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Other/Radiation Therapy

Radiation Therapy

24

Pipeline Programs↗

17

Active Trials↗

26

Companies Involved↗

Radiation Therapy is an emerging landscape with 24 programs across 26 companies. 10 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

53/100

Pipeline Velocity

11/100

Mech. Concentration

22/100

Completion Rate

68/100

Attrition Rate

25/100

Pipeline

Programs by Phase

Preclinical3

Systemic Chemotherapy

Sun Yat-sen University

Technetium Tc-99m DTPA

University of Washington

Zoladex

Luye Pharma Group Ltd.

Phase 12

Nelfinavir

Agouron Pharmaceuticals

Leucovorin

Glaxo Dba Glaxosmithkline

Phase 29

Anlotinib Hydrochloride

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Systemic Therapy

Bristol-Myers Squibb

Experimental

Biogen

MK-3475

Pfizer

ASG-22CE

Astellas

Phase 310

Dactinomycin

RECORDATI GROUP

Androgen Deprivation Therapy

Johnson & Johnson

Darolutamide

Bayer

Androgen Blockade

Abdenour Nabid

Cisplatin

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

No programs

Analysis

Modality Breakdown

86%

Small molecule

19 of 22 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 22 classified programs, each share of the total. Modality classified for 100% of 24 pipeline programs.

Analysis

Trial Status

165

clinical trials

Completed86 · 52%

Terminated34 · 21%

Unknown status21 · 13%

Recruiting14 · 8%

Withdrawn7 · 4%

Active, not recruiting2 · 1%

Other1 · 1%

Clinical Trials

Trial Activity

165 trials

Large Fraction Radiation Therapy Combined With Lenalidomide, and Glofitamab in Refractory Relapsed DLBCL

Recruiting·TThe First Affiliated Hospital of Xiamen University·Phase 2·NCT06651853·22 enrolled

Local Consolidative Radiation Therapy Plus TKI Versus TKI Alone in Driver Mutated OM-NSCLC

Recruiting·TTata Memorial Hospital·Phase 2·NCT05277844·106 enrolled

Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery

Recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT04169763·25 enrolled

68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.

Recruiting·PPeking Union Medical College Hospital·Phase 2·NCT06613269·40 enrolled

A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Cancer

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT05491512·121 enrolled

Pembrolizumab and EV With Radiation Therapy for MIBC Patients (PEVRAD)

Recruiting·—·Phase 2·NCT05879653·30 enrolled

Treatment With Darolutamide +/- Radiation Therapy for Patients With a Castration Resistant Cancer and Metastases Detected by Functional Imaging

Recruiting·UUNICANCER·Phase 3·NCT06276465·336 enrolled

Testing the Addition of Radiation Therapy to the Immune Therapy Treatment for ES-SCLC

Recruiting·ZZhejiang Cancer Hospital·Phase 2·NCT06350162·100 enrolled

Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

Recruiting·JJonsson Comprehensive Cancer Center·Phase 1·NCT04703101·25 enrolled

Concurrent Chemotherapy Plus HFR Radiation Therapy in Inoperable NSCLC

Recruiting·SState University of New York - Upstate Medical University·Phase 1·NCT02619448·12 enrolled

Radiation Therapy Followed by Tislelizumab and Anlotinib Aeoadjuvant/Adjuvant Therapy for Stage II-IIIA NSCLC

Recruiting·—·Phase 2·NCT06379087·20 enrolled

Development and Evaluation of Imaging Acquisition and Analysis Methods for Optimization of MRI and/or CT in Radiation Oncology Simulation, Treatment Planning, and Response Assessment

Recruiting·MMemorial Sloan Kettering Cancer Center·N/A·NCT02422550·937 enrolled

Capturing Food Intake in Patients Undergoing Radiation Therapy for Cancer

Recruiting·UUniversity of Minnesota·Preclinical·NCT07682714·20 enrolled

Effectiveness of Virtual Reality in the Management of Anxiety for Patients Undergoing Radiotherapy

Recruiting·WWake Forest University Health Sciences·Preclinical·NCT07324577·54 enrolled

Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor

Active, not recruiting·Children's Oncology Group·Phase 3·NCT00352534·808 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)