VivoSeq
Neurology

Sciatica

26

Pipeline Programs↗

3

Active Trials↗

15

Companies Involved↗

Sciatica is an emerging landscape with 26 programs across 15 companies. The most active players are Biogen, Hikma Pharmaceuticals LLC, Specgx. 7 therapies are approved with 7 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

0/100

Mech. Concentration

24/100

Completion Rate

88/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Biogen logo

Biogen

1 program

Phase 1H

Hikma Pharmaceuticals LLC

1 program

Phase 2S

Specgx

1 program

Phase 2AbbVie logo

AbbVie

1 program

Phase 2UCB logo

UCB

1 program

Phase 3C

Cerimon Pharmaceuticals

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

89%

Small molecule

25 of 28 classified programs — the dominant modality here.

11%ALL OTHERSProtein / enzyme27%Monoclonal antibody14%

Small molecule leads; the ring shows all 28 classified programs, each share of the total. Modality classified for 100% of 28 pipeline programs.

Analysis

Trial Status

24

clinical trials

Completed15 · 63%
Unknown status4 · 17%
Recruiting3 · 13%
Terminated2 · 8%

Clinical Trials

Trial Activity

24 trials

Prediction of TEI Success in Sciatica
Recruiting·—·N/A·NCT04540068·388 enrolled
Transforaminal Epidural Injection in Acute Sciatica
Recruiting·CC.L.A.Vleggeert-Lankamp·N/A·NCT03924791·142 enrolled
Prevalence of Three CT Signs of Nerve-root Suffering (Root Size Asymmetry/Hypertrophy, Peri-radicular Infiltration, Spontaneous Hyperdensity) in Patients With Low-back Sciatica Referred for CT-guided Foraminal Infiltration: a Single-centre Retrospective Study (Nice University Hospital - Pasteur 2).
Recruiting·CCentre Hospitalier Universitaire de Nice·N/A·NCT07690449·400 enrolled
PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
Completed·MMassachusetts General Hospital·N/A·NCT02130271·42 enrolled
NSAIDs in Sciatica NSAIDS IN SCIATICA
Completed·OOstfold Hospital Trust·Phase 4·NCT03347929·123 enrolled
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
Completed·PPakistan Institute of Medical Sciences·Phase 3·NCT05626140·120 enrolled
Pain Treatment for Sciatica
Completed·National Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00009672·80 enrolled
Topiramate in the Treatment of Sciatica
Completed·National Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00011804·65 enrolled
Efficacy of Soluble Dexamethasone in Refractory Sciatica
Completed·NNantes University Hospital·Phase 3·NCT05000658·109 enrolled
[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica
Completed·SStanford University·Phase 1·NCT02753101·24 enrolled
Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciatica.
Completed·Biogen logoBiogen·Phase 1·NCT01405833·56 enrolled
The Efficacy of Oral Steroids in the Treatment of Acute Sciatica
Completed·—·Phase 3·NCT00317447·160 enrolled
Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Participants
Completed·Biogen logoBiogen·Phase 1·NCT00961766·48 enrolled
Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica
Completed·UUniversity Hospital, Grenoble·Phase 4·NCT01816334·50 enrolled
Observational Study on Effectiveness and Safety of Integrative Korean Medicine Treatment for Inpatients With Sciatica Due to Lumbar Intervertebral Disc Herniation
Completed·JJaseng Medical Foundation·N/A·NCT03750591·1,000 enrolled
Page 1 of 2

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)