systemic chemotherapy

Phase 3Small molecule

SSun Yat-sen University

systemic chemotherapy is one of 161 small molecule programs targeting Adenocarcinoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

160

Competitors

Pipeline

Status by Indication[3][1]

Indication

AdenocarcinomaActive, not recruiting

Breast Ductal Carcinoma in SituActive, not recruiting

ChemotherapyTerminated

Radiation TherapyWithdrawn

Colorectal CancerRecruiting

AdenocarcinomaPreclinical

Active, not recruiting

Breast Ductal Carcinoma in SituPhase 3

Active, not recruiting

ChemotherapyPreclinical

Terminated

Radiation TherapyPreclinical

Withdrawn

Colorectal CancerPhase 3

Recruiting

Competition

Competitive Landscape

268 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

Opdivo

Bristol-Myers Squibb

Phase 3

24 2

Decadron

AAspen Global Incorporated

Phase 3

7 3

Trifluridine/tipiracil

AbbVie

Phase 3

3 4

Botensilimab

AAgenus Inc.

Phase 3

10 5

Zanzalintinib

Merck & Co.

Phase 3

1 6

systemic chemotherapy

SSun Yat-sen University

Phase 3

5 7

Huaier Granule

QQidong Gaitianli Medicines Co., Ltd

Phase 3

4 8

Calcium Folinate

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Phase 3

3 9

BL-M07D1

SSichuan Baili Pharmaceutical Co., Ltd.

Phase 3

1 10

SHR-A1811

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 3Active, not recruiting

Breast Ductal Carcinoma in Situ

NCT01272037

Clinical

Trials by Indication[1]

Colorectal Cancer5 trials

Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis

Recruiting·—·Phase 3·NCT04370925·688 enrolled

HIPEC and Systemic Chemotherapy in Unresectable Peritoneal Metastases From Colorectal Cancer

Terminated·WWuhan University·N/A·NCT03398512·15 enrolled

Second Look Laparoscopy in Colorectal Cancer

Unknown status·NNational Cancer Institute, Naples·Phase 2·NCT01628211·140 enrolled

Show 2 more trials

Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase

Completed·UUniversity of Ulm·Phase 2·NCT01212718·168 enrolled

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer

Completed·SSirtex Medical·N/A·NCT00724503·530 enrolled

Breast Cancer4 trials

Older Patients With Newly Diagnosed Breast Cancer or Colon Cancer

Terminated·—··NCT00740961·63 enrolled

Hormone Therapy Or Chemotherapy Before Surgery Based on Gene Expression Analysis in Treating Patients With Breast Cancer

Completed·VVirginia Commonwealth University·N/A·NCT01293032·59 enrolled

MRI in Predicting Early Response to Chemotherapy in Patients With Locally Advanced Breast Cancer

Completed·CCancer Clinical Trials Unit, Scotland·Phase 2·NCT00978770·50 enrolled

Show 1 more trial

Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00881361·756 enrolled

Gastric Cancer3 trials

HIPEC and Systemic Chemotherapy Combined With Apatinib in Unresectable Peritoneal Metastases From Gastric Cancer

Terminated·WWuhan University·N/A·NCT03349827·20 enrolled

Efficacy of HIPEC in the Treatment of Locally Advanced Gastric Cancer After radIcal Gastrectomy With D2

Unknown status·—·Phase 3·NCT02356276·584 enrolled

Intra-arterial Infusion Chemotherapy Combined With Sodium Bicarbonate for Unresectable Gastric Cancer

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1·NCT03822130·150 enrolled

Hepatocellular Carcinoma2 trials

Factors Affecting Post-treatment Outcomes in Patients With Hepatocellular Carcinoma

Completed·SSohag University··NCT04553458·407 enrolled

Adjuvant Transcatheter Arterial Chemoembolization Versus Adjuvant Systemic Chemotherapy for Hepatocellular Carcinoma

Withdrawn·GGuangxi Medical University·Phase 2/3·NCT02584556

Metastasis2 trials

Systemic Chemotherapy, Lenvatinib Plus Sintilimab for ICC With Distant Metastasis

Unknown status·SSun Yat-sen University·Phase 2·NCT04769908·40 enrolled

Systemic Chemotherapy, Apatinib Plus Sintilimab for Metastasis ICC

Withdrawn·SSun Yat-sen University·Phase 2·NCT04682249

13 more indications

Adenocarcinoma1 trial

Postoperative Chemotherapy in High-Grade Appendiceal Adenocarcinoma With Peritoneal Carcinomatosis

Terminated·UUniversity of California, San Diego··NCT02420509·2 enrolled

Nausea and vomiting1 trial

Fosaprepitant Dimeglumine in Treating Patients With Nausea and Vomiting Caused By Chemotherapy

Terminated·OOHSU Knight Cancer Institute·Phase 1/2·NCT01031953·34 enrolled

Melanoma1 trial

Hepatic Arterial Infusion With Melphalan Compared With Standard Therapy in Treating Patients With Unresectable Liver Metastases Due to Melanoma

Completed·DDelcath Systems Inc.·Phase 3·NCT00324727·93 enrolled

Stage III Rectal Cancer1 trial

Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing Chemotherapy and Radiation Therapy for Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery

Withdrawn·BBarbara Ann Karmanos Cancer Institute·Phase 1·NCT00960427

Glioma1 trial

ADV-TK Improves Outcome of Recurrent High-Grade Glioma

Completed·HHuazhong University of Science and Technology·Phase 2·NCT00870181·47 enrolled

Completed·VVanderbilt University··NCT00751816·23 enrolled

Rectum Cancer1 trial

Computed Tomography-guided Brachytherapy Plus Chemotherapy for Locally Recurrent Rectum Cancer

Completed·TThe First People's Hospital of Changzhou·Phase 2·NCT02423226·56 enrolled

Esophageal Squamous Cell Carcinoma1 trial

Esophageal Arterial Infusion Chemotherapy Versus Systemic Intravenous Chemotherapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: a Prospective, Multicentre, Randomised Controlled Clinical Study

Unknown status·TThe First Affiliated Hospital of Zhengzhou University·Phase 2·NCT05381636·120 enrolled

Metastatic Colorectal Cancer1 trial

Chemotherapy With or Without Surgery in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery

Completed·UUniversity College London Hospitals·Phase 2/3·NCT01086618·500 enrolled

Cholangiocarcinoma1 trial

Chemo Alone or in Combination With Radiation in Unresectable Cholangiocarcinoma

Unknown status·TTata Memorial Hospital·Phase 3·NCT02773485·155 enrolled

Breast Ductal Carcinoma in Situ1 trial

A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial Rx for Positive Node, Endocrine Responsive Breast Cancer

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 3·NCT01272037·5,018 enrolled

Sources

References

[1]
ClinicalTrials.gov — 29 trial records for systemic chemotherapy. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — systemic chemotherapy compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for systemic chemotherapy. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Sun Yat-sen University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: SSun Yat-sen University

systemic chemotherapy

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Trials by Indication[1]

Colorectal Cancer5 trials

Breast Cancer4 trials

Gastric Cancer3 trials

Hepatocellular Carcinoma2 trials

Metastasis2 trials

Adenocarcinoma1 trial

Nausea and vomiting1 trial

Melanoma1 trial

Stage III Rectal Cancer1 trial

Glioma1 trial

Chemotherapy1 trial

Radiation Therapy1 trial

Head Neck Cancer1 trial

Rectum Cancer1 trial

Esophageal Squamous Cell Carcinoma1 trial

Metastatic Colorectal Cancer1 trial

Cholangiocarcinoma1 trial

Breast Ductal Carcinoma in Situ1 trial

References

Drug Info

Quick Facts

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