Accidents

Unknown status·FFederal University of Rio Grande do Sul·Phase 4·NCT00536419·53 enrolled

Substance Abuse1 trial

A Study on Suicidality, Psychosis or Substance Abuse With Methylphenidate, Atomoxetine, Amphetamine/Dextroamphetamine or Lisdexamfetamine

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT04132557·430,000 enrolled

Memory1 trial

Ritalin, Memory and Attention in MCI: a Behaviour-EEG Study

Unknown status·MMaastricht University Medical Center·Phase 4·NCT02326038·40 enrolled

Psilocybin1 trial

Precision Functional Brain Mapping in Psilocybin

Completed·WWashington University School of Medicine·Phase 1·NCT04501653·11 enrolled

Pervasive Developmental Disorder1 trial

Methylphenidate in Children and Adolescents With Pervasive Developmental Disorders

Completed·NNational Institute of Mental Health (NIMH)·N/A·NCT00025779·60 enrolled

Autism1 trial

Eye Tracking as a Predictor of Methylphenidate Response in Autism With ADHD

Completed·—·Phase 1·NCT02874690·40 enrolled

Anorexia Nervosa1 trial

Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa

Completed·NNew York State Psychiatric Institute··NCT00670293·50 enrolled

Cerebral Palsy1 trial

Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy

Not yet recruiting·KKuwait University·Phase 1·NCT05675098·30 enrolled

Smoking1 trial

Testing Methylphenidate for Smoking Abstinence

Completed·MMayo Clinic·Phase 2·NCT00549640·80 enrolled

Tolerance1 trial

Examining Tolerance to CNS Stimulants in ADHD

Completed·FFlorida International University·Phase 4·NCT02039908·267 enrolled

Asthenia1 trial

Clinical Trial to Evaluate Short-term Efficacy of Palliative Methylphenidate in Asthenia in Advanced Cancer Patients

Terminated·—·Phase 3·NCT01773837·100 enrolled

Low back pain1 trial

Psilocybin in Chronic Low Back Pain and Depression

Recruiting·JJohns Hopkins University·Phase 1·NCT06355414·40 enrolled

Mental Disorders1 trial

Methylphenidate Study in Young Children With Developmental Disorders

Completed·UUniversity of Arizona·Phase 4·NCT00517504·48 enrolled

Addiction1 trial

Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET

Terminated·YYale University·N/A·NCT02152670·1 enrolled

Major Depressive Disorder1 trial

CONCERTA® (Methylphenidate Hydrochloride) as add-on Therapy in the Treatment of Adult Major Depressive Disorder.

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT00246233·145 enrolled

Alcohol1 trial

Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

Completed·CCraig Rush·Phase 1·NCT03575403·19 enrolled

Infants1 trial

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting·—··NCT03511118·1,600 enrolled

Substance Use1 trial

Intervention for Teens With ADHD and Substance Use

Terminated·FFlorida International University·Phase 3·NCT02502799·158 enrolled

NEC1 trial

Effect of Methylphenidate on Connectivity

Withdrawn·IIris Sommer·Phase 4·NCT01764672

Tramadol1 trial

The Discriminative Effects of Tramadol in Humans

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 1/2·NCT00499746·20 enrolled

Drug1 trial

Targeting Drug Memories With Methylphenidate

Active, not recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT05978167·51 enrolled

Cocaine Abuse1 trial

Methylphenidate Treatment for Cocaine Abuse and ADHD - 1

Completed·NNew York State Psychiatric Institute·Phase 1·NCT00136734·124 enrolled

Coma1 trial

The COMACS Study: A Comparison of Methylphenidates in an Analog Classroom Setting

Completed· UCB logo

UCB·Phase 4·NCT00381758·184 enrolled

Mood Disorder1 trial

EEG-MRI Imaging of Methylphenidate Effects in Adult ADHD and Attentional Symptoms in Mood Disorders

Recruiting·UUniversity Hospital, Strasbourg, France·Phase 3·NCT05832489·80 enrolled

Neurocognitive Function1 trial

Identify Peripheral Biomarkers of Symptomatology, Neurocognitive Functions, and Medication Response in ADHD

Unknown status·NNational Taiwan University Hospital·Phase 4·NCT02074228·120 enrolled

Abuse Potential1 trial

Study for Naltrexone on the Abuse Potential of Methylphenidate

Completed·AAvekshan LLC·Phase 1·NCT03769064·94 enrolled

Psychosis1 trial

A Multimodal Imaging Study of Dopamine in Early Psychosis

Not yet recruiting·NNew York State Psychiatric Institute·Phase 1·NCT06977308·115 enrolled

Growth1 trial

Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth

Completed·FFlorida International University·Phase 3·NCT01109849·230 enrolled

Effectiveness1 trial

Cost-Effectiveness Study Of The Treatment Of Attention Deficit/Hyperactivity Disorder In Brazil

Completed·HHospital de Clinicas de Porto Alegre·Phase 4·NCT01228604·23 enrolled

Sarcoidosis1 trial

Fatigue in Sarcoidosis - Treatment With Methylphenidate

Unknown status·UUniversity of East Anglia·N/A·NCT02643732·30 enrolled

Attention Deficit Hyperactivity Disorder (ADHD)1 trial

Adherence to Stimulant Treatment in Attention-Deficit Hyperactivity Disorder (ADHD) Patients (ASTA)

Terminated·PProf. Huss·Phase 4·NCT00852059·32 enrolled

Neuroimaging1 trial

Identification of Neuropsychological, Genetic and Neuroimaging Markers and Treatment Response Predictors of ADHD

Unknown status·—··NCT02430896·600 enrolled

Pediatric1 trial

Methylphenidate for Attention Problems After Pediatric TBI

Completed·—·Phase 4·NCT01933217·26 enrolled

Type 1 Diabetes1 trial

Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes

Recruiting·MMedical University of Lodz·Phase 2·NCT05957055·150 enrolled

Delirium1 trial

Methylphenidate, Rivastigmine or Haloperidol in Hypoactive Delirium in Intensive Care Patients

Terminated·UUMC Utrecht·Phase 3·NCT00599287·80 enrolled

Methamphetamine Dependence1 trial

Methylphenidate to Treat Methamphetamine Dependence

Unknown status·UUniversity of California, Los Angeles·Phase 2·NCT01044238·90 enrolled

Exercise1 trial

Methylphenidate (Ritalin®) Effect During Exposure to Exercise and Heat Stress in ADD/ADHD Treated Patients

Unknown status·SSheba Medical Center·N/A·NCT02704546·20 enrolled

Depressed1 trial

Study of Methylphenidate as Add on Therapy in Depressed Cancer Patients

Unknown status·UUniversity of Malaya·Phase 3·NCT01497548·120 enrolled

Acute Pain1 trial

Neural Correlates of Acute Pain Dynamics

Completed·NNorthwestern University·Phase 2·NCT05669924·40 enrolled

Excessive Daytime Sleepiness1 trial

Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease

Withdrawn·UUS Department of Veterans Affairs·N/A·NCT00393562

Combination Therapy1 trial

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

Recruiting·MM.D. Anderson Cancer Center·Phase 2/3·NCT05474846·188 enrolled

Toxicity1 trial

Oxygen Toxicity: Mechanisms in Humans

Recruiting·—·N/A·NCT05761756·62 enrolled

Chronic pain1 trial

The Role of Brain Dopamine in Chronic Pain

Recruiting·UUniversity of Rochester·Phase 2·NCT05285683·10 enrolled

Oral1 trial

Behavioral Effects of Drugs: Inpatient (35)

Completed·CCraig Rush·Phase 1·NCT03519022·9 enrolled

Sickle Cell Disease1 trial

Ameliorating Attention Problems in Children With Sickle Cell Disease (SCD)

Completed·TTemple University·Phase 3·NCT01411280·34 enrolled

Interaction1 trial

Cocaine-Methylphendidate Interaction Study - 4

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT00015067·8 enrolled

Social Behavior1 trial

Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

Completed·UUniversity of Zurich·Phase 1·NCT06081179·122 enrolled

Pediatric Patients1 trial

A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder

Completed· Eli Lilly logo

Eli Lilly·Phase 2/3·NCT00922636·340 enrolled

ISS1 trial

Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 4·NCT00015301

Neurofibromatosis Type 11 trial

NF1-Attention: Study of Children With Neurofibromatosis Type 1 Treated by Methylphenidate

Completed·HHospices Civils de Lyon·Phase 4·NCT00169611·80 enrolled

Epilepsy1 trial

Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

Recruiting·VVA Office of Research and Development·Phase 4·NCT04419272·226 enrolled

Imaging1 trial

Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

Recruiting·JJohns Hopkins University·Phase 4·NCT04781972·30 enrolled

Elderly1 trial

Methylphenidate and Cognitive Training in Elderly

Completed·UUniversity Hospital, Lille·Phase 2·NCT03280251·31 enrolled

Tourette syndrome1 trial

Methylphenidate for Treating Children With ADHD and Tourette Syndrome

Completed·SStony Brook University·N/A·NCT00441649·71 enrolled

Myotonic Dystrophy Type 11 trial

Methylphenidate in Myotonic Dystrophy Type 1

Completed·LLaval University·Phase 2/3·NCT01421992·28 enrolled

ESS1 trial

Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness

Active, not recruiting·MMassachusetts General Hospital·Phase 1·NCT03814356·10 enrolled

General Anesthesia1 trial

Reversal of General Anesthesia With Methylphenidate

Completed·MMassachusetts General Hospital·Phase 1/2·NCT02051452·32 enrolled

Bariatric Surgery1 trial

Bariatric Surgery and Pharmacokinetics of Methylphenidate

Completed·NNorwegian University of Science and Technology··NCT03440190·1 enrolled

Emotional Dysregulation1 trial

Efficacy of Reboxetine and Methylphenidate Treatment on Attentional, Sensory and Emotional Dysregulation in Adults With PTSD

Recruiting·—·Phase 2·NCT05133804·53 enrolled

Trichotillomania1 trial

Methylphenidate in ADHD With Trichotillomania

Unknown status·GGeha Mental Health Center·Phase 4·NCT00552266·30 enrolled

Clonidine1 trial

Preschool Supplement to Clonidine in ADHD (Kiddie-CAT)

Completed·UUniversity of Cincinnati·Phase 2·NCT00414921·30 enrolled

Magnetic Resonance Imaging1 trial

A Study of the Ability of Functional Magnetic Resonance Imaging (fMRI) to Detect and Characterize the Effects of Two Marketed Centrally Active Drugs, Placebo, and RO4917523 in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01045083·25 enrolled

Borderline personality disorder1 trial

The Effects of Methylphenidate on Symptomatology in Individuals With Borderline Personality Disorder

Not yet recruiting·TTanta University·Phase 1·NCT06759298·60 enrolled

MPR1 trial

Methylphenidate to Improve Balance and Walking in MS

Completed·OOregon Health and Science University·Phase 2/3·NCT01896700·24 enrolled

Unspecified5 trials

ERP Based Single-dose Predictions of Stimulants

Completed·OOstfold Hospital Trust·Phase 2·NCT02695355·87 enrolled

The Role of Methylphenidate on Performance in the Cold

Unknown status·—·Phase 4·NCT04283877·24 enrolled

Methylphenidate Effect on Humphrey Visual Fields

Completed·RRabin Medical Center·N/A·NCT02162381·32 enrolled

Show 2 more trials

Impulsivity and Stimulant Administration

Completed·YYale University·Phase 1·NCT01978431·29 enrolled

Emotional Effects of Methylphenidate and MDMA in Healthy Subjects

Completed·UUniversity Hospital, Basel, Switzerland·Phase 1·NCT01465685·16 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

RITALIN

NDA NDA010187

Mar 30, 1982

RITALIN-SR

NDA NDA018029

Aug 1, 2000

CONCERTA

NDA NDA021121

Dec 19, 2002

METHYLIN

NDA NDA021419

Apr 15, 2003

METHYLIN

NDA NDA021475

May 27, 2003

METADATE CD

NDA NDA021259

Apr 10, 2004

RITALIN LA

NDA NDA021284

Apr 6, 2006

DAYTRANA

NDA NDA021514

Sep 27, 2012

QUILLIVANT XR

NDA NDA202100

Apr 17, 2015

APTENSIO XR

NDA NDA205831

Dec 4, 2015

QUILLICHEW ER

NDA NDA207960

Jun 19, 2017

COTEMPLA XR-ODT

NDA NDA205489

Aug 8, 2018

JORNAY PM

NDA NDA209311

Feb 27, 2019

ADHANSIA XR

NDA NDA212038

Jun 23, 2022

RELEXXII

NDA NDA216117

Sources

References

[1]
ClinicalTrials.gov — 216 trial records for Methylphenidate. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ritalin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Methylphenidate compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Methylphenidate. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA216117). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Ritalin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Novartis company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Dopamine Transporter Inhibitor; Norepinephrine Transporter Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Novartis

Patent Landscape[6]

Patent Cliff

Mar 15, 2027

Earliest patent expiration — generic entry possible after this date

Patent #Expires

8202537Mar 15, 2027

9040083Feb 15, 2031

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